Abstract:
:The aim of our study was to evaluate the pro- and anti-inflammatory cytokine response during acute pancreatitis and its predictive value on severity of disease. A hospital-based prospective clinical study was conducted. Twenty patients with acute pancreatitis were enrolled during a 12-month period. Plasma concentrations of TNF-α, IL-1β, IL-6, and IL-10 were determined at days 1, 2, 3, 6, and 9. The patient population was analyzed by type of acute pancreatitis. Severity was defined according to the Atlanta criteria for assessing severity of acute pancreatitis. Clinical variables were recorded to patients classified in one of two groups: severe acute pancreatitis (SAP group) and mild acute pancreatitis (MILD group). Patients with SAP had significantly higher average levels of IL-6 compared to the MILD group patients (539.2 pg/L vs. 23.4 pg/L, p < 0.0001). Also, the values of IL-10 were significantly higher in patients with SAP (242.4 pg/L vs. 8.1 pg/L, p = 0.003). The values of TNF-α were not significantly different in both groups. The value of IL-6 and IL-10 showed a positive correlation (r = 0.7964, p < 0.0001). Although a relatively small sample of patients was used, we can conclude that the determination of the value of IL-6 and IL-10 can help in the clinical assessment of disease severity.
journal_name
Inflammationjournal_title
Inflammationauthors
Gunjaca I,Zunic J,Gunjaca M,Kovac Zdoi
10.1007/s10753-011-9371-zsubject
Has Abstractpub_date
2012-04-01 00:00:00pages
758-63issue
2eissn
0360-3997issn
1573-2576journal_volume
35pub_type
杂志文章相关文献
INFLAMMATION文献大全abstract::The possibility of inflammation and neutrophil activation in response to indoor air pollution (IAP) from biomass fuel use has been investigated. For this, 142 premenopausal, never-smoking women (median age, 34 years) who cook exclusively with biomass (wood, dung, crop wastes) and 126 age-matched control women who cook...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-011-9360-2
更新日期:2012-04-01 00:00:00
abstract::Asthma is the most common chronic disease of childhood, chronic airway inflammation; bronchial tissue fibrosis, is a pathological feature common to children asthma, and an emerging data has indicted that autophagy plays critical roles in airway inflammation and fibrosis-mediated airway remodeling. The aim of this stud...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-019-01076-0
更新日期:2020-02-01 00:00:00
abstract::Multiple forms of soluble phospholipase A2 (PLA2) are known to coexist in venoms of individual reptilian species. While similar observations in several mammalian species suggest that this is a common phenomenon, the functional implications are not yet understood. In attempting to devise therapeutic strategies for trea...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00917456
更新日期:1990-04-01 00:00:00
abstract::Sanggenon C (SC), a natural flavonoid extracted from Cortex Mori (Sang Bai Pi), is reported to possess anti-inflammatory and antioxidant properties in hypoxia. The present study aimed to investigate the therapeutic potential and the underlying mechanisms of SC in cerebral ischemia-reperfusion (I/R) injury. A rat model...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-020-01225-w
更新日期:2020-08-01 00:00:00
abstract::In this study, we aimed to investigate the effect of electro-acupuncture (EA) pretreatment at zusanli (ST36) acupoint on lipopolysaccharide (LPS)-induced endotoxemic rat model and explore the underlying molecular mechanisms. Rats were treated with EA at ST36 for 7 days before being subjected to LPS. Two hours post-LPS...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-018-0885-5
更新日期:2019-02-01 00:00:00
abstract::Damaged vascular endothelial cells after ischemic stroke release inflammatory cytokines and adhesion molecules, which could trigger platelet adhesion to vascular endothelial cells and platelet activation, and accelerate thrombus formation. Tetramethylpyrazine is the main bioactive component of Chuanxiong, which has de...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-019-01119-6
更新日期:2020-02-01 00:00:00
abstract::Kurloff cells are mononuclear cells possessing a large cytoplasmic inclusion body specific to the guinea pig. In this report, we present strong evidence that Kurloff cells can mediate NC activity against tumor cells in addition to their previously reported NK activity. Using an 18 h 51Cr-release assay we have shown th...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF01488203
更新日期:1996-06-01 00:00:00
abstract::Induction of hypoxia for 2.5 h in perfused cat livers resulted in a 10-fold increase in cathepsin D and a 15-fold increase in lactic dehydrogenase (LDH) activities in the perfusate and a 42% depression of the clearance rate of particles by the reticuloendothelial system (RES). Addition of 10(-3) M methylprednisolone (...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00920336
更新日期:1976-12-01 00:00:00
abstract::This study analyzed the neutrophils and sera of patients with rheumatoid arthritis and of normal controls. No significant differences were found in the activities of the granular enzymes beta-glucuronidase and lysozyme or the cytoplasmic enzyme lactic dehydrogenase (LDH). Normal neutrophils were found to release signi...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00914189
更新日期:1979-07-01 00:00:00
abstract::NSAIDs are widely used to alleviate the symptoms of OA. It remains controversial as to what effects these agents have on the progression of OA. In vitro studies showed several types of NSAIDs (e.g., sodium salicylate, indomethacin) inhibited the synthesis of cartilage matrix component, but some types of NSAIDs (e.g., ...
