Abstract:
:Rheumatoid synovial fluids generated significantly greater amounts of superoxide, lysosomal enzymes, and superoxide dismutase from neutrophils into extracellular fluid than osteoarthritic synovial fluids. Rheumatoid factors isolated from serum suppressed superoxide-generating activity of performed immune complexes, but did not suppress that of intermediate-sized immune complexes isolated from RA serum. Synovial fluid neutrophils has a greater capacity to generate superoxide and lower intracellular superoxide dismutase activity, compared with peripheral neutrophils of the corresponding patients. These results suggest that neutrophil superoxide release may be modulated, both by rheumatoid factor and by intracellular and extracellular superoxide dismutase.
journal_name
Inflammationjournal_title
Inflammationauthors
Shingu M,Todoroki T,Nobunaga Mdoi
10.1007/BF00916016subject
Has Abstractpub_date
1987-06-01 00:00:00pages
143-51issue
2eissn
0360-3997issn
1573-2576journal_volume
11pub_type
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