Abstract:
:Over the past decades, a number of novel compounds, which are produced in the marine environment, have been found to exhibit the anticancer effects. This review focuses on molecular targets of marine-derived anticancer candidates in clinical and preclinical studies. They are kinases, transcription factors, histone deacetylase, the ubiquitin-proteasome system, and so on. Specific emphasis of this review paper is to provide information on the optimization of new target compounds for future research and development of anticancer drugs, based on the identification of structures of these target molecules and parallel compounds.
journal_name
Mar Drugsjournal_title
Marine drugsauthors
Song X,Xiong Y,Qi X,Tang W,Dai J,Gu Q,Li Jdoi
10.3390/md16050175subject
Has Abstractpub_date
2018-05-22 00:00:00issue
5issn
1660-3397pii
md16050175journal_volume
16pub_type
杂志文章,评审相关文献
Marine Drugs文献大全abstract::Astaxanthin is one of the strongest natural antioxidants and a red pigment occurring in nature. This C40 carotenoid is used in a broad range of applications such as a colorant in the feed industry, an antioxidant in cosmetics or as a supplement in human nutrition. Natural astaxanthin is on the rise and, hence, alterna...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md17110621
更新日期:2019-10-31 00:00:00
abstract::Viridicatol is a quinoline alkaloid isolated from the deep-sea-derived fungus Penicillium griseofulvum. The structure of viridicatol was unambiguously established by X-ray diffraction analysis. In this study, a mouse model of ovalbumin-induced food allergy and the rat basophil leukemia (RBL)-2H3 cell model were establ...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md18100517
更新日期:2020-10-16 00:00:00
abstract::Climate change with increasing temperature and ocean acidification (OA) poses risks for marine ecosystems. According to Pörtner and Farrell, synergistic effects of elevated temperature and CO₂-induced OA on energy metabolism will narrow the thermal tolerance window of marine ectothermal animals. To test this hypothesi...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md8082318
更新日期:2010-08-11 00:00:00
abstract::Ten new diterpene glycosides virescenosides Z9-Z18 (1-10) together with three known analogues (11-13) and aglycon of virescenoside A (14) were isolated from the marine-derived fungus Acremonium striatisporum KMM 4401. These compounds were obtained by cultivating fungus on wort agar medium with the addition of potassiu...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md17110616
更新日期:2019-10-29 00:00:00
abstract::Two new bicyclogermacrenes, capgermacrenes A (1) and B (2), were isolated with two known compounds, palustrol (3) and litseagermacrane (4), from a population of Bornean soft coral Capnella sp. The structures of these metabolites were elucidated based on spectroscopic data. Compound 1 was found to inhibit the accumulat...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md13053103
更新日期:2015-05-19 00:00:00
abstract::The mucus produced by many marine organisms is a complex mixture of proteins and polysaccharides forming a weak watery gel. It is essential for vital processes including locomotion, navigation, structural support, heterotrophic feeding and defence against a multitude of environmental stresses, predators, parasites, an...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md13085276
更新日期:2015-08-19 00:00:00
abstract::Ascidians (tunicates) are invertebrate chordates, and prolific producers of a wide variety of biologically active secondary metabolites from cyclic peptides to aromatic alkaloids. Several of these compounds have properties which make them candidates for potential new drugs to treat diseases such as cancer. Many of the...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md16050162
更新日期:2018-05-13 00:00:00
abstract::Three new diphenyl ether derivatives-phomaethers A-C (1-3) and five known compounds-including a diphenyl ether analog, 2,3'-dihydroxy-4-methoxy-5',6-dimethyl diphenyl ether (4); and four isocoumarin derivatives, diaportinol (5), desmethyldiaportinol (6), citreoisocoumarinol (7), and citreoisocoumarin (8)-were isolated...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md15060146
更新日期:2017-05-25 00:00:00
abstract::Fish oil is used in the production of feed for cultured fish owing to its high polyunsaturated fatty acid content (PUFA). The over-exploitation of fisheries and events like "El Niño" are reducing the fish oil supply. Some marine microorganisms are considered potentially as alternative fatty acid sources. This study as...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md15120369
