Abstract:
:Previous studies have suggested that Interleukin-6 (IL-6) acts as a marker of vasculitis. To determine the role of IL-6 in vasculitis we utilized two models of immune complex induced vascular injury (dermal Arthus and acute pulmonary alveolitis) in IL-6 deficient (IL-6(-/-)) and IL-6 sufficient (IL-6(+/+)) mice. Plasma and bronchoalveolar lavage (BAL) levels of IL-6 were elevated in the injured IL-6(+/+) mice with acute alveolitis and in the plasma of IL-6(+/+) mice with dermal Arthus vasculitis. While, IL-6 levels in IL-6(-/-) mice were near or below the levels of detection. Histological examination of the intensity of vascular injury response demonstrated no significant differences between IL-6(-/-) and IL6(+/+) mice. More specifically, lung permeability (total protein in the BAL) in the lung injury model in IL-6(-/-) mice was the same as injured IL-6(+/+) mice. As a corollary, assessment of vascular permeability in both models was the same in the IL-6(-/-) as the IL-6(+/+) mice. Quantification of leukocyte influx into the injured tissues in both models also revealed no differences between the IL-6(-/-) and IL-6(+/+) mice. These data demonstrate that while IL-6 is upregulated in acute vascular injury it does not appear to be critical in the development of the vascular inflammatory response.
journal_name
Inflammationjournal_title
Inflammationauthors
McClintock SD,Barron AG,Olle EW,Deogracias MP,Warner RL,Opp M,Johnson KJdoi
10.1007/s10753-006-9011-1subject
Has Abstractpub_date
2005-12-01 00:00:00pages
154-62issue
4-6eissn
0360-3997issn
1573-2576journal_volume
29pub_type
杂志文章相关文献
INFLAMMATION文献大全abstract::Damaged vascular endothelial cells after ischemic stroke release inflammatory cytokines and adhesion molecules, which could trigger platelet adhesion to vascular endothelial cells and platelet activation, and accelerate thrombus formation. Tetramethylpyrazine is the main bioactive component of Chuanxiong, which has de...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-019-01119-6
更新日期:2020-02-01 00:00:00
abstract::In our study, we explored the bidirectional communication via soluble factors between bone cells and endotoxin-stimulated splenic lymphocytes in an in vitro coculture model that mimics the inflammatory environment. Both the ability of lymphocytes to affect differentiation and immune properties of bone cells, osteoblas...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-012-9477-y
更新日期:2012-10-01 00:00:00
abstract::Inflammatory bowel disease (IBD) has received much attention due to its increasing worldwide incidence and potential increased risk of colorectal cancer. The protective function of a Rho-associated protein kinase inhibitor (Y-27632) against 2,4,6-trinitrobenzene sulfonic acid (TNBS) induced mouse colitis has been prov...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-019-01171-2
更新日期:2020-06-01 00:00:00
abstract::Human neutrophils were demonstrated to possess interleukin-2 receptor (IL-2R) beta and gamma chains, not alpha chain and the binding of IL-2 to the IL-2R beta chain on neutrophils plays an important regulatory role in neutrophil functions. We have investigated in this study the hypothesis that recombinant human IL-2 (...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF01486739
更新日期:1996-08-01 00:00:00
abstract::Genetic messages for polypeptide growth factors were assessed in human alveolar macrophages, obtained by bronchoalveolar lavage (BAL) from normal subjects (N = 3) and from patients with pneumonia (N = 3), pulmonary lymphoma (N = 3), and idiopathic pulmonary fibrosis (N = 3). Complementary DNAs (cDNAs) were prepared by...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00917311
更新日期:1991-08-01 00:00:00
abstract::In vivo effects of cytokine-induced neutrophil chemotactic factor (CINC) derived from rats on neutrophil infiltration were investigated using an air-pouch-type inflammation model in rats, and effects of dexamethasone on neutrophil infiltration induced by CINC was also examined in order to gain further insight into the...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00918958
更新日期:1992-04-01 00:00:00
abstract::Four methods of severe disruption of human neutrophil membrane integrity resulted in the formation of substantial amounts of leukotriene B4 and its isomers. This synthesis took place from endogenous substrate in the absence of any cell activators. It is postulated that leukotriene formation could be a preserved cell f...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00916396
更新日期:1988-04-01 00:00:00
