Abstract:
:Shock is associated with inflammation-induced endothelial dysfunction. The aim of this study was to determine time-dependent alteration of blood biomarkers related to endothelial function in hemorrhagic and septic shocks. Hemorrhagic shock was induced by bleeding the animals. A cecal ligation and incision model was used to induce septicemia. Resuscitation was carried out by infusion of lactated Ringer's solution. Resuscitation extended survival time in both shock groups. Blood pressure increased by resuscitation in the hemorrhagic shock but not in the septic shock. While hemorrhage caused a decrease in plasma levels of nitric oxide (NO) and hydrogen sulfide (H2S), asymmetric dimethylarginine (ADMA) and total antioxidant capacity (TAC) levels were increased. Only NO and TAC levels at the late phase were reversed by resuscitation. On the other hand, plasma levels of NO, ADMA, and TAC were increased by septicemia and resuscitation did not alter the septicemia-induced increase. These results indicate that blood biomarkers related to endothelial function were differentially affected by hemorrhage and septicemia. The time scale of biomarker production should be taken into consideration for the diagnostic and therapeutic approaches to these life-threatening diseases.
journal_name
Inflammationjournal_title
Inflammationauthors
Coskun CN,Usanmaz SE,Savci V,Demirel-Yilmaz Edoi
10.1007/s10753-017-0660-zsubject
Has Abstractpub_date
2018-02-01 00:00:00pages
33-41issue
1eissn
0360-3997issn
1573-2576pii
10.1007/s10753-017-0660-zjournal_volume
41pub_type
杂志文章相关文献
INFLAMMATION文献大全abstract::Neurodegenerative diseases such as Alzheimer, Parkinson, amyotrophic lateral sclerosis, and Huntington are incurable and debilitating conditions that result in progressive death of the neurons. The definite diagnosis of a neurodegenerative disorder is disadvantaged by the difficulty in obtaining biopsies and thereby t...
journal_title:Inflammation
pub_type: 杂志文章,评审
doi:10.1007/s10753-013-9780-2
更新日期:2014-06-01 00:00:00
abstract::The diabetic organism is unable to produce normal amount of granulation tissue which results in delayed wound healing, a significant clinical problem. In the present study, the effect of oral administration of aminoguanidine (AG), in the diabetes-induced inhibition of angiogenesis and granulation tissue formation was ...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1023/a:1020246624605
更新日期:1999-12-01 00:00:00
abstract::Bee venom (BV) is used in folk medicine to treat arthritis. It has antiinflammatory effects in animal models of rheumatic disease. We have studied the effects of BV on human neutrophil production of superoxide (O2-) and hydrogen peroxide, finding potent, nontoxic, dose-dependent production inhibition. Melittin, the ma...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00915999
更新日期:1986-06-01 00:00:00
abstract::The present study was designed to evaluate inflammatory changes in collapsed lungs during one-lung ventilation using the assistance of a bronchoscopic microsampling probe. Serial albumin and interleukin (IL)-8 concentrations in epithelial lining fluid (ELF) were measured in seven patients undergoing resection of lung ...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-012-9505-y
更新日期:2012-12-01 00:00:00
abstract::This experiment was conducted to investigate the effects of a benzylideneacetophenone derivative ((2E)-3-(4-hydroxy-3-methoxyphenyl)phenylpro-2-en-l-one (JC3)) on trimellitic anhydride (TMA)-induced atopic dermatitis (AD)-like symptoms in mice. To induce AD, the dorsal skins of mice were treated with 5% TMA on day 0 a...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-019-00971-w
更新日期:2019-06-01 00:00:00
abstract::Factors affecting the retinoic acid modulated expression of mucin mRNA in rat tracheal cultures were studied. Actinomycin D had no effect on mucin mRNA in cultures grown with retinoic acid (RA+). The usual precipitous drop in mucin mRNA in cultures lacking retinoic acid (RA-) was prevented by actinomycin D. Cyclohexim...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF01535255
更新日期:1994-12-01 00:00:00
abstract::Endothelial-neutrophil adhesion is a critical step in acute inflammatory diseases, which is mediated in part by P-selectin and platelet-activating factor (PAF). Nitric oxide (NO) is well known as an endogenous second messenger derived from endothelial cells, and regulates many important physiological events, however, ...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1023/a:1020287516911
更新日期:1999-02-01 00:00:00
abstract::Drug delivery into immune cells has high potential for the treatment of all kinds of inflammation, allowing a target-oriented transport of active agents. The advantage of this local drug release is the prevention of negative effects of systemic applications and low-dose application. Thereby, the phagocytotic capabilit...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-010-9213-4
更新日期:2011-04-01 00:00:00
abstract::The purpose of the present study is to evaluate the effect of emu oil on bioavailability of curcumin when co-administered and to evaluate the property that enhances the anti-inflammatory potential of curcumin. Oral bioavailability of curcumin in combination with emu oil was determined by measuring the plasma concentra...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-014-9948-4
