The Diverse Biological Functions of Neutrophils, Beyond the Defense Against Infections.

abstract：:The respiratory epithelium is often exposed to oxidant gases, including ozone from photochemical smog and toxic oxygen metabolites released from neutrophils recruited in conditions of airway inflammation. We evaluated DNA single strand break formation by alkaline elution as a measure of oxidant-induced DNA damage to b...

journal_title：Inflammation

authors： McDonald RJ,Pan LC,St George JA,Hyde DM,Ducore JM

更新日期：1993-12-01 00:00:00

abstract：:1,8-Cineol is a major monoterpene principally from eucalyptus essential oils and has been shown to exert anti-inflammatory, antiviral, and inhibitory of nuclear factor (NF)-kB effect. In the present study, we evaluated the effect of 1,8-cineol on mice infected with influenza A virus. We found that 1,8-cineol protects ...

journal_title：Inflammation

authors： Li Y,Lai Y,Wang Y,Liu N,Zhang F,Xu P

更新日期：2016-08-01 00:00:00

abstract：:Berberine (Ber), the major constituent of Coptidis Rhizoma, possesses anti-inflammatory properties. In this study, we investigated the effects of Ber on cigarette smoke (CS)-mediated acute lung inflammation. C57BL/6 mice (6-8 weeks) were exposed to CS to induce acute lung injury. Ber was used to pretreat CS-exposed mi...

journal_title：Inflammation

authors： Lin K,Liu S,Shen Y,Li Q

更新日期：2013-10-01 00:00:00

abstract：:The impact of several environmental and genetic factors on diabetes and its complications is well documented. It has also been established that cytokines play a key role in the regulation of immune responses which have been shown to be important in the pathogenesis of diabetes. Studies showed that single-nucleotide po...

journal_title：Inflammation

authors： Arababadi MK,Reza Mirzaei M,Ali Sajadi SM,Hassanshahi G,Ahmadabadi BN,Salehabadi VA,Derakhshan R,Kennedy D

更新日期：2012-06-01 00:00:00

abstract：:Ischemic stroke is a major cause of death and motor disabilities all over the world. It is a muti-factorial disorder associated with inflammatory, apoptotic, and oxidative responses. Nateglinide (NAT), an insulinotropic agent used for the treatment of type 2 diabetes mellitus, recently showed potential anti-inflammato...

journal_title：Inflammation

authors： Saad MAE,Fahmy MIM,Al-Shorbagy M,Assaf N,Hegazy AAE,El-Yamany MF

更新日期：2020-04-01 00:00:00

abstract：:Low-grade chronic systemic inflammation is often associated with chronic non-communicable diseases, and its most frequently used marker, the C-reactive protein (CRP), has become an identifier of such diseases as well as an independent predictor for cardiovascular disorders and mortality. CRP is produced in response to...

journal_title：Inflammation

authors： Moreto F,de Oliveira EP,Manda RM,Torezan GA,Teixeira O,Michelin E,Burini RC

更新日期：2013-02-01 00:00:00

abstract：:The role of peptide leukotrienes (p-LTs), especially LTC4 and LTD4 in liver disease, was investigated in mice experimental liver injury models. The liver injury was induced by the injection of bacterial lipopolysaccharide (LPS) into Corynebacterium parvum pretreated mice. Carbon tetrachloride (CCl4)-induced liver inju...

journal_title：Inflammation

authors： Nagai H,Shimazawa T,Yakuo I,Aoki M,Koda A,Kasahara M

更新日期：1989-12-01 00:00:00

abstract：:By the use of the nuclear microprobe technique, the concentrations of zinc in isolated erythrocytes, platelets, and granulocytes were measured in patients with rheumatoid arthritis, other inflammatory arthritides, and scleroderma. Markedly reduced cellular zinc values were found compared to those measured in healthy s...

journal_title：Inflammation

authors： Svenson KL,Hällgren R,Johansson E,Lindh U

更新日期：1985-06-01 00:00:00

abstract：:Diabetic neuropathy (DNP) is the most common chronic complication of diabetes. Elevated free fatty acids (FFAs) have been recently recognized as major causes of inflammation and are relevant to the functional changes of nerve system in diabetes. Trans-resveratrol (RESV), a polyphenolic natural compound, has long been ...

journal_title：Inflammation

authors： Xu H,Xiong C,He L,Wu B,Peng L,Cheng Y,Jiang F,Tan L,Tang L,Tu Y,Yang Y,Liu C,Gao Y,Li G,Zhang C,Liu S,Xu C,Wu H,Li G,Liang S

更新日期：2015-02-01 00:00:00

abstract：:Endoplasmic reticulum stress (ERS) plays an important role in cerebral ischemia-reperfusion injury (CIRI) by regulating apoptosis. Although the role of long non-coding RNA (LncRNA) KCNQ1OT1 in CIRI has been reported, the specific mechanism is still unclear. In this paper, the regulation of ERS by LncRNA KCNQ1OT1 in CI...

