Sanggenon C Ameliorates Cerebral Ischemia-Reperfusion Injury by Inhibiting Inflammation and Oxidative Stress through Regulating RhoA-ROCK Signaling.

abstract：:D-limonene epoxidation generates (+)-limonene epoxide, an understudied compound in the pharmacologically point of view. Herein, we investigated the anti-inflammatory and antinociceptive potentialities of (+)-limonene epoxide and suggested a mechanism of action. The anti-inflammatory potential was analyzed using agents...

journal_title：Inflammation

authors： de Almeida AA,Silva RO,Nicolau LA,de Brito TV,de Sousa DP,Barbosa AL,de Freitas RM,Lopes LD,Medeiros JR,Ferreira PM

更新日期：2017-04-01 00:00:00

abstract：:Pig alveolar macrophages are a heterogeneous population of cells. Three subpopulations or bands exist when the whole population is separated according to density. Band 1 cells are the least dense cells and constitute 9% of the total population. Bands 2 and 3 represent 44 and 47% of the total population. The three subp...

journal_title：Inflammation

authors： Zeidler RB,Flynn JA,Arnold JC,Conley NS

更新日期：1987-09-01 00:00:00

abstract：:Myeloperoxidase (MPO), next to the NO synthase2 (NOS2), and NADPH oxidase, is the key enzyme of the oxidative burst responsible for the antimicrobial immunity. Because MPO participates in the eradication of Mycobacterium tuberculosis in the in vitro model and the extracellular enzyme may activate cells to cytokine syn...

journal_title：Inflammation

authors： Koziol-Montewka M,Kolodziejek A,Oles J

更新日期：2004-04-01 00:00:00

abstract：:Lipopolysaccharide (LPS) increases serum TNF-alpha levels due to TNF-alpha secretion by macrophages. The serum TNF-alpha response to LPS was augmented 10x when FcgammaR ligation was induced by the intravenous injection of Gig-coated erythrocytes (IgG) prior to the administration of LPS. The macrophage population respo...

journal_title：Inflammation

authors： Loegering DJ,Lennartz MR

更新日期：2002-12-01 00:00:00

abstract：:Lipids from the sputum of patients with asthma and with cystic fibrosis were isolated and characterized. In both cases, lipids constituted approximately 30% of the dry material. Phosphatidlycholine was the most abundant lipid, Significant amounts of phosphatidylethanolamine and phosphatidylglycerol were present. Hexos...

journal_title：Inflammation

authors： Sahu S,Lynn WS

更新日期：1978-03-01 00:00:00

abstract：:We investigated whether TESPA1 gene polymorphisms were associated with increased risk of developing ankylosing spondylitis (AS). We also studied whether TESPA1 gene interacts with environmental factors. A total of 494 patients with AS and 478 matched healthy controls were genotyped for four SNPs (rs1801876, rs2171497,...

journal_title：Inflammation

authors： Liu S,Liu L,Wu S,Yang T,Pan F,Laslett L,Xia G,Hu Y,Fan D,Ding N,Xu S,Cai G,Wang L,Xin L

更新日期：2014-12-01 00:00:00

abstract：:The effect of interleukin-1 beta (IL-1 beta) on the expression of cyclooxygenase-1 and -2 (COX-1 and COX-2) mRNA and its relation to prostaglandin E2 (PGE2) biosynthesis in human gingival fibroblasts was studied. IL-1 beta increased levels of mRNA for COX-2 whereas the COX-1 mRNA level was unaffected. The increased CO...

journal_title：Inflammation

authors： Yucel-Lindberg T,Ahola H,Nilsson S,Carlstedt-Duke J,Modéer T

更新日期：1995-10-01 00:00:00

abstract：:Two different substances, glycogen and thioglycollate, were used to recruit early peritoneal exudate cells (4h). In the acute phase of the inflammatory response the cellular infiltrate is large, and the predominant cell (greater than 95%) is the polymorphonuclear neutrophil. Supernatant had differing effects on lympho...

journal_title：Inflammation

authors： Rodrick ML,Lamster IB,Sonis ST,Pender SG,Kolodkin AB,Fitzgerald JE,Wilson RE

更新日期：1982-03-01 00:00:00

abstract：:The aim of the study was to determine the effect of direct application of rifampin, povidone-iodine, and hydrogen peroxide on the formation of epidural fibrosis in rats. Forty-eight adult male Wistar albino rats were equally and randomly divided into four groups (laminectomy, topical rifampin, topical povidone-iodine,...

journal_title：Inflammation

authors： Kizilay Z,Cetin NK,İsmailoglu Ö,Yılmaz A,Omurlu İK,Coskun ME,Aktaş S

更新日期：2016-08-01 00:00:00

abstract：:Neuroinflammation is believed to be involved in the pathogenesis of neurodegenerative diseases. Our novel synthetic compound 2-acetyl-1-ethyl-7-hydroxy-6-methoxy-1, 2, 3, 4-tetrahydroisoquinoline (AETIQ) was tested for its anti-inflammatory properties in activated microglial BV-2 cells. AETIQ attenuated nitric oxide (...

