当前位置： SCI文献检索 > Marine Drugs期刊下所有文献 > Spiromastixones Inhibit Foam Cell Formation via Regulation of Cholesterol Efflux and Uptake in RAW264.7 Macrophages.

Spiromastixones Inhibit Foam Cell Formation via Regulation of Cholesterol Efflux and Uptake in RAW264.7 Macrophages.

Abstract：

:Bioassay-guided evaluation shows that a deep sea-derived fungus, Spiromastix sp. MCCC 3A00308, possesses lipid-lowering activity. Chromatographic separation of a culture broth resulted in the isolation of 15 known depsidone-based analogues, labeled spiromastixones A-O (1-15). Each of these compounds was tested for its ability to inhibit oxidized low-density lipoprotein (oxLDL)-induced foam cell formation in RAW264.7 macrophages. Spiromastixones 6-8 and 12-14 significantly decreased oxLDL-induced lipid over-accumulation, reduced cell surface area, and reduced intracellular cholesterol concentration. Of these compounds, spiromastixones 6 and 14 exerted the strongest inhibitory effects. Spiromastixones 6 and 14 dramatically inhibited cholesterol uptake and stimulated cholesterol efflux to apolipoprotein A1 (ApoA1) and high-density lipoprotein (HDL) in RAW264.7 macrophages. Mechanistic investigation indicated that spiromastixones 6, 7, 12 and 14 significantly up-regulated the mRNA levels of ATP-binding cassette sub-family A1 (ABCA1) and down-regulated those of scavenger receptor CD36, while the transcription of ATP-binding cassette sub-family A1 (ABCG1) and proliferator-activated receptor gamma (PPARγ) were selectively up-regulated by 6 and 14. A transactivation reporter assay revealed that spiromastixones 6 and 14 remarkably enhanced the transcriptional activity of PPARγ. These results suggest that spiromastixones inhibit foam cell formation through upregulation of PPARγ and ABCA1/G1 and downregulation of CD36, indicating that spiromastixones 6 and 14 are promising lead compounds for further development as anti-atherogenic agents.

journal_name

Mar Drugs

journal_title

Marine drugs

authors

Wu C,Chen R,Liu M,Liu D,Li X,Wang S,Niu S,Guo P,Lin W

doi

10.3390/md13106352

subject

Has Abstract

pub_date

2015-10-14 00:00:00

pages

6352-65

issue

10

issn

1660-3397

pii

md13106352

journal_volume

13

pub_type

杂志文章

相关文献

Marine Drugs文献大全
  • Characterization of a New Trioxilin and a Sulfoquinovosyl Diacylglycerol with Anti-Inflammatory Properties from the Dinoflagellate Oxyrrhis marina.

    abstract：:Two new compounds-a trioxilin and a sulfoquinovosyl diacylglycerol (SQDG)-were isolated from the methanolic extract of the heterotrophic dinoflagellate Oxyrrhis marina cultivated by feeding on dried yeasts. The trioxilin was identified as (4Z,8E,13Z,16Z,19Z) -7(S),10(S),11(S)-trihydroxydocosapentaenoic acid (1), and t...

    journal_title：Marine drugs

    pub_type： 杂志文章

    doi：10.3390/md15030057

    authors： Yoon EY,Yang AR,Park J,Moon SJ,Jeong EJ,Rho JR

    更新日期：2017-02-27 00:00:00

  • Astaxanthin from Shrimp Cephalothorax Stimulates the Immune Response by Enhancing IFN-γ, IL-10, and IL-2 Secretion in Splenocytes of Helicobacter Pylori-Infected Mice.

    abstract：:Infection with Helicobacter pylori is a critical cause of gastrointestinal diseases. A crucial host response associated with H. pylori infection includes gastric inflammation, which is characterized by a sustained recruitment of T-helper (Th) cells to the site of infection and distinct patterns of cytokine production....

