Molecular Targets of Active Anticancer Compounds Derived from Marine Sources.

Abstract:

:Over the past decades, a number of novel compounds, which are produced in the marine environment, have been found to exhibit the anticancer effects. This review focuses on molecular targets of marine-derived anticancer candidates in clinical and preclinical studies. They are kinases, transcription factors, histone deacetylase, the ubiquitin-proteasome system, and so on. Specific emphasis of this review paper is to provide information on the optimization of new target compounds for future research and development of anticancer drugs, based on the identification of structures of these target molecules and parallel compounds.

journal_name

Mar Drugs

journal_title

Marine drugs

authors

Song X,Xiong Y,Qi X,Tang W,Dai J,Gu Q,Li J

doi

10.3390/md16050175

subject

Has Abstract

pub_date

2018-05-22 00:00:00

issue

5

issn

1660-3397

pii

md16050175

journal_volume

16

pub_type

杂志文章,评审
  • Marine and semi-synthetic hydroxysteroids as new scaffolds for pregnane X receptor modulation.

    abstract::In recent years many sterols with unusual structures and promising biological profiles have been identified from marine sources. Here we report the isolation of a series of 24-alkylated-hydroxysteroids from the soft coral Sinularia kavarattiensis, acting as pregnane X receptor (PXR) modulators. Starting from this scaf...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md12063091

    authors: Sepe V,Di Leva FS,D'Amore C,Festa C,De Marino S,Renga B,D'Auria MV,Novellino E,Limongelli V,D'Souza L,Majik M,Zampella A,Fiorucci S

    更新日期:2014-05-27 00:00:00

  • Impact of DHA on metabolic diseases from womb to tomb.

    abstract::Long chain polyunsaturated fatty acids (LC-PUFAs) are important mediators in improving and maintaining human health over the total lifespan. One topic we especially focus on in this review is omega-3 LC-PUFA docosahexaenoic acid (DHA). Adequate DHA levels are essential during neurodevelopment and, in addition, benefic...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审

    doi:10.3390/md12126190

    authors: Arnoldussen IA,Kiliaan AJ

    更新日期:2014-12-18 00:00:00

  • Astaxanthin attenuates early acute kidney injury following severe burns in rats by ameliorating oxidative stress and mitochondrial-related apoptosis.

    abstract::Early acute kidney injury (AKI) is a devastating complication in critical burn patients, and it is associated with severe morbidity and mortality. The mechanism of AKI is multifactorial. Astaxanthin (ATX) is a natural compound that is widely distributed in marine organisms; it is a strong antioxidant and exhibits othe...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md13042105

    authors: Guo SX,Zhou HL,Huang CL,You CG,Fang Q,Wu P,Wang XG,Han CM

    更新日期:2015-04-13 00:00:00

  • Theonellamide G, a potent antifungal and cytotoxic bicyclic glycopeptide from the Red Sea marine sponge Theonella swinhoei.

    abstract::In our search for bioactive metabolites from marine organisms, we have investigated the polar fraction of the organic extract of the Red Sea sponge Theonella swinhoei. Successive chromatographic separations and final HPLC purification of the potent antifungal fraction afforded a new bicyclic glycopeptide, theonellamid...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md12041911

    authors: Youssef DT,Shaala LA,Mohamed GA,Badr JM,Bamanie FH,Ibrahim SR

    更新日期:2014-04-01 00:00:00

  • Hatsusamides A and B: Two New Metabolites Produced by the Deep-Sea-Derived Fungal Strain Penicillium steckii FKJ-0213.

    abstract::Two new nitrogen-containing metabolites, designated hatsusamide A (1) and B (2), were isolated from a culture broth of Penicilliumsteckii FKJ-0213 together with the known compounds tanzawaic acid B (3) and trichodermamide C (4) by physicochemical (PC) screening. The structures of 1 and 2 were determined as a tanzawaic...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md18100513

    authors: Matsuo H,Hokari R,Ishiyama A,Iwatsuki M,Higo M,Nonaka K,Nagano Y,Takahashi Y,Ōmura S,Nakashima T

