Molecular Targets of Active Anticancer Compounds Derived from Marine Sources.

abstract：:After in situ incubation at the site for a year, phytoplanktons in surface water were exposed to natural light in temperate lakes (every month); thereafter, the net production rate of photoprotective compounds (mycosporine-like amino acids, MAAs) was calculated using (13)C labeled tracer. This is the first report desc...

journal_title：Marine drugs

authors： Ha SY,Lee Y,Kim MS,Kumar KS,Shin KH

更新日期：2015-11-06 00:00:00

abstract：:N,N-Didesmethylgrossularine-1 (DDMG-1), a compound with a rare alpha-carboline structure, was isolated from an Indonesian ascidian Polycarpa aurata as responsible for the observed inhibitory activity against TNF-alpha production in lipopolysaccharide-stimulated murine macrophage-like RAW264.7 cells. DDMG-1 inhibited t...

journal_title：Marine drugs

authors： Oda T,Lee JS,Sato Y,Kabe Y,Sakamoto S,Handa H,Mangindaan RE,Namikoshi M

更新日期：2009-11-17 00:00:00

abstract：:Chemical investigation of the methanol extract of the Vietnamese marine sponge Ircinia echinata led to the isolation of six new 9α-hydroxy-5α,6α-epoxysterols: 5α,6α-epoxycholesta-7,22(E)-dien-3β,9α-diol (1), 5α,6α-epoxycholesta-7,24(28)-dien-3β,9α-diol (2), (24R)-5α,6α-epoxy-24-ethyl-cholesta-7-en-3β,9α-diol (3), 5α,6...

journal_title：Marine drugs

authors： Trinh TTV,Truong BN,Longeon A,Doan TMH,Deville A,Chau VM,Pham VC,Bourguet-Kondracki ML

更新日期：2018-11-01 00:00:00

abstract：:Six kinds of chitinous materials have been used as sole carbon/nitrogen (C/N) sources for producing α-glucosidase inhibitors (aGI) by Paenibacillus sp. TKU042. The aGI productivity was found to be highest in the culture supernatants using demineralized crab shell powder (deCSP) and demineralized shrimp shell powder (d...

journal_title：Marine drugs

authors： Nguyen VB,Wang SL

更新日期：2017-11-07 00:00:00

abstract：:In this study, we elucidated the inhibitory effect of fucoidan from marine brown algae on the lipid accumulation in differentiated 3T3-L1 adipocytes and its mechanism. The treatment of fucoidan in a dose-dependent manner was examined on lipid inhibition in 3T3-L1 cells by using Oil Red O staining. Fucoidan showed high...

journal_title：Marine drugs

authors： Park MK,Jung U,Roh C

更新日期：2011-01-01 00:00:00

abstract：:This study describes the preparation, characterization and performance of a novel excipient for use in oro-dispersible tablets (ODT). The excipient (Cop-CM) consists of chitin and mannitol. The excipient with optimal physicochemical properties was obtained at a chitin: mannitol ratio of 2:8 (w/w) and produced by roll ...

journal_title：Marine drugs

authors： Daraghmeh N,Chowdhry BZ,Leharne SA,Al Omari MM,Badwan AA

更新日期：2015-03-30 00:00:00

abstract：:The antiproliferative activity of 52 volatile compounds released from bacteria was investigated in agar diffusion assays against medically important microorganisms and mouse fibroblasts. Furthermore, the activity of these compounds to interfere with the quorum-sensing-systems was tested with two different reporter str...

journal_title：Marine drugs

authors： Schulz S,Dickschat JS,Kunze B,Wagner-Dobler I,Diestel R,Sasse F

更新日期：2010-12-22 00:00:00

abstract：:Collagenases are the most important group of commercially-produced enzymes. However, even though biological resources are abundant in the sea, very few of these commercially popular enzymes are from marine sources, especially from marine bacteria. We optimized the production of marine collagenases by Pseudoalteromonas...

