Abstract：
:Three new epidithiodiketopiperazines pretrichodermamides D-F (1-3), together with the known N-methylpretrichodermamide B (4) and pretrichodermamide С (5), were isolated from the lipophilic extract of the marine algae-derived fungus Penicillium sp. KMM 4672. The structures of compounds 1-5 were determined based on spectroscopic methods. The absolute configuration of pretrichodermamide D (1) was established by a combination of modified Mosher's method, NOESY data, and biogenetic considerations. N-Methylpretrichodermamide B (5) showed strong cytotoxicity against 22Rv1 human prostate cancer cells resistant to androgen receptor targeted therapies.
journal_name
Mar Drugsjournal_title
Marine drugsauthors
Yurchenko AN,Smetanina OF,Ivanets EV,Kalinovsky AI,Khudyakova YV,Kirichuk NN,Popov RS,Bokemeyer C,von Amsberg G,Chingizova EA,Afiyatullov SSh,Dyshlovoy SAdoi
10.3390/md14070122subject
Has Abstractpub_date
2016-06-27 00:00:00issue
7issn
1660-3397pii
md14070122journal_volume
14pub_type
杂志文章相关文献
Marine Drugs文献大全abstract：:Global incidence of type 2 diabetes has escalated over the past few decades, necessitating a continued search for natural sources of enzyme inhibitors to offset postprandial hyperglycemia. The objective of this study was to evaluate coastal Alaskan seaweed inhibition of α-glucosidase and α-amylase, two carbolytic enzy...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md12105277
更新日期：2014-10-22 00:00:00
abstract：:Four 4-hydroxy-α-pyrones including three new ones named nipyrones A-C (1-3) together with one known analogue germicidin C (4) were discovered from a marine sponge-derived fungus Aspergillus niger cultivated in a solid rice culture. Their structures and absolute configurations were elucidated through a combination of s...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md17060344
更新日期：2019-06-10 00:00:00
abstract：:Nonalcoholic steatohepatitis (NASH) is a disease closely associated with obesity and diabetes. A prevalence of type 2 diabetes and a high body mass index in cryptogenic cirrhosis may imply that obesity leads to cirrhosis. Here, we examined the effects of an extract of Ecklonia cava, a brown algae, on the activation of...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md9122793
更新日期：2011-12-01 00:00:00
abstract：:Spumigins are marine natural products derived from cyanobacteria Nodulariaspumigena, which mimics the structure of the d-Phe-Pro-Arg sequence and is crucial for binding to the active site of serine proteases thrombin and factor Xa. Biological evaluation of spumigins showed that spumigins with a (2S,4S)-4-methylproline...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md16110413
更新日期：2018-10-27 00:00:00
abstract：:Cyanobacteria are a diverse group of Gram-negative bacteria that produce an array of secondary compounds with selective bioactivity against vertebrates, invertebrates, plants, microalgae, fungi, bacteria, viruses and cell lines. The aim of this study was to assess the toxic effects of aqueous, methanolic and hexane cr...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md803471
更新日期：2010-03-05 00:00:00
abstract：:The study of spatial distribution of secondary metabolites within microbial cells facilitates the screening of candidate strains from marine environments for functional metabolites and allows for the subsequent assessment of the production of metabolites, such as antibiotics. This paper demonstrates the first applicat...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md12052827
更新日期：2014-05-13 00:00:00
abstract：:The democratization of sequencing technologies fostered a leap in our knowledge of the diversity of marine phytoplanktonic microalgae, revealing many previously unknown species and lineages. The evolutionary history of the diversification of microalgae can be inferred from the analysis of their genome sequences. Howev...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md18020078
更新日期：2020-01-25 00:00:00
abstract：:Marine cyanobacteria, notably those from tropical regions, are a rich source of bioactive secondary metabolites. Tropical marine cyanobacteria often grow to high densities in the environment, allowing direct isolation of many secondary metabolites from field-collected material. However, in temperate environments cultu...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md11041316
更新日期：2013-04-22 00:00:00
abstract：:Ecklonia cava (E. cava) can alleviate vascular dysfunction in diseases associated with poor circulation. E. cava contains various polyphenols with different functions, but few studies have compared the effects of these polyphenols. Here, we comparatively investigated four major compounds present in an ethanoic extract...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md16110441
更新日期：2018-11-09 00:00:00
abstract：:Bacteria belonging to the Vibrionaceae family are widespread in the marine environment. Today, 128 species of vibrios are known. Several of them are infamous for their pathogenicity or symbiotic relationships. Despite their ability to interact with eukaryotes, the vibrios are greatly underexplored for their ability to...
