Abstract:
:The influences of extracellular Ca2+ and Mg2+ on chemotactic factor-induced rabbit polymorphonuclear neutrophil (PMN) aggregation was studied using a recently described Coulter counter assay technique. Compared with those of other PMN functional assays (adhesion, chemotaxis, degranulation, and phagocytosis), the cation requirements for cell aggregation appear unique. Chemotactic factor-induced aggregation did not occur in the absence of either cation. When the concentration of both cations was increased equivalently, aggregation increased. The effect plateaued at 2.8 mM of Ca2+ and Mg2+. When the concentration of one cation alone was increased, aggregation peaked. Further increases inhibited maximal aggregation. By systematic variation of the cation concentrations, optimal aggregation was found at Ca2+ and Mg2+ concentrations of 2.8 mM. At these concentrations, significant aggregation was induced with chemotactic doses of bacterial factor, the chemotactic fragment of human C5, and the synthetic chemotactic tripeptide, formyl-met-leu-phe. Thus, under these conditions, chemotactic factor-induced aggregation of neutrophils may be a useful indicator of interactions of chemotactic factors with neutrophils.
journal_name
Inflammationjournal_title
Inflammationauthors
O'Flaherty JT,Showell HJ,Ward PAdoi
10.1007/BF00921006subject
Has Abstractpub_date
1977-12-01 00:00:00pages
265-76issue
4eissn
0360-3997issn
1573-2576journal_volume
2pub_type
杂志文章相关文献
INFLAMMATION文献大全abstract::In the present study, we investigated the effect of lipoxin A4 on myocardial ischemia-reperfusion injury (IRI) following cardiac arrest (CA) in a rabbit model. Lipoxin A4 is a metabolite of arachidonic acid in the eicosanoid, it is called "brake signal" for its anti-inflammatory activity. Some inflammatory factors (IL...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-012-9567-x
更新日期:2013-04-01 00:00:00
abstract::IL-17-producing Th17 cells and IFN-γ and IL-17 double-producing Th1/17 cells have been identified as the pathogenic cells in inflammatory bowel disease (IBD). Retinoic acid-related orphan receptor γt (RORγt) is a master regulator for the differentiation and activation of Th17 and Th1/17 cells. We discovered a novel or...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-018-0875-7
更新日期:2019-02-01 00:00:00
abstract::Intrapleural tetracycline (TCN) results in pleural macrophage influx and pleural fibrosis; intrapleural carrageenan (CAR) induces macrophage influx without fibrosis. Because macrophage products can modulate mesothelial cell activity, we investigated the role of TCN- and CAR-induced pleural macrophages on mesothelial c...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00916387
更新日期:1993-02-01 00:00:00
abstract::In this study, the effects of tyrosol were investigated in DSS-induced experimental ulcerative colitis model. For this purpose, rats were divided into five groups of seven rats in each: control group, colitis group (DSS-4%), tyrosol group (tyrosol 20 mg/kg), sulfasalazine (sulfasalazine+DSS 100 mg/kg), and treatment g...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-019-01028-8
更新日期:2019-10-01 00:00:00
abstract::Fasudil, a rock kinase inhibitor, can inhibit systemic inflammation and prevent paraquat (PQ)-induced acute lung injuries in rats; however, the mechanisms for these protective effects remain elusive. This study investigated how the Rho/ROCK signaling pathway enables fasudil to protect against acute lung injuries in PQ...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-018-0860-1
更新日期:2018-12-01 00:00:00
abstract::Numerous cytokines, including vascular endothelial growth factor (VEGF), are implicated in the pathogenesis of sepsis. While overexpression of VEGF produces pulmonary capillary leak, the role of VEGF in sepsis is less clear. We investigated VEGF in sepsis, utilizing a VEGF trap (VEGF(T)). Polymicrobial sepsis was indu...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-004-6050-3
更新日期:2004-10-01 00:00:00
abstract::The release of inflammatory cytokines and chemokines and autophagy has been reported to be involved in the pathogenic mechanism of acute lung injury (ALI). Reportedly, alpha-7 nicotinic acetylcholine receptors (α7nAchR) might play a protective role in LPS-induced ALI. In the current research, we established LPS-induce...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-019-01088-w
更新日期:2019-12-01 00:00:00
abstract::Many patients with ulcerative colitis suffer from malnutrition and intestinal flora disorders, which affect the postoperative intestinal barrier function of the ileal pouch. This study aimed to investigate the effects of enteral nutrition combined with probiotics after ileal pouch-anal anastomosis in rats. Male Spragu...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-020-01372-0