更新日期:2017-12-01 00:00:00
abstract::Six regioisomers associated with the tricyclic core of thiaplakortones A-D have been synthesized. Reaction of 1H-indole-4,7-dione and 1-tosyl-1H-indole-4,7-dione with 2-aminoethanesulfinic acid afforded a regioisomeric series, which was subsequently deprotected and oxidized to yield the tricyclic core scaffolds presen...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md13095784
更新日期:2015-09-15 00:00:00
abstract::A green extraction process using only water was proposed for the simultaneous extraction of alginate and bioactive compounds from Laminaria ochroleuca. Operation was carried out during non-isothermal heating up to maximal temperatures over the range of 70 °C to 100 °C. Once separated, the alginate and the crude extrac...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md18070336
更新日期:2020-06-27 00:00:00
abstract::In the course of studies on bioactive metabolites from marine fungi, a new 10-membered lactone, named penicillinolide A (1) was isolated from the organic extract of Penicillium sp. SF-5292 as a potential anti-inflammatory compound. The structure of penicillinolide A (1) was mainly determined by analysis of NMR and MS ...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md11114510
更新日期:2013-11-12 00:00:00
abstract::Seagrasses are high plants sharing adaptive metabolic features with both terrestrial plants and marine algae, resulting in a phytocomplex possibly endowed with interesting biological properties. The aim of this study is to evaluate the in vitro activities on skin cells of an ethanolic extract obtained from the leaves ...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md16010021
更新日期:2018-01-10 00:00:00
abstract::Three new epidithiodiketopiperazines pretrichodermamides D-F (1-3), together with the known N-methylpretrichodermamide B (4) and pretrichodermamide С (5), were isolated from the lipophilic extract of the marine algae-derived fungus Penicillium sp. KMM 4672. The structures of compounds 1-5 were determined based on spec...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md14070122
更新日期:2016-06-27 00:00:00
abstract::The Antarctic sponge Dendrilla antarctica is rich in defensive terpenoids with promising antimicrobial potential. Investigation of this demosponge has resulted in the generation of a small chemical library containing diterpenoid secondary metabolites with bioactivity in an infectious disease screening campaign focused...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md18060327
更新日期:2020-06-23 00:00:00
abstract::Three major forms of the nicotinic agonist toxin anabaseine (cyclic iminium, cyclic imine and the monocationic open-chain ammonium-ketone) co-exist in almost equal concentrations at physiological pH. We asked the question: Which of these forms is pharmacologically active? First, we investigated the pH dependence of an...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md17110614
更新日期:2019-10-29 00:00:00
abstract::The nutritional and pharmaceutical values of long-chain polyunsaturated fatty acids (LC-PUFAs) such as arachidonic, eicosapentaenoic and docosahexaenoic acids have been well recognized. These LC-PUFAs are physiologically important compounds in bacteria and eukaryotes. Although little is known about the biosynthetic me...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md14050094
更新日期:2016-05-12 00:00:00
abstract::Four new sesquiterpene lactones (3, 4, 6 and 7) and three known compounds, purpuride (1), berkedrimane B (2) and purpuride B (5), were isolated from the marine fungus, Talaromyces minioluteus (Penicillium minioluteum). New compounds were drimane sesquiterpenes conjugated with N-acetyl-l-valine, and their structures we...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md13063567
更新日期:2015-06-05 00:00:00
abstract::Oxidative stress contributes to chronic inflammatory processes implicated in aging, referred to as "inflamm-aging." In this study, the potential anti-inflammatory and anti-aging effects of a pigment-protein complex (PPC) from Chlorella pyrenoidosa were investigated using lipopolysaccharide (LPS)-stimulated RAW 264.7 m...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md17100586
更新日期:2019-10-16 00:00:00
