Abstract:
:Chronic obstructive pulmonary disease (COPD) is a common chronic inflammatory disease with high morbidity and mortality rates. Cystatin C (Cys C) is a sensitive indicator for various chronic inflammatory diseases. In this study, we aimed to evaluate the role of Cys C in COPD patients comparing with the other well-known inflammatory markers. Ninety patients with acute exacerbated COPD were studied and were reassessed when convalescent. Ninety controls were matched for age, gender, body mass index, smoking index, and comorbidity. Serum Cys C was significantly increased in convalescent COPD patients compared with healthy controls and further increased in COPD patients with an acute exacerbation. Serum Cys C was positively correlated with hsCRP both in the exacerbation and convalescence periods of COPD and negatively correlated with FEV1% predicted and FEV1/FVC in the convalescent COPD patients. In conclusion, serum Cys C is a positive acute-phase reactant in COPD patients and might indicate systemic inflammation during the progression of COPD.
journal_name
Inflammationjournal_title
Inflammationauthors
Zhang M,Li Y,Yang X,Shan H,Zhang Q,Ming Z,Xie Y,Chen H,Liu Y,Zhang Jdoi
10.1007/s10753-015-0287-xsubject
Has Abstractpub_date
2016-04-01 00:00:00pages
625-31issue
2eissn
0360-3997issn
1573-2576pii
10.1007/s10753-015-0287-xjournal_volume
39pub_type
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