journal_title：Marine drugs

authors： Yang X,Xiao X,Liu D,Wu R,Wu C,Zhang J,Huang J,Liao B,He H

更新日期：2017-12-04 00:00:00

abstract：:Most giant groupers in the market are derived from inbred stock. Inbreeding can cause trait depression, compromising the animals' fitness and disease resistance, obligating farmers to apply increased amounts of drugs. In order to solve this problem, a pedigree classification method is needed. Here, microsatellite and ...

journal_title：Marine drugs

authors： Kuo HC,Hsu HH,Chua CS,Wang TY,Chen YM,Chen TY

更新日期：2014-04-30 00:00:00

abstract：:Certain strains of cyanobacteria produce a wide array of cyanotoxins, such as microcystins, lyngbyatoxins and aplysiatoxins, that are associated with public health issues. In this pilot study, an approach combining LC-MS/MS and molecular networking was employed as a rapid analytical method to detect aplysiatoxins pres...

journal_title：Marine drugs

authors： Ding CYG,Pang LM,Liang ZX,Goh KKK,Glukhov E,Gerwick WH,Tan LT

更新日期：2018-12-13 00:00:00

abstract：:Gut microbiota has been proved to be an indispensable link between nutrient excess and metabolic syndrome, and chitin oligosaccharide (NACOS) has displayed therapeutic effects on multiple diseases such as cancer and gastritis. In this study, we aim to confirm whether NACOS can ameliorate high-fat diet (HFD)-induced me...

journal_title：Marine drugs

authors： Zheng J,Cheng G,Li Q,Jiao S,Feng C,Zhao X,Yin H,Du Y,Liu H

更新日期：2018-02-19 00:00:00

abstract：:Chemical analysis of the Indonesian sponge Plakortis cfr. lita afforded two new analogues of the potent trypanocidal agent manadoperoxide B (1), namely 12-isomanadoperoxide B (2) and manadoperoxidic acid B (3). These compounds were isolated along with a new short chain dicarboxylate monoester (4), bearing some interes...

journal_title：Marine drugs

authors： Chianese G,Scala F,Calcinai B,Cerrano C,Dien HA,Kaiser M,Tasdemir D,Taglialatela-Scafati O

更新日期：2013-08-28 00:00:00

abstract：:Using theonellasterol as a novel FXR antagonist hit, we prepared a series of semi-synthetic derivatives in order to gain insight into the structural requirements for exhibiting antagonistic activity. These derivatives are characterized by modification at the exocyclic carbon-carbon double bond at C-4 and at the hydrox...

journal_title：Marine drugs

authors： Sepe V,Ummarino R,D'Auria MV,Taglialatela-Scafati O,Marino SD,D'Amore C,Renga B,Chini MG,Bifulco G,Nakao Y,Fusetani N,Fiorucci S,Zampella A

更新日期：2012-11-05 00:00:00

abstract：:Chemical examination of the Taiwanese soft coral Sinularia triangular led to the isolation of five cembrane-based diterpenoids 1-5, including two new metabolites, triangulenes A (1) and B (2). The structures of the new metabolites were determined on the basis of extensive spectroscopic analysis, particularly mass spec...

journal_title：Marine drugs

authors： Su JH,Wen ZH

更新日期：2011-01-01 00:00:00

abstract：:Several known sesquiterpenoid quinones and quinols (1-9), and kauamide (10), a new polyketide-peptide containing an 11-membered heterocycle, were isolated from the extracts of the Hawaiian marine sponge Dactylospongiaelegans. The planar structure of 10 was determined from spectroscopic analyses, and its relative and a...

journal_title：Marine drugs

authors： Neupane RP,Parrish SM,Neupane JB,Yoshida WY,Yip MLR,Turkson J,Harper MK,Head JD,Williams PG

