Calcitonin gene-related peptide partially reverses decreased production of chemokines KC and MIP-2 following murine sepsis.

abstract：:NSAIDs are widely used to alleviate the symptoms of OA. It remains controversial as to what effects these agents have on the progression of OA. In vitro studies showed several types of NSAIDs (e.g., sodium salicylate, indomethacin) inhibited the synthesis of cartilage matrix component, but some types of NSAIDs (e.g., ...

journal_title：Inflammation

authors： Ding C

更新日期：2002-06-01 00:00:00

abstract：:Chronic obstructive pulmonary disease (COPD) is a common chronic inflammatory disease with high morbidity and mortality rates. Cystatin C (Cys C) is a sensitive indicator for various chronic inflammatory diseases. In this study, we aimed to evaluate the role of Cys C in COPD patients comparing with the other well-know...

journal_title：Inflammation

authors： Zhang M,Li Y,Yang X,Shan H,Zhang Q,Ming Z,Xie Y,Chen H,Liu Y,Zhang J

更新日期：2016-04-01 00:00:00

abstract：:Crude extracts of human blood leukocytes were employed as a source of bactericidal and bacteriolytic agents againstStaphylococcus aureus. While the bactericidal action of the extracts was a very rapid process, bacteriolysis is a very slow process. Both the killing and the lysis of staphylococci depended on the age of ...

journal_title：Inflammation

authors： Ne'eman N,Duchan Z,Lahav M,Sela MN,Ginsburg I

更新日期：1976-06-01 00:00:00

abstract：:Chemerin is shown to be associated with inflammation which is involved in the pathogenesis of diabetic nephropathy. This study aims to determine whether rosiglitazone and pioglitazone ameliorate renal function through an effect on the expression of chemerin and ChemR23 in streptozotocin-induced diabetic rats. The rats...

journal_title：Inflammation

authors： Hu W,Yu Q,Zhang J,Liu D

更新日期：2012-08-01 00:00:00

abstract：:Injury to podocytes leads to proteinuria, a hallmark of most glomerular diseases as well as being associated with the progression of kidney disease. Activation of the Wnt/β-catenin pathway is associated with the pathogenesis of podocyte dysfunction and can play a role in renal injury. Furthermore, the expression of fr...

journal_title：Inflammation

authors： Senouthai S,Wang J,Fu D,You Y

更新日期：2019-08-01 00:00:00

abstract：:Genetic messages for polypeptide growth factors were assessed in human alveolar macrophages, obtained by bronchoalveolar lavage (BAL) from normal subjects (N = 3) and from patients with pneumonia (N = 3), pulmonary lymphoma (N = 3), and idiopathic pulmonary fibrosis (N = 3). Complementary DNAs (cDNAs) were prepared by...

journal_title：Inflammation

authors： Adolff CH,Golden JA,Kennedy PW,Goetzl EJ,Turck CW

更新日期：1991-08-01 00:00:00

abstract：:To evaluate the role of ALA treatment on the healing of acetic acid-induced gastric ulcer, rats were given ALA (35 mg/kg/day) or saline for 3 days before the induction of ulcer and the treatment was continued twice daily for 2 days (early) or 10 days (late) until they were decapitated. Gastric ulcer index, microscopic...

journal_title：Inflammation

authors： Karakoyun B,Yüksel M,Ercan F,Erzik C,Yeğen BC

更新日期：2009-02-01 00:00:00

abstract：:Mitogen- and stress-activated protein kinase (MSK) is a recently identified nuclear cAMP-regulated enhancer B (CREB) and histone H3 kinase that responds to both mitogen- and stress-activated protein kinases. This study was designed to investigate the protective effect of MSK on the rats with focal ischemia-reperfusion...

journal_title：Inflammation

authors： Zhou Y,Gao G,Li Z,Jiang L

更新日期：2019-12-01 00:00:00

abstract：:Alveolar macrophages (AMs) can initiate lung inflammation by producing pro-inflammatory cytokines and chemokines, but they participate actively in the prevention of inflammation during acute lung injury (ALI). Heme oxygenase-1 (HO-1) is mainly expressed in AMs and has anti-inflammatory properties in ALI, but the anti-...

journal_title：Inflammation

authors： Hualin C,Wenli X,Dapeng L,Xijing L,Xiuhua P,Qingfeng P

更新日期：2012-06-01 00:00:00

abstract：:The adhesive interactions between phagocytes and endothelial cells (EC) can be modulated by inflammatory cytokines and chemotactic proteins which are released during an inflammatory response. The aim of the present study was to investigate first whether the adhesive properties of granulocytes and monocytes from asthma...

