Diospyros blancoi attenuates asthmatic effects in a mouse model of airway inflammation.

abstract：:Inflammatory cells, macrophages induced by lipopolysaccharide (LPS) stimulation, lead to the production of inflammatory cytokines, which are crucial to host defense. MicroRNAs are short noncoding RNAs that regulate key biological processes via suppression of gene expression at posttranscriptional levels. Recently, miR...

journal_title：Inflammation

authors： He Y,Sun X,Huang C,Long XR,Lin X,Zhang L,Lv XW,Li J

更新日期：2014-02-01 00:00:00

abstract：:Sjögren's syndrome (SS) is a chronic autoimmune disease targeting salivary and lacrimal glands. C-X-C motif chemokine ligand 10 (CXCL10) expression is upregulated in lip salivary glands (LSGs) of primary SS (pSS) patients, and CXCL10 involved in SS pathogenesis via immune-cell accumulation. Moreover, interferon (IFN)-...

journal_title：Inflammation

authors： Aota K,Yamanoi T,Kani K,Ono S,Momota Y,Azuma M

更新日期：2021-02-01 00:00:00

abstract：:Neurodegenerative diseases such as Alzheimer, Parkinson, amyotrophic lateral sclerosis, and Huntington are incurable and debilitating conditions that result in progressive death of the neurons. The definite diagnosis of a neurodegenerative disorder is disadvantaged by the difficulty in obtaining biopsies and thereby t...

journal_title：Inflammation

authors： Nuzzo D,Picone P,Caruana L,Vasto S,Barera A,Caruso C,Di Carlo M

更新日期：2014-06-01 00:00:00

abstract：:Injury to podocytes leads to proteinuria, a hallmark of most glomerular diseases as well as being associated with the progression of kidney disease. Activation of the Wnt/β-catenin pathway is associated with the pathogenesis of podocyte dysfunction and can play a role in renal injury. Furthermore, the expression of fr...

journal_title：Inflammation

authors： Senouthai S,Wang J,Fu D,You Y

更新日期：2019-08-01 00:00:00

abstract：:Bee venom (BV) is used in folk medicine to treat arthritis. It has antiinflammatory effects in animal models of rheumatic disease. We have studied the effects of BV on human neutrophil production of superoxide (O2-) and hydrogen peroxide, finding potent, nontoxic, dose-dependent production inhibition. Melittin, the ma...

journal_title：Inflammation

authors： Somerfield SD,Stach JL,Mraz C,Gervais F,Skamene E

更新日期：1986-06-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is an autoimmune and inflammatory disease with strong genetic influence, especially upon immune response components. Several cytokines from the toll-like receptors activation pathway display recognized role for RA establishment. However, few studies have verified the role of key mediators suc...

journal_title：Inflammation

authors： Gomes da Silva IIF,Lima CAD,Silva JEA,Rushansky E,Mariano MHQA,Rolim P,Oliveira RDR,Louzada-Júnior P,Souto FO,Crovella S,de Azevêdo Silva J,Sandrin-Garcia P

更新日期：2021-01-06 00:00:00

abstract：:Strong anti-inflammatory activity has been found in Laminaria japonica dichloromethane fraction (LDF); however, the molecular mechanisms underlying its anti-inflammatory activity are not reported. Our results indicated that LDF inhibited LPS-induced nitric oxide and prostaglandin E(2) production in a dose-dependent ma...

journal_title：Inflammation

authors： Lee JY,Lee MS,Choi JW,Shin TS,Woo HC,Kim HR

更新日期：2012-10-01 00:00:00

abstract：:Protamine sulfate induces enzyme secretion from rabbit neutrophils. Enzyme secretion is mainly due to exocytosis but, depending on the experimental conditions, a small amount of cytolysis may occur. As compared with stimulation of neutrophil functions by other activators, protamine sulfate-induced enzyme release by ex...

journal_title：Inflammation

authors： Elferink JG,Deierkauf M

更新日期：1986-12-01 00:00:00

abstract：:The synthetic compound 7-4-[Bis-(2-hydroxyethyl)-amino]-butoxy-5-hydroxy-8-methoxy-2-phenylchromen-4-one (V8) is a novel flavonoid-derived compound. In this study, we investigated the effects of V8 on Toll-like receptor 4 (TLR4)-mediated inflammatory reaction in human cervical cancer SiHa cells and lipopolysaccharide ...

journal_title：Inflammation

authors： He A,Ji R,Shao J,He C,Jin M,Xu Y

更新日期：2016-02-01 00:00:00

abstract：:Endothelial activation with excessive recruitment and adhesion of immune cells plays a central role in the progression of sepsis. We established a microfluidic system to study the activation of human umbilical vein endothelial cells by conditioned medium containing plasma from lipopolysaccharide-stimulated whole blood...

