Abstract:
:This study aims to provide experimental proof that Rab6a is an efficient target of microRNA-155 in regulating pro-inflammatory tumor necrosis factor (TNF) secretion stimulated by lipopolysaccharide (LPS) in macrophages. We identified Rab6a as a new target of microRNA-155 (miR-155) and found that overexpression of miR-155 decreased Rab6a expression at both protein and mRNA levels, which resulted in a significant reduction of TNF secretion induced by lipopolysaccharide stimulation. We have demonstrated that miR-155 can negatively regulate inflammatory TNF secretion in lipopolysaccharide stimulated macrophages, partly by targeting Rab6a, thereby providing new insights into the role of miR-155 in cytokine secretion in inflammatory macrophages.
journal_name
Inflammationjournal_title
Inflammationauthors
Yang Y,Yang Ldoi
10.1007/s10753-015-0228-8subject
Has Abstractpub_date
2016-02-01 00:00:00pages
107-112issue
1eissn
0360-3997issn
1573-2576pii
10.1007/s10753-015-0228-8journal_volume
39pub_type
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