Effects of interferon-gamma on cell differentiation and cytokine production of a human monoblast cell line, U937.


:The U937 cell, a human monoblast cell line, has been used as a model to study the function of human monocytes. We investigated the effects of interferon-gamma (IFN-gamma) on superoxide anion (O2-) production, cell surface antigens, and cytokine production of U937 cells. IFN-gamma treatment enhanced O2- production of fMLP or PMA-stimulated U937 cells. IFN-gamma increased the ratio of CD23 and CD11b positive cells. The fluorescence intensity of CD14 and CD25 was enhanced by IFN-gamma treatment. U937 cells produced IL-1 alpha, IL-1 beta, IL-6, and TNF-alpha by lipopolysaccharide (LPS) stimulation. IFN-gamma treatment enhanced TNF-alpha production, but decreased IL-6 production. These results suggest that IFN-gamma differentiates U937 cells to monocyte-like cells and it regulates the production systems of IL-6 and TNF-alpha separately in U937 cells.






Ishizuka T,Hirata I,Adachi M,Kurimoto F,Hisada T,Dobashi K,Mori M




Has Abstract


1995-12-01 00:00:00












  • Urocanic acid suppresses the activation of human neutrophils in vitro.

    abstract::Exposure to ultraviolet (UV) light impairs the function of inflammatory cells. Urocanic acid (UCA) in an stratum corneum has been suggested as a mediator in the immunosuppression of lymphoid cells detected after irradiation with UVB (UV wavelengths 280-320 nm). In this study, we examined the effects of the two UCA iso...


    pub_type: 杂志文章


    authors: Kivistö K,Punnonen K,Toppari J,Leino L

    更新日期:1996-10-01 00:00:00

  • NADPH and "cocktails" containing polyarginine reactivate superoxide generation in leukocytes lysed by membrane-damaging agents.

    abstract::Human blood leukocytes generated large amounts of superoxide (O2-) following stimulation by certain "cocktails" of soluble agents consisting of poly-L-arginine (PARG), phytohemagglutinin, the chemotactic peptide formyl-methionyl-leucyl-phenylalanine and polyanethole sulfanote (liquoid). A variety of cytochalasins, whi...


    pub_type: 杂志文章


    authors: Ginsburg I,Borinski R,Pabst M

    更新日期:1985-12-01 00:00:00

  • LncRNA KCNQ1OT1 Regulates Endoplasmic Reticulum Stress to Affect Cerebral Ischemia-Reperfusion Injury Through Targeting miR-30b/GRP78.

    abstract::Endoplasmic reticulum stress (ERS) plays an important role in cerebral ischemia-reperfusion injury (CIRI) by regulating apoptosis. Although the role of long non-coding RNA (LncRNA) KCNQ1OT1 in CIRI has been reported, the specific mechanism is still unclear. In this paper, the regulation of ERS by LncRNA KCNQ1OT1 in CI...


    pub_type: 杂志文章


    authors: Li Y,Yi M,Wang D,Zhang Q,Yang L,Yang C

    更新日期:2020-12-01 00:00:00

  • Tetrahydrocoptisine protects rats from LPS-induced acute lung injury.

    abstract::Recent studies show that nuclear factor-kappa B (NF-κB) signaling pathway plays a key role in contributing to the development of lipopolysaccharide (LPS)-induced acute lung injury (ALI). Tetrahydrocoptisine is one of the main active components of Chelidonium majus L. and has been described to be effective in suppressi...


    pub_type: 杂志文章


    authors: Li W,Huang H,Niu X,Fan T,Hu H,Li Y,Yao H,Li H,Mu Q

    更新日期:2014-12-01 00:00:00

  • Imbalance Between Th17 Cells and Regulatory T Cells During Monophasic Experimental Autoimmune Uveitis.

    abstract::The aim of this study is to explore the dynamic changes in IL-17-expressing T cells (Th17)/Treg expression in monophasic experimental autoimmune uveitis (mEAU). mEAU was induced in Lewis rats with IRBP1177-1191 peptide and evaluated clinically and pathologically on days 9, 13, 18, 23, 28, 35, and 48. Lymphocytes isola...


