Ubiquitin-Proteasome Modulating Dolabellanes and Secosteroids from Soft Coral Clavularia flava.

abstract：:Two new piperazine-triones lansai E and F (1, 2), together with four known secondary metabolites lansai D (3), 1-N-methyl-(E,Z)-albonoursin (4), imidazo[4,5-e]-1,2,4-triazine (5), and streptonigrin (6) were isolated from a deep-sea-derived Streptomycetes sp. strain SMS636. The structures of the isolated compounds were...

journal_title：Marine drugs

authors： Xu X,Han J,Lin R,Polyak SW,Song F

更新日期：2019-03-21 00:00:00

abstract：:Chlorophenols (CPs) are environmental pollutants that are produced through various anthropogenic activities and introduced in the environment. Living organisms, including humans, are exposed to these toxic xenobiotics and suffer from adverse health effects. More specifically, 2,4-dichlorophenol (2,4-DCP) is released i...

journal_title：Marine drugs

authors： Nikolaivits E,Agrafiotis A,Termentzi A,Machera K,Le Goff G,Álvarez P,Chavanich S,Benayahu Y,Ouazzani J,Fokialakis N,Topakas E

更新日期：2019-09-30 00:00:00

abstract：:Mexico is one of the three areas of the world with the greatest terrestrial and cultural biological diversity. The diversity of Mexican medicinal flora has been studied for a long time and several bioactive compounds have been isolated. The investigation of marine resources, and particularly the potential of Mexican m...

journal_title：Marine drugs

authors： Pech-Puch D,Pérez-Povedano M,Lenis-Rojas OA,Rodríguez J,Jiménez C

更新日期：2020-01-16 00:00:00

abstract：:In aquatic microbial ecology, knowledge of the processes involved in the turnover of organic matter is of utmost importance to understand ecosystem functioning. Microorganisms are major players in the cycling of nutrients (nitrogen, phosphorus) and carbon, thanks to their enzymatic activities (leucine aminopeptidase, ...

journal_title：Marine drugs

authors： Caruso G

更新日期：2010-03-29 00:00:00

abstract：:Investigation of minor metabolites in the extracts of the red alga Sphaerococcus coronopifolius collected from the rocky coasts of Corfu Island in the Ionian Sea yielded two new diterpene alcohols, sphaerollanes I, and II (1, 2) featuring neodolabellane skeletons, and the new sphaeroane diterpene alcohol 16-hydroxy-9S...

journal_title：Marine drugs

authors： Smyrniotopoulos V,Vagias C,Roussis V

更新日期：2009-05-19 00:00:00

abstract：:Three new butenolide derivatives, namely aspernolides N-P (1-3), together with six known analogues (4-9), were isolated from the ethyl acetate (EtOAc) extract of the deep sea-derived fungus Aspergillus terreus YPGA10. The structures of compounds 1-3 were determined on the basis of comprehensive analyses of the nuclear...

journal_title：Marine drugs

authors： Cheng Z,Li Y,Liu W,Liu L,Liu J,Yuan W,Luo Z,Xu W,Li Q

更新日期：2019-06-03 00:00:00

abstract：:This study aimed to investigate the cardiovascular effects elicited by Dictyota pulchella, a brown alga, using in vivo and in vitro approaches. In normotensive conscious rats, CH(2)Cl(2)/MeOH Extract (CME, 5, 10, 20 and 40 mg/kg) from Dictyota pulchella produced dose-dependent hypotension (-4 ± 1; -8 ± 2; -53 ± 8 and ...

journal_title：Marine drugs

authors： Queiroz TM,Machado NT,Furtado FF,Oliveira-Filho AA,Alustau MC,Figueiredo CS,Miranda GE,Barbosa-Filho JM,Braga VA,Medeiros IA

更新日期：2011-01-01 00:00:00

abstract：:Paralytic shellfish poisoning (PSP), due to saxitoxin and related compounds, typically results from the consumption of filter-feeding molluscan shellfish that concentrate toxins from marine dinoflagellates. In addition to these microalgal sources, saxitoxin and related compounds, referred to in this review as STXs, ar...

journal_title：Marine drugs

authors： Deeds JR,Landsberg JH,Etheridge SM,Pitcher GC,Longan SW

更新日期：2008-06-10 00:00:00

abstract：:Astaxanthin captured peroxynitrite to form nitroastaxanthins. 15-Nitroastaxanthin was a major reaction product of astaxanthin with peroxynitrite. Here, the anti-oxidative, anti-tumor-promoting, and anti-carcinogensis activities of 15-nitroastaxanthin were investigated. In addition to astaxanthin, 15-nitroastaxanthin s...

journal_title：Marine drugs

authors： Maoka T,Tokuda H,Suzuki N,Kato H,Etoh H

更新日期：2012-06-01 00:00:00

abstract：:Two new bicyclogermacrenes, capgermacrenes A (1) and B (2), were isolated with two known compounds, palustrol (3) and litseagermacrane (4), from a population of Bornean soft coral Capnella sp. The structures of these metabolites were elucidated based on spectroscopic data. Compound 1 was found to inhibit the accumulat...

