Abstract：
:In the search for bioactive compounds, 11 fungal strains were isolated from Indonesian marine habitats. Ethyl acetate extracts of their culture broth were tested for cytotoxic activity against a urinary bladder carcinoma cell line and for antifungal and antibacterial activities against fish and human pathogenic bacteria as well as against plant and human pathogenic fungi. The crude extract of a sterile algicolous fungus (KT31), isolated from the red seaweed Kappaphycus alvarezii (Doty) Doty ex P.C. Silva exhibited potent cytotoxic activity with an IC₅₀ value of 1.5 μg/mL. Another fungal strain (KT29) displayed fungicidal properties against the plant pathogenic fungus Cladosporium cucumerinum Ell. et Arth. at 50 μg/spot. 2-Carboxy-8-methoxy-naphthalene-1-ol (1) could be isolated as a new natural product.
journal_name
Mar Drugsjournal_title
Marine drugsauthors
Tarman K,Lindequist U,Wende K,Porzel A,Arnold N,Wessjohann LAdoi
10.3390/md9030294subject
Has Abstractpub_date
2011-02-25 00:00:00pages
294-306issue
3issn
1660-3397journal_volume
9pub_type
杂志文章相关文献
Marine Drugs文献大全abstract：:Oxidative stress contributes to chronic inflammatory processes implicated in aging, referred to as "inflamm-aging." In this study, the potential anti-inflammatory and anti-aging effects of a pigment-protein complex (PPC) from Chlorella pyrenoidosa were investigated using lipopolysaccharide (LPS)-stimulated RAW 264.7 m...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md17100586
更新日期：2019-10-16 00:00:00
abstract：:The 7-Acetylsinumaximol B (7-AB), a bioactive cembranoid, was originally discovered from aquaculture soft coral Sinularia sandensis. The current study investigated the anti-proliferative property of 7-AB towards the NCI-N87 human gastric cancer cell line. An MTT cell proliferative assay was applied to evaluate cell su...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md16040104
更新日期：2018-03-26 00:00:00
abstract：:Mycothiazole, a polyketide metabolite isolated from the marine sponge Cacospongia mycofijiensis, is a potent inhibitor of metabolic activity and mitochondrial electron transport chain complex I in sensitive cells, but other cells are relatively insensitive to the drug. Sensitive cell lines (IC(50) 0.36-13.8 nM) includ...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md10040900
更新日期：2012-04-01 00:00:00
abstract：:Chondroitinase (ChSase), a type of glycosaminoglycan (GAG) lyase, can degrade chondroitin sulfate (CS) to unsaturate oligosaccharides, with various functional activities. In this study, ChSase AC II from a newly isolated marine bacterium Arthrobacter sp. CS01 was cloned, expressed in Pichia pastoris X33, purified, and...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md17030185
更新日期：2019-03-20 00:00:00
abstract：:Gliotoxin, a secondary metabolite produced by marine fungus Aspergillus sp., possesses various biological activities including anticancer activity. However, the mechanism underlying gliotoxin-induced cytotoxicity on human cervical cancer (Hela) and human chondrosarcoma (SW1353) cells remains unclear. In this study, we...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md12010069
更新日期：2013-12-24 00:00:00
abstract：:Chemical study of the secondary metabolites of a deep-sea-derived fungus Aspergillus sydowii MCCC 3A00324 led to the isolation of eleven compounds (1-11), including one novel (1) and one new (2) osmane-related monoterpenoids and two undescribed polyketides (3 and 4). The structures of the metabolites were determined b...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md18110561
更新日期：2020-11-17 00:00:00
abstract：:Carotenoids are lipid-soluble pigments that are produced in some plants, algae, fungi, and bacterial species, which accounts for their orange and yellow hues. Carotenoids are powerful antioxidants thanks to their ability to quench singlet oxygen, to be oxidized, to be isomerized, and to scavenge free radicals, which p...