    pub_type: 杂志文章


    authors: Zhang L,Wan F,Song J,Tang K,Zheng F,Guo J,Guo D,Bi H

    更新日期:2016-02-01 00:00:00

  • Bradykinin-stimulated prostaglandin E2 production by endothelial cells and its modulation by antiinflammatory compounds.

    abstract::Prostaglandin production was studied in cultures of pig aorta endothelial cells using radioimmunoassay, radiochromatography, and smooth muscle bioassay. PGE2 was produced in higher concentrations than other prostaglandins. Bradykinin produced a rapid dose-related stimulation of PGE2 production. These results provided ...


    pub_type: 杂志文章


    authors: Jose PJ,Page DA,Wolstenholme BE,Williams TJ,Dumonde DC

    更新日期:1981-12-01 00:00:00

  • Acute effect of Aloe vera gel extract on experimental models of pain.

    abstract::The present study was performed to explore the effect of aqueous extract of Aloe vera on behavioural parameters of pain. Pain assessment was performed by the tail-flick and formalin tests. A. vera (100 mg/kg, per oral (p.o.)) produced an insignificant decrease in the pain response in the tail-flick and formalin tests....


    pub_type: 杂志文章


    authors: Rathor N,Mehta AK,Sharma AK,Mediratta PK,Sharma KK

    更新日期:2012-12-01 00:00:00

  • The Effect of Coumaric Acid on Ischemia-Reperfusion Injury of Sciatic Nerve in Rats.

    abstract::The aim of the study was to determine the effect of coumaric acid on sciatic nerve ischemia/reperfusion (SNI) injury in rats. The rats were randomly divided into four groups: control group (no medication or surgical procedure), SNI group, SNI + coumaric acid (CA) group, and SNI + methylprednisolone (MP) group. Ischemi...


    pub_type: 杂志文章


    authors: Guven M,Yuksel Y,Sehitoglu MH,Tokmak M,Aras AB,Akman T,Golge UH,Goksel F,Karavelioglu E,Cosar M

    更新日期:2015-12-01 00:00:00

  • Gold compounds alter distribution of protein kinase C activity in human neutrophils.

    abstract::Slow translocation of protein kinase C was observed by both auranofin and gold sodium thiomalate pretreatment of neutrophils. Both gold compounds failed to influence the activity of this enzyme directly when cell-free studies were performed. In intact neutrophils incubated with 5.1-20.3 microM auranofin, protein kinas...


    pub_type: 杂志文章


    authors: Parente JE,Davis P,Wong K

    更新日期:1987-09-01 00:00:00

  • Tizoxanide Inhibits Inflammation in LPS-Activated RAW264.7 Macrophages via the Suppression of NF-κB and MAPK Activation.

    abstract::Tizoxanide is the main active metabolite of nitazoxanide. Nitazoxanide and tizoxanide have a broad-spectrum anti-infective effect, including parasites, bacteria, and virus. In the present study, we investigated the anti-inflammatory effect of tizoxanide on lipopolysaccharide (LPS)-stimulated RAW264.7 cells and reveale...


    pub_type: 杂志文章


    authors: Shou J,Kong X,Wang X,Tang Y,Wang C,Wang M,Zhang L,Liu Y,Fei C,Xue F,Li J,Zhang K

    更新日期:2019-08-01 00:00:00

  • Preventive effects of valnemulin on lipopolysaccharide-induced acute lung injury in mice.

    abstract::Valnemulin reportedly regulates inflammatory responses in addition to its in vitro antibacterial activity. In this study, we established a mouse model of lipopolysaccharide (LPS)-induced inflammatory lung injury and investigated the effect of valnemulin (100 mg/kg) on acute lung injury (ALI) 8 h after LPS challenge. W...