更新日期:2014-12-01 00:00:00
abstract::C3b receptor (CR1) expression by neutrophils (PMNs) and erythrocytes (Es) from patients with chronic granulomatous disease (CGD) or with hyper-IgE, frequent infection (Job's) syndrome was compared with that of control subjects. The control subjects consisted of one group of patients with infections and a second group ...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00918218
更新日期:1984-12-01 00:00:00
abstract::T cells adhere to human dermal fibroblasts (HDF). This cellular interaction leads to a pronounced secretion of the proinflammatory cytokines IL-6 and IL-8 via a juxtacrine stimulation induced by HDF-associated IL-1. Upon stimulation, fibroblasts express various surface proteins such as MCH-I molecules, which may inter...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1023/a:1027310218934
更新日期:1997-08-01 00:00:00
abstract::Stacks of six membrane filters (8-mu pore size) were placed over the mouths of plastic tubes. The tubes were filled with casein (test) or NaCl (control) solution and implanted subcutaneously in white rats; each animal received one tube with casein and one control tube. After 12, 18, 24, and 36 h, the tubes were remove...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00916239
更新日期:1982-06-01 00:00:00
abstract::Asthma is the most common chronic disease of childhood, chronic airway inflammation; bronchial tissue fibrosis, is a pathological feature common to children asthma, and an emerging data has indicted that autophagy plays critical roles in airway inflammation and fibrosis-mediated airway remodeling. The aim of this stud...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-019-01076-0
更新日期:2020-02-01 00:00:00
abstract::Nitric Oxide (NO) is a reactive metabolite produced by stimulated macrophages, and it has been demonstrated to exert cytotoxic actions on a number of microbes, parasites, and tumor cells. In addition, NO has been reported to have an autotoxic effect on murine macrophages, its site of synthesis. We have investigated th...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF01487404
更新日期:1996-04-01 00:00:00
abstract::The benzylideneacetophenone derivative JC3 [(2E)-3-(4-hydroxy-3-methoxyphenyl)phenylpro-2-en-l-one] (JC3) was synthesized by modifying yakuchinone B obtained from the seeds of Alpinia oxyphylla, a member of the ginger family (Zingiberaceae), which are widely used as a folk remedy and as an anti-inflammatory. The aim o...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-018-0947-8
更新日期:2019-06-01 00:00:00
abstract::Release and activation of pro-inflammatory mediators are among the most important induced factors that are involved in the scorpion envenomation pathogenesis. Inflammatory response and lung reactivity were studied in mice following subcutaneous injection with Androctonus australis hector (Aah) venom. Venom immunodetec...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-011-9338-0
更新日期:2012-04-01 00:00:00
abstract::The synthetic compound 7-4-[Bis-(2-hydroxyethyl)-amino]-butoxy-5-hydroxy-8-methoxy-2-phenylchromen-4-one (V8) is a novel flavonoid-derived compound. In this study, we investigated the effects of V8 on Toll-like receptor 4 (TLR4)-mediated inflammatory reaction in human cervical cancer SiHa cells and lipopolysaccharide ...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-015-0236-8
更新日期:2016-02-01 00:00:00
abstract::Central nervous system tuberculosis (CNS-TB) is caused by infection with Mycobacterium tuberculosis (Mtb). The inflammatory response following CNS-TB involves the activation of resident microglia and the infiltration of macrophages. However, it has not been clarified whether microglia can be polarized into the classic...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-015-0136-y
更新日期:2015-08-01 00:00:00
abstract::Lipopolysaccharide (LPS) increases serum TNF-alpha levels due to TNF-alpha secretion by macrophages. The serum TNF-alpha response to LPS was augmented 10x when FcgammaR ligation was induced by the intravenous injection of Gig-coated erythrocytes (IgG) prior to the administration of LPS. The macrophage population respo...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1023/a:1021468819285
更新日期:2002-12-01 00:00:00
abstract::The objective of this study was to compare systemic and local cytokine profiles and neutrophil responses in patients with severe versus non-severe community-acquired pneumonia (CAP). Hospitalized patients with CAP were grouped according to the pneumonia severity index (PSI), as non-severe (PSI < 91 points) or severe (...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-014-9840-2
更新日期:2014-08-01 00:00:00
abstract::Patients undergoing lobectomy are at risk of developing acute lung injury resulting from one-lung ventilation (OLV) during surgery. We investigated the morphological and functional behavior of neutrophils in patients who underwent lobectomy and assessed the ability of sivelestat to inhibit neutrophil activity. This wa...