    更新日期:2020-10-12 00:00:00

  • Ω3 Supplementation and intermittent hypobaric hypoxia induce cardioprotection enhancing antioxidant mechanisms in adult rats.

    abstract::Intermittent hypobaric hypoxia (IH) is linked with oxidative stress, impairing cardiac function. However, early IH also activate cardio-protective mechanisms. Omega 3 fatty acids (Ω3) induce cardioprotection by reducing infarct size and reinforcing antioxidant defenses. The aim of this work was to determine the combin...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md13020838

    authors: Herrera EA,Farías JG,González-Candia A,Short SE,Carrasco-Pozo C,Castillo RL

    更新日期:2015-02-04 00:00:00

  • Production, characterization and biocompatibility of marine collagen matrices from an alternative and sustainable source: the sea urchin Paracentrotus lividus.

    abstract::Collagen has become a key-molecule in cell culture studies and in the tissue engineering field. Industrially, the principal sources of collagen are calf skin and bones which, however, could be associated to risks of serious disease transmission. In fact, collagen derived from alternative and riskless sources is requir...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md12094912

    authors: Benedetto CD,Barbaglio A,Martinello T,Alongi V,Fassini D,Cullorà E,Patruno M,Bonasoro F,Barbosa MA,Carnevali MD,Sugni M

    更新日期:2014-09-24 00:00:00

  • Confirmation of pinnatoxins and spirolides in shellfish and passive samplers from Catalonia (Spain) by liquid chromatography coupled with triple quadrupole and high-resolution hybrid tandem mass spectrometry.

    abstract::Cyclic imines are lipophilic marine toxins that bioaccumulate in seafood. Their structure comprises a cyclic-imino moiety, responsible for acute neurotoxicity in mice. Cyclic imines have not been linked yet to human poisonings and are not regulated in Europe, although the European Food Safety Authority requires more d...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md12063706

    authors: García-Altares M,Casanova A,Bane V,Diogène J,Furey A,de la Iglesia P

    更新日期:2014-06-23 00:00:00

  • Evaluation of pseudopteroxazole and pseudopterosin derivatives against Mycobacterium tuberculosis and other pathogens.

    abstract::Pseudopterosins and pseudopteroxazole are intriguing marine natural products that possess notable antimicrobial activity with a commensurate lack of cytotoxicity. New semi-synthetic pseudopteroxazoles, pseudopteroquinoxalines and pseudopterosin congeners along with simple synthetic mimics of the terpene skeleton were ...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md10081711

    authors: McCulloch MW,Haltli B,Marchbank DH,Kerr RG

    更新日期:2012-08-01 00:00:00

  • Synthesis of Alkyl-Glycerolipids Standards for Gas Chromatography Analysis: Application for Chimera and Shark Liver Oils.

    abstract::Natural O-alkyl-glycerolipids, also known as alkyl-ether-lipids (AEL), feature a long fatty alkyl chain linked to the glycerol unit by an ether bond. AEL are ubiquitously found in different tissues but, are abundant in shark liver oil, breast milk, red blood cells, blood plasma, and bone marrow. Only a few AEL are com...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md16040101

    authors: Pinault M,Guimaraes C,Couthon H,Thibonnet J,Fontaine D,Chantôme A,Chevalier S,Besson P,Jaffrès PA,Vandier C

    更新日期:2018-03-23 00:00:00

  • λ-Carrageenan Suppresses Tomato Chlorotic Dwarf Viroid (TCDVd) Replication and Symptom Expression in Tomatoes.

