abstract：:Sjögren's syndrome (SS) is a chronic autoimmune disease targeting salivary and lacrimal glands. C-X-C motif chemokine ligand 10 (CXCL10) expression is upregulated in lip salivary glands (LSGs) of primary SS (pSS) patients, and CXCL10 involved in SS pathogenesis via immune-cell accumulation. Moreover, interferon (IFN)-...

journal_title：Inflammation

authors： Aota K,Yamanoi T,Kani K,Ono S,Momota Y,Azuma M

更新日期：2021-02-01 00:00:00

abstract：:Heterophragma adenophyllum is a traditional medicinal plant that has been used as anti-inflammatory and to relief muscular tension. In the current research, four isolated constitutes namely lapacho (1), peshawaraquinone (2), indanone derivatives (3), α-lapachone (4) of H. adenophyllum were tested for anti-inflammatory...

journal_title：Inflammation

authors： Abu-Izneid T,Shah ZA,Rauf A,Wadood A,Bawazeer S,Muhammad N,El-Esawi MA,Alhumaydhi FA,Aljohani ASM,El-Sharkawy E,Mubarak MS,Isayeva K,Shariati MA

更新日期：2021-02-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is an autoimmune and inflammatory disease with strong genetic influence, especially upon immune response components. Several cytokines from the toll-like receptors activation pathway display recognized role for RA establishment. However, few studies have verified the role of key mediators suc...

journal_title：Inflammation

authors： Gomes da Silva IIF,Lima CAD,Silva JEA,Rushansky E,Mariano MHQA,Rolim P,Oliveira RDR,Louzada-Júnior P,Souto FO,Crovella S,de Azevêdo Silva J,Sandrin-Garcia P

更新日期：2021-01-06 00:00:00

abstract：:Ulcerative colitis (UC) is a serious digestive system disease. Furthermore, the activation of C3a/C3aR axis promoted the expression of caspase-11. And higher levels of caspase-11 could induce the pyroptosis and inflammation of cells. However, some studies suggested that caspase-11 could promote and suppress the inflam...

journal_title：Inflammation

authors： Zhang X,Chen Y,Yu S,Jin B,Liu W

更新日期：2020-12-01 00:00:00

abstract：:Endoplasmic reticulum stress (ERS) plays an important role in cerebral ischemia-reperfusion injury (CIRI) by regulating apoptosis. Although the role of long non-coding RNA (LncRNA) KCNQ1OT1 in CIRI has been reported, the specific mechanism is still unclear. In this paper, the regulation of ERS by LncRNA KCNQ1OT1 in CI...

journal_title：Inflammation

authors： Li Y,Yi M,Wang D,Zhang Q,Yang L,Yang C

更新日期：2020-12-01 00:00:00

abstract：:The world's number one cause of death is cardiovascular diseases. The pathogenesis of different disease entities in the cardiovascular disease spectrum is complicated and multifactorial. Inflammation in these complicated etiologies serves as a key position and is a significant cause of atherosclerosis, which contribut...

journal_title：Inflammation

authors： Liaqat A,Asad M,Shoukat F,Khan AU

更新日期：2020-12-01 00:00:00

abstract：:Paeonol, a major ingredient isolated from Moutan Cort, has various pharmacological effects. Our previous studies have shown that paeonol can exert antioxidant and anti-inflammatory therapeutic effects on ethanol-induced experimental gastric ulcer (GU). Therefore, in this study, we designed two GU models in rats induce...

journal_title：Inflammation

authors： Guo Y,Du Y,Xie L,Pu Y,Yuan J,Wang Z,Zhang T,Wang B

更新日期：2020-12-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is a chronic inflammation that can lead to loss of range of joint abnormalities in severe cases. Diosgenin has anti-inflammatory effects. This paper discussed the effect and mechanism of diosgenin on excessive proliferation and inflammatory response of synovial cells in RA. CCK-8 detected the...

