New 9α-Hydroxy-5α,6α-epoxyhydroxysterols from the Vietnamese Marine Sponge Ircinia echinata.

abstract：:Numerous antimicrobial peptides (AMPs) from marine fish have been identified, isolated and characterized. These peptides act as host defense molecules that exert antimicrobial effects by targeting the lipopolysaccharide (LPS) of Gram-negative bacteria. The LPS-AMP interactions are driven by the biophysical properties ...

journal_title：Marine drugs

authors： Gopal R,Seo CH,Park Y

更新日期：2014-03-13 00:00:00

abstract：:Ten new triterpenoid compounds with structure diversity of the C-17 side-chain, including nine tirucallanes, named xylocarpols A⁻E (1⁻5) and agallochols A⁻D (6⁻9), and an apotirucallane, named 25-dehydroxy protoxylogranatin B (10), were isolated from the mangrove plants Xylocarpus granatum, Xylocarpus moluccensis, and...

journal_title：Marine drugs

authors： Jiang ZP,Luan ZL,Liu RX,Zhang Q,Ma XC,Shen L,Wu J

更新日期：2018-12-06 00:00:00

abstract：:A general protocol for the asymmetric synthesis of 3-N-arylmethylated right-half model compounds of renieramycins was developed, which enabled structure⁻activity relationship (SAR) study of several 3-N-arylmethyl derivatives. The most active compound (6a) showed significant cytotoxic activity against human prostate ca...

journal_title：Marine drugs

authors： Matsubara T,Yokoya M,Sirimangkalakitti N,Saito N

更新日期：2018-12-20 00:00:00

abstract：:Natural anionic polysaccharides fucosylated chondroitin sulfates (FCS) from sea cucumbers attract great attention nowadays due to their ability to influence various biological processes, such as blood coagulation, thrombosis, angiogenesis, inflammation, bacterial and viral adhesion. To determine pharmacophore fragment...

journal_title：Marine drugs

authors： Ustyuzhanina NE,Fomitskaya PA,Gerbst AG,Dmitrenok AS,Nifantiev NE

更新日期：2015-02-02 00:00:00

abstract：:A green extraction process using only water was proposed for the simultaneous extraction of alginate and bioactive compounds from Laminaria ochroleuca. Operation was carried out during non-isothermal heating up to maximal temperatures over the range of 70 °C to 100 °C. Once separated, the alginate and the crude extrac...

journal_title：Marine drugs

authors： Flórez-Fernández N,Álvarez-Viñas M,Guerreiro F,Torres MD,Grenha A,Domínguez H

更新日期：2020-06-27 00:00:00

abstract：:The study of spatial distribution of secondary metabolites within microbial cells facilitates the screening of candidate strains from marine environments for functional metabolites and allows for the subsequent assessment of the production of metabolites, such as antibiotics. This paper demonstrates the first applicat...

journal_title：Marine drugs

authors： Miyaoka R,Hosokawa M,Ando M,Mori T,Hamaguchi HO,Takeyama H

更新日期：2014-05-13 00:00:00

abstract：:Smenospongine, a sesquiterpene aminoquinone isolated from the marine sponge Dactylospongia elegans, was previously reported by us to induce erythroid differentiation and G1 phase arrest of K562 chronic myelogenous leukemia cells. In this study, we investigated the effect of smenospongine on the cell cycles of other le...

journal_title：Marine drugs

authors： Kong D,Aoki S,Sowa Y,Sakai T,Kobayashi M

更新日期：2008-01-01 00:00:00

abstract：:The red macroalga Agarophyton chilensis is a well-known producer of eicosanoids such as hydroxyeicosatetraenoic acids, but the alga produces almost no prostaglandins, unlike the closely related A. vermiculophyllum. This indicates that the related two algae would have different enzyme systems or substrate composition. ...

journal_title：Marine drugs

authors： Honda M,Ishimaru T,Itabashi Y,Vyssotski M

更新日期：2019-02-02 00:00:00

abstract：:Intermittent hypobaric hypoxia (IH) is linked with oxidative stress, impairing cardiac function. However, early IH also activate cardio-protective mechanisms. Omega 3 fatty acids (Ω3) induce cardioprotection by reducing infarct size and reinforcing antioxidant defenses. The aim of this work was to determine the combin...

journal_title：Marine drugs

authors： Herrera EA,Farías JG,González-Candia A,Short SE,Carrasco-Pozo C,Castillo RL

更新日期：2015-02-04 00:00:00

abstract：:Gorgonian octocorals are considered a prolific source of secondary metabolites with a wide range of biological activities, including anti-inflammatory activity. In particular, the genus Briareum is known for producing a wealth of diterpenes with complex chemical structures. The chemical study of the methanolic extract...

journal_title：Marine drugs

authors： Gutiérrez M,Santamaría R,Gómez-Reyes JF,Guzmán HM,Ávila-Román J,Motilva V,Talero E

