Cyclophilin A Aggravates Collagen-Induced Arthritis via Promoting Classically Activated Macrophages.

abstract：:Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by debilitating pain, cartilage destruction, and loss of joint function. Management of RA includes drugs that target NF-κB and downstream cytokine production. Therefore, molecules that act by inhibiting this signaling pathway without the severe si...

journal_title：Inflammation

authors： Zarpelon AC,Fattori V,Souto FO,Pinto LG,Pinho-Ribeiro FA,Ruiz-Miyazawa KW,Turato WM,Cunha TM,da Costa FB,Cunha FQ,Casagrande R,Arakawa NS,Verri WA Jr

更新日期：2017-12-01 00:00:00

abstract：:We have characterized leukocyte migration to the pleural cavity in a methylated-BSA (mBSA)-induced model of murine delayed-type hypersensitivity and evaluated the ability of IL-4 and IL-10 to modulate this response. Neutrophils, macrophages, T cells, and dendritic cells migrated to the pleural cavity in a time-depende...

journal_title：Inflammation

authors： Fine JS,Rojas-Triana A,Jackson JV,Engstrom LW,Deno GS,Lundell DJ,Bober LA

更新日期：2003-08-01 00:00:00

abstract：:Interactions of macrophages with epithelium represent one of the pathways involved in regulating local immune mechanisms. We studied the effect of cell-cell contact with an epithelial monolayer on the phenotype of macrophages. Human monocytes and THP-1 macrophages were co-cultured with monolayers of human bronchial ep...

journal_title：Inflammation

authors： Striz I,Slavcev A,Kalanin J,Jaresová M,Rennard SI

更新日期：2001-08-01 00:00:00

abstract：:Pyroptosis, a new pro-inflammatory programmed cell death, is linked to atherosclerosis (AS). Our previous studies suggested that salidroside (SAL) can alleviate AS and exert anti-oxidative and anti-inflammatory properties. However, the effect of SAL on atherosclerosis-related pyroptosis has not been studied. Here, we ...

journal_title：Inflammation

authors： Xing SS,Yang J,Li WJ,Li J,Chen L,Yang YT,Lei X,Li J,Wang K,Liu X

更新日期：2020-04-01 00:00:00

abstract：:Inflammatory response is required to proceed the optimal liver regeneration after liver injury. Recent reports demonstrated that inflammasomes are involved in the innate immune response. Several NOD-Like receptors (NLRs) participated in the formation of the inflammasomes. NACHT, LRR, and PYD domain-containing protein ...

journal_title：Inflammation

authors： Ando T,Ito H,Kanbe A,Hara A,Seishima M

更新日期：2017-10-01 00:00:00

abstract：:Prostaglandin production was studied in cultures of pig aorta endothelial cells using radioimmunoassay, radiochromatography, and smooth muscle bioassay. PGE2 was produced in higher concentrations than other prostaglandins. Bradykinin produced a rapid dose-related stimulation of PGE2 production. These results provided ...

journal_title：Inflammation

authors： Jose PJ,Page DA,Wolstenholme BE,Williams TJ,Dumonde DC

更新日期：1981-12-01 00:00:00

abstract：:Numerous studies have evaluated the association between -159C/T polymorphism of the CD14 gene and asthma risk; however, these studies have yielded inconsistent results. We performed meta-analyses to investigate the association between CD14-159C/T polymorphism and asthma risk. Studies were identified from PubMed, Embas...

journal_title：Inflammation

authors： Zhang R,Deng R,Li H,Chen H

更新日期：2016-02-01 00:00:00

abstract：:Simvastatin, which is primarily prescribed to lower cholesterol, may also mitigate lung injury caused by sepsis, although the mechanisms remain elusive. This study aimed to evaluate the protective effect of simvastatin on acute lung injury in rats with sepsis and to investigate possible mechanisms. Male Wistar rats we...

journal_title：Inflammation

authors： Wang Y,Yang W,Zhao X,Zhang R

更新日期：2018-02-01 00:00:00

abstract：:Protamine sulfate induces enzyme secretion from rabbit neutrophils. Enzyme secretion is mainly due to exocytosis but, depending on the experimental conditions, a small amount of cytolysis may occur. As compared with stimulation of neutrophil functions by other activators, protamine sulfate-induced enzyme release by ex...

journal_title：Inflammation

authors： Elferink JG,Deierkauf M

更新日期：1986-12-01 00:00:00

abstract：:Interleukin-1 receptor-associated kinase (IRAK1) is a key regulatory protein in TLR/IL1R-mediated cell activation during inflammatory response. Studies indicated that pending on the nature of the used inflammatory model, downregulation of IRAK1 may be beneficial or detrimental. However, the role of IRAK1 in affecting ...

journal_title：Inflammation

authors： Chandra R,Federici S,Bishwas T,Németh ZH,Deitch EA,Thomas JA,Spolarics Z