journal_title：Inflammation

authors： Wang R,Sun Y,Jin X,Wen W,Cao Y

更新日期：2020-11-25 00:00:00

abstract：:Following publication of our article [1], we noticed an error in Fig. 1. ...

journal_title：Inflammation

authors： Zhang X,Chen Y,Yu S,Jin B,Liu W

更新日期：2020-11-10 00:00:00

abstract：:The present study evaluated the anti-inflammatory effect of nanoencapsulated curcuminoid preparations of poly(vinyl pyrrolidone) (Nano-cur) and free curcuminoids (Cur) in an experimental model of croton oil-induced cutaneous inflammation. Male Swiss mice, weighing 25-30 g, received oral treatment by gavage 1 h before ...

journal_title：Inflammation

authors： Lima EP,Gonçalves OH,Ames FQ,Castro-Hoshino LV,Leimann FV,Cuman RKN,Comar JF,Bersani-Amado CA

更新日期：2020-11-09 00:00:00

abstract：:Many patients with ulcerative colitis suffer from malnutrition and intestinal flora disorders, which affect the postoperative intestinal barrier function of the ileal pouch. This study aimed to investigate the effects of enteral nutrition combined with probiotics after ileal pouch-anal anastomosis in rats. Male Spragu...

journal_title：Inflammation

authors： Zheng T,Gao Y,Xu Y,Chen Z,Wang X,Liu J,Liu G

更新日期：2020-11-05 00:00:00

abstract：:Intervertebral disc degeneration (IVDD) is considered to be the fundamental cause of the occurrence and development of lumbar disc herniation (LDH). The degeneration of IVDD is mainly caused by the participation of inflammatory factors. Thus, it is of great significance to analyze the pathogenesis of IVDD, which may g...

journal_title：Inflammation

authors： Lin X,Lin Q

更新日期：2020-10-01 00:00:00

abstract：:Potassium voltage-gated channel subfamily Q member 1 opposite strand 1 (KCNQ1OT1), a long non-coding RNA found in the KCNQ1 locus, has been evidenced to play important roles in the aggravation of inflammatory and oxidative stresses under hypoxia, but whether and how KCNQ1OT1 contributes to neuronal damages in the cere...

journal_title：Inflammation

authors： Yi M,Li Y,Wang D,Zhang Q,Yang L,Yang C

更新日期：2020-10-01 00:00:00

abstract：:Sanggenon C (SC), a natural flavonoid extracted from Cortex Mori (Sang Bai Pi), is reported to possess anti-inflammatory and antioxidant properties in hypoxia. The present study aimed to investigate the therapeutic potential and the underlying mechanisms of SC in cerebral ischemia-reperfusion (I/R) injury. A rat model...

journal_title：Inflammation

authors： Zhao Y,Xu J

更新日期：2020-08-01 00:00:00

abstract：:Synovium-derived mesenchymal stem cells (SMSCs) can migrate to the site of destroyed condylar cartilage and differentiate into chondrocytes to repair temporomandibular joint (TMJ) damage. Interleukin (IL)-1β-induced IL-6 secretion has been shown to inhibit the chondrogenic potential of SMSCs. The histone deacetylase i...

journal_title：Inflammation

authors： Sun J,Liao W,Su K,Jia J,Qin L,Liu W,He Y,Zhang H,Ou F,Zhang Z,Sun Y

更新日期：2020-08-01 00:00:00

abstract：:Integrin-α9 (ITGA9) and its corresponding ligands are involved in inflammatory and immune responses. The present study aimed to investigate whether ITGA9 participates in the development of chronic periodontitis (ChP) and to explore the underlying mechanisms. We collected gingival tissue and gingival crevicular fluid i...

journal_title：Inflammation

authors： Xu S,Jiang C,Liu H,Zhang H,Liao H,Wang X,Yao S,Ma L,Guo Y,Cao Z

更新日期：2020-08-01 00:00:00

abstract：:Our study is based on the establishment of a cohort of human obese omental adipose tissue and the culture of adipocytes in vitro. To observe the effect of high level of free fatty acid (FFA) on the expression of DNA methyltransferases (DNMTs) and the anti-inflammatory factor Kruppel-like factor 4 (KLF4) in adipocytes ...

