Abstract:
:Ziprasidone (ZIP) is an effective antipsychotic with low side effects than other second-generation antipsychotics. Despite this, there are reports of adverse events and previous studies associating the use of ZIP the inflammatory response. It is possible to infer that bioactive molecules present in some foods could attenuate peripheral inflammatory and oxidative stress potentially triggered ZIP. This is the case of guaraná xanthine-catechin chemical matrix (XC-Mix) that presents caffeine, theobromine, and catechin. The in vitro protocols using murine RAW 264.7 cell macrophages were ZIP-exposure in culture medium supplemented with chemical isolated and admixture of Caf, The, and Cat. Main results showed that supplementation with isolated and XC-mix had a lowering effect on 72 h macrophages proliferation. XC-mix with 1:1:1 proportion at 25 μg/mL of each caffeine, theobromine, and catechin, molecules present lowering effect on nitric oxide levels, oxidative stress markers (DNA oxidation quantified by 8-hydroxy-2' -deoxyguanosine), lipoperoxidation, and protein carbonylation. XC-mix also decreased protein levels and downregulated genes of proinflammatory cytokines (IL-1β, IL-6, TNF-α). At contrary, XC-Mix increased levels and upregulated gene of anti-inflammatory IL-10 cytokine. The results suggest that XC-matrix could present some beneficial action on peripheral proinflammatory effects ZIP-triggered. Complementary in vivo studies could be useful to confirm these in vitro findings described here.
journal_name
Inflammationjournal_title
Inflammationauthors
Duarte T,Barbisan F,da Cunha BSN,Azzolin VF,Turra BO,Duarte MMMF,da Cruz Jung IE,Ribeiro EE,do Prado-Lima PA,da Cruz IBMdoi
10.1007/s10753-018-0946-9subject
Has Abstractpub_date
2019-06-01 00:00:00pages
915-925issue
3eissn
0360-3997issn
1573-2576pii
10.1007/s10753-018-0946-9journal_volume
42pub_type
杂志文章相关文献
INFLAMMATION文献大全abstract::Baicalin, a flavonoid monomer derived from Scutellaria baicalensis called Huangqin in mandarin, is the main active ingredient contributing to S. baicalensis' efficacy. It is known in China that baicalin has potential therapeutic effects on inflammatory diseases. However, its anti-inflammatory mechanism has still not b...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-015-0124-2
更新日期:2015-08-01 00:00:00
abstract::Sublethal doses of LPS result in increased tolerance to high concentrations of oxygen and this is associated with decreased pulmonary inflammation in a rat model. To investigate the mechanism of decreased neutrophil influx into the lung in this model, we measured levels of mRNA in the lung for the endothelial adhesion...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1023/b:ifla.0000039561.37868.91
更新日期:2004-06-01 00:00:00
abstract::Rheumatoid arthritis (RA) is a chronic inflammation that can lead to loss of range of joint abnormalities in severe cases. Diosgenin has anti-inflammatory effects. This paper discussed the effect and mechanism of diosgenin on excessive proliferation and inflammatory response of synovial cells in RA. CCK-8 detected the...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-020-01389-5
更新日期:2020-11-25 00:00:00
abstract::Previous reports showed that Maresin 1 (MaR1) possessed organ protection effects and could attenuate acute lung injury. Here, we aim to figure out whether MaR1 can maintain the permeability of lung epithelial cells by regulating the expression of tight junction protein during lung injury. Monolayer of murine lung epit...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-016-0433-0
更新日期:2016-12-01 00:00:00
abstract::The etiology of the most autoimmune disorders is largely yet to be understood. However, major target antigens have been determined against some of clinically important molecules of human autoimmune diseases, such as insulin in type 1 diabetes mellitus (T1DM). T1DM is believed to be resulted from immune-mediated destru...