journal_title:Inflammation
pub_type: 杂志文章,随机对照试验
doi:10.1007/s10753-013-9689-9
更新日期:2013-12-01 00:00:00
abstract::Migration inhibitory factor (MIF) is associated with multiple organ dysfunction syndrome (MODS) in patients with systemic inflammatory response syndrome (SIRS). Our purposes were to determine the serum MIF, cortisol, and tumor narcosis factor-α (TNF-α) and to investigate the influences of the balance between the level...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-010-9223-2
更新日期:2011-06-01 00:00:00
abstract::The effects were studied of the non-specific phosphodiesterase inhibitor, theophylline (37.5-300 microM), on intracellular levels of cyclic adenosine monophosphate (cAMP) and superoxide generation following exposure of human neutrophils to four different stimuli of neutrophil membrane-associated oxidative metabolism, ...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1023/a:1022306328960
更新日期:1998-12-01 00:00:00
abstract::We have characterized leukocyte migration to the pleural cavity in a methylated-BSA (mBSA)-induced model of murine delayed-type hypersensitivity and evaluated the ability of IL-4 and IL-10 to modulate this response. Neutrophils, macrophages, T cells, and dendritic cells migrated to the pleural cavity in a time-depende...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1023/a:1025076111950
更新日期:2003-08-01 00:00:00
abstract::D-limonene epoxidation generates (+)-limonene epoxide, an understudied compound in the pharmacologically point of view. Herein, we investigated the anti-inflammatory and antinociceptive potentialities of (+)-limonene epoxide and suggested a mechanism of action. The anti-inflammatory potential was analyzed using agents...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-016-0496-y
更新日期:2017-04-01 00:00:00
abstract::The present study aimed to determine the protective effects and the underlying mechanisms of astragalin (AG) on ovalbumin (OVA)-induced allergic inflammation in a mouse model of allergic asthma. Our study demonstrated that AG inhibited OVA-induced increases in eosinophil count; IL-4, IL-5, IL-13, and IgE were recovere...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-015-0181-6
更新日期:2015-10-01 00:00:00
abstract::A full understanding of rheumatoid arthritis depends on the appreciation of clinical, radiological, immunological, genetic, biochemical, and structural mechanisms. Rheumatoid arthritis is characterized by the destruction of tissue structures such as articular cartilage and bone, but may also involve tendonous tissue, ...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00915710
更新日期:1984-06-01 00:00:00
abstract::The release of inflammatory cytokines and chemokines and autophagy has been reported to be involved in the pathogenic mechanism of acute lung injury (ALI). Reportedly, alpha-7 nicotinic acetylcholine receptors (α7nAchR) might play a protective role in LPS-induced ALI. In the current research, we established LPS-induce...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-019-01088-w
更新日期:2019-12-01 00:00:00
abstract::Interleukin-10 (IL-10) is a pleiotropic cytokine and plays an important role in the pathogenesis of systemic lupus erythematosus (SLE). Unlike IL-10 protein, few studies have focused on the potential association between IL-10 receptor (IL-10R) and SLE. The purpose of this study was to examine the association of a sing...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-013-9658-3
更新日期:2013-12-01 00:00:00
abstract::Crude extracts of human blood leukocytes were employed as a source of bactericidal and bacteriolytic agents againstStaphylococcus aureus. While the bactericidal action of the extracts was a very rapid process, bacteriolysis is a very slow process. Both the killing and the lysis of staphylococci depended on the age of ...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00917867
更新日期:1976-06-01 00:00:00