    abstract::The effect of carrageenans on tomato chlorotic dwarf viroid (TCDVd) replication and symptom expression was studied. Three-week-old tomato plants were spray-treated with iota(ɩ)-, lambda(λ)-, and kappa(κ)-carrageenan at 1 g·L-1 and inoculated with TCDVd after 48 h. The λ-carrageenan significantly suppressed viroid symp...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md13052875

    authors: Sangha JS,Kandasamy S,Khan W,Bahia NS,Singh RP,Critchley AT,Prithiviraj B

    更新日期:2015-05-08 00:00:00

  • Preparation of calibration standards of N1-H paralytic shellfish toxin analogues by large-scale culture of cyanobacterium Anabaena circinalis (TA04).

    abstract::Mouse bioassay is the official testing method to quantify paralytic shellfish toxins (PSTs) in bivalves. A number of alternative analytical methods have been reported. Some methods have been evaluated by a single laboratory validation. Among the different types of methods, chemical analyses are capable of identifying ...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md9030466

    authors: Watanabe R,Suzuki T,Oshima Y

    更新日期:2011-03-22 00:00:00

  • Mangrove Tirucallane- and Apotirucallane-Type Triterpenoids: Structure Diversity of the C-17 Side-Chain and Natural Agonists of Human Farnesoid/Pregnane⁻X⁻Receptor.

    abstract::Ten new triterpenoid compounds with structure diversity of the C-17 side-chain, including nine tirucallanes, named xylocarpols A⁻E (1⁻5) and agallochols A⁻D (6⁻9), and an apotirucallane, named 25-dehydroxy protoxylogranatin B (10), were isolated from the mangrove plants Xylocarpus granatum, Xylocarpus moluccensis, and...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md16120488

    authors: Jiang ZP,Luan ZL,Liu RX,Zhang Q,Ma XC,Shen L,Wu J

    更新日期:2018-12-06 00:00:00

  • Bioaccessibility of Marine Carotenoids.

    abstract::The benefit of carotenoids to human health is undeniable and consequently, their use for this purpose is growing rapidly. Additionally, the nutraceutical properties of carotenoids have attracted attention of the food industry, especially in a new market area, the 'cosmeceuticals.' Marine organisms (microalgae, seaweed...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审

    doi:10.3390/md16100397

    authors: Viera I,Pérez-Gálvez A,Roca M

    更新日期:2018-10-22 00:00:00

  • Synthesis and Antiplasmodial Evaluation of Analogues Based on the Tricyclic Core of Thiaplakortones A-D.

    abstract::Six regioisomers associated with the tricyclic core of thiaplakortones A-D have been synthesized. Reaction of 1H-indole-4,7-dione and 1-tosyl-1H-indole-4,7-dione with 2-aminoethanesulfinic acid afforded a regioisomeric series, which was subsequently deprotected and oxidized to yield the tricyclic core scaffolds presen...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md13095784

    authors: Schwartz BD,Coster MJ,Skinner-Adams TS,Andrews KT,White JM,Davis RA

    更新日期:2015-09-15 00:00:00

  • Spiromastixones Inhibit Foam Cell Formation via Regulation of Cholesterol Efflux and Uptake in RAW264.7 Macrophages.

    abstract::Bioassay-guided evaluation shows that a deep sea-derived fungus, Spiromastix sp. MCCC 3A00308, possesses lipid-lowering activity. Chromatographic separation of a culture broth resulted in the isolation of 15 known depsidone-based analogues, labeled spiromastixones A-O (1-15). Each of these compounds was tested for its...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md13106352

    authors: Wu C,Chen R,Liu M,Liu D,Li X,Wang S,Niu S,Guo P,Lin W

    更新日期:2015-10-14 00:00:00

  • Interpreting Microbial Biosynthesis in the Genomic Age: Biological and Practical Considerations.

