Abstract:
:The aim of the study was to determine the effect of direct application of rifampin, povidone-iodine, and hydrogen peroxide on the formation of epidural fibrosis in rats. Forty-eight adult male Wistar albino rats were equally and randomly divided into four groups (laminectomy, topical rifampin, topical povidone-iodine, and topical hydrogen peroxide). Laminectomy was performed at the T12 level in all rats. Four weeks later, the extent of epidural fibrosis was assessed both macroscopically and histopathologically. ANOVA test was used for the evaluation of dural thickness. Kruskal-Wallis test was used for the pathology and macroscopic evaluation. Chi-square test was used for evaluation of the arachnoid involvement. p value <0.05 was accepted as statistically significant. Our data revealed that topical application of both povidone-iodine and hydrogen peroxide were effective in reducing epidural fibrosis formation. The results of our study provide the experimental evidence of the preventive effects of topical application of povidone-iodine and hydrogen peroxide over epidural fibrosis.
journal_name
Inflammationjournal_title
Inflammationauthors
Kizilay Z,Cetin NK,İsmailoglu Ö,Yılmaz A,Omurlu İK,Coskun ME,Aktaş Sdoi
10.1007/s10753-016-0383-6subject
Has Abstractpub_date
2016-08-01 00:00:00pages
1495-502issue
4eissn
0360-3997issn
1573-2576pii
10.1007/s10753-016-0383-6journal_volume
39pub_type
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