    pub_type: 杂志文章


    authors: Chen Z,Zhang X,Chu X,Zhang X,Song K,Jiang Y,Yu L,Deng X

    更新日期:2010-10-01 00:00:00

  • Exogenous nitric oxide increases neutrophil adhesion to cultured human endothelial monolayers through a protein kinase G dependent mechanism.

    abstract::Endothelial-neutrophil adhesion is a critical step in acute inflammatory diseases, which is mediated in part by P-selectin and platelet-activating factor (PAF). Nitric oxide (NO) is well known as an endogenous second messenger derived from endothelial cells, and regulates many important physiological events, however, ...


    pub_type: 杂志文章


    authors: Okayama N,Coe L,Itoh M,Alexander JS

    更新日期:1999-02-01 00:00:00

  • The Influence of a Xanthine-Catechin Chemical Matrix on in vitro Macrophage-Activation Triggered by Antipsychotic Ziprasidone.

    abstract::Ziprasidone (ZIP) is an effective antipsychotic with low side effects than other second-generation antipsychotics. Despite this, there are reports of adverse events and previous studies associating the use of ZIP the inflammatory response. It is possible to infer that bioactive molecules present in some foods could at...


    pub_type: 杂志文章


    authors: Duarte T,Barbisan F,da Cunha BSN,Azzolin VF,Turra BO,Duarte MMMF,da Cruz Jung IE,Ribeiro EE,do Prado-Lima PA,da Cruz IBM

    更新日期:2019-06-01 00:00:00

  • The effect of cortisone on the accumulation, activation, and necrosis of macrophages in tuberculous lesions.

    abstract::Rabbits were injected intramuscularly with cortisone acetate (2 mg/kg) on alternate days. Six days after the first injection these rabbits and controls were injected intradermally in multiple sites with BCG (the vaccine strain of tubercle bacillus). Periodically, over the next 2 months, the resulting lesions were meas...


    pub_type: 杂志文章


    authors: McCue RE,Dannenberg AM Jr,Higuchi S,Sugimoto M

    更新日期:1978-06-01 00:00:00

  • Lentivirus-mediated ADAM17 RNA interference inhibited interleukin-8 expression via EGFR signaling in lung epithelial cells.

    abstract::Interleukin (IL)-8 and neutrophil inflammation play a vital role in the pathogenesis of chronic inflammatory airway diseases. A disintegrin and metalloproteinase 17 (ADAM17) cleaves ectodomains of various transmembrane proteins and is an important regulator of almost every cellular event. The aim of this work was to i...


    pub_type: 杂志文章


    authors: Li Y,Yan J,Xu W,Wang H,Xia Y

    更新日期:2012-06-01 00:00:00

  • Kinetic evaluation of nitric oxide production in pleural exudate after induction of two inflammatory reactions in the rat.

    abstract::NO generation in the course of two acute, non immune, inflammatory reactions (pleurisy induced by rat isologous serum and carrageenan) was assessed by means of nitrite measurement in pleural exudate from 0.5 to 24 h. NO release varied time-dependently, similarly for the two inflammatory reactions. A first, but transie...


    pub_type: 杂志文章


    authors: Regnault C,Roch-Arveiller M,Florentin I,Giroud JP,Postaire E,Delaforge M

    更新日期:1996-12-01 00:00:00

  • Rho kinase Blockade Ameliorates DSS-Induced Ulcerative Colitis in Mice Through Dual Inhibition of the NF-κB and IL-6/STAT3 Pathways.

    abstract::Inflammatory bowel disease (IBD) has received much attention due to its increasing worldwide incidence and potential increased risk of colorectal cancer. The protective function of a Rho-associated protein kinase inhibitor (Y-27632) against 2,4,6-trinitrobenzene sulfonic acid (TNBS) induced mouse colitis has been prov...


    pub_type: 杂志文章


    authors: Wang Y,Duan X,Liu X,Liu Y,Fan H,Xu M,Chen Q,Tang Q

    更新日期:2020-06-01 00:00:00

  • Icariin Attenuates High-cholesterol Diet Induced Atherosclerosis in Rats by Inhibition of Inflammatory Response and p38 MAPK Signaling Pathway.