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md13106226
更新日期：2015-09-30 00:00:00
abstract：:A new eunicellin diterpenoid, cladieunicellin I (1), and a new natural eunicellin, litophynin I diacetate (2), were isolated from a Formosan soft coral identified as Cladiella sp. The structures of eunicellins 1 and 2 were elucidated by spectroscopic methods and by comparison of the spectral data with those of related...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md11114585
更新日期：2013-11-14 00:00:00
abstract：:Long chain polyunsaturated fatty acids (LC-PUFAs) are important mediators in improving and maintaining human health over the total lifespan. One topic we especially focus on in this review is omega-3 LC-PUFA docosahexaenoic acid (DHA). Adequate DHA levels are essential during neurodevelopment and, in addition, benefic...
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md12126190
更新日期：2014-12-18 00:00:00
abstract：:In our search for quorum-sensing (QS) disrupting molecules, 75 fungal isolates were recovered from reef organisms (endophytes), saline lakes and mangrove rhizosphere. Their QS inhibitory activity was evaluated in Chromobacterium violaceum CVO26. Four strains of endophytic fungi stood out for their potent activity at c...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md12115503
更新日期：2014-11-19 00:00:00
abstract：:Collagen is involved in the formation of complex fibrillar networks, providing the structural integrity of tissues. Its low immunogenicity and mechanical properties make this molecule a biomaterial that is extremely suitable for tissue engineering and regenerative medicine (TERM) strategies in human health issues. Her...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md16040111
更新日期：2018-03-29 00:00:00
abstract：:Oxylipins such as polyunsaturated aldehydes (PUAs) and hydroxyacids (HEPEs) are signaling molecules derived from the oxidation of polyunsaturated fatty acids. They are common in diatoms that constitute a major group of microalgae in freshwater and oceanic ecosystems. Although HEPEs represent the most common oxylipins ...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md17030144
更新日期：2019-03-01 00:00:00
abstract：:Ten new cembrane-based diterpenes, locrassumins A-G (1-7), (-)-laevigatol B (8), (-)-isosarcophine (9), and (-)-7R,8S-dihydroxydeepoxysarcophytoxide (10), were isolated from a South China Sea collection of the soft coral Lobophytum crassum, together with eight known analogues (11-18). The structures of the new compoun...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md14060111
更新日期：2016-06-03 00:00:00
abstract：:Two novel biscembranoids, sarelengans A and B (1 and 2), five new cembranoids, sarelengans C-G (3-7), along with two known cembranoids (8 and 9) were isolated from the South China Sea soft coral Sarcophyton elegans. Their structures were determined by spectroscopic and chemical methods, and those of 1, 4, 5, and 6 wer...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md15040085
更新日期：2017-03-23 00:00:00
abstract：:Two new sesterterpenes analogs, namely, 12-acetoxy,16-epi-hyrtiolide (1) and 12β-acetoxy,16β-methoxy,20α-hydroxy-17-scalaren-19,20-olide (2), containing a scalarane-based framework along with seven previously reported scalarane-type sesterterpenes (3-9) have been isolated from the sponge Hyrtios erectus (order Dictyoc...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md14070130
更新日期：2016-07-08 00:00:00
abstract：:Hepatic fibrosis is an effusive wound healing process, characterized by an excessive deposition of extracellular matrix (ECM), as the consequence of chronic liver injury of any etiology. Current therapeutic repertoire for hepatic fibrosis is limited to withdrawal of the noxious agent, which is not always feasible. Hen...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md13085201
更新日期：2015-08-18 00:00:00
abstract：:Mere15 is a novel polypeptide from Meretrix meretrix Linnaeus with cytotoxicity in solid cancer cells. In this study, we investigated its activity on human K562 chronic myelogenous leukemia cells. Mere15 inhibited the growth of K562 cells with IC₅₀ values of 38.2 μg/mL. Mere15 also caused concentration dependent induc...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md10112596
更新日期：2012-11-21 00:00:00
abstract：:Chitin is an abundant polysaccharide primarily produced as an industrial waste stream during the processing of crustaceans. Despite the limited applications of chitin, there is interest from the medical, agrochemical, food and cosmetic industries because it can be converted into chitosan and partially acetylated chito...
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md17080452
更新日期：2019-08-01 00:00:00
abstract：:Marine biomass diversity is a tremendous source of potential anticancer compounds. Several natural marine products have been described to restore tumor cell sensitivity to TNF-related apoptosis inducing ligand (TRAIL)-induced cell death. TRAIL is involved during tumor immune surveillance. Its selectivity for cancer ce...