journal_title：Inflammation

authors： Li Y,Yi M,Wang D,Zhang Q,Yang L,Yang C

更新日期：2020-12-01 00:00:00

abstract：:The signaling system of phosphoinositides (PI) is involved in a variety of cell and tissue functions, including membrane trafficking, ion channel activity, cell cycle, apoptosis, differentiation, and cell and tissue polarity. Recently, PI and related molecules, such as the phosphoinositide-specific phospholipases C (P...

journal_title：Inflammation

authors： Lo Vasco VR,Leopizzi M,Chiappetta C,Puggioni C,Della Rocca C,Polonia P,Businaro R

更新日期：2013-08-01 00:00:00

abstract：:Chemical alteration of the glucocorticoid, methylprednisolone, has led to the introduction of a new class of compounds called the 21-aminosteroids (21-ASs). The purpose of this study was to investigate the effect of the 21-AS, U74389G, on silica-induced acute lung injury. Male Fischer 344 rats were treated intraperito...

journal_title：Inflammation

authors： Antonini JM,van Dyke K,DiMatteo M,Reasor MJ

更新日期：1995-02-01 00:00:00

abstract：:The possibility of inflammation and neutrophil activation in response to indoor air pollution (IAP) from biomass fuel use has been investigated. For this, 142 premenopausal, never-smoking women (median age, 34 years) who cook exclusively with biomass (wood, dung, crop wastes) and 126 age-matched control women who cook...

journal_title：Inflammation

authors： Banerjee A,Mondal NK,Das D,Ray MR

更新日期：2012-04-01 00:00:00

abstract：:The anti-inflammatory activities of kakkalide, a major constituent of the flower of Pueraria thunbergiana, and irisolidone, a metabolite of kakkalide produced by intestinal microflora, against carrageenan-induced inflammation in air pouches on the backs of mice and in lipopolysaccharide (LPS)-stimulated peritoneal mac...

journal_title：Inflammation

authors： Min SW,Park YJ,Kim DH

更新日期：2011-10-01 00:00:00

abstract：:This study analyzed the neutrophils and sera of patients with rheumatoid arthritis and of normal controls. No significant differences were found in the activities of the granular enzymes beta-glucuronidase and lysozyme or the cytoplasmic enzyme lactic dehydrogenase (LDH). Normal neutrophils were found to release signi...

journal_title：Inflammation

authors： Turner R,Martin M,Schroff J,Treadway W,DeChatelet L

更新日期：1979-07-01 00:00:00

abstract：:NSAIDs are widely used to alleviate the symptoms of OA. It remains controversial as to what effects these agents have on the progression of OA. In vitro studies showed several types of NSAIDs (e.g., sodium salicylate, indomethacin) inhibited the synthesis of cartilage matrix component, but some types of NSAIDs (e.g., ...

journal_title：Inflammation

authors： Ding C

更新日期：2002-06-01 00:00:00

abstract：:Karyopherin-α2 (KPNA2) functions as an adaptor that transports several proteins to the nucleus. We investigated the function and possible mechanisms of KPNA2 involved in rheumatoid arthritis (RA). Western blotting and immunohistochemistry showed the protein expression of KPNA2 increased in synovial tissue of RA patien...

journal_title：Inflammation

authors： Liu Z,Zhang D,Sun C,Tao R,Xu X,Xu L,Cheng H,Xiao M,Wang Y

更新日期：2015-12-01 00:00:00

abstract：:Although assist ventilation with FIO2 0.21 is the preferable mode of ventilation in the intensive care unit, sometimes controlled ventilation with hyperoxia is needed. But the impact of this setting has not been extensively studied in elderly subjects. We hypothesized that a high fraction of inspired oxygen (FiO(2)) a...

journal_title：Inflammation

authors： Andrade PV,dos Santos JM,Silva HC,Wilbert DD,Cavassani SS,Oliveira-Júnior IS

更新日期：2014-04-01 00:00:00

abstract：:Genetic messages for polypeptide growth factors were assessed in human alveolar macrophages, obtained by bronchoalveolar lavage (BAL) from normal subjects (N = 3) and from patients with pneumonia (N = 3), pulmonary lymphoma (N = 3), and idiopathic pulmonary fibrosis (N = 3). Complementary DNAs (cDNAs) were prepared by...

journal_title：Inflammation

authors： Adolff CH,Golden JA,Kennedy PW,Goetzl EJ,Turck CW

更新日期：1991-08-01 00:00:00

abstract：:Leukocyte chemoattractants markedly alter the morphology and membrane functions of leukocytes. Bacterial collagenase causes a change in cell shape similar to that seen with the leukocyte chemoattractant, f-Met-Leu-Phe, and also promotes capping of concanavalin A. Human neutrophils in suspension or adherent to cover gl...