journal_title：Inflammation

authors： Deng Y,Qiu T,Zhang M,Wu J,Zhang X,Wang J,Chen K,Feng J,Ha X,Xie J,Wang C,Zhang J

更新日期：2020-06-01 00:00:00

abstract：:Inflammatory bowel disease (IBD) has received much attention due to its increasing worldwide incidence and potential increased risk of colorectal cancer. The protective function of a Rho-associated protein kinase inhibitor (Y-27632) against 2,4,6-trinitrobenzene sulfonic acid (TNBS) induced mouse colitis has been prov...

journal_title：Inflammation

authors： Wang Y,Duan X,Liu X,Liu Y,Fan H,Xu M,Chen Q,Tang Q

更新日期：2020-06-01 00:00:00

abstract：:This study investigates the mode of action of Neophytadiene (MT), a molecule isolated from a marine algae Turbinaria ornata in LPS-induced inflammation in both in vitro and in vivo conditions. Neophytadiene (25, 50, 100 μM/mL) was treated to LPS-stimulated RAW 264.7 macrophages cells to identify its anti-inflammatory ...

journal_title：Inflammation

authors： Bhardwaj M,Sali VK,Mani S,Vasanthi HR

更新日期：2020-06-01 00:00:00

abstract：:The bacterial keratitis causes viability loss and apoptosis in the corneal epithelial cells (CECs). The cyanidin-3-O-glucoside (C3G) benefits visual system and also possess anti-bacterial and anti-inflammatory potentials. In the current study, the effects of C3G on human CECs (HCECs) against bacterial lipopolysacchari...

journal_title：Inflammation

authors： Li X,Sun M,Long Y

更新日期：2020-06-01 00:00:00

abstract：:Pyroptosis, a new pro-inflammatory programmed cell death, is linked to atherosclerosis (AS). Our previous studies suggested that salidroside (SAL) can alleviate AS and exert anti-oxidative and anti-inflammatory properties. However, the effect of SAL on atherosclerosis-related pyroptosis has not been studied. Here, we ...

journal_title：Inflammation

authors： Xing SS,Yang J,Li WJ,Li J,Chen L,Yang YT,Lei X,Li J,Wang K,Liu X

更新日期：2020-04-01 00:00:00

abstract：:Psoriasis, a common skin inflammatory disorder, is characterized by the aberrant growth and differentiation of keratinocytes. Ar-Turmerone, a main bioactive ingredient of Curcuma longa, has been found to alleviate skin inflammation in psoriasis-like mice. However, the effects and underlying mechanism of ar-turmerone o...

journal_title：Inflammation

authors： Yang S,Liu J,Jiao J,Jiao L

更新日期：2020-04-01 00:00:00

abstract：:Ischemic stroke is a major cause of death and motor disabilities all over the world. It is a muti-factorial disorder associated with inflammatory, apoptotic, and oxidative responses. Nateglinide (NAT), an insulinotropic agent used for the treatment of type 2 diabetes mellitus, recently showed potential anti-inflammato...

journal_title：Inflammation

authors： Saad MAE,Fahmy MIM,Al-Shorbagy M,Assaf N,Hegazy AAE,El-Yamany MF

更新日期：2020-04-01 00:00:00

abstract：:Lipopolysaccharide (LPS) is demonstrated to cause "two-hit" injury to liver. Proprotein convertase subtilisin/kexin type 9 (PCSK9) plays an important role in LPS clearance. Hepatocyte nuclear factor-1 alpha (HNF-1α) and sterol regulatory element-binding protein 2 (SREBP2) were reported to be responsible for PCSK9 gene...