    journal_title：Marine drugs

    pub_type： 杂志文章

    doi：10.3390/md17070382

    authors： Davinelli S,Melvang HM,Andersen LP,Scapagnini G,Nielsen ME

    更新日期：2019-06-26 00:00:00

  • Collagen Extraction Optimization from the Skin of the Small-Spotted Catshark (S. canicula) by Response Surface Methodology.

    abstract：:The small-spotted catshark is one of the most abundant elasmobranchs in the Northeastern Atlantic Ocean. Although its landings are devoted for human consumption, in general this species has low commercial value with high discard rates, reaching 100% in some European fisheries. The reduction of post-harvest losses (dis...

    journal_title：Marine drugs

    pub_type： 杂志文章

    doi：10.3390/md17010040

    authors： Blanco M,Vázquez JA,Pérez-Martín RI,G Sotelo C

    更新日期：2019-01-09 00:00:00

  • Bacterial exopolysaccharides from extreme marine habitats: production, characterization and biological activities.

    abstract：:Many marine bacteria produce exopolysaccharides (EPS) as a strategy for growth, adhering to solid surfaces, and to survive adverse conditions. There is growing interest in isolating new EPS producing bacteria from marine environments, particularly from extreme marine environments such as deep-sea hydrothermal vents ch...

    journal_title：Marine drugs

    pub_type： 杂志文章,评审

    doi：10.3390/md8061779

    authors： Poli A,Anzelmo G,Nicolaus B

    更新日期：2010-06-03 00:00:00

  • Expression, Purification and Characterization of Chondroitinase AC II from Marine Bacterium Arthrobacter sp. CS01.

    abstract：:Chondroitinase (ChSase), a type of glycosaminoglycan (GAG) lyase, can degrade chondroitin sulfate (CS) to unsaturate oligosaccharides, with various functional activities. In this study, ChSase AC II from a newly isolated marine bacterium Arthrobacter sp. CS01 was cloned, expressed in Pichia pastoris X33, purified, and...

    journal_title：Marine drugs

    pub_type： 杂志文章

    doi：10.3390/md17030185

    authors： Fang Y,Yang S,Fu X,Xie W,Li L,Liu Z,Mou H,Zhu C

    更新日期：2019-03-20 00:00:00

  • New Insights on the terpenome of the red seaweed Laurencia dendroidea (Florideophyceae, Rhodophyta).

    abstract：:The red seaweeds belonging to the genus Laurencia are well known as halogenated secondary metabolites producers, mainly terpenoids and acetogennins. Several of these chemicals exhibit important ecological roles and biotechnological applications. However, knowledge regarding the genes involved in the biosynthesis of th...

    journal_title：Marine drugs

    pub_type： 杂志文章

    doi：10.3390/md13020879

    authors： de Oliveira LS,Tschoeke DA,de Oliveira AS,Hill LJ,Paradas WC,Salgado LT,Thompson CC,Pereira RC,Thompson FL

    更新日期：2015-02-10 00:00:00

  • Plakofuranolactone as a Quorum Quenching Agent from the Indonesian Sponge Plakortis cf. lita.

    abstract：:There is an urgent need for novel strategies to fight drug resistance and multi-drug resistance. As an alternative to the classic antibiotic therapy, attenuation of the bacteria virulence affecting their Quorum sensing (QS) system is a promising approach. Quorum sensing (QS) is a genetic regulation system that allows ...

    journal_title：Marine drugs

    pub_type： 杂志文章

    doi：10.3390/md15030059

    authors： Costantino V,Della Sala G,Saurav K,Teta R,Bar-Shalom R,Mangoni A,Steindler L

    更新日期：2017-02-28 00:00:00

  • Microginins from a Microcystis sp. Bloom Material Collected from the Kishon Reservoir, Israel.

    abstract：:During blooms, cyanobacteria produce diverse modified peptides. Among these are the microginins, which inhibit zinc-containing metalloproteases. Ten microginins, microginins KR767 (1), KR801(2), KR835 (3), KR785 (4), KR604 (5), KR638 (6), KR781 (7), KR815 (8), FR3 (9), and FR4 (10), were isolated from the extract of a...