journal_title：Inflammation

authors： Son HJ,Shin N,Shin EJ,Chi DY,Seo JW,Lee CS,Hwang O

更新日期：2014-06-01 00:00:00

abstract：:1-O-Alkyl-2-O-acetyl-sn-glycerol-3-phosphorylcholine (i.e., platelet-activating factor) was prepared and confirmed to possess potent platelet aggregating activity. It was also potent in aggregating and degranulating rabbit and human neutrophils. When injected into rabbits, the lipid induced profound neutropenia, throm...

journal_title：Inflammation

authors： O'Flaherty JT,Miller CH,Lewis JC,Wykle RL,Bass DA,McCall CE,Waite M,DeChatelet LR

更新日期：1981-09-01 00:00:00

abstract：:Pyroptosis, a new pro-inflammatory programmed cell death, is linked to atherosclerosis (AS). Our previous studies suggested that salidroside (SAL) can alleviate AS and exert anti-oxidative and anti-inflammatory properties. However, the effect of SAL on atherosclerosis-related pyroptosis has not been studied. Here, we ...

journal_title：Inflammation

authors： Xing SS,Yang J,Li WJ,Li J,Chen L,Yang YT,Lei X,Li J,Wang K,Liu X

更新日期：2020-04-01 00:00:00

abstract：:We compared exhaled breath condensate (EBC) and induced sputum (IS) for assessing inflammation in pulmonary diseases in patients with obstructive lung disease (n = 20), persistent cough >6 months (n = 20), interstitial lung disease (n = 25) and controls (n = 10). EBC was collected by suspending a Teflon perfluoroalkox...

journal_title：Inflammation

authors： Fireman E,Shtark M,Priel IE,Shiner R,Mor R,Kivity S,Fireman Z

更新日期：2007-04-01 00:00:00

abstract：:Endothelial-neutrophil adhesion is a critical step in acute inflammatory diseases, which is mediated in part by P-selectin and platelet-activating factor (PAF). Nitric oxide (NO) is well known as an endogenous second messenger derived from endothelial cells, and regulates many important physiological events, however, ...

journal_title：Inflammation

authors： Okayama N,Coe L,Itoh M,Alexander JS

更新日期：1999-02-01 00:00:00

abstract：:The signaling system of phosphoinositides (PI) is involved in a variety of cell and tissue functions, including membrane trafficking, ion channel activity, cell cycle, apoptosis, differentiation, and cell and tissue polarity. Recently, PI and related molecules, such as the phosphoinositide-specific phospholipases C (P...

journal_title：Inflammation

authors： Lo Vasco VR,Leopizzi M,Chiappetta C,Puggioni C,Della Rocca C,Polonia P,Businaro R

更新日期：2013-08-01 00:00:00

abstract：:Diabetic retinopathy shares some similarity with chronic inflammation and Müller cells dysfunction may play an important role in its initiation and progression since these cells are thought to be a major source of inflammatory factors. The goal of this study was to examine the effect of cytokines on human retinal Müll...

journal_title：Inflammation

authors： Liu X,Ye F,Xiong H,Hu D,Limb GA,Xie T,Peng L,Yang W,Sun Y,Zhou M,Song E,Zhang DY

更新日期：2014-10-01 00:00:00

abstract：:Many patients with ulcerative colitis suffer from malnutrition and intestinal flora disorders, which affect the postoperative intestinal barrier function of the ileal pouch. This study aimed to investigate the effects of enteral nutrition combined with probiotics after ileal pouch-anal anastomosis in rats. Male Spragu...

journal_title：Inflammation

authors： Zheng T,Gao Y,Xu Y,Chen Z,Wang X,Liu J,Liu G

更新日期：2020-11-05 00:00:00

abstract：:Numerous studies have evaluated the association between -159C/T polymorphism of the CD14 gene and asthma risk; however, these studies have yielded inconsistent results. We performed meta-analyses to investigate the association between CD14-159C/T polymorphism and asthma risk. Studies were identified from PubMed, Embas...

journal_title：Inflammation

authors： Zhang R,Deng R,Li H,Chen H

更新日期：2016-02-01 00:00:00

abstract：:The world's number one cause of death is cardiovascular diseases. The pathogenesis of different disease entities in the cardiovascular disease spectrum is complicated and multifactorial. Inflammation in these complicated etiologies serves as a key position and is a significant cause of atherosclerosis, which contribut...

journal_title：Inflammation

authors： Liaqat A,Asad M,Shoukat F,Khan AU

更新日期：2020-12-01 00:00:00

abstract：:The role of peptide leukotrienes (p-LTs), especially LTC4 and LTD4 in liver disease, was investigated in mice experimental liver injury models. The liver injury was induced by the injection of bacterial lipopolysaccharide (LPS) into Corynebacterium parvum pretreated mice. Carbon tetrachloride (CCl4)-induced liver inju...

