Abstract:
:Immune dysfunction contributes to secondary infection and worse outcomes in sepsis. Regulatory T cells (Tregs) have been implicated in sepsis-induced immunosuppression. Nevertheless, the role of Tregs in secondary infection after sepsis remains to be determined. In the present study, a two-hit model which mimics clinical conditions was used and the potential role of Tregs in secondary Pseudomonas aeruginosa infection post-sepsis was investigated. Results showed that mice were susceptible to secondary P. aeruginosa infection 3 days, but not 7 days, post-cecal ligation and puncture (CLP). The levels of IL-17A, IL-1β, and IL-6 remained low in CLP mice after P. aeruginosa infection, while the levels of IL-10 increased significantly. Additionally, increased number of Tregs in both lung and spleen was observed in "two-hit" mice. Injection with PC61 (anti-CD25) mAb reduced the number of Tregs by 50% in spleen and 60% in lung of septic mice. This partial depletion of Tregs elevated IL-17A, IL-1β, and IL-6 production and decreased IL-10 levels in septic mice with P. aeruginosa infection, leading to lower bacterial load, attenuation of lung injury, and improvement of survival. The present findings demonstrate that Tregs play a crucial role in secondary P. aeruginosa infection after sepsis by modulating the inflammatory response.
journal_name
Inflammationjournal_title
Inflammationauthors
Hu ZQ,Yao YM,Chen W,Bian JL,Zhao LJ,Chen LW,Hong GL,Lu ZQ,Zhao GJdoi
10.1007/s10753-018-0821-8subject
Has Abstractpub_date
2018-10-01 00:00:00pages
1780-1790issue
5eissn
0360-3997issn
1573-2576pii
10.1007/s10753-018-0821-8journal_volume
41pub_type
杂志文章相关文献
INFLAMMATION文献大全abstract::We analyzed the effect of the PAF receptor antagonist (+)-cis-3,5-dimethyl-2-(3-pyridyl)thiazolidin-4-one hydrochloride (SM-12502) on human platelet aggregation as well as mediator release. After incubation of human platelet with different concentrations of SM-12502 the cells were subsequently stimulated with either t...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF01487746
更新日期:1996-02-01 00:00:00
abstract::The purpose of the present study is to evaluate the effect of emu oil on bioavailability of curcumin when co-administered and to evaluate the property that enhances the anti-inflammatory potential of curcumin. Oral bioavailability of curcumin in combination with emu oil was determined by measuring the plasma concentra...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-014-9948-4
更新日期:2014-12-01 00:00:00
abstract::Increased susceptibility of neonates to infection may be related to defects in newborn neutrophil (PMN) functional activities, including altered responses to complement fragments (Cf) and defective microbicidal activity. We therefore compared the kinetics of newborn and adult bovine PMN membrane shape change responses...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00914305
更新日期:1989-12-01 00:00:00
abstract::Thermal injury in rats leads to an impairment of polymorphonuclear leukocyte (PMN) functions, particularly oxidative metabolism and phosphoinositide turnover. As prostaglandin E2, which has immunosuppressive properties, is released in high levels after burn trauma, we investigated the in vitro and in vivo effects of a...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00919347
更新日期:1992-12-01 00:00:00
abstract::A new in vivo method for measuring leukocyte migration in man involves the insertion of "platelets" prepared from membrane filters into the lower conjunctival sac. The "platelets" contain casein and are coated unilaterally with a foil, permitting the casein to diffuse in one direction only. A chemotactic gradient is t...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00914167
更新日期:1980-06-01 00:00:00
abstract::An inflammatory cytokine, tumor necrosis factor (TNF)-alpha, has been implicated in the pathogenesis of inflammatory lung diseases such as interstitial pneumonia (IP). To clarify the role of the inflammatory cytokine in the pathogenesis of lung inflammation, we introduced a murine TNF-alpha gene into murine lungs by t...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1023/a:1006992408052
更新日期:2000-02-01 00:00:00
abstract::The present study aimed to determine the protective effects and the underlying mechanisms of astragalin (AG) on ovalbumin (OVA)-induced allergic inflammation in a mouse model of allergic asthma. Our study demonstrated that AG inhibited OVA-induced increases in eosinophil count; IL-4, IL-5, IL-13, and IgE were recovere...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-015-0181-6
更新日期:2015-10-01 00:00:00