journal_title：Marine drugs

authors： Phan CS,Ng SY,Kim EA,Jeon YJ,Palaniveloo K,Vairappan CS

更新日期：2015-05-19 00:00:00

abstract：:A new tetramic acid glycoside, aurantoside K, was isolated from a marine sponge belonging to the genus Melophlus. The structure of the compound was elucidated on the basis of spectroscopic analysis (¹H NMR, ¹H-¹H COSY, HSQC, and HMBC, as well as high-resolution ESILCMS). Aurantoside K did not show any significant acti...

journal_title：Marine drugs

authors： Kumar R,Subramani R,Feussner KD,Aalbersberg W

更新日期：2012-01-01 00:00:00

abstract：:The authors wish to correct Figure 1 in this paper [1] to be as follows:[...]. ...

journal_title：Marine drugs

authors： Zhang G,Cheng G,Jia P,Jiao S,Feng C,Hu T,Liu H,Du Y

更新日期：2017-09-20 00:00:00

abstract：:The review is devoted to the chemical diversity of steroids produced by soft corals and their determined and potential activities. There are about 200 steroids that belong to different types of steroids such as secosteroids, spirosteroids, epoxy- and peroxy-steroids, steroid glycosides, halogenated steroids, polyoxyge...

journal_title：Marine drugs

authors： Ermolenko EV,Imbs AB,Gloriozova TA,Poroikov VV,Sikorskaya TV,Dembitsky VM

更新日期：2020-12-02 00:00:00

abstract：:When the aquaculture water environment deteriorates or the temperature rises, shrimp are susceptible to viral or bacterial infections, causing a large number of deaths. This study comprehensively evaluated the effects of the oral administration of a chitosan-gentamicin conjugate (CS-GT) after Litopenaeus vannamei were...

journal_title：Marine drugs

authors： Liang F,Li C,Hou T,Wen C,Kong S,Ma D,Sun C,Li S

更新日期：2020-08-10 00:00:00

abstract：:A bioactivity guided study of a cf. Caldora penicillata species, collected during a 2013 expedition to the Pacific island of Saipan, Northern Mariana Islands (a commonwealth of the USA), led to the isolation of a new thiazoline-containing alkaloid, laucysteinamide A (1). Laucysteinamide A is a new monomeric analogue o...

journal_title：Marine drugs

authors： Zhang C,Naman CB,Engene N,Gerwick WH

更新日期：2017-04-14 00:00:00

abstract：:Ulvan lyases can degrade ulvan to oligosaccharides with potent biological activity. A new ulvan lyase gene, ALT3695, was identified in Alteromonas sp. A321. Soluble expression of ALT3695 was achieved in Escherichia coli BL21 (DE3). The 1314-bp gene encoded a protein with 437 amino acid residues. The amino acid sequenc...

journal_title：Marine drugs

authors： Gao J,Du C,Chi Y,Zuo S,Ye H,Wang P

更新日期：2019-10-08 00:00:00

abstract：:Diabetes mellitus is a group of metabolic disorders of the endocrine system characterised by hyperglycaemia. Type II diabetes mellitus (T2DM) constitutes the majority of diabetes cases around the world and are due to unhealthy diet, sedentary lifestyle, as well as rise of obesity in the population, which warrants the ...

journal_title：Marine drugs

authors： Sharifuddin Y,Chin YX,Lim PE,Phang SM

更新日期：2015-08-21 00:00:00

abstract：:Marine ecosystems are the most prevalent ecosystems on the planet, providing a diversity of living organisms and resources. The development of nanotechnology may provide solutions for utilizing these thousands of potential compounds as marine pharmaceuticals. Here, we designed a liposomal glycol chitosan formulation t...

journal_title：Marine drugs

authors： Kim MW,Niidome T,Lee R

更新日期：2019-10-12 00:00:00

abstract：:Death-associated protein kinase 1 (DAPK1) expression induced by diverse death stimuli mediates apoptotic activity in various cancers, including ovarian cancer. In addition, mutual interaction between the tumor suppressor p53 and DAPK1 influences survival and death in several cancer cell lines. However, the exact role ...

journal_title：Marine drugs

authors： Park GB,Jeong JY,Kim D

更新日期：2019-07-12 00:00:00

abstract：:Chitosan is sensitive to environmental pH values due to its electric property. This study investigates whether the pH-responsive chitosan assay can provide a simple method to evaluate the aggressive behavior of cancer cells with cell detachment ratio. The epithelial-mesenchymal transition (EMT) is induced with transfo...

journal_title：Marine drugs

authors： Yen CH,Young TH,Hsieh MC,Liao LJ,Huang TW

更新日期：2019-11-23 00:00:00

abstract：:Fucoxanthin is a marine carotenoid exhibiting several health benefits. The anti-cancer effect of fucoxanthin and its deacetylated metabolite, fucoxanthinol, is well documented. In view of its potent anti-carcinogenic activity, the need to understand the underlying mechanisms has gained prominence. Towards achieving th...