journal_title:Inflammation
pub_type: 杂志文章,评审
doi:10.1023/a:1015504632021
更新日期:2002-06-01 00:00:00
abstract::Ziprasidone (ZIP) is an effective antipsychotic with low side effects than other second-generation antipsychotics. Despite this, there are reports of adverse events and previous studies associating the use of ZIP the inflammatory response. It is possible to infer that bioactive molecules present in some foods could at...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-018-0946-9
更新日期:2019-06-01 00:00:00
abstract::The purpose of this study was to evaluate the rabbit anterior eye chamber as a quantitative measure of leukotaxis using 51Cr-labeled homologous leukocytes and then to determine the effects of ibuprofen on N-formyl-methionyl-leucyl-phenylalanine (FMLP) -induced leukotaxis. Leukocyte accumulation was assessed at various...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00916277
更新日期:1985-09-01 00:00:00
abstract::Ulcerative colitis (UC) is a serious digestive system disease. Furthermore, the activation of C3a/C3aR axis promoted the expression of caspase-11. And higher levels of caspase-11 could induce the pyroptosis and inflammation of cells. However, some studies suggested that caspase-11 could promote and suppress the inflam...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-020-01280-3
更新日期:2020-12-01 00:00:00
abstract::The objective of this study was to determine nitric oxide (NO) and superoxide anion release (O-2) by neutrophils (PMNs) in the septic multiple organ dysfunction syndrome (MODS) and to compare them with the response of normal cells to lipopolysaccharide (LPS) and cytokines. NO production was measured by the release of ...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF01534556
更新日期:1994-04-01 00:00:00
abstract::Vascular inflammation plays a key role in the initiation and progression of atherosclerosis, a major complication of diabetes mellitus. Orientin, a C-glycosyl flavonoid, is known to have anxiolytic and antioxidative activity. In this study, we assessed whether orientin can suppress vascular inflammation induced by hig...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-014-9950-x
更新日期:2014-12-01 00:00:00
abstract::Rheumatoid synovial fluids generated significantly greater amounts of superoxide, lysosomal enzymes, and superoxide dismutase from neutrophils into extracellular fluid than osteoarthritic synovial fluids. Rheumatoid factors isolated from serum suppressed superoxide-generating activity of performed immune complexes, bu...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00916016
更新日期:1987-06-01 00:00:00
abstract::Induction of colitis by 2,4,6-Trinitrobenzenesulphonic acid (TNB) in the rat is a widely used experimental model of inflammatory bowel disease. Action of TNB as a hapten, induces colitis involving infiltration of colonic mucosa by neutrophils and macrophages and increased production of inflammatory mediators. The aim ...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1023/a:1020241028723
更新日期:1999-04-01 00:00:00
abstract::CD4+ T cell subset imbalance plays an important role in the development of diabetic complications. Neutrophils have recently been known as the regulator of CD4+ T cell differentiation. However, whether neutrophils affect CD4+ T cell population in diabetes is still elusive. In this study, we investigated the effect of ...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-018-0913-5
更新日期:2019-04-01 00:00:00
abstract::The aim of this present study is to compare the effect of pressure-controlled ventilation and volume-controlled ventilation on pulmonary mechanics and inflammatory markers in prone position. The study included 41 patients undergoing to vertebrae surgery. The patients were randomized into two groups: Group 1 received v...