abstract::The aim of this study was to investigate the effect of high-intensity swimming exercise (HISE) on atopic dermatitis (AD). For the study, we established an AD model in BALB/c mice by repeated local exposure of house dust mite extract (Dermatophagoides farinae extract, DFE) and 1-chloro-2,4-dinitrobenzene (CDNB) to the ...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-014-9843-z
更新日期:2014-08-01 00:00:00
abstract::Recent studies have demonstrated that a calcium-sensitive protease converts Ca2+/phospholipid-dependent protein kinase C to a Ca2+/phospholipid-independent form during the activation of human neutrophils. In this paper, the results of the purification and characterization of a calcium-dependent cytosolic protease from...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00915892
更新日期:1988-02-01 00:00:00
abstract::Simvastatin, which is primarily prescribed to lower cholesterol, may also mitigate lung injury caused by sepsis, although the mechanisms remain elusive. This study aimed to evaluate the protective effect of simvastatin on acute lung injury in rats with sepsis and to investigate possible mechanisms. Male Wistar rats we...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-017-0668-4
更新日期:2018-02-01 00:00:00
abstract::Current treatments for ischemia-reperfusion (IR)-induced acute lung injury are limited. Mesenchymal stem cell-conditioned medium (CM) has been reported to attenuate lung injury. Neural crest stem cells (NCSCs), a type of multipotent stem cells, are more easily obtained than mesenchymal stem cells. We hypothesize that ...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-017-0594-5
更新日期:2017-10-01 00:00:00
abstract::Neutrophil production of reactive oxygen species is dependent on an assembly process that involves a translocation of the cytosolic NADPH-oxidase components (p47phox; p67phox; Rac2) to a b cytochrome containing membrane. Based on the fact that an intracellular Ca2+ rise can activate the oxidase without any extracellul...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1023/a:1027363730746
更新日期:1997-10-01 00:00:00
abstract::Periodontitis has been advocated as a systematic chronic low-grade infection burden. However, the relationship between periodontitis and bone defect healing has not been elucidated. One hundred and eight male Wister rats were randomly assigned into three groups: control (healthy) group, periodontitis group, and period...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-018-0751-5
更新日期:2018-06-01 00:00:00
abstract::Previous studies indicate that aspirin can promote neutrophil (PMN) adhesion to endothelial cells and neutrophil-mediated endothelial cell detachment. The objectives of the present study were to determine whether PMN adhesion is a prerequisite for aspirin-induced, PMN-mediated endothelial cell detachment and whether n...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF01534389
更新日期:1995-06-01 00:00:00
abstract::The present study aimed at characterizing the phenotype and functions of adherent synovial fluid (SF) cells derived from rheumatoid arthritis (RA), comparing with fibroblast-like synoviocytes (FLS) derived from RA synovial tissue (ST). Adherent SF-derived cells were spindle-shaped from passages 1-6 under light microsc...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-008-9087-x
更新日期:2008-12-01 00:00:00
abstract::Medical ozone has therapeutic properties as an antimicrobial, anti-inflammatory, modulator of antioxidant defense system. Major ozonated autohemotherapy (MOA) is a new therapeutic approach that is widely used in the treatment of many diseases. The objective of the present study was to determine whether preischemic app...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-015-0240-z
更新日期:2016-02-01 00:00:00
abstract::Postoperative ileus is a common complication after intra-abdominal surgery. Nitric oxide produced by macrophages in the inflamed gastrointestinal tract plays a crucial role in the pathogeny of postoperative ileus. Honokiol, extracted from the bark of Magnolia spp., is a natural compound with a biphenolic structure. In...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-017-0576-7
更新日期:2017-08-01 00:00:00
abstract::In the present study, we investigated the effect of lipoxin A4 on myocardial ischemia-reperfusion injury (IRI) following cardiac arrest (CA) in a rabbit model. Lipoxin A4 is a metabolite of arachidonic acid in the eicosanoid, it is called "brake signal" for its anti-inflammatory activity. Some inflammatory factors (IL...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-012-9567-x
更新日期:2013-04-01 00:00:00
abstract::The original version of this article contained mistakes, and the authors would like to correct them. ...
