The Effects of Rifampin, Povidone-Iodine and Hydrogen Peroxide on the Formation of Epidural Fibrosis in the Experimental Epidural Fibrosis Model.

Abstract:

:The aim of the study was to determine the effect of direct application of rifampin, povidone-iodine, and hydrogen peroxide on the formation of epidural fibrosis in rats. Forty-eight adult male Wistar albino rats were equally and randomly divided into four groups (laminectomy, topical rifampin, topical povidone-iodine, and topical hydrogen peroxide). Laminectomy was performed at the T12 level in all rats. Four weeks later, the extent of epidural fibrosis was assessed both macroscopically and histopathologically. ANOVA test was used for the evaluation of dural thickness. Kruskal-Wallis test was used for the pathology and macroscopic evaluation. Chi-square test was used for evaluation of the arachnoid involvement. p value <0.05 was accepted as statistically significant. Our data revealed that topical application of both povidone-iodine and hydrogen peroxide were effective in reducing epidural fibrosis formation. The results of our study provide the experimental evidence of the preventive effects of topical application of povidone-iodine and hydrogen peroxide over epidural fibrosis.

journal_name

Inflammation

journal_title

Inflammation

authors

Kizilay Z,Cetin NK,İsmailoglu Ö,Yılmaz A,Omurlu İK,Coskun ME,Aktaş S

doi

10.1007/s10753-016-0383-6

subject

Has Abstract

pub_date

2016-08-01 00:00:00

pages

1495-502

issue

4

eissn

0360-3997

issn

1573-2576

pii

10.1007/s10753-016-0383-6

journal_volume

39

pub_type

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