Abstract:
:Factors affecting the retinoic acid modulated expression of mucin mRNA in rat tracheal cultures were studied. Actinomycin D had no effect on mucin mRNA in cultures grown with retinoic acid (RA+). The usual precipitous drop in mucin mRNA in cultures lacking retinoic acid (RA-) was prevented by actinomycin D. Cycloheximide also had no effect on mucin mRNA in RA+ cultures, but, like actinomycin D, it prevented the precipitous drop in mucin mRNA in RA- cultures. cAMP agonists had some marginal effects on the mucin mRNA, but none as dramatic as those noted by actinomycin D and cycloheximide in the RA- cultures. An antisense oligomer (18 bases) to rat mucin cDNA inhibited the mucin mRNA expression in RA+ cultures.
journal_name
Inflammationjournal_title
Inflammationauthors
Bhattacharyya SN,Ashbaugh P,Kaufman B,Manna Bdoi
10.1007/BF01535255subject
Has Abstractpub_date
1994-12-01 00:00:00pages
565-74issue
6eissn
0360-3997issn
1573-2576journal_volume
18pub_type
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