更新日期：2020-01-27 00:00:00

abstract：:This study describes the preparation, characterization and performance of a novel excipient for use in oro-dispersible tablets (ODT). The excipient (Cop-CM) consists of chitin and mannitol. The excipient with optimal physicochemical properties was obtained at a chitin: mannitol ratio of 2:8 (w/w) and produced by roll ...

journal_title：Marine drugs

authors： Daraghmeh N,Chowdhry BZ,Leharne SA,Al Omari MM,Badwan AA

更新日期：2015-03-30 00:00:00

abstract：:Chemical investigation on the soft coral Sarcophyton sp. collected from the South China Sea yielded three new polyhydroxylated steroids, compounds (1-3), together with seven known ones (4-10). Their structures were established by extensive spectroscopic methods and comparison of their data with those of the related kn...

journal_title：Marine drugs

authors： Gong KK,Tang XL,Zhang G,Cheng CL,Zhang XW,Li PL,Li GQ

更新日期：2013-12-02 00:00:00

abstract：:Two strains of Azadinium poporum, one from the Korean West coast and the other from the North Sea, were mass cultured for isolation of new azaspiracids. Approximately 0.9 mg of pure AZA-36 (1) and 1.3 mg of pure AZA-37 (2) were isolated from the Korean (870 L) and North Sea (120 L) strains, respectively. The structure...

journal_title：Marine drugs

authors： Krock B,Tillmann U,Potvin É,Jeong HJ,Drebing W,Kilcoyne J,Al-Jorani A,Twiner MJ,Göthel Q,Köck M

更新日期：2015-10-30 00:00:00

abstract：:We aimed to investigate the pharmacokinetics and the underlying mechanisms of the intestinal absorption, distribution, metabolism, and excretion of Jaspine B in rats. The oral bioavailability of Jaspine B was 6.2%, but it decreased to 1.6% in bile-depleted rats and increased to 41.2% (normal) and 23.5% (bile-depleted)...

journal_title：Marine drugs

authors： Choi MK,Lee J,Nam SJ,Kang YJ,Han Y,Choi K,Choi YA,Kwon M,Lee D,Song IS

更新日期：2017-09-01 00:00:00

abstract：:One new α-pyrone (nocapyrone R (1)), and three known γ-pyrones (nocapyrones B, H and L (2-4)) were isolated from the culture extract of a Nocardiopsis strain collected from marine sediment. Structures of these compounds were determined on the basis of spectroscopic data including NMR and MS. γ-Pyrones 2-4 were found t...

journal_title：Marine drugs

authors： Kim Y,Ogura H,Akasaka K,Oikawa T,Matsuura N,Imada C,Yasuda H,Igarashi Y

更新日期：2014-07-08 00:00:00

abstract：:The red seaweeds belonging to the genus Laurencia are well known as halogenated secondary metabolites producers, mainly terpenoids and acetogennins. Several of these chemicals exhibit important ecological roles and biotechnological applications. However, knowledge regarding the genes involved in the biosynthesis of th...

journal_title：Marine drugs

authors： de Oliveira LS,Tschoeke DA,de Oliveira AS,Hill LJ,Paradas WC,Salgado LT,Thompson CC,Pereira RC,Thompson FL

更新日期：2015-02-10 00:00:00

abstract：:Ten new diterpene glycosides virescenosides Z9-Z18 (1-10) together with three known analogues (11-13) and aglycon of virescenoside A (14) were isolated from the marine-derived fungus Acremonium striatisporum KMM 4401. These compounds were obtained by cultivating fungus on wort agar medium with the addition of potassiu...

journal_title：Marine drugs

authors： Zhuravleva OI,Antonov AS,Oleinikova GK,Khudyakova YV,Popov RS,Denisenko VA,Pislyagin EA,Chingizova EA,Afiyatullov SS

更新日期：2019-10-29 00:00:00

abstract：:Green seaweeds are rich sources of sulfated polysaccharides (SPs) with potential biomedical and nutraceutical applications. The aim of this work was to evaluate the immunostimulatory activity of SPs from the seaweed, Caulerpa cupressoides var. flabellata on murine RAW 264.7 macrophages. SPs were evaluated for their ab...

journal_title：Marine drugs

authors： Barbosa JDS,Costa MSSP,Melo LFM,Medeiros MJC,Pontes DL,Scortecci KC,Rocha HAO

更新日期：2019-02-09 00:00:00

abstract：:In the search for bioactive compounds, 11 fungal strains were isolated from Indonesian marine habitats. Ethyl acetate extracts of their culture broth were tested for cytotoxic activity against a urinary bladder carcinoma cell line and for antifungal and antibacterial activities against fish and human pathogenic bacter...

journal_title：Marine drugs

authors： Tarman K,Lindequist U,Wende K,Porzel A,Arnold N,Wessjohann LA

更新日期：2011-02-25 00:00:00

abstract：:Hepatic fibrosis is an effusive wound healing process, characterized by an excessive deposition of extracellular matrix (ECM), as the consequence of chronic liver injury of any etiology. Current therapeutic repertoire for hepatic fibrosis is limited to withdrawal of the noxious agent, which is not always feasible. Hen...