abstract::To investigate the role of glutathione (GSH) synthesis in the regulation on nuclear factor (NF)-kappaB activity and tumor necrosis factor-alpha (TNF-alpha) release by glutamine (GLN) in lipopolysaccharide (LPS)-stimulated alveolar type II (AT-II) epithelial cells of rat lungs. Primary cultured AT-II cells were pre-tre...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-008-9084-0
更新日期:2008-10-01 00:00:00
abstract::To investigate the effect of dexmedetomidine post-conditioning on the inflammatory response and autophagy effect of focal cerebral ischemia reperfusion injury in rats, and further to study its potential mechanisms. Water maze was conducted to evaluate spatial learning and memory ability of middle cerebral artery occlu...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-019-01082-2
更新日期:2019-12-01 00:00:00
abstract::Mastitis is a major disease in humans and other animals and is characterized by mammary gland inflammation. It is a major disease of the dairy industry. Bergenin is an active constituent of the plants of genus Bergenia. Research indicates that bergenin has multiple biological activities, including anti-inflammatory an...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-014-0079-8
更新日期:2015-01-01 00:00:00
abstract::This study was performed to evaluate the effects of epigallocatechin 3 gallate (EGCG) on lipopolysaccharide (LPS)-induced acute lung injury in a murine model. In the present study, production of TNF-alpha and MIP-2 and activation of extracellular signal-regulated kinases (ERK)1/2, c-Jun amino terminal kinases (JNK) an...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-009-9161-z
更新日期:2010-04-01 00:00:00
abstract::Chemerin is shown to be associated with inflammation which is involved in the pathogenesis of diabetic nephropathy. This study aims to determine whether rosiglitazone and pioglitazone ameliorate renal function through an effect on the expression of chemerin and ChemR23 in streptozotocin-induced diabetic rats. The rats...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-012-9440-y
更新日期:2012-08-01 00:00:00
abstract::We compared exhaled breath condensate (EBC) and induced sputum (IS) for assessing inflammation in pulmonary diseases in patients with obstructive lung disease (n = 20), persistent cough >6 months (n = 20), interstitial lung disease (n = 25) and controls (n = 10). EBC was collected by suspending a Teflon perfluoroalkox...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-007-9020-8
更新日期:2007-04-01 00:00:00
abstract::The excessive activation of microglia plays a key role in the pathogenesis of neurodegenerative diseases. The neuroprotective properties of rosmarinic acid have been reported in a variety of disease models both in vitro and in vivo; however, the mechanism underlying its anti-neuroinflammatory activity has not been cle...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-017-0728-9
更新日期:2018-03-01 00:00:00
abstract::Increased susceptibility of neonates to infection may be related to defects in newborn neutrophil (PMN) functional activities, including altered responses to complement fragments (Cf) and defective microbicidal activity. We therefore compared the kinetics of newborn and adult bovine PMN membrane shape change responses...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00914305
更新日期:1989-12-01 00:00:00
abstract::Mitogen- and stress-activated protein kinase (MSK) is a recently identified nuclear cAMP-regulated enhancer B (CREB) and histone H3 kinase that responds to both mitogen- and stress-activated protein kinases. This study was designed to investigate the protective effect of MSK on the rats with focal ischemia-reperfusion...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-019-01080-4
更新日期:2019-12-01 00:00:00
abstract::Asthma is a complex disease linked to various pathophysiological events, including proteinase activity. In this study, we examined whether a Diospyros blancoi methanolic extract (DBE) exerts protective effects on allergic asthma in a murine asthma model. To investigate the specific role of DBE, we employed a murine mo...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-011-9354-0
更新日期:2012-04-01 00:00:00
abstract::Protamine sulfate induces enzyme secretion from rabbit neutrophils. Enzyme secretion is mainly due to exocytosis but, depending on the experimental conditions, a small amount of cytolysis may occur. As compared with stimulation of neutrophil functions by other activators, protamine sulfate-induced enzyme release by ex...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00915825
更新日期:1986-12-01 00:00:00
abstract::The newly discovered gamma-PKC-related-protein of human leukocytes (gamma-rp) crossreacts with a polyclonal antibody preparation originally designed to be specific for PKC-gamma (gammaMb-Ab). As this antibody is currently the only suitable probe for gamma-rp, we sought to characterize the binding of the two proteins. ...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1023/a:1020265701407