    abstract::Genome mining has become an increasingly powerful, scalable, and economically accessible tool for the study of natural product biosynthesis and drug discovery. However, there remain important biological and practical problems that can complicate or obscure biosynthetic analysis in genomic and metagenomic sequencing pr...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审

    doi:10.3390/md15060165

    authors: Miller IJ,Chevrette MG,Kwan JC

    更新日期:2017-06-06 00:00:00

  • Antitumor Effects of Laminaria Extract Fucoxanthin on Lung Cancer.

    abstract::Lung cancer is the leading cause of cancer mortality worldwide and non-small-cell lung cancer (NSCLC) is the most common type. Marine plants provide rich resources for anticancer drug discovery. Fucoxanthin (FX), a Laminaria japonica extract, has attracted great research interest for its antitumor activities. Accumula...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md15020039

    authors: Mei C,Zhou S,Zhu L,Ming J,Zeng F,Xu R

    更新日期:2017-02-15 00:00:00

  • Biotechnological Production of Docosahexaenoic Acid Using Aurantiochytrium limacinum: Carbon Sources Comparison And Growth Characterization.

    abstract::Aurantiochytrium limacinum, a marine heterotrophic protist/microalga has shown interesting yields of docosahexaenoic acid (DHA) when cultured with different carbon sources: glucose, pure and crude glycerol. A complete study in a lab-scale fermenter allowed for the characterization and comparison of the growth kinetic ...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md13127064

    authors: Abad S,Turon X

    更新日期:2015-12-05 00:00:00

  • Structures and Bioactivities of Psolusosides B1, B2, J, K, L, M, N, O, P, and Q from the Sea Cucumber Psolus fabricii. The First Finding of Tetrasulfated Marine Low Molecular Weight Metabolites.

    abstract::Ten new di-, tri- and tetrasulfated triterpene glycosides, psolusosides B1 (1), B2 (2), J (3), K (4), L (5), M (6), N (7), O (8), P (9), and Q (10), were isolated from the sea cucumber Psolus fabricii collected in the Sea of Okhotsk near the Kurile Islands. Structures of these glycosides were established by two-dimens...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md17110631

    authors: Silchenko AS,Kalinovsky AI,Avilov SA,Kalinin VI,Andrijaschenko PV,Dmitrenok PS,Popov RS,Chingizova EA

    更新日期:2019-11-06 00:00:00

  • Co-processed chitin-mannitol as a new excipient for Oro-dispersible tablets.

    abstract::This study describes the preparation, characterization and performance of a novel excipient for use in oro-dispersible tablets (ODT). The excipient (Cop-CM) consists of chitin and mannitol. The excipient with optimal physicochemical properties was obtained at a chitin: mannitol ratio of 2:8 (w/w) and produced by roll ...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md13041739

    authors: Daraghmeh N,Chowdhry BZ,Leharne SA,Al Omari MM,Badwan AA

    更新日期:2015-03-30 00:00:00

  • Phlorotannins from Alaskan seaweed inhibit carbolytic enzyme activity.

    abstract::Global incidence of type 2 diabetes has escalated over the past few decades, necessitating a continued search for natural sources of enzyme inhibitors to offset postprandial hyperglycemia. The objective of this study was to evaluate coastal Alaskan seaweed inhibition of α-glucosidase and α-amylase, two carbolytic enzy...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md12105277

    authors: Kellogg J,Grace MH,Lila MA

    更新日期:2014-10-22 00:00:00

  • Biotransfer of β-N-methylamino-L-alanine (BMAA) in a eutrophicated freshwater lake.

    abstract::β-N-Methylamino-L-alanine (BMAA), a neurotoxic non-protein amino acid, plays a significant role as an environmental risk factor in neurodegenerative diseases, such as amyotrophic lateral sclerosis. BMAA producers occur globally, colonizing almost all habitats and represent species from distinct phytoplanktonic groups,...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md13031185

    authors: Lage S,Annadotter H,Rasmussen U,Rydberg S

    更新日期:2015-03-02 00:00:00

  • Induction of apoptosis, G₀/G₁ phase arrest and microtubule disassembly in K562 leukemia cells by Mere15, a novel polypeptide from Meretrix meretrix Linnaeus.