更新日期：2013-12-01 00:00:00

abstract：:Several experiments have detected that melatonin exerts a marked influence on the inflammatory process. In the present study we evaluated the effect of exogenous melatonin on the experimental granulomatous tissues in rat. Our data show that subcutaneous administration of different doses of melatonin given daily during...

journal_title：Inflammation

authors： de la Rocha NE,Rotelli AE,Guardia T,Pelzer LE

更新日期：2004-08-01 00:00:00

abstract：:The secretion of calcitonin gene-related peptide (CGRP) and the chemokines KC and MIP-2 are increased in the animal models of endotoxemic and septic shock. We tested whether CGRP could modulate KC and MIP-2 secretion from different sources of macrophages after murine sepsis induced by cecal ligation and puncture (CLP)...

journal_title：Inflammation

authors： Wang X,Ebong SJ,Call DR,Newcomb DE,Bolgos GR,Remick DG

更新日期：2002-08-01 00:00:00

abstract：:Asthma is a complex disease linked to various pathophysiological events, including proteinase activity. In this study, we examined whether a Diospyros blancoi methanolic extract (DBE) exerts protective effects on allergic asthma in a murine asthma model. To investigate the specific role of DBE, we employed a murine mo...

journal_title：Inflammation

authors： Lee KY,Jung JY,Lee MY,Jung D,Cho ES,Son HY

更新日期：2012-04-01 00:00:00

abstract：:The effect of leukocyte hydrolytic enzymes on periodontopathic bacteria was examined in vitro. A frozen and thawed extract of human peripheral blood leukocytes (LE) and human gingival crevicular exudate (GE) were shown to be able to cause the release of 50% of the radioactivity from a leukotoxic strain of Actinobacill...

journal_title：Inflammation

authors： Sela MN

更新日期：1983-06-01 00:00:00

abstract：:The respiratory epithelium is often exposed to oxidant gases, including ozone from photochemical smog and toxic oxygen metabolites released from neutrophils recruited in conditions of airway inflammation. We evaluated DNA single strand break formation by alkaline elution as a measure of oxidant-induced DNA damage to b...

journal_title：Inflammation

authors： McDonald RJ,Pan LC,St George JA,Hyde DM,Ducore JM

更新日期：1993-12-01 00:00:00

abstract：:Human blood leukocytes generated large amounts of superoxide (O2-) following stimulation by certain "cocktails" of soluble agents consisting of poly-L-arginine (PARG), phytohemagglutinin, the chemotactic peptide formyl-methionyl-leucyl-phenylalanine and polyanethole sulfanote (liquoid). A variety of cytochalasins, whi...

journal_title：Inflammation

authors： Ginsburg I,Borinski R,Pabst M

更新日期：1985-12-01 00:00:00

abstract：:The present study aimed at characterizing the phenotype and functions of adherent synovial fluid (SF) cells derived from rheumatoid arthritis (RA), comparing with fibroblast-like synoviocytes (FLS) derived from RA synovial tissue (ST). Adherent SF-derived cells were spindle-shaped from passages 1-6 under light microsc...

journal_title：Inflammation

authors： Ahn JK,Kim H,Lee J,Bae EK,Cha HS,Koh EM

更新日期：2008-12-01 00:00:00

abstract：:Heterophragma adenophyllum is a traditional medicinal plant that has been used as anti-inflammatory and to relief muscular tension. In the current research, four isolated constitutes namely lapacho (1), peshawaraquinone (2), indanone derivatives (3), α-lapachone (4) of H. adenophyllum were tested for anti-inflammatory...

journal_title：Inflammation

authors： Abu-Izneid T,Shah ZA,Rauf A,Wadood A,Bawazeer S,Muhammad N,El-Esawi MA,Alhumaydhi FA,Aljohani ASM,El-Sharkawy E,Mubarak MS,Isayeva K,Shariati MA

更新日期：2021-02-01 00:00:00

abstract：:Human neutrophils were demonstrated to possess interleukin-2 receptor (IL-2R) beta and gamma chains, not alpha chain and the binding of IL-2 to the IL-2R beta chain on neutrophils plays an important regulatory role in neutrophil functions. We have investigated in this study the hypothesis that recombinant human IL-2 (...

journal_title：Inflammation

authors： Li J,Gyorffy S,Lee S,Kwok CS

更新日期：1996-08-01 00:00:00

abstract：:This study aimed to investigate the protective effect of emodin on endoplasmic reticulum (ER) stress in rats with severe acute pancreatitis (SAP) and the underlying molecular mechanism. Sprague-Dawley male rats were randomly divided into sham operation group, SAP model group, and emodin treatment group. SAP was constr...