更新日期：2019-07-19 00:00:00

abstract：:Chinese white dolphin (Sousa chinensis), also known as the Indo-Pacific humpback dolphin, has been classified as "Vulnerable" on the IUCN Red List of Threatened Species. It is a special cetacean species that lives in tropical and subtropical nearshore waters, with significant differences from other cetaceans. Here, we...

journal_title：Marine drugs

authors： Jia K,Bian C,Yi Y,Li Y,Jia P,Gui D,Zhang X,Lin W,Sun X,Lv Y,Li J,You X,Shi Q,Yi M,Wu Y

更新日期：2019-08-28 00:00:00

abstract：:Azaspiracids (AZA) are polyether marine toxins that accumulate in various shellfish species and have been associated with severe gastrointestinal human intoxications since 1995. This toxin class has since been reported from several countries, including Morocco and much of western Europe. A regulatory limit of 160 micr...

journal_title：Marine drugs

authors： Twiner MJ,Rehmann N,Hess P,Doucette GJ

更新日期：2008-05-07 00:00:00

abstract：:During an investigation of the chemistry of the Red Sea Verongiid sponge Pseudoceratina arabica, we discovered a small molecule, pseudoceratonic acid (1), along with the new moloka'iamine derivatives, ceratinines N (2), O (3), and the previously reported compounds moloka'iamine (4), hydroxymoloka'iamine (5) and cerati...

journal_title：Marine drugs

authors： Shaala LA,Youssef DTA

更新日期：2020-10-23 00:00:00

abstract：:Pectenotoxin-2 (PTX-2), which was first identified as a cytotoxic entity in marine sponges, has been reported to display significant cytotoxicity to human cancer cells where it inhibits mitotic separation and cytokinesis through the depolymerization of actin filaments. In the late stage of endoreduplication, the effec...

journal_title：Marine drugs

authors： Kim GY,Kim WJ,Choi YH

更新日期：2011-01-01 00:00:00

abstract：:A new germacrane-type sesquiterpenoid, menelloide E (1), and a new cembrane-type diterpenoid, lobocrassin F (2), were isolated from the octocorals Menella sp. and Lobophytum crassum, respectively. The structures of terpenoids 1 and 2 were determined by spectroscopic and chemical methods and compound 2 was found to dis...

journal_title：Marine drugs

authors： Lee CH,Kao CY,Kao SY,Chang CH,Su JH,Hwang TL,Kuo YH,Wen ZH,Sung PJ

更新日期：2012-02-01 00:00:00

abstract：:The tropical marine cyanobacterium Moorena bouillonii occupies a large geographic range across the Indian and Western Tropical Pacific Oceans and is a prolific producer of structurally unique and biologically active natural products. An ensemble of computational approaches, including the creation of the ORCA (Objectiv...

journal_title：Marine drugs

authors： Leber CA,Naman CB,Keller L,Almaliti J,Caro-Diaz EJE,Glukhov E,Joseph V,Sajeevan TP,Reyes AJ,Biggs JS,Li T,Yuan Y,He S,Yan X,Gerwick WH

更新日期：2020-10-14 00:00:00

abstract：:The hypoxia/reoxygenation (H/R) injury causes serious complications after the blood supply to the kidney is stopped during surgery. The main mechanism of I/R injury is the release of high-mobility group protein B1 (HMGB1) from injured tubular epithelial cells (TEC, TCMK-1 cell), which triggers TLR4 or RAGE signaling, ...

journal_title：Marine drugs

authors： Son M,Oh S,Choi CH,Park KY,Son KH,Byun K

更新日期：2019-10-24 00:00:00

abstract：:In this study, we aimed to illustrate the potential bio-effects of 3-bromo-4,5-dihydroxybenzaldehyde (3-BDB) on the antioxidant/cytoprotective enzyme heme oxygenase-1 (HO-1) in keratinocytes. The antioxidant effects of 3-BDB were examined via reverse transcription PCR, Western blotting, HO-1 activity assay, and immuno...

