Abstract:
:1,8-Cineol is a major monoterpene principally from eucalyptus essential oils and has been shown to exert anti-inflammatory, antiviral, and inhibitory of nuclear factor (NF)-kB effect. In the present study, we evaluated the effect of 1,8-cineol on mice infected with influenza A virus. We found that 1,8-cineol protects against influenza viral infection in mice. Moreover, 1,8-cineol efficiently decreased the level of IL-4, IL-5, IL-10, and MCP-1 in nasal lavage fluids and the level of IL-1β, IL-6, TNF-α, and IFN-γ in lung tissues of mice infected with influenza virus. The results also showed that 1,8-cineol reduced the expression of NF-kB p65, intercellular adhesion molecule (ICAM)-1, and vascular cell adhesion molecule (VCAM)-1 in lung tissues. Thus, 1,8-cineol appears to be able to augment protection against IFV infection in mice via attenuation of pulmonary inflammatory responses.
journal_name
Inflammationjournal_title
Inflammationauthors
Li Y,Lai Y,Wang Y,Liu N,Zhang F,Xu Pdoi
10.1007/s10753-016-0394-3subject
Has Abstractpub_date
2016-08-01 00:00:00pages
1582-93issue
4eissn
0360-3997issn
1573-2576pii
10.1007/s10753-016-0394-3journal_volume
39pub_type
杂志文章相关文献
INFLAMMATION文献大全abstract::The liver is an immunocompetent organ that plays a key role in the immune response to infections, and the development of hepatic immune function during early postnatal stages has not been thoroughly characterized. This study analyzed the constitutive expression of complement factors, namely C3 and C9, and pattern reco...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-010-9265-5
更新日期:2011-12-01 00:00:00
abstract::The aim of our study was to evaluate the pro- and anti-inflammatory cytokine response during acute pancreatitis and its predictive value on severity of disease. A hospital-based prospective clinical study was conducted. Twenty patients with acute pancreatitis were enrolled during a 12-month period. Plasma concentratio...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-011-9371-z
更新日期:2012-04-01 00:00:00
abstract::C3b receptor (CR1) expression by neutrophils (PMNs) and erythrocytes (Es) from patients with chronic granulomatous disease (CGD) or with hyper-IgE, frequent infection (Job's) syndrome was compared with that of control subjects. The control subjects consisted of one group of patients with infections and a second group ...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00918218
更新日期:1984-12-01 00:00:00
abstract::To determine the effect of heat stress on histopathology of acute lung injury (ALI) caused by administration of lipopolysaccharide (LPS), and to determine the roles of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, interferon (IFN)-gamma, IL-10 and surfactants in heat-induced tolerance to ALI, we administe...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1023/a:1011040515262
更新日期:2001-06-01 00:00:00
abstract::Berberine (Ber), the major constituent of Coptidis Rhizoma, possesses anti-inflammatory properties. In this study, we investigated the effects of Ber on cigarette smoke (CS)-mediated acute lung inflammation. C57BL/6 mice (6-8 weeks) were exposed to CS to induce acute lung injury. Ber was used to pretreat CS-exposed mi...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-013-9640-0
更新日期:2013-10-01 00:00:00
abstract::The aim of the study was to determine the effect of coumaric acid on sciatic nerve ischemia/reperfusion (SNI) injury in rats. The rats were randomly divided into four groups: control group (no medication or surgical procedure), SNI group, SNI + coumaric acid (CA) group, and SNI + methylprednisolone (MP) group. Ischemi...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-015-0195-0
更新日期:2015-12-01 00:00:00
abstract::Neuroinflammation is believed to be involved in the pathogenesis of neurodegenerative diseases. Our novel synthetic compound 2-acetyl-1-ethyl-7-hydroxy-6-methoxy-1, 2, 3, 4-tetrahydroisoquinoline (AETIQ) was tested for its anti-inflammatory properties in activated microglial BV-2 cells. AETIQ attenuated nitric oxide (...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-013-9795-8
更新日期:2014-06-01 00:00:00
abstract::The biological effects of asiatic acid (AA) on spinal cord injury (SCI)-induced acute lung injury (ALI) have not been investigated. We aimed to investigate the therapeutic efficacy and molecular mechanisms of AA on SCI-induced ALI. One-hundred and fifty Sprague-Dawley rats were randomly assigned to five groups: sham, ...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-016-0414-3
更新日期:2016-12-01 00:00:00
