Abstract:
:By the use of the nuclear microprobe technique, the concentrations of zinc in isolated erythrocytes, platelets, and granulocytes were measured in patients with rheumatoid arthritis, other inflammatory arthritides, and scleroderma. Markedly reduced cellular zinc values were found compared to those measured in healthy subjects. No relation was found to inflammatory activity or disease duration. Plasma zinc was reduced in the majority of the patients and was negatively correlated to the inflammatory activity estimated by ESR and serum orosomucoid. No relation was found between total zinc values in plasma or cells or disease duration. Corticosteroid therapy was instituted in a number of the patients with inflammatory arthritides and induced a significant elevation of total zinc in all cell types, although normalization was not achieved. Plasma zinc values remained unchanged during the treatment.
journal_name
Inflammationjournal_title
Inflammationauthors
Svenson KL,Hällgren R,Johansson E,Lindh Udoi
10.1007/BF00917591subject
Has Abstractpub_date
1985-06-01 00:00:00pages
189-99issue
2eissn
0360-3997issn
1573-2576journal_volume
9pub_type
杂志文章相关文献
INFLAMMATION文献大全abstract::Prostaglandin production was studied in cultures of pig aorta endothelial cells using radioimmunoassay, radiochromatography, and smooth muscle bioassay. PGE2 was produced in higher concentrations than other prostaglandins. Bradykinin produced a rapid dose-related stimulation of PGE2 production. These results provided ...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00911100
更新日期:1981-12-01 00:00:00
abstract::Our study is based on the establishment of a cohort of human obese omental adipose tissue and the culture of adipocytes in vitro. To observe the effect of high level of free fatty acid (FFA) on the expression of DNA methyltransferases (DNMTs) and the anti-inflammatory factor Kruppel-like factor 4 (KLF4) in adipocytes ...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-019-01168-x
更新日期:2020-06-01 00:00:00
abstract::Tizoxanide is the main active metabolite of nitazoxanide. Nitazoxanide and tizoxanide have a broad-spectrum anti-infective effect, including parasites, bacteria, and virus. In the present study, we investigated the anti-inflammatory effect of tizoxanide on lipopolysaccharide (LPS)-stimulated RAW264.7 cells and reveale...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-019-00994-3
更新日期:2019-08-01 00:00:00
abstract::An acute neutrophilic lung injury was compared in Balb/c normal and nu/nu (nude) mice to assess the role of T lymphocytes in the resolution of acute pulmonary neutrophilic inflammation following the administration of endotoxin. Maximal neutrophilic infiltration occurred on day 1 post-endotoxin treatment and declined t...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1023/a:1027393715300
更新日期:1997-06-01 00:00:00
abstract::Neuroinflammation is believed to be involved in the pathogenesis of neurodegenerative diseases. Our novel synthetic compound 2-acetyl-1-ethyl-7-hydroxy-6-methoxy-1, 2, 3, 4-tetrahydroisoquinoline (AETIQ) was tested for its anti-inflammatory properties in activated microglial BV-2 cells. AETIQ attenuated nitric oxide (...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-013-9795-8
更新日期:2014-06-01 00:00:00
abstract::In the present study the content of substance P (SP)-, neurokinin A (NKA)-, calcitonin gene-related peptide (CGRP)- and neuropeptide Y (NPY)-like immunoreactivity (-LI) was measured in rats cerebrospinal fluid (CSF), plasma and perfusates (PF) from both elbow enthesis during acute inflammation. Either substance P, SP,...