abstract::The red seaweeds belonging to the genus Laurencia are well known as halogenated secondary metabolites producers, mainly terpenoids and acetogennins. Several of these chemicals exhibit important ecological roles and biotechnological applications. However, knowledge regarding the genes involved in the biosynthesis of th...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md13020879
更新日期:2015-02-10 00:00:00
abstract::Recently, the studies on the prevention and treatment of human papillomavirus (HPV) which is closely related to the cervical cancer and other genital diseases are attracting more and more attention all over the world. Marine-derived polysaccharides and other bioactive compounds have been shown to possess a variety of ...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md12042019
更新日期:2014-04-03 00:00:00
abstract::An alginate lyase-producing bacterial strain, Pseudoalteromonas sp. SM0524, was screened from marine rotten kelp. In an optimized condition, the production of alginate lyase from Pseudoalteromonas sp. SM0524 reached 62.6 U/mL, suggesting that strain SM0524 is a good producer of alginate lyases. The bifunctional algina...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md9010109
更新日期:2011-01-21 00:00:00
abstract::Chemical study of the secondary metabolites of a deep-sea-derived fungus Aspergillus sydowii MCCC 3A00324 led to the isolation of eleven compounds (1-11), including one novel (1) and one new (2) osmane-related monoterpenoids and two undescribed polyketides (3 and 4). The structures of the metabolites were determined b...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md18110561
更新日期:2020-11-17 00:00:00
abstract::In this study, thirteen sponge-derived terpenoids, including five linear furanoterpenes: furospinulosin-1 (1), furospinulosin-2 (2), furospongin-1 (3), furospongin-4 (4), and demethylfurospongin-4 (5); four linear meroterpenes: 2-(hexaprenylmethyl)-2-methylchromenol (6), 4-hydroxy-3-octaprenylbenzoic acid (7), 4-hydro...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md8010047
更新日期:2010-01-15 00:00:00
abstract::Long chain polyunsaturated fatty acids (LC-PUFAs) are important mediators in improving and maintaining human health over the total lifespan. One topic we especially focus on in this review is omega-3 LC-PUFA docosahexaenoic acid (DHA). Adequate DHA levels are essential during neurodevelopment and, in addition, benefic...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md12126190
更新日期:2014-12-18 00:00:00
abstract::Polymeric 3-alkylpyridinium salts (poly-APS) present in the marine sponge Reniera sarai show a broad spectrum of biological activities. They are lytic to erythrocytes and various other mammalian cells, enabling the transfection of the latter with alien DNA. Furthermore, they show inhibitory effects to marine bacteria ...
journal_title:Marine drugs
pub_type: 杂志文章
doi:
更新日期:2007-11-13 00:00:00
abstract::The marine nemertean Cephalothrix simula originates from the Pacific Ocean but in recent years has been discovered in northern Europe. The species has been associated with high levels of the marine neurotoxin Tetrodotoxin, traditionally associated with Pufferfish Poisoning. This study reports the first discovery of tw...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md16110452
更新日期:2018-11-16 00:00:00
abstract::Chitosan has been the subject of interest for its use as a polymeric drug carrier material in dosage form design due to its appealing properties such as biocompatibility, biodegradability, low toxicity and relatively low production cost from abundant natural sources. However, one drawback of using this natural polysac...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md8041305
更新日期:2010-04-19 00:00:00
abstract::The biologically active lipopeptide kalkitoxin was previously isolated from the marine cyanobacterium Moorea producens (Lyngbya majuscula). Kalkitoxin exhibited N-methyl-D-aspartate (NMDA)-mediated neurotoxicity and acted as an inhibitory ligand for voltage-sensitive sodium channels in cultured rat cerebellar granule ...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md13031552
更新日期:2015-03-20 00:00:00
abstract::The aim of this research was to prepare and characterize alginate-chitosan mucoadhesive microparticles containing puerarin. The microparticles were prepared by an emulsification-internal gelatin method using a combination of chitosan and Ca2+ as cationic components and alginate as anions. Surface morphology, particle ...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md12125764
更新日期:2014-12-01 00:00:00