Inhibition of Carrageenan/Kaolin-Induced Arthritis in Rats and of Inflammatory Cytokine Expressions in Human IL-1β-Stimulated Fibroblast-like Synoviocytes by a Benzylideneacetophenone Derivative.

abstract：:Four methods of severe disruption of human neutrophil membrane integrity resulted in the formation of substantial amounts of leukotriene B4 and its isomers. This synthesis took place from endogenous substrate in the absence of any cell activators. It is postulated that leukotriene formation could be a preserved cell f...

journal_title：Inflammation

authors： Green FA

更新日期：1988-04-01 00:00:00

abstract：:Slow translocation of protein kinase C was observed by both auranofin and gold sodium thiomalate pretreatment of neutrophils. Both gold compounds failed to influence the activity of this enzyme directly when cell-free studies were performed. In intact neutrophils incubated with 5.1-20.3 microM auranofin, protein kinas...

journal_title：Inflammation

authors： Parente JE,Davis P,Wong K

更新日期：1987-09-01 00:00:00

abstract：:Chemical alteration of the glucocorticoid, methylprednisolone, has led to the introduction of a new class of compounds called the 21-aminosteroids (21-ASs). The purpose of this study was to investigate the effect of the 21-AS, U74389G, on silica-induced acute lung injury. Male Fischer 344 rats were treated intraperito...

journal_title：Inflammation

authors： Antonini JM,van Dyke K,DiMatteo M,Reasor MJ

更新日期：1995-02-01 00:00:00

abstract：:Nicotine has anti- and pro-inflammatory properties in various cells. Its role in aortic vascular smooth muscle cells (VSMC) was explored. Human aortic VSMC were cultured. After nicotine (1.0 μM) and/or pyrrolidinedithiocarbamic acid (PDTC, 50 μM) treatment, the activation of nuclear factor κB (NFκB) was investigated. ...

journal_title：Inflammation

authors： Wang Y,Zhang F,Yang W,Xue S

更新日期：2012-02-01 00:00:00

abstract：:1,8-Cineol is a major monoterpene principally from eucalyptus essential oils and has been shown to exert anti-inflammatory, antiviral, and inhibitory of nuclear factor (NF)-kB effect. In the present study, we evaluated the effect of 1,8-cineol on mice infected with influenza A virus. We found that 1,8-cineol protects ...

journal_title：Inflammation

authors： Li Y,Lai Y,Wang Y,Liu N,Zhang F,Xu P

更新日期：2016-08-01 00:00:00

abstract：:Currently, only tumor necrosis factor alpha (TNF-α) and interleukin family cytokines have been found to be elicited in Vibrio vulnificus (V. vulnificus)-infected animal models and humans. However, multiple other cytokines are also involved in the immune and inflammatory responses to foreign microorganism infection. An...

journal_title：Inflammation

authors： Liu XF,Wu J,Wang MY,Chen YJ,Cao Y,Hu CJ

更新日期：2015-10-01 00:00:00

abstract：:In order to establish a model of lung disease in which the usefulness of potential antiinflammatory compounds can be evaluated, we have analyzed the biochemical and cellular responses of rabbits to zymosan deposition in their lungs. A suspension of zymosan particles was instilled into the lungs of rabbits using an int...

journal_title：Inflammation

authors： Kuhn SH,Rossouw DJ,Hoffstein S,Finkelstein MC

更新日期：1983-06-01 00:00:00

abstract：:Ruta graveolens L. (Rutaceae) are traditionally used for the treatment of rheumatism, arthritis and other inflammatory conditions in the traditional medicine of India, were evaluated for their protective effect in acute and chronic models of inflammation. Carrageenan induced rat paw edema and adjuvant induced arthriti...

journal_title：Inflammation

authors： Ratheesh M,Shyni GL,Sindhu G,Helen A

更新日期：2010-02-01 00:00:00

abstract：:Bee venom (BV) is used in folk medicine to treat arthritis. It has antiinflammatory effects in animal models of rheumatic disease. We have studied the effects of BV on human neutrophil production of superoxide (O2-) and hydrogen peroxide, finding potent, nontoxic, dose-dependent production inhibition. Melittin, the ma...

journal_title：Inflammation

authors： Somerfield SD,Stach JL,Mraz C,Gervais F,Skamene E

更新日期：1986-06-01 00:00:00

abstract：:Interleukin-1 receptor-associated kinase (IRAK1) is a key regulatory protein in TLR/IL1R-mediated cell activation during inflammatory response. Studies indicated that pending on the nature of the used inflammatory model, downregulation of IRAK1 may be beneficial or detrimental. However, the role of IRAK1 in affecting ...

journal_title：Inflammation

authors： Chandra R,Federici S,Bishwas T,Németh ZH,Deitch EA,Thomas JA,Spolarics Z