更新日期:2020-11-05 00:00:00
abstract::Naringin (COG) is a flavanone with various bioactivities including an expectorant effect, antitussive effect, and inhibitory effect on asthma and acute lung injury. The aims of the present study were to investigate the antiarthritis activities of COG and elucidate the underlying mechanisms with regard to its molecular...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-014-0027-7
更新日期:2015-02-01 00:00:00
abstract::This study investigates the mode of action of Neophytadiene (MT), a molecule isolated from a marine algae Turbinaria ornata in LPS-induced inflammation in both in vitro and in vivo conditions. Neophytadiene (25, 50, 100 μM/mL) was treated to LPS-stimulated RAW 264.7 macrophages cells to identify its anti-inflammatory ...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-020-01179-z
更新日期:2020-06-01 00:00:00
abstract::Dialysate and serum levels of granulocyte-colony stimulating factor (G-CSF), granulocyte macrophage colony stimulating factor (GM-CSF) and leukemia inhibitory factor (LIF) were analyzed in patients with continuous ambulatory peritoneal dialysis (CAPD). Samples from the peritoneal effluent and from serum were obtained ...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1023/a:1022320916105
更新日期:1998-08-01 00:00:00
abstract::1,8-Cineol is a major monoterpene principally from eucalyptus essential oils and has been shown to exert anti-inflammatory, antiviral, and inhibitory of nuclear factor (NF)-kB effect. In the present study, we evaluated the effect of 1,8-cineol on mice infected with influenza A virus. We found that 1,8-cineol protects ...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-016-0394-3
更新日期:2016-08-01 00:00:00
abstract::Postoperative ileus is a common complication after intra-abdominal surgery. Nitric oxide produced by macrophages in the inflamed gastrointestinal tract plays a crucial role in the pathogeny of postoperative ileus. Honokiol, extracted from the bark of Magnolia spp., is a natural compound with a biphenolic structure. In...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-017-0576-7
更新日期:2017-08-01 00:00:00
abstract::Numerous studies have evaluated the association between -159C/T polymorphism of the CD14 gene and asthma risk; however, these studies have yielded inconsistent results. We performed meta-analyses to investigate the association between CD14-159C/T polymorphism and asthma risk. Studies were identified from PubMed, Embas...
journal_title:Inflammation
pub_type: 杂志文章,meta分析
doi:10.1007/s10753-015-0269-z
更新日期:2016-02-01 00:00:00
abstract::Leukocyte chemoattractants markedly alter the morphology and membrane functions of leukocytes. Bacterial collagenase causes a change in cell shape similar to that seen with the leukocyte chemoattractant, f-Met-Leu-Phe, and also promotes capping of concanavalin A. Human neutrophils in suspension or adherent to cover gl...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00915819
更新日期:1986-12-01 00:00:00
abstract::Exposure of human neutrophils to concanavalin A (Con A) resulted in a time- and concentration-dependent extracellular release of granule-associated lysozyme but not beta-glucuronidase or cytosolic lactate dehydrogenase. Maximum extrusion of lysozyme occurred 30 min after cell contact with Con A. The percent of total g...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00916046
更新日期:1980-12-01 00:00:00
abstract::Ulcerative colitis (UC) is a serious digestive system disease. Furthermore, the activation of C3a/C3aR axis promoted the expression of caspase-11. And higher levels of caspase-11 could induce the pyroptosis and inflammation of cells. However, some studies suggested that caspase-11 could promote and suppress the inflam...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-020-01280-3
更新日期:2020-12-01 00:00:00
abstract::Slow translocation of protein kinase C was observed by both auranofin and gold sodium thiomalate pretreatment of neutrophils. Both gold compounds failed to influence the activity of this enzyme directly when cell-free studies were performed. In intact neutrophils incubated with 5.1-20.3 microM auranofin, protein kinas...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00915842
更新日期:1987-09-01 00:00:00
abstract::Baicalin, a flavonoid monomer derived from Scutellaria baicalensis called Huangqin in mandarin, is the main active ingredient contributing to S. baicalensis' efficacy. It is known in China that baicalin has potential therapeutic effects on inflammatory diseases. However, its anti-inflammatory mechanism has still not b...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-015-0124-2