journal_title：Inflammation

authors： Eichhorn T,Rauscher S,Hammer C,Gröger M,Fischer MB,Weber V

更新日期：2016-10-01 00:00:00

abstract：:Several experiments have detected that melatonin exerts a marked influence on the inflammatory process. In the present study we evaluated the effect of exogenous melatonin on the experimental granulomatous tissues in rat. Our data show that subcutaneous administration of different doses of melatonin given daily during...

journal_title：Inflammation

authors： de la Rocha NE,Rotelli AE,Guardia T,Pelzer LE

更新日期：2004-08-01 00:00:00

abstract：:Macrophage polarization is a dynamic and integral process of tissue inflammation and remodeling. Here we demonstrate an important role of Aurora kinase A in the regulation of inflammatory M1 macrophage polarization. We found that there was an elevated expression of Aurora-A in M1 macrophages and inhibition of Aurora-A...

journal_title：Inflammation

authors： Ding L,Gu H,Gao X,Xiong S,Zheng B

更新日期：2015-04-01 00:00:00

abstract：:Cyanidin-3-O-glucoside (C3G), an anthocyanin belonging to the flavonoid family and commonly present in food and vegetables in human diet, has exhibited anti-inflammatory and anti-oxidant effects. This study aimed to investigate the protective ability of C3G against inflammatory and oxidative injuries, as well as to cl...

journal_title：Inflammation

authors： Ma MM,Li Y,Liu XY,Zhu WW,Ren X,Kong GQ,Huang X,Wang LP,Luo LQ,Wang XZ

更新日期：2015-08-01 00:00:00

abstract：:Polymorphonuclear neutrophils are among the first defense against infection and closely involved in the initiation of inflammatory response. It is well recognized that this function of neutrophils was mainly mediated by phagocytosis, intracellular degradation, releasing of granules, and formation of neutrophil extrace...

journal_title：Inflammation

authors： Yang F,Feng C,Zhang X,Lu J,Zhao Y

更新日期：2017-02-01 00:00:00

abstract：:Mastitis is a major disease in humans and other animals and is characterized by mammary gland inflammation. It is a major disease of the dairy industry. Bergenin is an active constituent of the plants of genus Bergenia. Research indicates that bergenin has multiple biological activities, including anti-inflammatory an...

journal_title：Inflammation

authors： Gao XJ,Guo MY,Zhang ZC,Wang TC,Cao YG,Zhang NS

更新日期：2015-01-01 00:00:00

abstract：:The effects were studied of the non-specific phosphodiesterase inhibitor, theophylline (37.5-300 microM), on intracellular levels of cyclic adenosine monophosphate (cAMP) and superoxide generation following exposure of human neutrophils to four different stimuli of neutrophil membrane-associated oxidative metabolism, ...

journal_title：Inflammation

authors： Mahomed AG,Theron AJ,Anderson R,Feldman C

更新日期：1998-12-01 00:00:00

abstract：:Calgranulins are small calcium-binding proteins with several immunological functions involved in inflammatory processes. Calgranulin A is reported to be mainly associated with acute inflammation while calgranulin B seems to play a role in chronic inflammatory disorders. In this study we used a proteomic approach to an...

journal_title：Inflammation

authors： Bargagli E,Olivieri C,Prasse A,Bianchi N,Magi B,Cianti R,Bini L,Rottoli P

更新日期：2008-10-01 00:00:00

abstract：:The present study was designed to investigate the effects of pilose antler peptide (PAP) on lipopolysaccharide (LPS)-induced lung injury. BalB/c mice intraperitoneally received PAP (10 and 20 mg/kg) or dexamethasone (2 mg/kg) 1 h prior to intratracheal instillation of LPS. PAP significantly decreased lung wet-to-dry w...

journal_title：Inflammation

authors： Ma C,Long H,Yang C,Cai W,Zhang T,Zhao W

更新日期：2017-06-01 00:00:00

abstract：:IFN-τ, which is a type I interferon with low cytotoxicity, is defined as a pregnancy recognition signal in ruminants. Type I interferons have been used as anti-inflammatory agents, but their side effects limit their clinical application. The present study aimed to determine the anti-inflammatory effects of IFN-τ in a ...

journal_title：Inflammation

authors： Wu H,Zhao G,Jiang K,Chen X,Rui G,Qiu C,Guo M,Deng G

更新日期：2016-06-01 00:00:00

abstract：:Two different substances, glycogen and thioglycollate, were used to recruit early peritoneal exudate cells (4h). In the acute phase of the inflammatory response the cellular infiltrate is large, and the predominant cell (greater than 95%) is the polymorphonuclear neutrophil. Supernatant had differing effects on lympho...

journal_title：Inflammation

authors： Rodrick ML,Lamster IB,Sonis ST,Pender SG,Kolodkin AB,Fitzgerald JE,Wilson RE