journal_title：Marine drugs

authors： Kumar SR,Hosokawa M,Miyashita K

更新日期：2013-12-16 00:00:00

abstract：:Tuberculosis is the leading cause of death due to infectious disease worldwide. There is an urgent need for more effective compounds against this pathogen to control the disease. Investigation of the anti-mycobacterial activity of a deep-water sponge of the genus Plakina revealed the presence of a new steroidal alkalo...

journal_title：Marine drugs

authors： Rodrigues Felix C,Roberts JC,Winder PL,Gupta R,Diaz MC,Pomponi SA,Wright AE,Rohde KH

更新日期：2019-12-16 00:00:00

abstract：:Sea anemones are a remarkable source of active principles due to a decentralized venom system. New blood vessel growth or angiogenesis is a very promising target against cancer, but the few available antiangiogenic compounds have limited efficacy. In this study, a protein fraction, purified from tentacles of Anemonia ...

journal_title：Marine drugs

authors： Loret EP,Luis J,Nuccio C,Villard C,Mansuelle P,Lebrun R,Villard PH

更新日期：2018-04-19 00:00:00

abstract：:In this study, as part of our continuous search for environmentally-friendly antifoulants from natural resources, subergorgic acid (SA) was identified from the gorgonian coral Subergorgia suberosa, demonstrating non-toxic, significant inhibitory effects (EC50 1.25 μg/mL, LC50 > 25 μg/mL) against the settlement of Bala...

journal_title：Marine drugs

authors： Zhang J,Ling W,Yang Z,Liang Y,Zhang L,Guo C,Wang K,Zhong B,Xu S,Xu Y

更新日期：2019-02-06 00:00:00

abstract：:The effect of carrageenans on tomato chlorotic dwarf viroid (TCDVd) replication and symptom expression was studied. Three-week-old tomato plants were spray-treated with iota(ɩ)-, lambda(λ)-, and kappa(κ)-carrageenan at 1 g·L-1 and inoculated with TCDVd after 48 h. The λ-carrageenan significantly suppressed viroid symp...

journal_title：Marine drugs

authors： Sangha JS,Kandasamy S,Khan W,Bahia NS,Singh RP,Critchley AT,Prithiviraj B

更新日期：2015-05-08 00:00:00

abstract：:In this study, we aimed to illustrate the potential bio-effects of 3-bromo-4,5-dihydroxybenzaldehyde (3-BDB) on the antioxidant/cytoprotective enzyme heme oxygenase-1 (HO-1) in keratinocytes. The antioxidant effects of 3-BDB were examined via reverse transcription PCR, Western blotting, HO-1 activity assay, and immuno...

journal_title：Marine drugs

authors： Ryu YS,Fernando PDSM,Kang KA,Piao MJ,Zhen AX,Kang HK,Koh YS,Hyun JW

更新日期：2019-04-19 00:00:00

abstract：:Oxylipins such as polyunsaturated aldehydes (PUAs) and hydroxyacids (HEPEs) are signaling molecules derived from the oxidation of polyunsaturated fatty acids. They are common in diatoms that constitute a major group of microalgae in freshwater and oceanic ecosystems. Although HEPEs represent the most common oxylipins ...

journal_title：Marine drugs

authors： Albarano L,Ruocco N,Ianora A,Libralato G,Manfra L,Costantini M

更新日期：2019-03-01 00:00:00

abstract：:Prostate cancer (PCa), the most common malignancy in men, is a major cause of cancer deaths. A better understanding of the mechanisms that drive tumor initiation and progression may identify actionable targets to improve treatment of this patient group. As a dietary carotenoid, astaxanthin has been demonstrated to exe...

journal_title：Marine drugs

authors： Ni X,Yu H,Wang S,Zhang C,Shen S

更新日期：2017-03-08 00:00:00

abstract：:To sustainably produce marine fish with a high lipid quality rich in omega-3 fatty acids, alternative sources of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are being identified. Moreover, the use of bioactive compounds that would stimulate the in vivo fatty acid synthesis, such as resveratrol (RV), wou...

journal_title：Marine drugs

authors： Torno C,Staats S,Michl SC,de Pascual-Teresa S,Izquierdo M,Rimbach G,Schulz C

更新日期：2018-10-10 00:00:00

abstract：:A glycopeptide fraction (GPF) from internal organs of green sea urchins (Strongylocentrotus droebachiensis Müller, Strongylocentrotidae) has been reported to be an effective bronchitis treatment. In this study, we evaluated the pharmacokinetic and tissue distribution of GPF, following single and repeated intranasal (i...

journal_title：Marine drugs

authors： Shikov AN,Pozharitskaya ON,Faustova NM,Kosman VM,Makarov VG,Razzazi-Fazeli E,Novak J

更新日期：2019-10-11 00:00:00