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md9091440
更新日期：2011-01-01 00:00:00
abstract：:We test previous claims that the bacteria Vibrio alginolyticus produces tetrodotoxin (TTX) when living in symbiosis with the nemertean Lineus longissimus by a setup with bacteria cultivation for TTX production. Toxicity experiments on the shore crab, Carcinus maenas, demonstrated the presence of a paralytic toxin, but...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md14040063
更新日期：2016-03-25 00:00:00
abstract：:Anemonia viridis is a widespread and extensively studied Mediterranean species of sea anemone from which a large number of polypeptide toxins, such as blood depressing substances (BDS) peptides, have been isolated. The first members of this class, BDS-1 and BDS-2, are polypeptides belonging to the β-defensin fold fami...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md11114213
更新日期：2013-10-30 00:00:00
abstract：:Carrageenans are abundant and safe non-starch polysaccharides exerting their biological effects in living organisms. Apart from their known pro-inflammation properties and some pharmacological activity, carrageenans can also strongly bind and hold metal ions. This property can be used for creation of the new drugs for...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md8041106
更新日期：2010-04-01 00:00:00
abstract：:Sponge-associated bacteria have been mostly cultured from shallow water (≤30 m) sponges, whereas only few studies targeted specimens from below 30 m. This study assessed the cultivability of bacteria from two marine sponges Xestospongia muta and Agelas sventres collected from shallow (<30 m), upper mesophotic (30-60 m...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md17100578
更新日期：2019-10-11 00:00:00
abstract：:The methods to obtain chitooligosaccharides are tightly related to the physicochemical properties of the end products. Knowledge of these physicochemical characteristics is crucial to describing the biological functions of chitooligosaccharides. Chitooligosaccharides were prepared either in a single-step enzymatic hyd...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md16110430
更新日期：2018-11-02 00:00:00
abstract：:Fucoidan is a polysaccharide built from L-fucose molecules. The main source of this polysaccharide is the extracellular matrix of brown seaweed (Phaeophyta), but it can be also isolated from invertebrates such as sea urchins (Echinoidea) and sea cucumbers (Holothuroidea). Interest in fucoidan is related to its broad b...
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md17080458
更新日期：2019-08-05 00:00:00
abstract：:Haloferax mediterranei produces C50 carotenoids that have strong antioxidant properties. The response surface methodology (RSM) tool helps to accurately analyze the most suitable conditions to maximize C50 carotenoids production by haloarchaea. The effects of temperature (15⁻50 °C), pH (4-10), and salinity (5⁻28% NaCl...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md16100372
更新日期：2018-10-09 00:00:00
abstract：:Tetracenomycin X (Tcm X) has been reported to have antitumour activity in various cancers, but there have not been any studies on its activity with respect to lung cancer to date. Therefore, this study aims to investigate the anti-lung cancer activity of Tcm X. In this study, we found that tetracenomycin X showed anti...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md17010063
更新日期：2019-01-18 00:00:00
abstract：:Certain strains of cyanobacteria produce a wide array of cyanotoxins, such as microcystins, lyngbyatoxins and aplysiatoxins, that are associated with public health issues. In this pilot study, an approach combining LC-MS/MS and molecular networking was employed as a rapid analytical method to detect aplysiatoxins pres...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md16120505
更新日期：2018-12-13 00:00:00
abstract：:The Asian coastal communities have used the brown seaweeds Fucus vesiculosus and Ascophyllum nodosum since ancient times. Recently, some in vitro and in vivo studies have demonstrated their abilities in reducing risk factors for metabolic syndrome. Here, we analyzed the protective effect of a phytocomplex extracted fr...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md18010062
更新日期：2020-01-17 00:00:00
abstract：:Many marine bacteria produce exopolysaccharides (EPS) as a strategy for growth, adhering to solid surfaces, and to survive adverse conditions. There is growing interest in isolating new EPS producing bacteria from marine environments, particularly from extreme marine environments such as deep-sea hydrothermal vents ch...