journal_title：Marine drugs

authors： Wang Y,Zhang X,Yang Y,Yang X,Ye B

更新日期：2015-08-18 00:00:00

abstract：:Carotenoids are lipophilic pigments found in plants and algae, as well as some bacteria, archaea, and fungi that serve two functions-(1) as light harvesting molecules-primary carotenoids, and (2) as antioxidants, acting against reactive oxygen species⁻secondary carotenoids. Because of their strong antioxidant properti...

journal_title：Marine drugs

authors： Laje K,Seger M,Dungan B,Cooke P,Polle J,Holguin FO

更新日期：2019-03-22 00:00:00

abstract：:A novel tetranorditerpenoid, sinubatin A (1) (having an unprecedented carbon skeleton), a new norditerpenoid, sinubatin B (2) (a 4,5-epoxycaryophyllene possessing an unusual methylfuran moiety side chain), and a known diterpenoid, gibberosin J (3) were isolated from soft coral Sinulariananolobata. The structures of th...

journal_title：Marine drugs

authors： Hsu FY,Wang SK,Duh CY

更新日期：2018-01-24 00:00:00

abstract：:Preliminary biological investigation of a collection of Comorian soft corals resulted in the selection of two specimens, one of Sarcophyton and the other of Lobophytum, on the basis of their toxicity on larvae of the brine shrimp (Artemia salina) and inhibition of acetylcholinesterase, respectively. Bioassay-guided fr...

journal_title：Marine drugs

authors： Bonnard I,Jhaumeer-Laulloo SB,Bontemps N,Banaigs B,Aknin M

更新日期：2010-02-23 00:00:00

abstract：:The aim of this research was to prepare and characterize alginate-chitosan mucoadhesive microparticles containing puerarin. The microparticles were prepared by an emulsification-internal gelatin method using a combination of chitosan and Ca2+ as cationic components and alginate as anions. Surface morphology, particle ...

journal_title：Marine drugs

authors： Hou JY,Gao LN,Meng FY,Cui YL

更新日期：2014-12-01 00:00:00

abstract：:PT-peptide is derived from the anti-lipopolysaccharide factor of the swimming crab Portunus trituberculatus. The peptide, consisting of 34 amino acids, contains a lipopolysaccharide binding domain. In this study, we investigated the effect of PT-peptide encapsulated in raw milk-derived extracellular vesicles (EVs), de...

journal_title：Marine drugs

authors： Lee BH,Chen BR,Huang CT,Lin CH

更新日期：2019-04-26 00:00:00

abstract：:The biosynthetic gene cluster for bisucaberin B (1, bsb gene cluster), an N-hydroxy-N-succinyl diamine (HSD)-based siderophore, was cloned from the marine bacterium Tenacibaculum mesophilum, originated from a marine sponge. The bsb gene cluster consists of six open reading frames (ORFs), in contrast to the four ORFs t...

journal_title：Marine drugs

authors： Fujita MJ,Goto Y,Sakai R

更新日期：2018-09-19 00:00:00

abstract：:A series of novel cyclic marinopyrroles were designed and synthesized. Their activity to disrupt the binding of the pro-apoptotic protein, Bim, to the pro-survival proteins, Mcl-1 and Bcl-x(L), was evaluated using ELISA assays. Both atropisomers of marinopyrrole A (1) show similar potency. A tetrabromo congener 9 is t...

journal_title：Marine drugs

authors： Cheng C,Liu Y,Balasis ME,Simmons NL,Li J,Song H,Pan L,Qin Y,Nicolaou KC,Sebti SM,Li R

更新日期：2014-03-07 00:00:00

abstract：:Two new piperazine-triones lansai E and F (1, 2), together with four known secondary metabolites lansai D (3), 1-N-methyl-(E,Z)-albonoursin (4), imidazo[4,5-e]-1,2,4-triazine (5), and streptonigrin (6) were isolated from a deep-sea-derived Streptomycetes sp. strain SMS636. The structures of the isolated compounds were...

journal_title：Marine drugs

authors： Xu X,Han J,Lin R,Polyak SW,Song F

更新日期：2019-03-21 00:00:00

abstract：:A glycopeptide fraction (GPF) from internal organs of green sea urchins (Strongylocentrotus droebachiensis Müller, Strongylocentrotidae) has been reported to be an effective bronchitis treatment. In this study, we evaluated the pharmacokinetic and tissue distribution of GPF, following single and repeated intranasal (i...

journal_title：Marine drugs

authors： Shikov AN,Pozharitskaya ON,Faustova NM,Kosman VM,Makarov VG,Razzazi-Fazeli E,Novak J

更新日期：2019-10-11 00:00:00

abstract：:α-Conotoxin TxID was discovered from Conus textile by gene cloning, which has 4/6 inter-cysteine loop spacing and selectively inhibits α3β4 nicotinic acetylcholine receptor (nAChR) subtype. However, TxID is susceptible to modification due to it containing a methionine (Met) residue that easily forms m...

journal_title：Marine drugs

authors： Ren J,Li R,Ning J,Zhu X,Zhangsun D,Wu Y,Luo S

更新日期：2018-06-20 00:00:00