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Gliotoxin Inhibits Proliferation and Induces Apoptosis in Colorectal Cancer Cells.

Abstract：

:The discovery of new bioactive compounds from marine natural sources is very important in pharmacological research. Here we developed a Wnt responsive luciferase reporter assay to screen small molecule inhibitors of cancer associated constitutive Wnt signaling pathway. We identified that gliotoxin (GTX) and some of its analogues, the secondary metabolites from marine fungus Neosartorya pseufofischeri, acted as inhibitors of the Wnt signaling pathway. In addition, we found that GTX downregulated the β-catenin levels in colorectal cancer cells with inactivating mutations of adenomatous polyposis coli (APC) or activating mutations of β-catenin. Furthermore, we demonstrated that GTX induced growth inhibition and apoptosis in multiple colorectal cancer cell lines with mutations of the Wnt signaling pathway. Together, we illustrated a practical approach to identify small-molecule inhibitors of the Wnt signaling pathway and our study indicated that GTX has therapeutic potential for the prevention or treatment of Wnt dependent cancers and other Wnt related diseases.

journal_name

Mar Drugs

journal_title

Marine drugs

authors

Chen J,Wang C,Lan W,Huang C,Lin M,Wang Z,Liang W,Iwamoto A,Yang X,Liu H

doi

10.3390/md13106259

subject

Has Abstract

pub_date

2015-10-02 00:00:00

pages

6259-73

issue

10

issn

1660-3397

pii

md13106259

journal_volume

13

pub_type

杂志文章

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