Abstract:
:The present study was designed to address the relationship between iron homeostasis and bone metabolism. Cultured hFOB 1.19 osteoblasts were incubated with selected concentrations of hepcidin (50, 100, and 200 nmol/L) for 20 h, harvested for extraction of total RNA and proteins, and the expression of ferroportin 1 was analyzed by RT-PCR and western blotting. The results showed the presence of ferroportin 1 expression in cultured hFOB 1.19 cells. Furthermore, the ferroportin 1 had a similar expression pattern in hFOB cells as in hepatocytes and enterocytes and was downregulated by hepcidin. Our data indicate that osteoblasts are target cells for hepcidin, suggest that hepcidin may have many more targets than previously recognized, and support the role of hepcidin in the development of osteoporosis.
journal_name
Inflammationjournal_title
Inflammationauthors
Xu Y,Zhang W,Zhang P,Xiao L,Wang A,Sirois P,Li Kdoi
10.1007/s10753-011-9411-8subject
Has Abstractpub_date
2012-06-01 00:00:00pages
1058-61issue
3eissn
0360-3997issn
1573-2576journal_volume
35pub_type
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