journal_title:Inflammation
pub_type: 杂志文章,已发布勘误
doi:10.1007/s10753-018-0770-2
更新日期:2018-06-01 00:00:00
abstract::Interleukin-1 receptor-associated kinase (IRAK1) is a key regulatory protein in TLR/IL1R-mediated cell activation during inflammatory response. Studies indicated that pending on the nature of the used inflammatory model, downregulation of IRAK1 may be beneficial or detrimental. However, the role of IRAK1 in affecting ...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-013-9692-1
更新日期:2013-12-01 00:00:00
abstract::CD4(+)Foxp3(+)T cells (Tregs) mediate homeostatic peripheral tolerance by suppressing helper T2 cells in allergy. However, the regulation of asthmatic inflammation by local (in situ) Tregs in asthma remains unclear. BALB/c mice sensitized and challenged with ovalbumin (OVA) (asthma group) developed asthmatic inflammat...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-014-9892-3
更新日期:2014-10-01 00:00:00
abstract::Current knowledge implicates pleural mesothelial cells as mainly responsible for inflammatory responses in the pleural space. However, a vast body of recent evidence underscores the important role of fibroblasts in the process of inflammation in several types of tissues. We hypothesize that HPFBs (human pleural fibrob...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1023/a:1014884127573
更新日期:2002-04-01 00:00:00
abstract::Chronic obstructive pulmonary disease (COPD) is a common chronic inflammatory disease with high morbidity and mortality rates. Cystatin C (Cys C) is a sensitive indicator for various chronic inflammatory diseases. In this study, we aimed to evaluate the role of Cys C in COPD patients comparing with the other well-know...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-015-0287-x
更新日期:2016-04-01 00:00:00
abstract::Most cases of posttraumatic ankle osteoarthritis (PTAOA) represent a sequela of ankle fractures. The cytoplasmic polyadenylation element-binding protein 1 (CPEB1) is an RNA binding protein that controls protein expression. Here, we report the previously unappreciated association of CPEB1 with PTAOA. We found that CPEB...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-018-0920-6
更新日期:2019-04-01 00:00:00
abstract::Nitric Oxide (NO) is a reactive metabolite produced by stimulated macrophages, and it has been demonstrated to exert cytotoxic actions on a number of microbes, parasites, and tumor cells. In addition, NO has been reported to have an autotoxic effect on murine macrophages, its site of synthesis. We have investigated th...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF01487404
更新日期:1996-04-01 00:00:00
abstract::The respiratory burst is a series of metabolic events which result in the production of microbicidal oxidants by phagocytes. The enzyme responsible for the respiratory burst is a membrane-bound oxidase which catalyzes the production of O-2 by the NADPH-dependent reduction of oxygen. Activity of this oxidase is diminis...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00917260
更新日期:1983-09-01 00:00:00
abstract::Sublethal doses of LPS result in increased tolerance to high concentrations of oxygen and this is associated with decreased pulmonary inflammation in a rat model. To investigate the mechanism of decreased neutrophil influx into the lung in this model, we measured levels of mRNA in the lung for the endothelial adhesion...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1023/b:ifla.0000039561.37868.91
更新日期:2004-06-01 00:00:00
abstract::Tissue macrophages can be activated by endogenous danger signals released from cells that are stressed or injured, leading to infiltration of inflammatory macrophages and neutrophils. We postulated that macrophage-related markers might be closely associated with the existence of endogenous danger signals, reflecting o...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-015-0214-1
更新日期:2015-12-01 00:00:00
abstract::The effect of leukocyte hydrolytic enzymes on periodontopathic bacteria was examined in vitro. A frozen and thawed extract of human peripheral blood leukocytes (LE) and human gingival crevicular exudate (GE) were shown to be able to cause the release of 50% of the radioactivity from a leukotoxic strain of Actinobacill...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00917824
更新日期:1983-06-01 00:00:00
abstract::The widely used mouse air pouch model of acute inflammation is inducible in a variety of inbred strains, but the potential influence of genetic background and gender on inflammation severity has never been examined. We directly compared the degree of inflammation induced in the air pouch model across four commonly uti...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-006-8962-6
更新日期:2005-02-01 00:00:00