journal_title：Inflammation

authors： Zou Y,Li S,Xu B,Guo H,Zhang S,Cai Y

更新日期：2020-02-01 00:00:00

abstract：:Damaged vascular endothelial cells after ischemic stroke release inflammatory cytokines and adhesion molecules, which could trigger platelet adhesion to vascular endothelial cells and platelet activation, and accelerate thrombus formation. Tetramethylpyrazine is the main bioactive component of Chuanxiong, which has de...

journal_title：Inflammation

authors： Zhang H,Tang W,Wang S,Zhang J,Fan X

更新日期：2020-02-01 00:00:00

abstract：:Asthma is the most common chronic disease of childhood, chronic airway inflammation; bronchial tissue fibrosis, is a pathological feature common to children asthma, and an emerging data has indicted that autophagy plays critical roles in airway inflammation and fibrosis-mediated airway remodeling. The aim of this stud...

journal_title：Inflammation

authors： Li BB,Chen YL,Pang F

更新日期：2020-02-01 00:00:00

abstract：:Air pollution events frequently occur in China during the winter. Most investigations of pollution studies have focused on the physical and chemical properties of PM2.5. Many of these studies have indicated that PM2.5 exacerbates asthma or eosinophil inflammation. However, few studies have evaluated the relationship b...

journal_title：Inflammation

authors： Zheng XY,Tong L,Shen D,Yu JE,Hu ZQ,Li YJ,Zhang LJ,Xue EF,Tang HF

更新日期：2020-02-01 00:00:00

abstract：:Acute lung injury (ALI)/acute respiratory distress syndrome is characterized by increased pulmonary inflammation, where T helper 17 (Th17) cells play an important regulatory role. Notch signaling critically regulates Th17 differentiation and is known to be linked with proximal T cell by protein kinase C theta (PKCθ). ...

journal_title：Inflammation

authors： Li M,Zhao Y,He J,Deng W,Cheng L,Jiang Z,Wang D

更新日期：2019-12-01 00:00:00

abstract：:Mitogen- and stress-activated protein kinase (MSK) is a recently identified nuclear cAMP-regulated enhancer B (CREB) and histone H3 kinase that responds to both mitogen- and stress-activated protein kinases. This study was designed to investigate the protective effect of MSK on the rats with focal ischemia-reperfusion...

journal_title：Inflammation

authors： Zhou Y,Gao G,Li Z,Jiang L

更新日期：2019-12-01 00:00:00

abstract：:To investigate the effect of dexmedetomidine post-conditioning on the inflammatory response and autophagy effect of focal cerebral ischemia reperfusion injury in rats, and further to study its potential mechanisms. Water maze was conducted to evaluate spatial learning and memory ability of middle cerebral artery occlu...

journal_title：Inflammation

authors： Zhu Y,Li S,Liu J,Wen Q,Yu J,Yu L,Xie K

更新日期：2019-12-01 00:00:00

abstract：:The release of inflammatory cytokines and chemokines and autophagy has been reported to be involved in the pathogenic mechanism of acute lung injury (ALI). Reportedly, alpha-7 nicotinic acetylcholine receptors (α7nAchR) might play a protective role in LPS-induced ALI. In the current research, we established LPS-induce...

journal_title：Inflammation

authors： Zhao X,Yu Z,Lv Z,Meng L,Xu J,Yuan S,Fu Z

更新日期：2019-12-01 00:00:00

abstract：:Inflammatory bowel disease (IBD) in humans is closely related to bacterial infection and the disruption of the intestinal barrier. Paeoniflorin (PF), a bioactive compound from Paeonia lactiflora Pallas plants, exerts a potential effect of anti-inflammatory reported in various researches. However, the effect of PF on i...

journal_title：Inflammation

authors： Wu XX,Huang XL,Chen RR,Li T,Ye HJ,Xie W,Huang ZM,Cao GZ

更新日期：2019-12-01 00:00:00

abstract：:The molecular mechanisms of innate immunity are closely associated with the development of non-alcoholic fatty liver disease (NAFLD). TNF-α is a key cytokine involved in the pathogenesis of metabolic inflammation like NAFLD. Melanoma differentiation-associated gene 5 (MDA5) is a member of the intracellular RNA helicas...