    journal_title：Marine drugs

    pub_type： 杂志文章

    doi：10.3390/md16030078

    authors： Lodin-Friedman A,Carmeli S

    更新日期：2018-03-02 00:00:00

  • Characterization of a Newly Isolated Marine Fungus Aspergillus dimorphicus for Optimized Production of the Anti-Tumor Agent Wentilactones.

    abstract：:The potential anti-tumor agent wentilactones were produced by a newly isolated marine fungus Aspergillus dimorphicus. This fungus was derived from deep-sea sediment and identified by polyphasic approach, combining phenotypic, molecular, and extrolite profiles. However, wentilactone production was detected only under s...

    journal_title：Marine drugs

    pub_type： 杂志文章

    doi：10.3390/md13117040

    authors： Xu R,Xu GM,Li XM,Li CS,Wang BG

    更新日期：2015-11-19 00:00:00

  • MS/MS-Based Molecular Networking Approach for the Detection of Aplysiatoxin-Related Compounds in Environmental Marine Cyanobacteria.

    abstract：:Certain strains of cyanobacteria produce a wide array of cyanotoxins, such as microcystins, lyngbyatoxins and aplysiatoxins, that are associated with public health issues. In this pilot study, an approach combining LC-MS/MS and molecular networking was employed as a rapid analytical method to detect aplysiatoxins pres...

    journal_title：Marine drugs

    pub_type： 杂志文章

    doi：10.3390/md16120505

    authors： Ding CYG,Pang LM,Liang ZX,Goh KKK,Glukhov E,Gerwick WH,Tan LT

    更新日期：2018-12-13 00:00:00

  • Mannose-Specific Lectins from Marine Algae: Diverse Structural Scaffolds Associated to Common Virucidal and Anti-Cancer Properties.

    abstract：:To date, a number of mannose-specific lectins have been isolated and characterized from seaweeds, especially from red algae. In fact, man-specific seaweed lectins consist of different structural scaffolds harboring a single or a few carbohydrate-binding sites which specifically recognize mannose-containing glycans. De...

    journal_title：Marine drugs

    pub_type： 杂志文章,评审

    doi：10.3390/md17080440

    authors： Barre A,Simplicien M,Benoist H,Van Damme EJM,Rougé P

    更新日期：2019-07-26 00:00:00

  • Design, synthesis and biological evaluation of tasiamide analogues as tumor inhibitors.

    abstract：:Eighteen analogues of the marine cytotoxic linear peptide tasiamide were designed, synthesized and screened for their inhibitory activities against the growth of human nasopharyngeal carcinoma (KB) and human non-small cell lung tumor (A549) cell lines. The results indicated that minor modifications of the C-terminus w...

    journal_title：Marine drugs

    pub_type： 杂志文章

    doi：10.3390/md12042308

    authors： Zhang W,Sun T,Ma Z,Li Y

    更新日期：2014-04-22 00:00:00

  • Plakinamine P, A Steroidal Alkaloid with Bactericidal Activity against Mycobacterium tuberculosis.

    abstract：:Tuberculosis is the leading cause of death due to infectious disease worldwide. There is an urgent need for more effective compounds against this pathogen to control the disease. Investigation of the anti-mycobacterial activity of a deep-water sponge of the genus Plakina revealed the presence of a new steroidal alkalo...

    journal_title：Marine drugs

    pub_type： 杂志文章

    doi：10.3390/md17120707

    authors： Rodrigues Felix C,Roberts JC,Winder PL,Gupta R,Diaz MC,Pomponi SA,Wright AE,Rohde KH

    更新日期：2019-12-16 00:00:00

  • Functional feed assessment on Litopenaeus vannamei using 100% fish meal replacement by soybean meal, high levels of complex carbohydrates and Bacillus probiotic strains.