journal_title：Marine drugs

authors： Ryu YS,Fernando PDSM,Kang KA,Piao MJ,Zhen AX,Kang HK,Koh YS,Hyun JW

更新日期：2019-04-19 00:00:00

abstract：:Marine biotoxin-contaminated seafood has caused thousands of poisonings worldwide this century. Given these threats, there is an increasing need for improved technologies that can be easily integrated into coastal monitoring programs. This study evaluates approaches for monitoring toxins associated with recurrent toxi...

journal_title：Marine drugs

authors： Hattenrath-Lehmann TK,Lusty MW,Wallace RB,Haynes B,Wang Z,Broadwater M,Deeds JR,Morton SL,Hastback W,Porter L,Chytalo K,Gobler CJ

更新日期：2018-01-13 00:00:00

abstract：:Fungi associated with the marine sponge Tethya aurantium were isolated and identified by morphological criteria and phylogenetic analyses based on internal transcribed spacer (ITS) regions. They were evaluated with regard to their secondary metabolite profiles. Among the 81 isolates which were characterized, members o...

journal_title：Marine drugs

authors： Wiese J,Ohlendorf B,Blümel M,Schmaljohann R,Imhoff JF

更新日期：2011-01-01 00:00:00

abstract：:The effect of carrageenans on tomato chlorotic dwarf viroid (TCDVd) replication and symptom expression was studied. Three-week-old tomato plants were spray-treated with iota(ɩ)-, lambda(λ)-, and kappa(κ)-carrageenan at 1 g·L-1 and inoculated with TCDVd after 48 h. The λ-carrageenan significantly suppressed viroid symp...

journal_title：Marine drugs

authors： Sangha JS,Kandasamy S,Khan W,Bahia NS,Singh RP,Critchley AT,Prithiviraj B

更新日期：2015-05-08 00:00:00

abstract：:A glycopeptide fraction (GPF) from internal organs of green sea urchins (Strongylocentrotus droebachiensis Müller, Strongylocentrotidae) has been reported to be an effective bronchitis treatment. In this study, we evaluated the pharmacokinetic and tissue distribution of GPF, following single and repeated intranasal (i...

journal_title：Marine drugs

authors： Shikov AN,Pozharitskaya ON,Faustova NM,Kosman VM,Makarov VG,Razzazi-Fazeli E,Novak J

更新日期：2019-10-11 00:00:00

abstract：:The vast oceans of the world, which comprise a huge variety of unique ecosystems, are emerging as a rich and relatively untapped source of novel bioactive compounds with invaluable biotechnological and pharmaceutical potential. Evidence accumulated over the last decade has revealed that the diversity of marine microor...

journal_title：Marine drugs

authors： Reen FJ,Gutiérrez-Barranquero JA,Dobson AD,Adams C,O'Gara F

更新日期：2015-05-13 00:00:00

abstract：:Aaptos is a genus of marine sponge which belongs to Suberitidae and is distributed in tropical and subtropical oceans. Bioactivity-guided fractionation of Aaptos sp. methanolic extract resulted in the isolation of aaptamine, demethyloxyaaptamine, and isoaaptamine. The cytotoxic activity of the isolated compounds was e...

journal_title：Marine drugs

authors： Wu CF,Lee MG,El-Shazly M,Lai KH,Ke SC,Su CW,Shih SP,Sung PJ,Hong MC,Wen ZH,Lu MC

更新日期：2018-01-09 00:00:00

abstract：:The Antarctic sponge Dendrilla antarctica is rich in defensive terpenoids with promising antimicrobial potential. Investigation of this demosponge has resulted in the generation of a small chemical library containing diterpenoid secondary metabolites with bioactivity in an infectious disease screening campaign focused...

journal_title：Marine drugs

authors： Bory A,Shilling AJ,Allen J,Azhari A,Roth A,Shaw LN,Kyle DE,Adams JH,Amsler CD,McClintock JB,Baker BJ

更新日期：2020-06-23 00:00:00