更新日期：2013-12-01 00:00:00

abstract：:An inflammatory cytokine, tumor necrosis factor (TNF)-alpha, has been implicated in the pathogenesis of inflammatory lung diseases such as interstitial pneumonia (IP). To clarify the role of the inflammatory cytokine in the pathogenesis of lung inflammation, we introduced a murine TNF-alpha gene into murine lungs by t...

journal_title：Inflammation

authors： Sakuma-Mochizuki J,Yoshida M,Abe K,Arai T,Mori M,Kaneda Y,Hayashi S

更新日期：2000-02-01 00:00:00

abstract：:Potassium voltage-gated channel subfamily Q member 1 opposite strand 1 (KCNQ1OT1), a long non-coding RNA found in the KCNQ1 locus, has been evidenced to play important roles in the aggravation of inflammatory and oxidative stresses under hypoxia, but whether and how KCNQ1OT1 contributes to neuronal damages in the cere...

journal_title：Inflammation

authors： Yi M,Li Y,Wang D,Zhang Q,Yang L,Yang C

更新日期：2020-10-01 00:00:00

abstract：:Free radicals play an important role in the initiation and progression of inflammatory bowel disease (IBD). Therefore, the reduction or elimination of adverse oxidant effects can provide novel therapy for IBD. Here, the antioxidant capacity and protective effects of a new class of chemically modified hetastarch (polyn...

journal_title：Inflammation

authors： Park JH,Ma L,Oshima T,Carter P,Coe L,Ma JW,Specian R,Grisham MB,Trimble CE,Hsia CJ,Liu JE,Alexander JS

更新日期：2002-02-01 00:00:00

abstract：:Myeloperoxidase (MPO), next to the NO synthase2 (NOS2), and NADPH oxidase, is the key enzyme of the oxidative burst responsible for the antimicrobial immunity. Because MPO participates in the eradication of Mycobacterium tuberculosis in the in vitro model and the extracellular enzyme may activate cells to cytokine syn...

journal_title：Inflammation

authors： Koziol-Montewka M,Kolodziejek A,Oles J

更新日期：2004-04-01 00:00:00

abstract：:Human blood leukocytes generated large amounts of superoxide (O2-) following stimulation by certain "cocktails" of soluble agents consisting of poly-L-arginine (PARG), phytohemagglutinin, the chemotactic peptide formyl-methionyl-leucyl-phenylalanine and polyanethole sulfanote (liquoid). A variety of cytochalasins, whi...

journal_title：Inflammation

authors： Ginsburg I,Borinski R,Pabst M

更新日期：1985-12-01 00:00:00

abstract：:Periodontitis has been advocated as a systematic chronic low-grade infection burden. However, the relationship between periodontitis and bone defect healing has not been elucidated. One hundred and eight male Wister rats were randomly assigned into three groups: control (healthy) group, periodontitis group, and period...

journal_title：Inflammation

authors： Zhou R,Shen L,Yang C,Wang L,Guo H,Yang P,Song A

更新日期：2018-06-01 00:00:00

abstract：:In the present study, the anti-inflammatory effect of piperine was investigated on monosodium urate crystal-induced inflammation in mice, an experimental model for gouty arthritis, and compared it with that of the nonsteroidal anti-inflammatory drug, indomethacin. The levels of lysosomal enzymes, lipid peroxidation, t...

journal_title：Inflammation

authors： Sabina EP,Nagar S,Rasool M

更新日期：2011-06-01 00:00:00

abstract：:TanshinoneIIA (TanIIA) has been demonstrated to possess numerous biological effects. However, the specific effect of TanIIA on macrophage polarization has not been reported. In this study, it was revealed that TanIIA might play a pivotal role in macrophage polarization. As our results indicated, cell morphology was ch...

journal_title：Inflammation

authors： Gao S,Wang Y,Li D,Guo Y,Zhu M,Xu S,Mao J,Fan G

更新日期：2019-02-01 00:00:00

abstract：:Sjögren's syndrome (SS) is a chronic autoimmune disease targeting salivary and lacrimal glands. C-X-C motif chemokine ligand 10 (CXCL10) expression is upregulated in lip salivary glands (LSGs) of primary SS (pSS) patients, and CXCL10 involved in SS pathogenesis via immune-cell accumulation. Moreover, interferon (IFN)-...

journal_title：Inflammation

authors： Aota K,Yamanoi T,Kani K,Ono S,Momota Y,Azuma M

更新日期：2021-02-01 00:00:00

abstract：:Asthma is the most common chronic disease of childhood, chronic airway inflammation; bronchial tissue fibrosis, is a pathological feature common to children asthma, and an emerging data has indicted that autophagy plays critical roles in airway inflammation and fibrosis-mediated airway remodeling. The aim of this stud...