abstract::We analyzed the effect of the PAF receptor antagonist (+)-cis-3,5-dimethyl-2-(3-pyridyl)thiazolidin-4-one hydrochloride (SM-12502) on human platelet aggregation as well as mediator release. After incubation of human platelet with different concentrations of SM-12502 the cells were subsequently stimulated with either t...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF01487746
更新日期:1996-02-01 00:00:00
abstract::Ischemic stroke is a major cause of death and motor disabilities all over the world. It is a muti-factorial disorder associated with inflammatory, apoptotic, and oxidative responses. Nateglinide (NAT), an insulinotropic agent used for the treatment of type 2 diabetes mellitus, recently showed potential anti-inflammato...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-019-01154-3
更新日期:2020-04-01 00:00:00
abstract::Inflammatory cells, macrophages induced by lipopolysaccharide (LPS) stimulation, lead to the production of inflammatory cytokines, which are crucial to host defense. MicroRNAs are short noncoding RNAs that regulate key biological processes via suppression of gene expression at posttranscriptional levels. Recently, miR...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-013-9713-0
更新日期:2014-02-01 00:00:00
abstract::Chronic prostatitis was the most common type of prostatitis and oxidative stress was reported to be highly elevated in prostatitis patients. In this study, we determined the effect of N-acetylcysteine (NAC) on prostatitis and the molecular mechanism involved in it. Male Sprague-Dawley rats were divided into three grou...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-016-0327-1
更新日期:2016-04-01 00:00:00
abstract::We aim to determine the extent of the CD40-CD40L pathway involvement in activated platelet-induced changes in human umbilical endothelial cells (HUVECs). Activated platelets were co-incubated with HUVECs in the presence or absence of CD40LmAb. HUVECs were also directly stimulated with rhCD40L. HUVEC endothelial cycloo...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-011-9427-0
更新日期:2012-06-01 00:00:00
abstract::A rat sponge implant model was used to examine the role of protein kinase C (PKC) in angiogenesis. Neovascular response was determined by measurements of relative sponge blood flow by a 133Xe clearance technique and confirmed histologically. Morphometric analysis was used to quantitate the amount of fibrovascular grow...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF01534379
更新日期:1995-02-01 00:00:00
abstract::The widely used mouse air pouch model of acute inflammation is inducible in a variety of inbred strains, but the potential influence of genetic background and gender on inflammation severity has never been examined. We directly compared the degree of inflammation induced in the air pouch model across four commonly uti...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-006-8962-6
更新日期:2005-02-01 00:00:00
abstract::The objective of this study was to determine nitric oxide (NO) and superoxide anion release (O-2) by neutrophils (PMNs) in the septic multiple organ dysfunction syndrome (MODS) and to compare them with the response of normal cells to lipopolysaccharide (LPS) and cytokines. NO production was measured by the release of ...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF01534556
更新日期:1994-04-01 00:00:00
abstract::This study examined the hypothesis that tumor cells metastatic to the pleura secrete a soluble factor(s) that directly increases endothelial cell permeability. Nitrocellulose filters were endothelialized with bovine pulmonary artery endothelial cells and exposed to conditioned media from either human lung adenocarcino...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF01534438
更新日期:1994-08-01 00:00:00
abstract::The present study aimed at characterizing the phenotype and functions of adherent synovial fluid (SF) cells derived from rheumatoid arthritis (RA), comparing with fibroblast-like synoviocytes (FLS) derived from RA synovial tissue (ST). Adherent SF-derived cells were spindle-shaped from passages 1-6 under light microsc...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-008-9087-x
更新日期:2008-12-01 00:00:00
abstract::Myeloperoxidase (MPO), next to the NO synthase2 (NOS2), and NADPH oxidase, is the key enzyme of the oxidative burst responsible for the antimicrobial immunity. Because MPO participates in the eradication of Mycobacterium tuberculosis in the in vitro model and the extracellular enzyme may activate cells to cytokine syn...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1023/b:ifla.0000033020.28446.a6
更新日期:2004-04-01 00:00:00