journal_title:Inflammation
pub_type: 杂志文章,评审
doi:10.1007/s10753-012-9555-1
更新日期:2013-04-01 00:00:00
abstract::Numerous cytokines, including vascular endothelial growth factor (VEGF), are implicated in the pathogenesis of sepsis. While overexpression of VEGF produces pulmonary capillary leak, the role of VEGF in sepsis is less clear. We investigated VEGF in sepsis, utilizing a VEGF trap (VEGF(T)). Polymicrobial sepsis was indu...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-004-6050-3
更新日期:2004-10-01 00:00:00
abstract::The release of inflammatory cytokines and chemokines and autophagy has been reported to be involved in the pathogenic mechanism of acute lung injury (ALI). Reportedly, alpha-7 nicotinic acetylcholine receptors (α7nAchR) might play a protective role in LPS-induced ALI. In the current research, we established LPS-induce...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-019-01088-w
更新日期:2019-12-01 00:00:00
abstract::The respiratory burst is a series of metabolic events which result in the production of microbicidal oxidants by phagocytes. The enzyme responsible for the respiratory burst is a membrane-bound oxidase which catalyzes the production of O-2 by the NADPH-dependent reduction of oxygen. Activity of this oxidase is diminis...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00917260
更新日期:1983-09-01 00:00:00
abstract::Alveolar macrophages (AM) are the primary target cell of the lung for inhaled mycobacterial pathogens. We investigated the effect of the synthetic lipopeptide MALP-2 on the interaction between AM from rats and Mycobacterium bovis BCG. AM were infected with M. bovis BCG at a multiplicity of infection (MOI) of 10 and th...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-009-9127-1
更新日期:2009-08-01 00:00:00
abstract::IFN-τ, which is a type I interferon with low cytotoxicity, is defined as a pregnancy recognition signal in ruminants. Type I interferons have been used as anti-inflammatory agents, but their side effects limit their clinical application. The present study aimed to determine the anti-inflammatory effects of IFN-τ in a ...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-016-0348-9
更新日期:2016-06-01 00:00:00
abstract::Strong anti-inflammatory activity has been found in Laminaria japonica dichloromethane fraction (LDF); however, the molecular mechanisms underlying its anti-inflammatory activity are not reported. Our results indicated that LDF inhibited LPS-induced nitric oxide and prostaglandin E(2) production in a dose-dependent ma...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-012-9481-2
更新日期:2012-10-01 00:00:00
abstract::The ability of peripheral blood neutrophils to injure elements of the alveolar septum was assessed. Experiments consisted of activating previously isolated neutrophils (PMNs) with a soluble (phorbol myristate acetate, PMA) and a particulate (zymosan) trigger, and measuring detachment of 51Cr-labeled epithelial cells. ...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00917512
更新日期:1992-02-01 00:00:00
abstract::Current knowledge implicates pleural mesothelial cells as mainly responsible for inflammatory responses in the pleural space. However, a vast body of recent evidence underscores the important role of fibroblasts in the process of inflammation in several types of tissues. We hypothesize that HPFBs (human pleural fibrob...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1023/a:1014884127573
更新日期:2002-04-01 00:00:00
abstract::Central nervous system tuberculosis (CNS-TB) is caused by infection with Mycobacterium tuberculosis (Mtb). The inflammatory response following CNS-TB involves the activation of resident microglia and the infiltration of macrophages. However, it has not been clarified whether microglia can be polarized into the classic...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-015-0136-y
更新日期:2015-08-01 00:00:00
abstract::The effects were studied of the non-specific phosphodiesterase inhibitor, theophylline (37.5-300 microM), on intracellular levels of cyclic adenosine monophosphate (cAMP) and superoxide generation following exposure of human neutrophils to four different stimuli of neutrophil membrane-associated oxidative metabolism, ...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1023/a:1022306328960
更新日期:1998-12-01 00:00:00
abstract::Chronic obstructive pulmonary disease (COPD) is a common chronic inflammatory disease with high morbidity and mortality rates. Cystatin C (Cys C) is a sensitive indicator for various chronic inflammatory diseases. In this study, we aimed to evaluate the role of Cys C in COPD patients comparing with the other well-know...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-015-0287-x
更新日期:2016-04-01 00:00:00
abstract::The possibility of inflammation and neutrophil activation in response to indoor air pollution (IAP) from biomass fuel use has been investigated. For this, 142 premenopausal, never-smoking women (median age, 34 years) who cook exclusively with biomass (wood, dung, crop wastes) and 126 age-matched control women who cook...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-011-9360-2
更新日期:2012-04-01 00:00:00