journal_title：Inflammation

authors： Li BB,Chen YL,Pang F

更新日期：2020-02-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is a chronic autoimmune disease which involves many organs and presents with various symptoms. It has been shown that genetic and environmental factors play a major role in this disease and may affect the onset, activity, damage, and mortality of the disease. According to recent stud...

journal_title：Inflammation

authors： Alesaeidi S,Karami J,Mahmoudi M,Akbarian M,Poursani S,Amirzadeh A,Haddadi NS,Saffari E,Jamshidi AR

更新日期：2015-12-01 00:00:00

abstract：:To elucidate the role of major chemotactic factors, cytokine-induced neutrophil chemoattractant (CINC), leukotriene B4 (LTB4) and C5a in lipopolysaccharide (LPS)-induced acute lung injury in rat, we employed three reagents: anti-CINC-1 antibody, an LTB4 receptor antagonist (ONO-4057) and an anti-complementary agent (K...

journal_title：Inflammation

authors： Yamasawa H,Ishii Y,Kitamura S

更新日期：1999-06-01 00:00:00

abstract：:Different studies have shown the regulatory effects of vitamin D(3) on the immune system and bone metabolism. Regarding the effects of vitamin D on immune cells and the importance of cytokines on bone metabolism, we assessed the association between serum levels of interleukin (IL)-6, IL-10, IL-12, IL-17 and IFN-γ cyto...

journal_title：Inflammation

authors： Jamali Z,Arababadi MK,Asadikaram G

更新日期：2013-02-01 00:00:00

abstract：:Mitogen- and stress-activated protein kinase (MSK) is a recently identified nuclear cAMP-regulated enhancer B (CREB) and histone H3 kinase that responds to both mitogen- and stress-activated protein kinases. This study was designed to investigate the protective effect of MSK on the rats with focal ischemia-reperfusion...

journal_title：Inflammation

authors： Zhou Y,Gao G,Li Z,Jiang L

更新日期：2019-12-01 00:00:00

abstract：:Induction of hypoxia for 2.5 h in perfused cat livers resulted in a 10-fold increase in cathepsin D and a 15-fold increase in lactic dehydrogenase (LDH) activities in the perfusate and a 42% depression of the clearance rate of particles by the reticuloendothelial system (RES). Addition of 10(-3) M methylprednisolone (...

journal_title：Inflammation

authors： Carlson RP,Lefer AM

更新日期：1976-12-01 00:00:00

abstract：:Systemic sclerosis (SSc) is a disease characterized by skin and internal organ involvement. There is progressive accumulation of extracellular matrix components in the skin and involved organs. Tissue fibrosis is the prominent reason for mortality, and still, there is no satisfactory treatment. The aim of this study w...

journal_title：Inflammation

authors： Demir T,Turkbeyler I,Kaplan DS,Pehlivan Y,Orkmez M,Tutar E,Taysi S,Kisacik B,Onat AM,Bagcı C

更新日期：2013-02-01 00:00:00

abstract：:Genetic susceptibility may partially explain the clinical variability observed during the course of similar infections. To establish the contribution of genetic host factors in the susceptibility to critical illness, we genotyped 750 subjects (419 at high risk of critical illness) for 14 single nucleotide polymorphism...

journal_title：Inflammation

authors： Salnikova LE,Smelaya TV,Vesnina IN,Golubev AM,Moroz VV

更新日期：2014-04-01 00:00:00

abstract：:Immune dysfunction contributes to secondary infection and worse outcomes in sepsis. Regulatory T cells (Tregs) have been implicated in sepsis-induced immunosuppression. Nevertheless, the role of Tregs in secondary infection after sepsis remains to be determined. In the present study, a two-hit model which mimics clini...

journal_title：Inflammation

authors： Hu ZQ,Yao YM,Chen W,Bian JL,Zhao LJ,Chen LW,Hong GL,Lu ZQ,Zhao GJ

更新日期：2018-10-01 00:00:00

abstract：:Effects of several cytokines on kinetics of Intercellular Adhesion Molecule-1 (ICAM-1) and Vascular Cell Adhesion Molecule-1 (VCAM-1) expression were studied on a bronchial epithelial cell line (BEAS-2B). VCAM-I was neither constitutively expressed on BEAS-2B cells nor induced by Interferon-gamma (IFN-gamma). Tumor Ne...

journal_title：Inflammation

authors： Subauste MC,Choi DC,Proud D

更新日期：2001-12-01 00:00:00

abstract：:The purpose of the study was to explore the association between plasma platelet activating factor (PAF) and platelet activating factor acetylhydrolase (PAF-AH) levels and risk of coronary heart disease (CHD) or blood stasis syndrome (BSS) of CHD. Questionnaire, routine clinical assays and plasma levels of PAF, PAF-AH ...

journal_title：Inflammation

authors： Zheng GH,Xiong SQ,Mei LJ,Chen HY,Wang T,Chu JF

更新日期：2012-08-01 00:00:00