abstract::Recombinant human tumor necrosis factor-alpha (rTNF) stimulated increased generation of superoxide anion (O2-) by human neutrophils in a concentration-dependent fashion. Preincubation of human neutrophils with rTNF (2.2-2200 units/ml) for 10 min enhanced the subsequent generation of O2- in response to C5a and f-Met-Le...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00918813
更新日期:1992-06-01 00:00:00
abstract::The aim of this study is to explore the dynamic changes in IL-17-expressing T cells (Th17)/Treg expression in monophasic experimental autoimmune uveitis (mEAU). mEAU was induced in Lewis rats with IRBP1177-1191 peptide and evaluated clinically and pathologically on days 9, 13, 18, 23, 28, 35, and 48. Lymphocytes isola...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-015-0229-7
更新日期:2016-02-01 00:00:00
abstract::The adhesive interactions between phagocytes and endothelial cells (EC) can be modulated by inflammatory cytokines and chemotactic proteins which are released during an inflammatory response. The aim of the present study was to investigate first whether the adhesive properties of granulocytes and monocytes from asthma...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1023/a:1022344307926
更新日期:1998-04-01 00:00:00
abstract::The ability of peripheral blood neutrophils to injure elements of the alveolar septum was assessed. Experiments consisted of activating previously isolated neutrophils (PMNs) with a soluble (phorbol myristate acetate, PMA) and a particulate (zymosan) trigger, and measuring detachment of 51Cr-labeled epithelial cells. ...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00917512
更新日期:1992-02-01 00:00:00
abstract::CD4+ T cell subset imbalance plays an important role in the development of diabetic complications. Neutrophils have recently been known as the regulator of CD4+ T cell differentiation. However, whether neutrophils affect CD4+ T cell population in diabetes is still elusive. In this study, we investigated the effect of ...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-018-0913-5
更新日期:2019-04-01 00:00:00
abstract::Patients undergoing lobectomy are at risk of developing acute lung injury resulting from one-lung ventilation (OLV) during surgery. We investigated the morphological and functional behavior of neutrophils in patients who underwent lobectomy and assessed the ability of sivelestat to inhibit neutrophil activity. This wa...
journal_title:Inflammation
pub_type: 杂志文章,随机对照试验
doi:10.1007/s10753-013-9689-9
更新日期:2013-12-01 00:00:00
abstract::Factors affecting the retinoic acid modulated expression of mucin mRNA in rat tracheal cultures were studied. Actinomycin D had no effect on mucin mRNA in cultures grown with retinoic acid (RA+). The usual precipitous drop in mucin mRNA in cultures lacking retinoic acid (RA-) was prevented by actinomycin D. Cyclohexim...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF01535255
更新日期:1994-12-01 00:00:00
abstract::This study was performed to evaluate the effects of epigallocatechin 3 gallate (EGCG) on lipopolysaccharide (LPS)-induced acute lung injury in a murine model. In the present study, production of TNF-alpha and MIP-2 and activation of extracellular signal-regulated kinases (ERK)1/2, c-Jun amino terminal kinases (JNK) an...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-009-9161-z
更新日期:2010-04-01 00:00:00
abstract::IFN-τ, which is a type I interferon with low cytotoxicity, is defined as a pregnancy recognition signal in ruminants. Type I interferons have been used as anti-inflammatory agents, but their side effects limit their clinical application. The present study aimed to determine the anti-inflammatory effects of IFN-τ in a ...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-016-0348-9
更新日期:2016-06-01 00:00:00
abstract::Our study is based on the establishment of a cohort of human obese omental adipose tissue and the culture of adipocytes in vitro. To observe the effect of high level of free fatty acid (FFA) on the expression of DNA methyltransferases (DNMTs) and the anti-inflammatory factor Kruppel-like factor 4 (KLF4) in adipocytes ...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-019-01168-x
更新日期:2020-06-01 00:00:00
abstract::Macrophages are one of the most heterogenic immune cells involved in skeletal muscle regeneration. After skeletal muscle damage, M1 phenotypes exhibit pro-inflammatory reaction. In a later stage, they are converted to M2 phenotypes with anti-inflammatory properties. To study when gene expressions of macrophage polariz...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-014-0024-x
更新日期:2015-02-01 00:00:00