更新日期:2015-08-01 00:00:00
abstract::To investigate the role of glutathione (GSH) synthesis in the regulation on nuclear factor (NF)-kappaB activity and tumor necrosis factor-alpha (TNF-alpha) release by glutamine (GLN) in lipopolysaccharide (LPS)-stimulated alveolar type II (AT-II) epithelial cells of rat lungs. Primary cultured AT-II cells were pre-tre...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-008-9084-0
更新日期:2008-10-01 00:00:00
abstract::In the present study, the anti-inflammatory effect of piperine was investigated on monosodium urate crystal-induced inflammation in mice, an experimental model for gouty arthritis, and compared it with that of the nonsteroidal anti-inflammatory drug, indomethacin. The levels of lysosomal enzymes, lipid peroxidation, t...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-010-9222-3
更新日期:2011-06-01 00:00:00
abstract::Our study showed that S-methylisothiourea (SMT) had anti-inflammatory effects in treating herpes simplex encephalitis in mice, and SMT also induced apoptosis of herpes simplex virus (HSV-1)-infected microglial cells. Both animal and cell models were employed in this study. Both models included the following five group...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-010-9246-8
更新日期:2011-10-01 00:00:00
abstract::Neurodegenerative diseases such as Alzheimer, Parkinson, amyotrophic lateral sclerosis, and Huntington are incurable and debilitating conditions that result in progressive death of the neurons. The definite diagnosis of a neurodegenerative disorder is disadvantaged by the difficulty in obtaining biopsies and thereby t...
journal_title:Inflammation
pub_type: 杂志文章,评审
doi:10.1007/s10753-013-9780-2
更新日期:2014-06-01 00:00:00
abstract::Crohn's disease is an idiopathic, chronic inflammation of the gastrointestinal tract that causes narrowing and stricturing of primarily the small and large intestine. Although the mechanism(s) by which chronic inflammation promotes stricture formation remain to be defined, it does appear to be associated histologicall...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00916587
更新日期:1993-08-01 00:00:00
abstract::Systemic lupus erythematosus (SLE) is a chronic autoimmune disease which involves many organs and presents with various symptoms. It has been shown that genetic and environmental factors play a major role in this disease and may affect the onset, activity, damage, and mortality of the disease. According to recent stud...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-015-0201-6
更新日期:2015-12-01 00:00:00
abstract::Ruta graveolens L. (Rutaceae) are traditionally used for the treatment of rheumatism, arthritis and other inflammatory conditions in the traditional medicine of India, were evaluated for their protective effect in acute and chronic models of inflammation. Carrageenan induced rat paw edema and adjuvant induced arthriti...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-009-9154-y
更新日期:2010-02-01 00:00:00
abstract::In order to establish a model of lung disease in which the usefulness of potential antiinflammatory compounds can be evaluated, we have analyzed the biochemical and cellular responses of rabbits to zymosan deposition in their lungs. A suspension of zymosan particles was instilled into the lungs of rabbits using an int...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00917816
更新日期:1983-06-01 00:00:00
abstract::NSAIDs are widely used to alleviate the symptoms of OA. It remains controversial as to what effects these agents have on the progression of OA. In vitro studies showed several types of NSAIDs (e.g., sodium salicylate, indomethacin) inhibited the synthesis of cartilage matrix component, but some types of NSAIDs (e.g., ...
journal_title:Inflammation
pub_type: 杂志文章,评审
doi:10.1023/a:1015504632021
更新日期:2002-06-01 00:00:00
abstract::Previous data that alimentation with fish oil rich in eicosapentaenoic acid (EPA; 20:n-3) or vegetable oil rich in gamma-linolenic acid (GLA; 18:3n-6) can reduce symptoms of inflammatory skin disorders lead us to determine the effects of dietary supplements of oils rich in EPA or GLA on guinea pig (GP) neutrophil (PMN...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00914278
更新日期:1990-10-01 00:00:00
abstract::The present study evaluated the anti-inflammatory effect of nanoencapsulated curcuminoid preparations of poly(vinyl pyrrolidone) (Nano-cur) and free curcuminoids (Cur) in an experimental model of croton oil-induced cutaneous inflammation. Male Swiss mice, weighing 25-30 g, received oral treatment by gavage 1 h before ...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-020-01360-4
更新日期:2020-11-09 00:00:00