    abstract：:Functional feed supplemented with alternative-economic nutrient sources (protein, carbohydrates, lipids) and probiotics are being considered in shrimp/fish aquaculture production systems as an option to increase yield and profits and to reduce water pollution. In this study the probiotic potential to formulate functio...

    journal_title：Marine drugs

    pub_type： 杂志文章

    doi：10.3390/md9061119

    authors： Olmos J,Ochoa L,Paniagua-Michel J,Contreras R

    更新日期：2011-01-01 00:00:00

  • Structure elucidation of new acetylated saponins, Lessoniosides A, B, C, D, and E, and non-acetylated saponins, Lessoniosides F and G, from the viscera of the sea cucumber Holothuria lessoni.

    abstract：:Sea cucumbers produce numerous compounds with a wide range of chemical structural diversity. Among these, saponins are the most diverse and include sulfated, non-sulfated, acetylated and methylated congeners with different aglycone and sugar moieties. In this study, MALDI and ESI tandem mass spectrometry, in the posit...

    journal_title：Marine drugs

    pub_type： 杂志文章

    doi：10.3390/md13010597

    authors： Bahrami Y,Franco CM

    更新日期：2015-01-16 00:00:00

  • Fucus vesiculosus and Ascophyllum nodosum Ameliorate Liver Function by Reducing Diet-Induced Steatosis in Rats.

    abstract：:The Asian coastal communities have used the brown seaweeds Fucus vesiculosus and Ascophyllum nodosum since ancient times. Recently, some in vitro and in vivo studies have demonstrated their abilities in reducing risk factors for metabolic syndrome. Here, we analyzed the protective effect of a phytocomplex extracted fr...

    journal_title：Marine drugs

    pub_type： 杂志文章

    doi：10.3390/md18010062

    authors： Gabbia D,Saponaro M,Sarcognato S,Guido M,Ferri N,Carrara M,De Martin S

    更新日期：2020-01-17 00:00:00

  • The Oxepane Motif in Marine Drugs.

    abstract：:Oceans have shown to be a remarkable source of natural products. The biological properties of many of these compounds have helped to produce great advances in medicinal chemistry. Within them, marine natural products containing an oxepanyl ring are present in a great variety of algae, sponges, fungus and corals and sh...

    journal_title：Marine drugs

    pub_type： 杂志文章,评审

    doi：10.3390/md15110361

    authors： Barbero H,Díez-Poza C,Barbero A

    更新日期：2017-11-15 00:00:00

  • Pinnatoxins' Deleterious Effects on Cholinergic Networks: From Experimental Models to Human Health.

    abstract：:Pinnatoxins (PnTXs) are emerging neurotoxins that were discovered about 30 years ago. They are solely produced by the marine dinoflagellate Vulcanodinium rugosum, and may be transferred into the food chain, as they have been found in various marine invertebrates, including bivalves. No human intoxication has been repo...

    journal_title：Marine drugs

    pub_type： 杂志文章,评审

    doi：10.3390/md17070425

    authors： Delcourt N,Lagrange E,Abadie E,Fessard V,Frémy JM,Vernoux JP,Peyrat MB,Maignien T,Arnich N,Molgó J,Mattei C

    更新日期：2019-07-20 00:00:00

  • Gliotoxin isolated from marine fungus Aspergillus sp. induces apoptosis of human cervical cancer and chondrosarcoma cells.

    abstract：:Gliotoxin, a secondary metabolite produced by marine fungus Aspergillus sp., possesses various biological activities including anticancer activity. However, the mechanism underlying gliotoxin-induced cytotoxicity on human cervical cancer (Hela) and human chondrosarcoma (SW1353) cells remains unclear. In this study, we...

    journal_title：Marine drugs

    pub_type： 杂志文章

    doi：10.3390/md12010069

    authors： Nguyen VT,Lee JS,Qian ZJ,Li YX,Kim KN,Heo SJ,Jeon YJ,Park WS,Choi IW,Je JY,Jung WK