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md13116884
更新日期：2015-11-13 00:00:00
abstract：:The Antarctic sponge Dendrilla antarctica is rich in defensive terpenoids with promising antimicrobial potential. Investigation of this demosponge has resulted in the generation of a small chemical library containing diterpenoid secondary metabolites with bioactivity in an infectious disease screening campaign focused...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md18060327
更新日期：2020-06-23 00:00:00
abstract：:In this study, sulfated polysaccharide-rich extracts were isolated from 22 tropical seaweeds (4 red, 11 brown, and 7 green) found in northeastern Brazil, and evaluated for the role of anticoagulant agents. Fifteen of the extracts showed anticoagulant activity, including all the extracts from green seaweeds. Udoteaflab...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md17010005
更新日期：2018-12-21 00:00:00
abstract：:Crude extracts and column fractions from the red algae Asparagopsis taxiformis and A. armata from the Strait of Messina (Italy) were screened for the production of antimicrobial compounds. Extracts from both species revealed remarkable antiprotozoal activity against Leishmania, revealing such algae as a great source o...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md7030361
更新日期：2009-08-11 00:00:00
abstract：:Conotoxins in the venom of cone snails (Conus spp.) are a mixture of active peptides that work as blockers, agonists, antagonists, or inactivators of various ion channels. Recently we reported a high-throughput method to identify 215 conotoxin transcripts from the Chinese tubular cone snail, C. betulinus. Here, based ...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md15070228
更新日期：2017-07-18 00:00:00
abstract：:Natural anionic polysaccharides fucosylated chondroitin sulfates (FCS) from sea cucumbers attract great attention nowadays due to their ability to influence various biological processes, such as blood coagulation, thrombosis, angiogenesis, inflammation, bacterial and viral adhesion. To determine pharmacophore fragment...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md13020770
更新日期：2015-02-02 00:00:00
abstract：:Green seaweeds are rich sources of sulfated polysaccharides (SPs) with potential biomedical and nutraceutical applications. The aim of this work was to evaluate the immunostimulatory activity of SPs from the seaweed, Caulerpa cupressoides var. flabellata on murine RAW 264.7 macrophages. SPs were evaluated for their ab...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md17020105
更新日期：2019-02-09 00:00:00
abstract：:The secondary metabolite Tyrian purple, also known as shellfish purple and royal purple, is a dye with historical importance for humans. The biosynthetic origin of Tyrian purple in Muricidae molluscs is not currently known. A possible role for symbiotic bacteria in the production of tyrindoxyl sulphate, the precursor ...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md17050264
更新日期：2019-05-03 00:00:00
abstract：:Application of cytostatics in cancer patients' chemotherapy results in a number of side effects, including the inhibition of various parts of hematopoiesis. Two sulfated polysaccharides, fucoidan from the seaweed Chordaria flagelliformis (PS-Fuc) and fucosylated chondroitin sulfate from the sea cucumber Massinium magn...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md15100301
更新日期：2017-09-30 00:00:00
abstract：:Anemonia viridis is a widespread and extensively studied Mediterranean species of sea anemone from which a large number of polypeptide toxins, such as blood depressing substances (BDS) peptides, have been isolated. The first members of this class, BDS-1 and BDS-2, are polypeptides belonging to the β-defensin fold fami...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md11114213
更新日期：2013-10-30 00:00:00
abstract：:Sea cucumbers belonging to echinoderm are traditionally used as tonic food in China and other Asian countries. They produce abundant biologically active triterpene glycosides. More than 300 triterpene glycosides have been isolated and characterized from various species of sea cucumbers, which are classified as holosta...
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md15100317
更新日期：2017-10-17 00:00:00
abstract：:Fucoidan is a polysaccharide built from L-fucose molecules. The main source of this polysaccharide is the extracellular matrix of brown seaweed (Phaeophyta), but it can be also isolated from invertebrates such as sea urchins (Echinoidea) and sea cucumbers (Holothuroidea). Interest in fucoidan is related to its broad b...
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md17080458
更新日期：2019-08-05 00:00:00