journal_title：Inflammation

authors： Wu L,Cai B,Zheng S,Liu X,Cai H,Li H

更新日期：2013-10-01 00:00:00

abstract：:Crude extracts of human blood leukocytes were employed as a source of bactericidal and bacteriolytic agents againstStaphylococcus aureus. While the bactericidal action of the extracts was a very rapid process, bacteriolysis is a very slow process. Both the killing and the lysis of staphylococci depended on the age of ...

journal_title：Inflammation

authors： Ne'eman N,Duchan Z,Lahav M,Sela MN,Ginsburg I

更新日期：1976-06-01 00:00:00

abstract：:Alveolar macrophages (AM) are the primary target cell of the lung for inhaled mycobacterial pathogens. We investigated the effect of the synthetic lipopeptide MALP-2 on the interaction between AM from rats and Mycobacterium bovis BCG. AM were infected with M. bovis BCG at a multiplicity of infection (MOI) of 10 and th...

journal_title：Inflammation

authors： Jörgens G,Bange FC,Mühlradt PF,Pabst R,Maus UA,Tschernig T

更新日期：2009-08-01 00:00:00

abstract：:This study analyzed the neutrophils and sera of patients with rheumatoid arthritis and of normal controls. No significant differences were found in the activities of the granular enzymes beta-glucuronidase and lysozyme or the cytoplasmic enzyme lactic dehydrogenase (LDH). Normal neutrophils were found to release signi...

journal_title：Inflammation

authors： Turner R,Martin M,Schroff J,Treadway W,DeChatelet L

更新日期：1979-07-01 00:00:00

abstract：:Polymorphonuclear neutrophils are among the first defense against infection and closely involved in the initiation of inflammatory response. It is well recognized that this function of neutrophils was mainly mediated by phagocytosis, intracellular degradation, releasing of granules, and formation of neutrophil extrace...

journal_title：Inflammation

authors： Yang F,Feng C,Zhang X,Lu J,Zhao Y

更新日期：2017-02-01 00:00:00

abstract：:Cyanidin-3-O-glucoside (C3G), an anthocyanin belonging to the flavonoid family and commonly present in food and vegetables in human diet, has exhibited anti-inflammatory and anti-oxidant effects. This study aimed to investigate the protective ability of C3G against inflammatory and oxidative injuries, as well as to cl...

journal_title：Inflammation

authors： Ma MM,Li Y,Liu XY,Zhu WW,Ren X,Kong GQ,Huang X,Wang LP,Luo LQ,Wang XZ

更新日期：2015-08-01 00:00:00

abstract：:Exposure to ultraviolet (UV) light impairs the function of inflammatory cells. Urocanic acid (UCA) in an stratum corneum has been suggested as a mediator in the immunosuppression of lymphoid cells detected after irradiation with UVB (UV wavelengths 280-320 nm). In this study, we examined the effects of the two UCA iso...

journal_title：Inflammation

authors： Kivistö K,Punnonen K,Toppari J,Leino L

更新日期：1996-10-01 00:00:00

abstract：:Alveolar type I epithelial cells (AECIs) play an important role in the pathogenesis of acute lung injury. The receptor for advanced glycation end-products (RAGEs) is expressed at a high basal level in AECIs, and its soluble isoform is suggested as a marker of AECI injury. However, the molecular mechanism by which RAGE...

journal_title：Inflammation

authors： Li Y,Wu R,Zhao S,Cheng H,Ji P,Yu M,Tian Z

更新日期：2014-10-01 00:00:00

abstract：:Induction of colitis by 2,4,6-Trinitrobenzenesulphonic acid (TNB) in the rat is a widely used experimental model of inflammatory bowel disease. Action of TNB as a hapten, induces colitis involving infiltration of colonic mucosa by neutrophils and macrophages and increased production of inflammatory mediators. The aim ...

journal_title：Inflammation

authors： Kankuri E,Asmawi MZ,Korpela R,Vapaatalo H,Moilanen E

更新日期：1999-04-01 00:00:00

abstract：:Factors affecting the retinoic acid modulated expression of mucin mRNA in rat tracheal cultures were studied. Actinomycin D had no effect on mucin mRNA in cultures grown with retinoic acid (RA+). The usual precipitous drop in mucin mRNA in cultures lacking retinoic acid (RA-) was prevented by actinomycin D. Cyclohexim...

journal_title：Inflammation

authors： Bhattacharyya SN,Ashbaugh P,Kaufman B,Manna B

更新日期：1994-12-01 00:00:00

abstract：:Age-related macular degeneration (AMD) is the predominant cause of irreversible blindness in the elderly population. Despite intensive basic and clinical research, its pathogenesis remains unclear. However, evidence suggests that immunological and inflammatory factors contribute to the pathogenesis of AMD. A newly ide...

journal_title：Inflammation

authors： Liu XC,Liu XF,Jian CX,Li CJ,He SZ

更新日期：2012-04-01 00:00:00