journal_title:Inflammation
pub_type: 杂志文章,收录出版
doi:10.1023/a:1027386724444
更新日期:1997-02-01 00:00:00
abstract::Dysregulated release of neutrophil reactive oxygen species and proteolytic enzymes contributes to both acute and chronic inflammatory diseases. Therefore, molecular regulators of these processes are potential targets for new anti-inflammatory therapies. We have shown previously that myristoylated alanine-rich C-kinase...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-014-0078-9
更新日期:2015-01-01 00:00:00
abstract::To investigate the effect of dexmedetomidine post-conditioning on the inflammatory response and autophagy effect of focal cerebral ischemia reperfusion injury in rats, and further to study its potential mechanisms. Water maze was conducted to evaluate spatial learning and memory ability of middle cerebral artery occlu...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-019-01082-2
更新日期:2019-12-01 00:00:00
abstract::Sepsis, a clinical syndrome occurring in patients following infection or injury, is a leading cause of morbidity and mortality worldwide. CD86 (B7-2) is a costimulatory molecule on antigen-presenting cells and plays critical roles in immune responses. In the current study, we investigated the association of two CD86 p...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-014-9997-8
更新日期:2015-04-01 00:00:00
abstract::Alveolar type I epithelial cells (AECIs) play an important role in the pathogenesis of acute lung injury. The receptor for advanced glycation end-products (RAGEs) is expressed at a high basal level in AECIs, and its soluble isoform is suggested as a marker of AECI injury. However, the molecular mechanism by which RAGE...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-014-9889-y
更新日期:2014-10-01 00:00:00
abstract::Immune dysfunction contributes to secondary infection and worse outcomes in sepsis. Regulatory T cells (Tregs) have been implicated in sepsis-induced immunosuppression. Nevertheless, the role of Tregs in secondary infection after sepsis remains to be determined. In the present study, a two-hit model which mimics clini...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-018-0821-8
更新日期:2018-10-01 00:00:00
abstract::Low-grade chronic systemic inflammation is often associated with chronic non-communicable diseases, and its most frequently used marker, the C-reactive protein (CRP), has become an identifier of such diseases as well as an independent predictor for cardiovascular disorders and mortality. CRP is produced in response to...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-012-9515-9
更新日期:2013-02-01 00:00:00
abstract::Alveolar macrophages (AM) are the primary target cell of the lung for inhaled mycobacterial pathogens. We investigated the effect of the synthetic lipopeptide MALP-2 on the interaction between AM from rats and Mycobacterium bovis BCG. AM were infected with M. bovis BCG at a multiplicity of infection (MOI) of 10 and th...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-009-9127-1
更新日期:2009-08-01 00:00:00
abstract::The respiratory burst is a series of metabolic events which result in the production of microbicidal oxidants by phagocytes. The enzyme responsible for the respiratory burst is a membrane-bound oxidase which catalyzes the production of O-2 by the NADPH-dependent reduction of oxygen. Activity of this oxidase is diminis...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00917260
更新日期:1983-09-01 00:00:00
abstract::To investigate whether oligomerization domains (NODs) are involved in Porphyromonas gingivalis-induced interleukin (IL)-6, IL-8, and vascular cell adhesion molecule (VCAM)-1 expression beyond Toll-like receptors (TLRs), we investigated the role of NOD1/2 in P. gingivalis-induced IL-6, IL-8, and VCAM-1 expression in hu...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-013-9766-0
更新日期:2014-04-01 00:00:00
abstract::Extracellular phospholipase A2 (PLA2) activity was detected in exudate from rat carrageenan-induced pleurisy using [3H]oleic acid-labeled Escherichia coli as substrate. Both exudate volume and PLA2 activity increased up to 24 h after carrageenin injection. Specific absorption of this activity by anti-group II PLA2 (PL...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00916098
更新日期:1993-04-01 00:00:00
abstract::Aseptic joint loosening is a key factor that reduces the life span of arthroplasty. There are currently few effective treatments for joint loosening except surgical revision. We explored the inhibitory effects of p110β-targeted small interfering RNA (siRNA) and lentivirus on particle-induced inflammatory cytokine expr...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-013-9636-9
更新日期:2013-10-01 00:00:00
abstract::Four methods of severe disruption of human neutrophil membrane integrity resulted in the formation of substantial amounts of leukotriene B4 and its isomers. This synthesis took place from endogenous substrate in the absence of any cell activators. It is postulated that leukotriene formation could be a preserved cell f...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00916396
更新日期:1988-04-01 00:00:00
abstract::IL-17-producing Th17 cells and IFN-γ and IL-17 double-producing Th1/17 cells have been identified as the pathogenic cells in inflammatory bowel disease (IBD). Retinoic acid-related orphan receptor γt (RORγt) is a master regulator for the differentiation and activation of Th17 and Th1/17 cells. We discovered a novel or...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-018-0875-7
更新日期:2019-02-01 00:00:00
abstract::The ability of peripheral blood neutrophils to injure elements of the alveolar septum was assessed. Experiments consisted of activating previously isolated neutrophils (PMNs) with a soluble (phorbol myristate acetate, PMA) and a particulate (zymosan) trigger, and measuring detachment of 51Cr-labeled epithelial cells. ...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00917512
更新日期:1992-02-01 00:00:00
abstract::Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by debilitating pain, cartilage destruction, and loss of joint function. Management of RA includes drugs that target NF-κB and downstream cytokine production. Therefore, molecules that act by inhibiting this signaling pathway without the severe si...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-017-0642-1
更新日期:2017-12-01 00:00:00
abstract::The etiology of the most autoimmune disorders is largely yet to be understood. However, major target antigens have been determined against some of clinically important molecules of human autoimmune diseases, such as insulin in type 1 diabetes mellitus (T1DM). T1DM is believed to be resulted from immune-mediated destru...
