Nateglinide Exerts Neuroprotective Effects via Downregulation of HIF-1α/TIM-3 Inflammatory Pathway and Promotion of Caveolin-1 Expression in the Rat's Hippocampus Subjected to Focal Cerebral Ischemia/Reperfusion Injury.

abstract：:Using crossed immunoelectrophoresis, immunoelectrodiffusion, autoradiography, and equilibrium binding techniques, we demonstrate that the rat fetus, directly challenged in utero at 18 days by a single subcutaneous turpentine injection, presents a complex acute-phase plasma inflammatory response. A number of fetal seru...

journal_title：Inflammation

authors： Vranckx R,Savu L,Cohen A,Maya M,Nunez E

更新日期：1989-02-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is a chronic autoimmune disease which involves many organs and presents with various symptoms. It has been shown that genetic and environmental factors play a major role in this disease and may affect the onset, activity, damage, and mortality of the disease. According to recent stud...

journal_title：Inflammation

authors： Alesaeidi S,Karami J,Mahmoudi M,Akbarian M,Poursani S,Amirzadeh A,Haddadi NS,Saffari E,Jamshidi AR

更新日期：2015-12-01 00:00:00

abstract：:Diabetic neuropathy (DNP) is the most common chronic complication of diabetes. Elevated free fatty acids (FFAs) have been recently recognized as major causes of inflammation and are relevant to the functional changes of nerve system in diabetes. Trans-resveratrol (RESV), a polyphenolic natural compound, has long been ...

journal_title：Inflammation

authors： Xu H,Xiong C,He L,Wu B,Peng L,Cheng Y,Jiang F,Tan L,Tang L,Tu Y,Yang Y,Liu C,Gao Y,Li G,Zhang C,Liu S,Xu C,Wu H,Li G,Liang S

更新日期：2015-02-01 00:00:00

abstract：:Our study is based on the establishment of a cohort of human obese omental adipose tissue and the culture of adipocytes in vitro. To observe the effect of high level of free fatty acid (FFA) on the expression of DNA methyltransferases (DNMTs) and the anti-inflammatory factor Kruppel-like factor 4 (KLF4) in adipocytes ...

journal_title：Inflammation

authors： Deng Y,Qiu T,Zhang M,Wu J,Zhang X,Wang J,Chen K,Feng J,Ha X,Xie J,Wang C,Zhang J

更新日期：2020-06-01 00:00:00

abstract：:We analyzed the effect of the PAF receptor antagonist (+)-cis-3,5-dimethyl-2-(3-pyridyl)thiazolidin-4-one hydrochloride (SM-12502) on human platelet aggregation as well as mediator release. After incubation of human platelet with different concentrations of SM-12502 the cells were subsequently stimulated with either t...

journal_title：Inflammation

authors： Köller M,Hilger RA,König W

更新日期：1996-02-01 00:00:00

abstract：:The effects were studied of the non-specific phosphodiesterase inhibitor, theophylline (37.5-300 microM), on intracellular levels of cyclic adenosine monophosphate (cAMP) and superoxide generation following exposure of human neutrophils to four different stimuli of neutrophil membrane-associated oxidative metabolism, ...

journal_title：Inflammation

authors： Mahomed AG,Theron AJ,Anderson R,Feldman C

更新日期：1998-12-01 00:00:00

abstract：:Polymorphonuclear neutrophils are among the first defense against infection and closely involved in the initiation of inflammatory response. It is well recognized that this function of neutrophils was mainly mediated by phagocytosis, intracellular degradation, releasing of granules, and formation of neutrophil extrace...

journal_title：Inflammation

authors： Yang F,Feng C,Zhang X,Lu J,Zhao Y

更新日期：2017-02-01 00:00:00

abstract：:The levels of mRNA for plasma proteins and for metallothionein in rat liver during the acute-phase response were studied by hybridization to specific cDNA probes. The mRNA for alpha 2-macroglobulin, the beta-chain of fibrinogen, alpha 1-acid glycoprotein (so-called acute-phase reactants) reached a maximum level betwee...

journal_title：Inflammation

authors： Schreiber G,Aldred AR,Thomas T,Birch HE,Dickson PW,Tu GF,Heinrich PC,Northemann W,Howlett GJ,de Jong FA

更新日期：1986-03-01 00:00:00

abstract：:Patients undergoing lobectomy are at risk of developing acute lung injury resulting from one-lung ventilation (OLV) during surgery. We investigated the morphological and functional behavior of neutrophils in patients who underwent lobectomy and assessed the ability of sivelestat to inhibit neutrophil activity. This wa...

journal_title：Inflammation

authors： Eguchi T,Yoshida K,Kondo R,Hamanaka K,Shiina T,Komatsu Y,Yamamoto H,Kubo K,Hasegawa J,Koizumi T