    abstract::Mere15 is a novel polypeptide from Meretrix meretrix Linnaeus with cytotoxicity in solid cancer cells. In this study, we investigated its activity on human K562 chronic myelogenous leukemia cells. Mere15 inhibited the growth of K562 cells with IC₅₀ values of 38.2 μg/mL. Mere15 also caused concentration dependent induc...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md10112596

    authors: Liu M,Zhao X,Zhao J,Xiao L,Liu H,Wang C,Cheng L,Wu N,Lin X

    更新日期:2012-11-21 00:00:00

  • Functional metabolomics uncovers metabolic alterations associated to severe oxidative stress in MCF7 breast cancer cells exposed to ascididemin.

    abstract::Marine natural products are a source of promising agents for cancer treatment. However, there is a need to improve the evaluation of their mechanism of action in tumors. Metabolomics of the response to anti-tumor agents is a tool to reveal candidate biomarkers and metabolic targets. We used two-dimensional high-resolu...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md11103846

    authors: Morvan D

    更新日期:2013-10-11 00:00:00

  • Algal lectins as potential HIV microbicide candidates.

    abstract::The development and use of topical microbicides potentially offers an additional strategy to reduce the spread of the Human Immunodeficiency Virus (HIV). Carbohydrate-binding agents (CBAs) that show specificity for high mannose carbohydrates on the surface of the heavily glycosylated envelope of HIV are endowed with p...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审

    doi:10.3390/md10071476

    authors: Huskens D,Schols D

    更新日期:2012-07-01 00:00:00

  • Total synthesis of fellutamide B and deoxy-fellutamides B, C, and D.

    abstract::The total syntheses of the marine-derived lipopeptide natural product fellutamide B and deoxy-fellutamides B, C, and D are reported. These compounds were accessed through a novel solid-phase synthetic strategy using Weinreb amide-derived resin. As part of the synthesis, a new enantioselective route to (3R)-hydroxy lau...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md11072382

    authors: Giltrap AM,Cergol KM,Pang A,Britton WJ,Payne RJ

    更新日期:2013-07-08 00:00:00

  • Purification and characterization of a bifunctional alginate lyase from Pseudoalteromonas sp. SM0524.

    abstract::An alginate lyase-producing bacterial strain, Pseudoalteromonas sp. SM0524, was screened from marine rotten kelp. In an optimized condition, the production of alginate lyase from Pseudoalteromonas sp. SM0524 reached 62.6 U/mL, suggesting that strain SM0524 is a good producer of alginate lyases. The bifunctional algina...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md9010109

    authors: Li JW,Dong S,Song J,Li CB,Chen XL,Xie BB,Zhang YZ

    更新日期:2011-01-21 00:00:00

  • Biological activity of volatiles from marine and terrestrial bacteria.

    abstract::The antiproliferative activity of 52 volatile compounds released from bacteria was investigated in agar diffusion assays against medically important microorganisms and mouse fibroblasts. Furthermore, the activity of these compounds to interfere with the quorum-sensing-systems was tested with two different reporter str...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md8122976

    authors: Schulz S,Dickschat JS,Kunze B,Wagner-Dobler I,Diestel R,Sasse F

    更新日期:2010-12-22 00:00:00

  • Increased Cell Detachment Ratio of Mesenchymal-Type Lung Cancer Cells on pH-Responsive Chitosan through the β3 Integrin.

    abstract::Chitosan is sensitive to environmental pH values due to its electric property. This study investigates whether the pH-responsive chitosan assay can provide a simple method to evaluate the aggressive behavior of cancer cells with cell detachment ratio. The epithelial-mesenchymal transition (EMT) is induced with transfo...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md17120659

    authors: Yen CH,Young TH,Hsieh MC,Liao LJ,Huang TW

    更新日期:2019-11-23 00:00:00