journal_title:Inflammation
pub_type: 杂志文章,评审
doi:10.1007/s10753-012-9555-1
更新日期:2013-04-01 00:00:00
abstract::Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease, in which pathogenesis is not clear. Many research demonstrated that fibroblast-like synoviocytes (FLSs) play a key role in RA pathogenesis, join in the cartilage injury and hyperplasia of the synovium, and contribute to the release of inflammatory...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-017-0591-8
更新日期:2017-10-01 00:00:00
abstract::Polymorphonuclear neutrophils are among the first defense against infection and closely involved in the initiation of inflammatory response. It is well recognized that this function of neutrophils was mainly mediated by phagocytosis, intracellular degradation, releasing of granules, and formation of neutrophil extrace...
journal_title:Inflammation
pub_type: 杂志文章,评审
doi:10.1007/s10753-016-0458-4
更新日期:2017-02-01 00:00:00
abstract::To investigate patients with severe acute pancreatitis (SAP) by dynamic levels of pro-/anti-inflammatory cytokines and endotoxin (ET) in plasma and the relationship between immunity and infection, organ dysfunction. Seventy-two patients with SAP were recruited. The ET, tumor necrosis factor-α (TNF-α), interleukin-6 (I...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-010-9205-4
更新日期:2011-02-01 00:00:00
abstract::The aim of this study was to investigate the effect of high-intensity swimming exercise (HISE) on atopic dermatitis (AD). For the study, we established an AD model in BALB/c mice by repeated local exposure of house dust mite extract (Dermatophagoides farinae extract, DFE) and 1-chloro-2,4-dinitrobenzene (CDNB) to the ...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-014-9843-z
更新日期:2014-08-01 00:00:00
abstract::Exposure to ultraviolet (UV) light impairs the function of inflammatory cells. Urocanic acid (UCA) in an stratum corneum has been suggested as a mediator in the immunosuppression of lymphoid cells detected after irradiation with UVB (UV wavelengths 280-320 nm). In this study, we examined the effects of the two UCA iso...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF01487038
更新日期:1996-10-01 00:00:00
abstract::Induction of hypoxia for 2.5 h in perfused cat livers resulted in a 10-fold increase in cathepsin D and a 15-fold increase in lactic dehydrogenase (LDH) activities in the perfusate and a 42% depression of the clearance rate of particles by the reticuloendothelial system (RES). Addition of 10(-3) M methylprednisolone (...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00920336
更新日期:1976-12-01 00:00:00
abstract::Lipopolysaccharide (LPS) can activate endothelial cells and induce inflammatory injury. Toll-like receptor-4 (TLR-4) is integrally involved in LPS signaling and has a requisite role in the activation of nuclear factor (NF)-κB. A number of studies have demonstrated the cytoprotective action of perfluorocarbon (PFC) bot...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-012-9572-0
更新日期:2013-04-01 00:00:00
abstract::Human blood leukocytes generated large amounts of superoxide (O2-) following stimulation by certain "cocktails" of soluble agents consisting of poly-L-arginine (PARG), phytohemagglutinin, the chemotactic peptide formyl-methionyl-leucyl-phenylalanine and polyanethole sulfanote (liquoid). A variety of cytochalasins, whi...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00916335
更新日期:1985-12-01 00:00:00