    abstract::Icariin is a flavonoid isolated from the traditional Chinese herbal medicine Epimedium brevicornum Maxim and has been reported to be effective for the treatment of a variety of cardiovascular diseases. The aim of the present study was to investigate the effect and mechanism of icariin on atherosclerosis (AS) using a h...


    pub_type: 杂志文章


    authors: Hu Y,Sun B,Liu K,Yan M,Zhang Y,Miao C,Ren L

    更新日期:2016-02-01 00:00:00

  • Retinoic acid modulation of mucin mRNA in rat tracheal explants: response to actinomycin D, cycloheximide, signal transduction effectors and antisense oligodeoxynucleotide.

    abstract::Factors affecting the retinoic acid modulated expression of mucin mRNA in rat tracheal cultures were studied. Actinomycin D had no effect on mucin mRNA in cultures grown with retinoic acid (RA+). The usual precipitous drop in mucin mRNA in cultures lacking retinoic acid (RA-) was prevented by actinomycin D. Cyclohexim...


    pub_type: 杂志文章


    authors: Bhattacharyya SN,Ashbaugh P,Kaufman B,Manna B

    更新日期:1994-12-01 00:00:00

  • A high-fat diet increases IL-1, IL-6, and TNF-α production by increasing NF-κB and attenuating PPAR-γ expression in bone marrow mesenchymal stem cells.

    abstract::It is well established that a high-fat diet (HFD) can lead to overweight and ultimately to obesity, as well as promoting low-grade chronic inflammation associated with increased levels of such mediators as TNF-α, IL-1, and IL-6. Bone marrow mesenchymal stem cells (MSCs), which are involved in hematopoietic niches and ...


    pub_type: 杂志文章


    authors: Cortez M,Carmo LS,Rogero MM,Borelli P,Fock RA

    更新日期:2013-04-01 00:00:00

  • Phagocytotic competence of differentiated U937 cells for colloidal drug delivery systems in immune cells.

    abstract::Drug delivery into immune cells has high potential for the treatment of all kinds of inflammation, allowing a target-oriented transport of active agents. The advantage of this local drug release is the prevention of negative effects of systemic applications and low-dose application. Thereby, the phagocytotic capabilit...


    pub_type: 杂志文章


    authors: Lessig J,Neu B,Glander HJ,Arnhold J,Reibetanz U

    更新日期:2011-04-01 00:00:00

  • Protein Kinase C Theta Inhibition Attenuates Lipopolysaccharide-Induced Acute Lung Injury through Notch Signaling Pathway via Suppressing Th17 Cell Response in Mice.

    abstract::Acute lung injury (ALI)/acute respiratory distress syndrome is characterized by increased pulmonary inflammation, where T helper 17 (Th17) cells play an important regulatory role. Notch signaling critically regulates Th17 differentiation and is known to be linked with proximal T cell by protein kinase C theta (PKCθ). ...


    pub_type: 杂志文章


    authors: Li M,Zhao Y,He J,Deng W,Cheng L,Jiang Z,Wang D

    更新日期:2019-12-01 00:00:00

  • An experimental study of the neurogenic and the immunological contribution to "tennis elbow" in rats.

    abstract::In the present study the content of substance P (SP)-, neurokinin A (NKA)-, calcitonin gene-related peptide (CGRP)- and neuropeptide Y (NPY)-like immunoreactivity (-LI) was measured in rats cerebrospinal fluid (CSF), plasma and perfusates (PF) from both elbow enthesis during acute inflammation. Either substance P, SP,...


    pub_type: 杂志文章,收录出版


    authors: Haker E,Theodorsson E,Lundeberg T

    更新日期:1997-02-01 00:00:00

  • MiR-217 Inhibits M2-Like Macrophage Polarization by Suppressing Secretion of Interleukin-6 in Ovarian Cancer.