更新日期：2013-12-01 00:00:00

abstract：:Postoperative ileus is a common complication after intra-abdominal surgery. Nitric oxide produced by macrophages in the inflamed gastrointestinal tract plays a crucial role in the pathogeny of postoperative ileus. Honokiol, extracted from the bark of Magnolia spp., is a natural compound with a biphenolic structure. In...

journal_title：Inflammation

authors： Mihara T,Mikawa S,Kaji N,Endo M,Oikawa T,Tong-Rong J,Ozaki H,Hori M

更新日期：2017-08-01 00:00:00

abstract：:Inflammatory bowel disease (IBD) in humans is closely related to bacterial infection and the disruption of the intestinal barrier. Paeoniflorin (PF), a bioactive compound from Paeonia lactiflora Pallas plants, exerts a potential effect of anti-inflammatory reported in various researches. However, the effect of PF on i...

journal_title：Inflammation

authors： Wu XX,Huang XL,Chen RR,Li T,Ye HJ,Xie W,Huang ZM,Cao GZ

更新日期：2019-12-01 00:00:00

abstract：:Inflammatory bowel disease (IBD) has received much attention due to its increasing worldwide incidence and potential increased risk of colorectal cancer. The protective function of a Rho-associated protein kinase inhibitor (Y-27632) against 2,4,6-trinitrobenzene sulfonic acid (TNBS) induced mouse colitis has been prov...

journal_title：Inflammation

authors： Wang Y,Duan X,Liu X,Liu Y,Fan H,Xu M,Chen Q,Tang Q

更新日期：2020-06-01 00:00:00

abstract：:We investigated the molecular mechanisms underlying the role of miRNAs in the pathogenesis of psoriasis to discover novel potential diagnostic markers and treatment targets. We screened Chinese Han individuals using gene chip technology to identify differentially expressed miRNAs in the epidermal tissue of lesions fro...

journal_title：Inflammation

authors： Wang Y,Yu X,Wang L,Ma W,Sun Q

更新日期：2018-12-01 00:00:00

abstract：:Alveolar type I epithelial cells (AECIs) play an important role in the pathogenesis of acute lung injury. The receptor for advanced glycation end-products (RAGEs) is expressed at a high basal level in AECIs, and its soluble isoform is suggested as a marker of AECI injury. However, the molecular mechanism by which RAGE...

journal_title：Inflammation

authors： Li Y,Wu R,Zhao S,Cheng H,Ji P,Yu M,Tian Z

更新日期：2014-10-01 00:00:00

abstract：:Sublethal doses of LPS result in increased tolerance to high concentrations of oxygen and this is associated with decreased pulmonary inflammation in a rat model. To investigate the mechanism of decreased neutrophil influx into the lung in this model, we measured levels of mRNA in the lung for the endothelial adhesion...

journal_title：Inflammation

authors： Thompson LR,Keeney SE,Tarrant D,Rudloff E,Dallas DV,Schmalstieg FC

更新日期：2004-06-01 00:00:00

abstract：:Asthma is the most common chronic disease of childhood, chronic airway inflammation; bronchial tissue fibrosis, is a pathological feature common to children asthma, and an emerging data has indicted that autophagy plays critical roles in airway inflammation and fibrosis-mediated airway remodeling. The aim of this stud...

journal_title：Inflammation

authors： Li BB,Chen YL,Pang F

更新日期：2020-02-01 00:00:00

abstract：:The U937 cell, a human monoblast cell line, has been used as a model to study the function of human monocytes. We investigated the effects of interferon-gamma (IFN-gamma) on superoxide anion (O2-) production, cell surface antigens, and cytokine production of U937 cells. IFN-gamma treatment enhanced O2- production of f...

journal_title：Inflammation

authors： Ishizuka T,Hirata I,Adachi M,Kurimoto F,Hisada T,Dobashi K,Mori M

更新日期：1995-12-01 00:00:00

abstract：:Immune dysfunction contributes to secondary infection and worse outcomes in sepsis. Regulatory T cells (Tregs) have been implicated in sepsis-induced immunosuppression. Nevertheless, the role of Tregs in secondary infection after sepsis remains to be determined. In the present study, a two-hit model which mimics clini...

journal_title：Inflammation

authors： Hu ZQ,Yao YM,Chen W,Bian JL,Zhao LJ,Chen LW,Hong GL,Lu ZQ,Zhao GJ

更新日期：2018-10-01 00:00:00

abstract：:Various disease states are associated with eosinophilia and the release of eosinophil peroxidase (EPO) into the microenvironment. The present study targets the effects of low levels of EPO on macrophage (M phi) phagocytosis and intracellular killing of Candida albicans as well as M phi oxidative activity measured as t...

journal_title：Inflammation

authors： Lefkowitz DL,Lincoln JA,Howard KR,Stuart R,Lefkowitz SS,Allen RC

更新日期：1997-04-01 00:00:00

abstract：:Paeonol, a major ingredient isolated from Moutan Cort, has various pharmacological effects. Our previous studies have shown that paeonol can exert antioxidant and anti-inflammatory therapeutic effects on ethanol-induced experimental gastric ulcer (GU). Therefore, in this study, we designed two GU models in rats induce...