journal_title：Inflammation

authors： Verdegaal EM,Zegveld ST,Beekhuizen H,Bakker W,van Furth R

更新日期：1998-04-01 00:00:00

abstract：:In the present study, the anti-inflammatory effect of piperine was investigated on monosodium urate crystal-induced inflammation in mice, an experimental model for gouty arthritis, and compared it with that of the nonsteroidal anti-inflammatory drug, indomethacin. The levels of lysosomal enzymes, lipid peroxidation, t...

journal_title：Inflammation

authors： Sabina EP,Nagar S,Rasool M

更新日期：2011-06-01 00:00:00

abstract：:Systemic sclerosis (SSc) is a disease characterized by skin and internal organ involvement. There is progressive accumulation of extracellular matrix components in the skin and involved organs. Tissue fibrosis is the prominent reason for mortality, and still, there is no satisfactory treatment. The aim of this study w...

journal_title：Inflammation

authors： Demir T,Turkbeyler I,Kaplan DS,Pehlivan Y,Orkmez M,Tutar E,Taysi S,Kisacik B,Onat AM,Bagcı C

更新日期：2013-02-01 00:00:00

abstract：:Four methods of severe disruption of human neutrophil membrane integrity resulted in the formation of substantial amounts of leukotriene B4 and its isomers. This synthesis took place from endogenous substrate in the absence of any cell activators. It is postulated that leukotriene formation could be a preserved cell f...

journal_title：Inflammation

authors： Green FA

更新日期：1988-04-01 00:00:00

abstract：:Polymorphonuclear neutrophil (PMN) function is thought to be critical in resistance to infectious agents and this implies that the PMN must be able to migrate into, and to function in, environments that may have high levels of bacterial lipopolysaccharide (LPS). Therefore, we have evaluated the effect of LPS on the in...

journal_title：Inflammation

authors： Creamer HR,Hunter N,Bullock WW,Gabler WL

更新日期：1991-06-01 00:00:00

abstract：:Enzyme-inducing drugs such as phenobarbital (PB) increase serum concentrations of an acute-phase protein, alpha 1-acid glycoprotein (AGP), in man, dogs, and rats via an unknown mechanism. We studied the effects of PB on components of an acute inflammatory reaction in rats in order to determine if PB acts only on this ...

journal_title：Inflammation

authors： Levy FE,Chauvelot-Moachon L,Florentin I,Forest M,Poüs C,Fournier C,Giroud JP

更新日期：1991-12-01 00:00:00

abstract：:Acute lung injury (ALI)/acute respiratory distress syndrome is characterized by increased pulmonary inflammation, where T helper 17 (Th17) cells play an important regulatory role. Notch signaling critically regulates Th17 differentiation and is known to be linked with proximal T cell by protein kinase C theta (PKCθ). ...

journal_title：Inflammation

authors： Li M,Zhao Y,He J,Deng W,Cheng L,Jiang Z,Wang D

更新日期：2019-12-01 00:00:00

abstract：:Thermal injury in rats leads to an impairment of polymorphonuclear leukocyte (PMN) functions, particularly oxidative metabolism and phosphoinositide turnover. As prostaglandin E2, which has immunosuppressive properties, is released in high levels after burn trauma, we investigated the in vitro and in vivo effects of a...

journal_title：Inflammation

authors： Tissot M,Roch-Arveiller M,Fontagne J,Giroud JP

更新日期：1992-12-01 00:00:00

abstract：:Strong anti-inflammatory activity has been found in Laminaria japonica dichloromethane fraction (LDF); however, the molecular mechanisms underlying its anti-inflammatory activity are not reported. Our results indicated that LDF inhibited LPS-induced nitric oxide and prostaglandin E(2) production in a dose-dependent ma...

journal_title：Inflammation

authors： Lee JY,Lee MS,Choi JW,Shin TS,Woo HC,Kim HR

更新日期：2012-10-01 00:00:00

abstract：:Potassium voltage-gated channel subfamily Q member 1 opposite strand 1 (KCNQ1OT1), a long non-coding RNA found in the KCNQ1 locus, has been evidenced to play important roles in the aggravation of inflammatory and oxidative stresses under hypoxia, but whether and how KCNQ1OT1 contributes to neuronal damages in the cere...

journal_title：Inflammation

authors： Yi M,Li Y,Wang D,Zhang Q,Yang L,Yang C

更新日期：2020-10-01 00:00:00

abstract：:Several experiments have detected that melatonin exerts a marked influence on the inflammatory process. In the present study we evaluated the effect of exogenous melatonin on the experimental granulomatous tissues in rat. Our data show that subcutaneous administration of different doses of melatonin given daily during...

journal_title：Inflammation

authors： de la Rocha NE,Rotelli AE,Guardia T,Pelzer LE

更新日期：2004-08-01 00:00:00

abstract：:Valnemulin reportedly regulates inflammatory responses in addition to its in vitro antibacterial activity. In this study, we established a mouse model of lipopolysaccharide (LPS)-induced inflammatory lung injury and investigated the effect of valnemulin (100 mg/kg) on acute lung injury (ALI) 8 h after LPS challenge. W...