journal_title：Inflammation

authors： Kawaguchi S,Sakuraba H,Haga T,Matsumiya T,Seya K,Endo T,Sawada N,Iino C,Kikuchi H,Hiraga H,Fukuda S,Imaizumi T

更新日期：2019-12-01 00:00:00

abstract：:In this study, the effects of tyrosol were investigated in DSS-induced experimental ulcerative colitis model. For this purpose, rats were divided into five groups of seven rats in each: control group, colitis group (DSS-4%), tyrosol group (tyrosol 20 mg/kg), sulfasalazine (sulfasalazine+DSS 100 mg/kg), and treatment g...

journal_title：Inflammation

authors： Güvenç M,Cellat M,Özkan H,Tekeli İO,Uyar A,Gökçek İ,İşler CT,Yakan A

更新日期：2019-10-01 00:00:00

abstract：:Treg cells are crucial for maintaining immune homeostasis in CP/CPPS, but the molecular mechanisms underlying the modulation of the function of Treg in CP/CPPS remain unclear. The main purpose of this study is to investigate the relationship between immunosuppressive function of Treg and the methylation level of Foxp3...

journal_title：Inflammation

authors： Chen J,Zhan C,Zhang L,Zhang L,Liu Y,Zhang Y,Du H,Liang C,Chen X

更新日期：2019-10-01 00:00:00

abstract：:Ovarian cancer is one of the most deadly cancers with rapid proliferation and poor prognosis among patients. Therapies focusing on regulation of tumor immunity and microenvironments are developing. MiR-217 was dysregulated in cancer progress and plays important roles in tumorigenesis and metastasis. However, the role ...

journal_title：Inflammation

authors： Jiang B,Zhu SJ,Xiao SS,Xue M

更新日期：2019-10-01 00:00:00

abstract：:Injury to podocytes leads to proteinuria, a hallmark of most glomerular diseases as well as being associated with the progression of kidney disease. Activation of the Wnt/β-catenin pathway is associated with the pathogenesis of podocyte dysfunction and can play a role in renal injury. Furthermore, the expression of fr...

journal_title：Inflammation

authors： Senouthai S,Wang J,Fu D,You Y

更新日期：2019-08-01 00:00:00

abstract：:Tizoxanide is the main active metabolite of nitazoxanide. Nitazoxanide and tizoxanide have a broad-spectrum anti-infective effect, including parasites, bacteria, and virus. In the present study, we investigated the anti-inflammatory effect of tizoxanide on lipopolysaccharide (LPS)-stimulated RAW264.7 cells and reveale...

journal_title：Inflammation

authors： Shou J,Kong X,Wang X,Tang Y,Wang C,Wang M,Zhang L,Liu Y,Fei C,Xue F,Li J,Zhang K

更新日期：2019-08-01 00:00:00

abstract：:The benzylideneacetophenone derivative JC3 [(2E)-3-(4-hydroxy-3-methoxyphenyl)phenylpro-2-en-l-one] (JC3) was synthesized by modifying yakuchinone B obtained from the seeds of Alpinia oxyphylla, a member of the ginger family (Zingiberaceae), which are widely used as a folk remedy and as an anti-inflammatory. The aim o...

journal_title：Inflammation

authors： Sur B,Kang S,Kim M,Oh S

更新日期：2019-06-01 00:00:00

abstract：:The exact etiology and pathogenesis of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) are still unknown, as a result, available therapeutic options for patients are far from satisfactory. Therefore, there is a need to develop a valid therapeutic approach that can ameliorate the manifestations of CP/CPPS. F...

journal_title：Inflammation

authors： Cheng Y,Cao Y,Ihsan AU,Khan FU,Li X,Xie D,Cui X,Wang W,Liu Z,Li C,Ahmad KA,Sembatya KR,Mikrani R,Zhou X

更新日期：2019-06-01 00:00:00