    abstract::Ovarian cancer is one of the most deadly cancers with rapid proliferation and poor prognosis among patients. Therapies focusing on regulation of tumor immunity and microenvironments are developing. MiR-217 was dysregulated in cancer progress and plays important roles in tumorigenesis and metastasis. However, the role ...


    pub_type: 杂志文章


    authors: Jiang B,Zhu SJ,Xiao SS,Xue M

    更新日期:2019-10-01 00:00:00

  • Impact of environmental factors on efficacy of glucocorticoids in Chinese population with systemic lupus erythematosus.

    abstract::Although glucocorticoids (GCs) are effective in inducing remission in systemic lupus erythematosus (SLE) patients, there is a significant variation in response to therapeutic GCs, and some patients do not achieve full remission. The aim of this study was to explore the impact of environmental factors on the efficacy o...


    pub_type: 杂志文章


    authors: Zou YF,Xu JH,Tao JH,Xu SQ,Liu S,Chen SY,Cai J,Lian L,Chen PL,Wang DG,Liu SX,Liang CM,Ye QL,Tian G,Wu M,Pan HF,Pan FM,Su H,Ye DQ

    更新日期:2013-12-01 00:00:00

  • Role of T-lymphocytes in the resolution of endotoxin-induced lung injury.

    abstract::An acute neutrophilic lung injury was compared in Balb/c normal and nu/nu (nude) mice to assess the role of T lymphocytes in the resolution of acute pulmonary neutrophilic inflammation following the administration of endotoxin. Maximal neutrophilic infiltration occurred on day 1 post-endotoxin treatment and declined t...


    pub_type: 杂志文章


    authors: Morris PE,Glass J,Cross R,Cohen DA

    更新日期:1997-06-01 00:00:00

  • The association between self-reported symptoms of recent airway infection and CRP values in a general population.

    abstract::C-reactive protein (CRP) is a much used biomarker for respiratory tract infection; however, the influence of airway infection on the CRP level in the general population has not been well described. The study aimed to evaluate the impact of recent symptoms of airway infection on the CRP level and how the predictive pow...


    pub_type: 杂志文章


    authors: Melbye H,Amundsen K,Brox J,Eggen AE

    更新日期:2012-06-01 00:00:00

  • Guinea pig Kurloff (NK-like) cells mediate TNF-dependent cytotoxic activity: analogy with NC effector cells.

    abstract::Kurloff cells are mononuclear cells possessing a large cytoplasmic inclusion body specific to the guinea pig. In this report, we present strong evidence that Kurloff cells can mediate NC activity against tumor cells in addition to their previously reported NK activity. Using an 18 h 51Cr-release assay we have shown th...


    pub_type: 杂志文章


    authors: Pouliot N,Maghni K,Sirois P,Rola-Pleszczynski M

    更新日期:1996-06-01 00:00:00

  • Nateglinide Exerts Neuroprotective Effects via Downregulation of HIF-1α/TIM-3 Inflammatory Pathway and Promotion of Caveolin-1 Expression in the Rat's Hippocampus Subjected to Focal Cerebral Ischemia/Reperfusion Injury.

    abstract::Ischemic stroke is a major cause of death and motor disabilities all over the world. It is a muti-factorial disorder associated with inflammatory, apoptotic, and oxidative responses. Nateglinide (NAT), an insulinotropic agent used for the treatment of type 2 diabetes mellitus, recently showed potential anti-inflammato...


    pub_type: 杂志文章


    authors: Saad MAE,Fahmy MIM,Al-Shorbagy M,Assaf N,Hegazy AAE,El-Yamany MF

    更新日期:2020-04-01 00:00:00

  • Current understanding of rheumatoid arthritis.

    abstract::A full understanding of rheumatoid arthritis depends on the appreciation of clinical, radiological, immunological, genetic, biochemical, and structural mechanisms. Rheumatoid arthritis is characterized by the destruction of tissue structures such as articular cartilage and bone, but may also involve tendonous tissue, ...


    pub_type: 杂志文章


    authors: Fassbender HG

    更新日期:1984-06-01 00:00:00