abstract::Air pollution events frequently occur in China during the winter. Most investigations of pollution studies have focused on the physical and chemical properties of PM2.5. Many of these studies have indicated that PM2.5 exacerbates asthma or eosinophil inflammation. However, few studies have evaluated the relationship b...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-019-01071-5
更新日期:2020-02-01 00:00:00
abstract::Diabetic neuropathy (DNP) is the most common chronic complication of diabetes. Elevated free fatty acids (FFAs) have been recently recognized as major causes of inflammation and are relevant to the functional changes of nerve system in diabetes. Trans-resveratrol (RESV), a polyphenolic natural compound, has long been ...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-014-0036-6
更新日期:2015-02-01 00:00:00
abstract::The present study was designed to address the relationship between iron homeostasis and bone metabolism. Cultured hFOB 1.19 osteoblasts were incubated with selected concentrations of hepcidin (50, 100, and 200 nmol/L) for 20 h, harvested for extraction of total RNA and proteins, and the expression of ferroportin 1 was...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-011-9411-8
更新日期:2012-06-01 00:00:00
abstract::The phenotypic alterations between blood monocytes from 11 patients with end-stage renal disease, who had been on peritoneal dialysis for less than one week, and blood monocytes from 10 healthy controls, were analyzed. In addition, peritoneal macrophages in the dialysate effluent were enclosed. Analysis of functional ...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1023/a:1022395723972
更新日期:1998-02-01 00:00:00
abstract::Oroxylin A, a natural flavonoid isolated from the medicinal herb Scutellaria baicalensis Georgi, has been reported to have anti-inflammatory property. In this study, we aimed to investigate the protective effects and mechanism of oroxylin A on allergic inflammation in OVA-induced asthma murine model. BABL/c mice were ...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-016-0317-3
更新日期:2016-04-01 00:00:00
abstract::The aim of our study was to evaluate the pro- and anti-inflammatory cytokine response during acute pancreatitis and its predictive value on severity of disease. A hospital-based prospective clinical study was conducted. Twenty patients with acute pancreatitis were enrolled during a 12-month period. Plasma concentratio...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-011-9371-z
更新日期:2012-04-01 00:00:00
abstract::Previous data that alimentation with fish oil rich in eicosapentaenoic acid (EPA; 20:n-3) or vegetable oil rich in gamma-linolenic acid (GLA; 18:3n-6) can reduce symptoms of inflammatory skin disorders lead us to determine the effects of dietary supplements of oils rich in EPA or GLA on guinea pig (GP) neutrophil (PMN...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00914278
更新日期:1990-10-01 00:00:00
abstract::Diabetic retinopathy shares some similarity with chronic inflammation and Müller cells dysfunction may play an important role in its initiation and progression since these cells are thought to be a major source of inflammatory factors. The goal of this study was to examine the effect of cytokines on human retinal Müll...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-014-9874-5
更新日期:2014-10-01 00:00:00
abstract::CD4+ T cell subset imbalance plays an important role in the development of diabetic complications. Neutrophils have recently been known as the regulator of CD4+ T cell differentiation. However, whether neutrophils affect CD4+ T cell population in diabetes is still elusive. In this study, we investigated the effect of ...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-018-0913-5
更新日期:2019-04-01 00:00:00
abstract::Myeloperoxidase (MPO), next to the NO synthase2 (NOS2), and NADPH oxidase, is the key enzyme of the oxidative burst responsible for the antimicrobial immunity. Because MPO participates in the eradication of Mycobacterium tuberculosis in the in vitro model and the extracellular enzyme may activate cells to cytokine syn...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1023/b:ifla.0000033020.28446.a6
更新日期:2004-04-01 00:00:00
abstract::Influenza A virus pandemics and emerging antiviral resistance highlight the urgent need for novel generic pharmacological strategies that reduce both viral replication and inflammation of the lung. We have previously investigated the therapeutic efficacy of recombinant human catalase (rhCAT) against viral pneumonia in...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-013-9800-2
更新日期:2014-06-01 00:00:00
abstract::Simvastatin, which is primarily prescribed to lower cholesterol, may also mitigate lung injury caused by sepsis, although the mechanisms remain elusive. This study aimed to evaluate the protective effect of simvastatin on acute lung injury in rats with sepsis and to investigate possible mechanisms. Male Wistar rats we...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-017-0668-4
更新日期:2018-02-01 00:00:00
abstract::Pyroptosis, a new pro-inflammatory programmed cell death, is linked to atherosclerosis (AS). Our previous studies suggested that salidroside (SAL) can alleviate AS and exert anti-oxidative and anti-inflammatory properties. However, the effect of SAL on atherosclerosis-related pyroptosis has not been studied. Here, we ...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-019-01106-x
更新日期:2020-04-01 00:00:00