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md8061779
更新日期：2010-06-03 00:00:00
abstract：:Polymeric 3-alkylpyridinium salts (poly-APS) present in the marine sponge Reniera sarai show a broad spectrum of biological activities. They are lytic to erythrocytes and various other mammalian cells, enabling the transfection of the latter with alien DNA. Furthermore, they show inhibitory effects to marine bacteria ...
journal_title：Marine drugs
pub_type： 杂志文章
doi：
更新日期：2007-11-13 00:00:00
abstract：:Chinese white dolphin (Sousa chinensis), also known as the Indo-Pacific humpback dolphin, has been classified as "Vulnerable" on the IUCN Red List of Threatened Species. It is a special cetacean species that lives in tropical and subtropical nearshore waters, with significant differences from other cetaceans. Here, we...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md17090504
更新日期：2019-08-28 00:00:00
abstract：:Antimicrobial peptides (AMPs) are not only cytotoxic towards host pathogens or cancer cells but also are able to act as immunomodulators. It was shown that some human and non-human AMPs can interact with complement proteins and thereby modulate complement activity. Thus, AMPs could be considered as the base for comple...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md18120631
更新日期：2020-12-10 00:00:00
abstract：:Separacenes A-D (1-4), novel polyene polyols, were isolated from Streptomyces sp. collected from the southern area of Jeju Island, Korea. The chemical structures of 1-4 were established by NMR, mass, UV, and IR spectroscopy as well as the modified Mosher's method. Separacenes A-B (1-2), which share an identical planar...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md11082882
更新日期：2013-08-13 00:00:00
abstract：:D. salina is one of the recognized natural sources to produce beta-carotene, and an useful model for studying the role of inhibitors and enhancers of carotenogenesis. However there is little information in D. salina regarding whether the isoprenoid substrate can be influenced by stress factors (carotenogenic) or selec...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md7010045
更新日期：2009-01-01 00:00:00
abstract：:The small-spotted catshark is one of the most abundant elasmobranchs in the Northeastern Atlantic Ocean. Although its landings are devoted for human consumption, in general this species has low commercial value with high discard rates, reaching 100% in some European fisheries. The reduction of post-harvest losses (dis...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md17010040
更新日期：2019-01-09 00:00:00
abstract：:The immunomodulatory effect of triterpene glycoside cucumarioside A₂-2 (CA₂-2), isolated from the Far Eastern sea cucumber Cucumaria japonica, was compared with lipopolysaccharide (LPS) on mouse spleen. It has been shown that the intraperitoneal (i.p.) glycoside administration leads to increased spleen macrophage acti...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md15110341
更新日期：2017-11-01 00:00:00
abstract：:Sea cucumbers have been valued for many centuries as a tonic and functional food, dietary delicacies and important ingredients of traditional medicine in many Asian countries. An assortment of bioactive compounds has been described in sea cucumbers. The most important and abundant secondary metabolites from sea cucumb...
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md14080147
更新日期：2016-08-04 00:00:00
abstract：:Peridinin and fucoxanthin, which are natural carotenoids isolated from a symbiotic dinoflagellate, Symbiodinium sp., and a brown alga, Petalonia fascia, respectively, were compared for inhibitory effects on delayed-type hypersensitivity in mice. The number of eosinophils at the site of inflammation and in peripheral b...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md12041773
更新日期：2014-03-27 00:00:00