更新日期:1999-08-01 00:00:00
abstract::Ischemic stroke is a major cause of death and motor disabilities all over the world. It is a muti-factorial disorder associated with inflammatory, apoptotic, and oxidative responses. Nateglinide (NAT), an insulinotropic agent used for the treatment of type 2 diabetes mellitus, recently showed potential anti-inflammato...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-019-01154-3
更新日期:2020-04-01 00:00:00
abstract::Lipopolysaccharide (LPS) increases serum TNF-alpha levels due to TNF-alpha secretion by macrophages. The serum TNF-alpha response to LPS was augmented 10x when FcgammaR ligation was induced by the intravenous injection of Gig-coated erythrocytes (IgG) prior to the administration of LPS. The macrophage population respo...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1023/a:1021468819285
更新日期:2002-12-01 00:00:00
abstract::Currently, only tumor necrosis factor alpha (TNF-α) and interleukin family cytokines have been found to be elicited in Vibrio vulnificus (V. vulnificus)-infected animal models and humans. However, multiple other cytokines are also involved in the immune and inflammatory responses to foreign microorganism infection. An...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-015-0166-5
更新日期:2015-10-01 00:00:00
abstract::This study investigated the expression of miRNA-221 in asthmatics in order to determine whether miRNA-221 plays a role in the development of asthma. Real-time PCR was used to detect the miRNA-221 in both asthmatic and control subjects. In addition, airway inflammation was evaluated by cell counting and tissue biopsy i...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-012-9474-1
更新日期:2012-08-01 00:00:00
abstract::We analyzed the influence of heparins (unfractionated heparin, UFH and low molecular weight heparin certoparin) on the generation of IL-1ra, IL-6, IL-10, and IL-12p40 and from leukocyte fractions in vitro. Polymorphonuclear neutrophil leukocytes (PMN) and peripheral blood mononuclear cells (PBMC) from 16 different hea...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1023/a:1012883916991
更新日期:2001-10-01 00:00:00
abstract::The anti-inflammatory activities of kakkalide, a major constituent of the flower of Pueraria thunbergiana, and irisolidone, a metabolite of kakkalide produced by intestinal microflora, against carrageenan-induced inflammation in air pouches on the backs of mice and in lipopolysaccharide (LPS)-stimulated peritoneal mac...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-010-9240-1
更新日期:2011-10-01 00:00:00
abstract::In this study, the effects of tyrosol were investigated in DSS-induced experimental ulcerative colitis model. For this purpose, rats were divided into five groups of seven rats in each: control group, colitis group (DSS-4%), tyrosol group (tyrosol 20 mg/kg), sulfasalazine (sulfasalazine+DSS 100 mg/kg), and treatment g...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-019-01028-8
更新日期:2019-10-01 00:00:00
abstract::This study aims to provide experimental proof that Rab6a is an efficient target of microRNA-155 in regulating pro-inflammatory tumor necrosis factor (TNF) secretion stimulated by lipopolysaccharide (LPS) in macrophages. We identified Rab6a as a new target of microRNA-155 (miR-155) and found that overexpression of miR-...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-015-0228-8
更新日期:2016-02-01 00:00:00
abstract::Streptococcus suis serotype 2 (SS2) is an emerging zoonosis, and meningitis is the most frequent clinical manifestation, but mechanism of its virulent factor, enolase (Eno), is unknown in meningitis. In this study, Eno was inducibly expressed and added to an in vitro Transwell co-culture model of the blood-brain barri...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-015-0298-7
更新日期:2016-04-01 00:00:00
abstract::The release of inflammatory cytokines and chemokines and autophagy has been reported to be involved in the pathogenic mechanism of acute lung injury (ALI). Reportedly, alpha-7 nicotinic acetylcholine receptors (α7nAchR) might play a protective role in LPS-induced ALI. In the current research, we established LPS-induce...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-019-01088-w
更新日期:2019-12-01 00:00:00
abstract::The influences of extracellular Ca2+ and Mg2+ on chemotactic factor-induced rabbit polymorphonuclear neutrophil (PMN) aggregation was studied using a recently described Coulter counter assay technique. Compared with those of other PMN functional assays (adhesion, chemotaxis, degranulation, and phagocytosis), the catio...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00921006
更新日期:1977-12-01 00:00:00