    更新日期：2013-12-24 00:00:00

  • Lipidomic Approaches towards Deciphering Glycolipids from Microalgae as a Reservoir of Bioactive Lipids.

    abstract：:In recent years, noteworthy research has been performed around lipids from microalgae. Among lipids, glycolipids (GLs) are quite abundant in microalgae and are considered an important source of fatty acids (FAs). GLs are rich in 16- and 18-carbon saturated and unsaturated fatty acids and often contain polyunsaturated ...

    journal_title：Marine drugs

    pub_type： 杂志文章,评审

    doi：10.3390/md14050101

    authors： da Costa E,Silva J,Mendonça SH,Abreu MH,Domingues MR

    更新日期：2016-05-19 00:00:00

  • Anticancer Activity of Fascaplysin against Lung Cancer Cell and Small Cell Lung Cancer Circulating Tumor Cell Lines.

    abstract：:Lung cancer is a leading cause of tumor-associated mortality. Fascaplysin, a bis-indole of a marine sponge, exhibit broad anticancer activity as specific CDK4 inhibitor among several other mechanisms, and is investigated as a drug to overcome chemoresistance after the failure of targeted agents or immunotherapy. The c...

    journal_title：Marine drugs

    pub_type： 杂志文章

    doi：10.3390/md16100383

    authors： Rath B,Hochmair M,Plangger A,Hamilton G

    更新日期：2018-10-14 00:00:00

  • Cloning and characterization of glutamate receptors in Californian sea lions (Zalophus californianus).

    abstract：:Domoic acid produced by marine algae has been shown to cause acute and chronic neurologic sequelae in Californian sea lions following acute or low-dose exposure. Histological findings in affected animals included a degenerative cardiomyopathy that was hypothesized to be caused by over-excitation of the glutamate recep...

    journal_title：Marine drugs

    pub_type： 杂志文章

    doi：10.3390/md8051637

    authors： Gill S,Goldstein T,Situ D,Zabka TS,Gulland FM,Mueller RW

    更新日期：2010-05-06 00:00:00

  • A kinetic study of accumulation and elimination of microcystin-LR in yellow perch (Perca flavescens) tissue and implications for human fish consumption.

    abstract：:Fish consumption is a potential route of human exposure to the hepatotoxic microcystins, especially in lakes and reservoirs that routinely experience significant toxic Microcystis blooms. Understanding the rates of uptake and elimination for microcystins as well as the transfer efficiency into tissues of consumers are...

    journal_title：Marine drugs

    pub_type： 杂志文章

    doi：10.3390/md9122553

    authors： Dyble J,Gossiaux D,Landrum P,Kashian DR,Pothoven S

    更新日期：2011-12-01 00:00:00

  • Carotenoid Profiling of a Red Seaweed Pyropia yezoensis: Insights into Biosynthetic Pathways in the Order Bangiales.

    abstract：:Carotenoids are natural pigments that contribute to light harvesting and photo-protection in photosynthetic organisms. In this study, we analyzed the carotenoid profiles, including mono-hydroxy and epoxy-carotenoids, in the economically valuable red seaweed Pyropia yezoensis, to clarify the detailed biosynthetic and m...

    journal_title：Marine drugs

    pub_type： 杂志文章

    doi：10.3390/md16110426

    authors： Koizumi J,Takatani N,Kobayashi N,Mikami K,Miyashita K,Yamano Y,Wada A,Maoka T,Hosokawa M

    更新日期：2018-11-01 00:00:00

  • Innovative Approach to Sustainable Marine Invertebrate Chemistry and a Scale-Up Technology for Open Marine Ecosystems.

    abstract：:Isolation of marine compounds from living invertebrates represents a major challenge for sustainable and environmentally friendly exploitation of marine bio-resources. To develop innovative technology to trap invertebrate compounds in the open sea, the proof of concept of a system combining external continuous circula...