journal_title：Inflammation

authors： Guo Y,Du Y,Xie L,Pu Y,Yuan J,Wang Z,Zhang T,Wang B

更新日期：2020-12-01 00:00:00

abstract：:Inflammatory cells, macrophages induced by lipopolysaccharide (LPS) stimulation, lead to the production of inflammatory cytokines, which are crucial to host defense. MicroRNAs are short noncoding RNAs that regulate key biological processes via suppression of gene expression at posttranscriptional levels. Recently, miR...

journal_title：Inflammation

authors： He Y,Sun X,Huang C,Long XR,Lin X,Zhang L,Lv XW,Li J

更新日期：2014-02-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is a chronic inflammation that can lead to loss of range of joint abnormalities in severe cases. Diosgenin has anti-inflammatory effects. This paper discussed the effect and mechanism of diosgenin on excessive proliferation and inflammatory response of synovial cells in RA. CCK-8 detected the...

journal_title：Inflammation

authors： Wang R,Sun Y,Jin X,Wen W,Cao Y

更新日期：2020-11-25 00:00:00

abstract：:Two methods for quantitating polymorphonuclear leukocyte (PMN) accumulation in inflammatory skin lesions were studied. The lesions were produced in rats by intradermal injections of different dilutions of zymosan-activated plasma (ZAP). PMN accumulation in the skin lesions was estimated by determination of (1) homolog...

journal_title：Inflammation

authors： Lundberg C,Arfors KE

更新日期：1983-09-01 00:00:00

abstract：:Asthma is a complex disease linked to various pathophysiological events, including proteinase activity. In this study, we examined whether a Diospyros blancoi methanolic extract (DBE) exerts protective effects on allergic asthma in a murine asthma model. To investigate the specific role of DBE, we employed a murine mo...

journal_title：Inflammation

authors： Lee KY,Jung JY,Lee MY,Jung D,Cho ES,Son HY

更新日期：2012-04-01 00:00:00

abstract：:Chemerin is shown to be associated with inflammation which is involved in the pathogenesis of diabetic nephropathy. This study aims to determine whether rosiglitazone and pioglitazone ameliorate renal function through an effect on the expression of chemerin and ChemR23 in streptozotocin-induced diabetic rats. The rats...

journal_title：Inflammation

authors： Hu W,Yu Q,Zhang J,Liu D

更新日期：2012-08-01 00:00:00

abstract：:A rat sponge implant model was used to examine the role of protein kinase C (PKC) in angiogenesis. Neovascular response was determined by measurements of relative sponge blood flow by a 133Xe clearance technique and confirmed histologically. Morphometric analysis was used to quantitate the amount of fibrovascular grow...

journal_title：Inflammation

authors： Hu DE,Fan TP

更新日期：1995-02-01 00:00:00

abstract：:Acute lung injury (ALI)/acute respiratory distress syndrome is characterized by increased pulmonary inflammation, where T helper 17 (Th17) cells play an important regulatory role. Notch signaling critically regulates Th17 differentiation and is known to be linked with proximal T cell by protein kinase C theta (PKCθ). ...

journal_title：Inflammation

authors： Li M,Zhao Y,He J,Deng W,Cheng L,Jiang Z,Wang D

更新日期：2019-12-01 00:00:00

abstract：:Rabbits were injected intramuscularly with cortisone acetate (2 mg/kg) on alternate days. Six days after the first injection these rabbits and controls were injected intradermally in multiple sites with BCG (the vaccine strain of tubercle bacillus). Periodically, over the next 2 months, the resulting lesions were meas...

journal_title：Inflammation

authors： McCue RE,Dannenberg AM Jr,Higuchi S,Sugimoto M

更新日期：1978-06-01 00:00:00

abstract：:Human neutrophils were demonstrated to possess interleukin-2 receptor (IL-2R) beta and gamma chains, not alpha chain and the binding of IL-2 to the IL-2R beta chain on neutrophils plays an important regulatory role in neutrophil functions. We have investigated in this study the hypothesis that recombinant human IL-2 (...

journal_title：Inflammation

authors： Li J,Gyorffy S,Lee S,Kwok CS

更新日期：1996-08-01 00:00:00

abstract：:The synthetic compound 7-4-[Bis-(2-hydroxyethyl)-amino]-butoxy-5-hydroxy-8-methoxy-2-phenylchromen-4-one (V8) is a novel flavonoid-derived compound. In this study, we investigated the effects of V8 on Toll-like receptor 4 (TLR4)-mediated inflammatory reaction in human cervical cancer SiHa cells and lipopolysaccharide ...

journal_title：Inflammation

authors： He A,Ji R,Shao J,He C,Jin M,Xu Y

更新日期：2016-02-01 00:00:00