journal_title：Inflammation

authors： Chen Z,Zhang X,Chu X,Zhang X,Song K,Jiang Y,Yu L,Deng X

更新日期：2010-10-01 00:00:00

abstract：:Parthenolide, a naturally occurring sesquiterpene lactone derived from feverfew (Tanacetum parthenium), exhibits exceptional anti-cancer and anti-inflammatory properties, making it a prominent candidate for further studies and drug development. In this review, we briefly investigate molecular events and cell-specific ...

journal_title：Inflammation

authors： Mathema VB,Koh YS,Thakuri BC,Sillanpää M

更新日期：2012-04-01 00:00:00

abstract：:Immune dysfunction contributes to secondary infection and worse outcomes in sepsis. Regulatory T cells (Tregs) have been implicated in sepsis-induced immunosuppression. Nevertheless, the role of Tregs in secondary infection after sepsis remains to be determined. In the present study, a two-hit model which mimics clini...

journal_title：Inflammation

authors： Hu ZQ,Yao YM,Chen W,Bian JL,Zhao LJ,Chen LW,Hong GL,Lu ZQ,Zhao GJ

更新日期：2018-10-01 00:00:00

abstract：:Diabetic neuropathy (DNP) is the most common chronic complication of diabetes. Elevated free fatty acids (FFAs) have been recently recognized as major causes of inflammation and are relevant to the functional changes of nerve system in diabetes. Trans-resveratrol (RESV), a polyphenolic natural compound, has long been ...

journal_title：Inflammation

authors： Xu H,Xiong C,He L,Wu B,Peng L,Cheng Y,Jiang F,Tan L,Tang L,Tu Y,Yang Y,Liu C,Gao Y,Li G,Zhang C,Liu S,Xu C,Wu H,Li G,Liang S

更新日期：2015-02-01 00:00:00

abstract：:Cepharanthine (CEP), a biscoclaurine alkaloid isolated from Stephania cepharantha Hayata, has been reported to have potent anti-inflammatory properties. However, the anti-inflammatory effects of CEP on a mouse model of lipopolysaccharide (LPS)-induced mastitis and its underlying molecular mechanisms remain to be eluci...

journal_title：Inflammation

authors： Ershun Z,Yunhe F,Zhengkai W,Yongguo C,Naisheng Z,Zhengtao Y

更新日期：2014-04-01 00:00:00

abstract：:Mastitis is a major disease in humans and other animals and is characterized by mammary gland inflammation. It is a major disease of the dairy industry. Bergenin is an active constituent of the plants of genus Bergenia. Research indicates that bergenin has multiple biological activities, including anti-inflammatory an...

journal_title：Inflammation

authors： Gao XJ,Guo MY,Zhang ZC,Wang TC,Cao YG,Zhang NS

更新日期：2015-01-01 00:00:00

abstract：:The ability of peripheral blood neutrophils to injure elements of the alveolar septum was assessed. Experiments consisted of activating previously isolated neutrophils (PMNs) with a soluble (phorbol myristate acetate, PMA) and a particulate (zymosan) trigger, and measuring detachment of 51Cr-labeled epithelial cells. ...

journal_title：Inflammation

authors： Brown DM,Brown GM,Macnee W,Donaldson K

更新日期：1992-02-01 00:00:00

abstract：:An acute neutrophilic lung injury was compared in Balb/c normal and nu/nu (nude) mice to assess the role of T lymphocytes in the resolution of acute pulmonary neutrophilic inflammation following the administration of endotoxin. Maximal neutrophilic infiltration occurred on day 1 post-endotoxin treatment and declined t...

journal_title：Inflammation

authors： Morris PE,Glass J,Cross R,Cohen DA

更新日期：1997-06-01 00:00:00

abstract：:Sepsis, a clinical syndrome occurring in patients following infection or injury, is a leading cause of morbidity and mortality worldwide. CD86 (B7-2) is a costimulatory molecule on antigen-presenting cells and plays critical roles in immune responses. In the current study, we investigated the association of two CD86 p...

journal_title：Inflammation

authors： Song H,Tang L,Xu M,Li H,Xu S,Li G,Bao X,Sun B,Cheng T,Yang Q,Bai J

更新日期：2015-04-01 00:00:00

abstract：:Exposure to ultraviolet (UV) light impairs the function of inflammatory cells. Urocanic acid (UCA) in an stratum corneum has been suggested as a mediator in the immunosuppression of lymphoid cells detected after irradiation with UVB (UV wavelengths 280-320 nm). In this study, we examined the effects of the two UCA iso...

journal_title：Inflammation

authors： Kivistö K,Punnonen K,Toppari J,Leino L

更新日期：1996-10-01 00:00:00