journal_title：Inflammation

authors： Nagai H,Shimazawa T,Yakuo I,Aoki M,Koda A,Kasahara M

更新日期：1989-12-01 00:00:00

abstract：:The present study evaluated the anti-inflammatory effect of nanoencapsulated curcuminoid preparations of poly(vinyl pyrrolidone) (Nano-cur) and free curcuminoids (Cur) in an experimental model of croton oil-induced cutaneous inflammation. Male Swiss mice, weighing 25-30 g, received oral treatment by gavage 1 h before ...

journal_title：Inflammation

authors： Lima EP,Gonçalves OH,Ames FQ,Castro-Hoshino LV,Leimann FV,Cuman RKN,Comar JF,Bersani-Amado CA

更新日期：2020-11-09 00:00:00

abstract：:A heat-stable factor present in extracts of human blood leukocytes is capable of lysing young Staphylococcus aureus at pH 5.0. Lysis is characterized by breakdown of cell-wall components as judged by electron microscopic and biochemical analysis. The leukocyte extracts can be replaced by a variety of agents known to i...

journal_title：Inflammation

authors： Lahav M,Ginsburg I

更新日期：1977-06-01 00:00:00

abstract：:The aim of our study was to evaluate the pro- and anti-inflammatory cytokine response during acute pancreatitis and its predictive value on severity of disease. A hospital-based prospective clinical study was conducted. Twenty patients with acute pancreatitis were enrolled during a 12-month period. Plasma concentratio...

journal_title：Inflammation

authors： Gunjaca I,Zunic J,Gunjaca M,Kovac Z

更新日期：2012-04-01 00:00:00

abstract：:Strong anti-inflammatory activity has been found in Laminaria japonica dichloromethane fraction (LDF); however, the molecular mechanisms underlying its anti-inflammatory activity are not reported. Our results indicated that LDF inhibited LPS-induced nitric oxide and prostaglandin E(2) production in a dose-dependent ma...

journal_title：Inflammation

authors： Lee JY,Lee MS,Choi JW,Shin TS,Woo HC,Kim HR

更新日期：2012-10-01 00:00:00

abstract：:The purpose of this study was to investigate the effect of 6 months aerobic exercise and diet alone or in combination on markers of inflammation (MOI) in circulation and in adipose abdominal tissue (AT) in obese women. Thirty obese subjects were randomized into a 24-week intervention: (1) exercise (EX), (2) diet (DI),...

journal_title：Inflammation

authors： Lakhdar N,Denguezli M,Zaouali M,Zbidi A,Tabka Z,Bouassida A

更新日期：2013-12-01 00:00:00

abstract：:Human blood leukocytes generated large amounts of superoxide (O2-) following stimulation by certain "cocktails" of soluble agents consisting of poly-L-arginine (PARG), phytohemagglutinin, the chemotactic peptide formyl-methionyl-leucyl-phenylalanine and polyanethole sulfanote (liquoid). A variety of cytochalasins, whi...

journal_title：Inflammation

authors： Ginsburg I,Borinski R,Pabst M

更新日期：1985-12-01 00:00:00

abstract：:Induction of colitis by 2,4,6-Trinitrobenzenesulphonic acid (TNB) in the rat is a widely used experimental model of inflammatory bowel disease. Action of TNB as a hapten, induces colitis involving infiltration of colonic mucosa by neutrophils and macrophages and increased production of inflammatory mediators. The aim ...

journal_title：Inflammation

authors： Kankuri E,Asmawi MZ,Korpela R,Vapaatalo H,Moilanen E

更新日期：1999-04-01 00:00:00

abstract：:We analyzed the effect of the PAF receptor antagonist (+)-cis-3,5-dimethyl-2-(3-pyridyl)thiazolidin-4-one hydrochloride (SM-12502) on human platelet aggregation as well as mediator release. After incubation of human platelet with different concentrations of SM-12502 the cells were subsequently stimulated with either t...

journal_title：Inflammation

authors： Köller M,Hilger RA,König W

更新日期：1996-02-01 00:00:00

abstract：:Aqueous extracts of calf thymus from immunologically stimulated animals contain trypsin- and neuraminidase-labile macromolecules with molecular weights of less than 30,000 daltons which will specifically attract chemotactically lymphocytes. This activity we ascribe to "lymphotactin." ...

journal_title：Inflammation

authors： Houck JC,Chang CM

更新日期：1976-03-01 00:00:00

abstract：:This study was performed to evaluate the effects of epigallocatechin 3 gallate (EGCG) on lipopolysaccharide (LPS)-induced acute lung injury in a murine model. In the present study, production of TNF-alpha and MIP-2 and activation of extracellular signal-regulated kinases (ERK)1/2, c-Jun amino terminal kinases (JNK) an...

journal_title：Inflammation

authors： Bae HB,Li M,Kim JP,Kim SJ,Jeong CW,Lee HG,Kim WM,Kim HS,Kwak SH

更新日期：2010-04-01 00:00:00