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New ikarugamycin derivatives with antifungal and antibacterial properties from Streptomyces zhaozhouensis.

Abstract：

:A bioassay guided fractionation of the ethyl acetate extract from culture broths of the strain Streptomyces zhaozhouensis CA-185989 led to the isolation of three new polycyclic tetramic acid macrolactams (1-3) and four known compounds. All the new compounds were structurally related to the known Streptomyces metabolite ikarugamycin (4). Their structural elucidation was accomplished using a combination of electrospray-time of flight mass spectrometry (ESI-TOF MS) and 1D and 2D NMR analyses. Compounds 1-3 showed antifungal activity against Aspergillus fumigatus, Candida albicans and antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA).

journal_name

Mar Drugs

journal_title

Marine drugs

authors

Lacret R,Oves-Costales D,Gómez C,Díaz C,de la Cruz M,Pérez-Victoria I,Vicente F,Genilloud O,Reyes F

doi

10.3390/md13010128

subject

Has Abstract

pub_date

2014-12-29 00:00:00

pages

128-40

issue

1

issn

1660-3397

pii

md13010128

journal_volume

13

pub_type

杂志文章

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