journal_title：Inflammation

authors： Walter RJ

更新日期：1986-12-01 00:00:00

abstract：:IL-17-producing Th17 cells and IFN-γ and IL-17 double-producing Th1/17 cells have been identified as the pathogenic cells in inflammatory bowel disease (IBD). Retinoic acid-related orphan receptor γt (RORγt) is a master regulator for the differentiation and activation of Th17 and Th1/17 cells. We discovered a novel or...

journal_title：Inflammation

authors： Igaki K,Nakamura Y,Komoike Y,Uga K,Shibata A,Ishimura Y,Yamasaki M,Tsukimi Y,Tsuchimori N

更新日期：2019-02-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is an autoimmune disease accompanying excessive inflammatory responses. Phosphoinositide 3-kinase p110δ (PI3Kδ) is reported to associate with autoimmune conditions. We here aimed to determine whether selective inhibition of PI3Kδ is effective in a lupus model of BXSB mice, using the ...

journal_title：Inflammation

authors： Wang Y,Zhang L,Wei P,Zhang H,Liu C

更新日期：2014-06-01 00:00:00

abstract：:Aseptic joint loosening is a key factor that reduces the life span of arthroplasty. There are currently few effective treatments for joint loosening except surgical revision. We explored the inhibitory effects of p110β-targeted small interfering RNA (siRNA) and lentivirus on particle-induced inflammatory cytokine expr...

journal_title：Inflammation

authors： Huang JB,Ding Y,Huang DS,Zeng WK,Guan ZP,Zhang ML

更新日期：2013-10-01 00:00:00

abstract：:The U937 cell, a human monoblast cell line, has been used as a model to study the function of human monocytes. We investigated the effects of interferon-gamma (IFN-gamma) on superoxide anion (O2-) production, cell surface antigens, and cytokine production of U937 cells. IFN-gamma treatment enhanced O2- production of f...

journal_title：Inflammation

authors： Ishizuka T,Hirata I,Adachi M,Kurimoto F,Hisada T,Dobashi K,Mori M

更新日期：1995-12-01 00:00:00

abstract：:The adhesive interactions between phagocytes and endothelial cells (EC) can be modulated by inflammatory cytokines and chemotactic proteins which are released during an inflammatory response. The aim of the present study was to investigate first whether the adhesive properties of granulocytes and monocytes from asthma...

journal_title：Inflammation

authors： Verdegaal EM,Zegveld ST,Beekhuizen H,Bakker W,van Furth R

更新日期：1998-04-01 00:00:00

abstract：:It has been well established that diet high in cholesterol and saturated fatty acids could significantly elevate plasma cholesterol levels and also increase the risk of cardiovascular diseases. We hypothesize that repeated systemic Escherichia coli (E. coli) in conjunction with hypercholesterolemia, leads to developme...

journal_title：Inflammation

authors： Dutta K,Nandi D,Bishayi B

更新日期：2009-04-01 00:00:00

abstract：:Lipopolysaccharide (LPS) is demonstrated to cause "two-hit" injury to liver. Proprotein convertase subtilisin/kexin type 9 (PCSK9) plays an important role in LPS clearance. Hepatocyte nuclear factor-1 alpha (HNF-1α) and sterol regulatory element-binding protein 2 (SREBP2) were reported to be responsible for PCSK9 gene...

journal_title：Inflammation

authors： Zou Y,Li S,Xu B,Guo H,Zhang S,Cai Y

更新日期：2020-02-01 00:00:00

abstract：:Baicalein shows anti-inflammatory effects in human rheumatoid arthritis fibroblast-like synoviocytes (RAFLS). Considering its anti-proliferatory effects on various cancer cells, we investigated the effects of baicalein on interleukin-1 beta (IL-1β)-induced proliferation of human RAFLS. Cell proliferation was examined ...

journal_title：Inflammation

authors： Chen S,Yang Y,Feng H,Wang H,Zhao R,Liu H

更新日期：2014-02-01 00:00:00

abstract：:We have characterized leukocyte migration to the pleural cavity in a methylated-BSA (mBSA)-induced model of murine delayed-type hypersensitivity and evaluated the ability of IL-4 and IL-10 to modulate this response. Neutrophils, macrophages, T cells, and dendritic cells migrated to the pleural cavity in a time-depende...

journal_title：Inflammation

authors： Fine JS,Rojas-Triana A,Jackson JV,Engstrom LW,Deno GS,Lundell DJ,Bober LA

更新日期：2003-08-01 00:00:00

abstract：:In the present study the content of substance P (SP)-, neurokinin A (NKA)-, calcitonin gene-related peptide (CGRP)- and neuropeptide Y (NPY)-like immunoreactivity (-LI) was measured in rats cerebrospinal fluid (CSF), plasma and perfusates (PF) from both elbow enthesis during acute inflammation. Either substance P, SP,...

journal_title：Inflammation

authors： Haker E,Theodorsson E,Lundeberg T

更新日期：1997-02-01 00:00:00