journal_title:Inflammation
pub_type: 杂志文章,随机对照试验
doi:10.1007/s10753-016-0379-2
更新日期:2016-08-01 00:00:00
abstract::Strong anti-inflammatory activity has been found in Laminaria japonica dichloromethane fraction (LDF); however, the molecular mechanisms underlying its anti-inflammatory activity are not reported. Our results indicated that LDF inhibited LPS-induced nitric oxide and prostaglandin E(2) production in a dose-dependent ma...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-012-9481-2
更新日期:2012-10-01 00:00:00
abstract::Systemic sclerosis (SSc) is a disease characterized by skin and internal organ involvement. There is progressive accumulation of extracellular matrix components in the skin and involved organs. Tissue fibrosis is the prominent reason for mortality, and still, there is no satisfactory treatment. The aim of this study w...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-012-9521-y
更新日期:2013-02-01 00:00:00
abstract::The respiratory epithelium is often exposed to oxidant gases, including ozone from photochemical smog and toxic oxygen metabolites released from neutrophils recruited in conditions of airway inflammation. We evaluated DNA single strand break formation by alkaline elution as a measure of oxidant-induced DNA damage to b...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00920476
更新日期:1993-12-01 00:00:00
abstract::Polymorphonuclear neutrophils are among the first defense against infection and closely involved in the initiation of inflammatory response. It is well recognized that this function of neutrophils was mainly mediated by phagocytosis, intracellular degradation, releasing of granules, and formation of neutrophil extrace...
journal_title:Inflammation
pub_type: 杂志文章,评审
doi:10.1007/s10753-016-0458-4
更新日期:2017-02-01 00:00:00
abstract::Sepsis is a systemic inflammatory response syndrome caused by infection. The core mechanism underlying sepsis is immune dysfunction, with macrophages, as important cells of the innate immune system, playing an essential role. Autophagy has been shown to be closely related to inflammation and immunity, and autophagy en...
journal_title:Inflammation
pub_type: 杂志文章,评审
doi:10.1007/s10753-018-0890-8
更新日期:2019-02-01 00:00:00
abstract::The excessive activation of microglia plays a key role in the pathogenesis of neurodegenerative diseases. The neuroprotective properties of rosmarinic acid have been reported in a variety of disease models both in vitro and in vivo; however, the mechanism underlying its anti-neuroinflammatory activity has not been cle...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-017-0728-9
更新日期:2018-03-01 00:00:00
abstract::Gram-positive and Gram-negative bacteria induce different cytokine patterns in human mononuclear cells. We have seen that Gram-positives preferentially induce IL-12 and TNF-alpha, whereas Gram-negatives induce more IL-10, IL-6, and IL-8. In this study, we compared the capacity of these two groups of bacteria to induce...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1023/b:ifla.0000006700.41614.21
更新日期:2003-12-01 00:00:00
abstract::Ovarian cancer is one of the most deadly cancers with rapid proliferation and poor prognosis among patients. Therapies focusing on regulation of tumor immunity and microenvironments are developing. MiR-217 was dysregulated in cancer progress and plays important roles in tumorigenesis and metastasis. However, the role ...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-019-01004-2
更新日期:2019-10-01 00:00:00
abstract::Studies have shown that apolipoprotein M (apoM), the main carrier of sphingosine-1-phosphate (S1P), is closely related to lipid metabolism and inflammation. While there are many studies on apoM and lipid metabolism, little is known about the role of apoM in inflammation. Atherosclerosis is a chronic inflammatory proce...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-018-0918-0
更新日期:2019-04-01 00:00:00
abstract::NO generation in the course of two acute, non immune, inflammatory reactions (pleurisy induced by rat isologous serum and carrageenan) was assessed by means of nitrite measurement in pleural exudate from 0.5 to 24 h. NO release varied time-dependently, similarly for the two inflammatory reactions. A first, but transie...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF01488799
更新日期:1996-12-01 00:00:00
abstract::This study investigates the mode of action of Neophytadiene (MT), a molecule isolated from a marine algae Turbinaria ornata in LPS-induced inflammation in both in vitro and in vivo conditions. Neophytadiene (25, 50, 100 μM/mL) was treated to LPS-stimulated RAW 264.7 macrophages cells to identify its anti-inflammatory ...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-020-01179-z
更新日期:2020-06-01 00:00:00