    journal_title：Marine drugs

    pub_type： 杂志文章

    doi：10.3390/md16050152

    authors： Vlachou P,Le Goff G,Alonso C,Álvarez PA,Gallard JF,Fokialakis N,Ouazzani J

    更新日期：2018-05-06 00:00:00

  • The Epiphytic Genus Gambierdiscus (Dinophyceae) in the Kermadec Islands and Zealandia Regions of the Southwestern Pacific and the Associated Risk of Ciguatera Fish Poisoning.

    abstract：:Species in the genus Gambierdiscus produce ciguatoxins (CTXs) and/or maitotoxins (MTXs), which may cause ciguatera fish poisoning (CFP) in humans if contaminated fish are consumed. Species of Gambierdiscus have previously been isolated from macroalgae at Rangitahua (Raoul Island and North Meyer Islands, northern Kerma...

    journal_title：Marine drugs

    pub_type： 杂志文章

    doi：10.3390/md15070219

    authors： Rhodes LL,Smith KF,Murray S,Harwood DT,Trnski T,Munday R

    更新日期：2017-07-11 00:00:00

  • Inhibitory effects of Ecklonia cava extract on high glucose-induced hepatic stellate cell activation.

    abstract：:Nonalcoholic steatohepatitis (NASH) is a disease closely associated with obesity and diabetes. A prevalence of type 2 diabetes and a high body mass index in cryptogenic cirrhosis may imply that obesity leads to cirrhosis. Here, we examined the effects of an extract of Ecklonia cava, a brown algae, on the activation of...

    journal_title：Marine drugs

    pub_type： 杂志文章

    doi：10.3390/md9122793

    authors： Yokogawa K,Matsui-Yuasa I,Tamura A,Terada M,Kojima-Yuasa A

    更新日期：2011-12-01 00:00:00

  • Co-processed chitin-mannitol as a new excipient for Oro-dispersible tablets.

    abstract：:This study describes the preparation, characterization and performance of a novel excipient for use in oro-dispersible tablets (ODT). The excipient (Cop-CM) consists of chitin and mannitol. The excipient with optimal physicochemical properties was obtained at a chitin: mannitol ratio of 2:8 (w/w) and produced by roll ...

    journal_title：Marine drugs

    pub_type： 杂志文章

    doi：10.3390/md13041739

    authors： Daraghmeh N,Chowdhry BZ,Leharne SA,Al Omari MM,Badwan AA

    更新日期：2015-03-30 00:00:00

  • The Protective Effects of Clams on Hypercholesterolemia in Late-Stage Triple-Transgenic Alzheimer's Diseased Mice Hearts.

    abstract：:To investigate a high cholesterol diet in Alzheimer's disease (AD) mice, they were fed with (2% cholesterol) in five groups with a control group, AD mice group, AD mice plus Meretrix lusoria group, AD mice plus Geloina eros group, and, AD mice plus Corbicula fluminea group for three months, and treated with the fatty ...

    journal_title：Marine drugs

    pub_type： 杂志文章

    doi：10.3390/md16080263

    authors： Hsieh YL,Teng HJ,Yeh YH,Hsieh CH,Huang CY

    更新日期：2018-08-01 00:00:00

  • Diphlorethohydroxycarmalol Attenuates Fine Particulate Matter-Induced Subcellular Skin Dysfunction.

    abstract：:The skin, the largest organ in humans, is exposed to major sources of outdoor air pollution, such as fine particulate matter with a diameter ≤ 2.5 µm (PM2.5). Diphlorethohydroxycarmalol (DPHC), a marine-based compound, possesses multiple activities including antioxidant effects. In the present study, we evaluated the ...

    journal_title：Marine drugs

    pub_type： 杂志文章

    doi：10.3390/md17020095

    authors： Zhen AX,Piao MJ,Hyun YJ,Kang KA,Madushan Fernando PDS,Cho SJ,Ahn MJ,Hyun JW

    更新日期：2019-02-01 00:00:00