更新日期：1982-03-01 00:00:00

abstract：:The objective of this study was to compare systemic and local cytokine profiles and neutrophil responses in patients with severe versus non-severe community-acquired pneumonia (CAP). Hospitalized patients with CAP were grouped according to the pneumonia severity index (PSI), as non-severe (PSI < 91 points) or severe (...

journal_title：Inflammation

authors： Fernandez-Botran R,Uriarte SM,Arnold FW,Rodriguez-Hernandez L,Rane MJ,Peyrani P,Wiemken T,Kelley R,Uppatla S,Cavallazzi R,Blasi F,Morlacchi L,Aliberti S,Jonsson C,Ramirez JA,Bordon J

更新日期：2014-08-01 00:00:00

abstract：:Simvastatin, which is primarily prescribed to lower cholesterol, may also mitigate lung injury caused by sepsis, although the mechanisms remain elusive. This study aimed to evaluate the protective effect of simvastatin on acute lung injury in rats with sepsis and to investigate possible mechanisms. Male Wistar rats we...

journal_title：Inflammation

authors： Wang Y,Yang W,Zhao X,Zhang R

更新日期：2018-02-01 00:00:00

abstract：:The present study was performed to explore the effect of aqueous extract of Aloe vera on behavioural parameters of pain. Pain assessment was performed by the tail-flick and formalin tests. A. vera (100 mg/kg, per oral (p.o.)) produced an insignificant decrease in the pain response in the tail-flick and formalin tests....

journal_title：Inflammation

authors： Rathor N,Mehta AK,Sharma AK,Mediratta PK,Sharma KK

更新日期：2012-12-01 00:00:00

abstract：:In the present study, we investigated the anti-inflammatory effect of roburic acid on production of nitric oxide (NO) and interlukin-6 (IL-6) in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells. We found that roburic acid reduced production of NO and IL-6, and the expression of inducible nitric oxide synt...

journal_title：Inflammation

authors： Chen Y,Ji N,Pan S,Zhang Z,Wang R,Qiu Y,Jin M,Kong D

更新日期：2017-12-01 00:00:00

abstract：:Various disease states are associated with eosinophilia and the release of eosinophil peroxidase (EPO) into the microenvironment. The present study targets the effects of low levels of EPO on macrophage (M phi) phagocytosis and intracellular killing of Candida albicans as well as M phi oxidative activity measured as t...

journal_title：Inflammation

authors： Lefkowitz DL,Lincoln JA,Howard KR,Stuart R,Lefkowitz SS,Allen RC

更新日期：1997-04-01 00:00:00

abstract：:The diabetic organism is unable to produce normal amount of granulation tissue which results in delayed wound healing, a significant clinical problem. In the present study, the effect of oral administration of aminoguanidine (AG), in the diabetes-induced inhibition of angiogenesis and granulation tissue formation was ...

journal_title：Inflammation

authors： Teixeira AS,Caliari MV,Rocha OA,Machado RD,Andrade SP

更新日期：1999-12-01 00:00:00

abstract：:Previous reports showed that Maresin 1 (MaR1) possessed organ protection effects and could attenuate acute lung injury. Here, we aim to figure out whether MaR1 can maintain the permeability of lung epithelial cells by regulating the expression of tight junction protein during lung injury. Monolayer of murine lung epit...

journal_title：Inflammation

authors： Chen L,Liu H,Wang Y,Xia H,Gong J,Li B,Yao S,Shang Y

更新日期：2016-12-01 00:00:00

abstract：:By the use of the nuclear microprobe technique, the concentrations of zinc in isolated erythrocytes, platelets, and granulocytes were measured in patients with rheumatoid arthritis, other inflammatory arthritides, and scleroderma. Markedly reduced cellular zinc values were found compared to those measured in healthy s...

journal_title：Inflammation

authors： Svenson KL,Hällgren R,Johansson E,Lindh U

更新日期：1985-06-01 00:00:00

abstract：:Two methods for quantitating polymorphonuclear leukocyte (PMN) accumulation in inflammatory skin lesions were studied. The lesions were produced in rats by intradermal injections of different dilutions of zymosan-activated plasma (ZAP). PMN accumulation in the skin lesions was estimated by determination of (1) homolog...

journal_title：Inflammation

authors： Lundberg C,Arfors KE

更新日期：1983-09-01 00:00:00

abstract：:Leukocyte chemoattractants markedly alter the morphology and membrane functions of leukocytes. Bacterial collagenase causes a change in cell shape similar to that seen with the leukocyte chemoattractant, f-Met-Leu-Phe, and also promotes capping of concanavalin A. Human neutrophils in suspension or adherent to cover gl...

journal_title：Inflammation

authors： Walter RJ

更新日期：1986-12-01 00:00:00