Cytoprotection of perfluorocarbon on PMVECs in vitro.

Abstract:

:Lipopolysaccharide (LPS) can activate endothelial cells and induce inflammatory injury. Toll-like receptor-4 (TLR-4) is integrally involved in LPS signaling and has a requisite role in the activation of nuclear factor (NF)-κB. A number of studies have demonstrated the cytoprotective action of perfluorocarbon (PFC) both in vivo and in vitro, but the exact mechanisms have yet to be elucidated. In this study, we examined in an in vitro model the cytoprotective effect of PFC on LPS-stimulated pulmonary vascular endothelial cells (PMVECs). Intercellular adhesion molecule-1 (ICAM-1), tumor necrosis factor-α (TNF-α), and interleukin-8 (IL-8) were significantly increased in the LPS-stimulated PMVECs groups. The expression of TLR-4 mRNA and protein in LPS groups was markedly increased. Meanwhile, NF-κB was activated. There were no significant effects of PFC alone on any of the factors studied while the coculture group showed significant downregulation of the secretion of ICAM-1, TNF-α, and IL-8; the expression of TLR-4 mRNA; and the activity of NF-κB. LPS can induce PMVEC inflammatory injury via the activation of TLR-4 and subsequent activation of NF-κB. PFC is able to protect PMVECs from LPS-induced inflammatory injury by blocking the initiation of the LPS signaling pathway.

journal_name

Inflammation

journal_title

Inflammation

authors

Xu S,Wang P,Wei K,Liu F,Liang Z,Zhao X,Li A,Chen L

doi

10.1007/s10753-012-9572-0

subject

Has Abstract

pub_date

2013-04-01 00:00:00

pages

512-20

issue

2

eissn

0360-3997

issn

1573-2576

journal_volume

36

pub_type

杂志文章
  • Effects of Naringenin on inflammation in complete freund's adjuvant-induced arthritis by regulating Bax/Bcl-2 balance.

    abstract::Naringin (COG) is a flavanone with various bioactivities including an expectorant effect, antitussive effect, and inhibitory effect on asthma and acute lung injury. The aims of the present study were to investigate the antiarthritis activities of COG and elucidate the underlying mechanisms with regard to its molecular...

    journal_title:Inflammation

    pub_type: 杂志文章

    doi:10.1007/s10753-014-0027-7

    authors: Zhu L,Wang J,Wei T,Gao J,He H,Chang X,Yan T

    更新日期:2015-02-01 00:00:00

  • AETIQ: a novel synthetic compound with anti-inflammatory properties in activated microglia.

    abstract::Neuroinflammation is believed to be involved in the pathogenesis of neurodegenerative diseases. Our novel synthetic compound 2-acetyl-1-ethyl-7-hydroxy-6-methoxy-1, 2, 3, 4-tetrahydroisoquinoline (AETIQ) was tested for its anti-inflammatory properties in activated microglial BV-2 cells. AETIQ attenuated nitric oxide (...

    journal_title:Inflammation

    pub_type: 杂志文章

    doi:10.1007/s10753-013-9795-8

    authors: Son HJ,Shin N,Shin EJ,Chi DY,Seo JW,Lee CS,Hwang O

    更新日期:2014-06-01 00:00:00

  • Protective effects of Lactobacillus plantarum NDC 75017 against lipopolysaccharide-induced liver injury in mice.

    abstract::This study investigated the protective effect of Lactobacillus plantarum NDC 75017 (L. plantarum NDC 75017) against acute liver injury induced by lipopolysaccharide (LPS). Thirty male mice were randomly divided into the control, LPS, and LPS + L. plantarum NDC 75017 groups. In the LPS + L. plantarum group, the mice we...

    journal_title:Inflammation

    pub_type: 杂志文章

    doi:10.1007/s10753-014-9886-1

    authors: Peng X,Jiang Y

    更新日期:2014-10-01 00:00:00

  • Leukotriene production associated with leukocyte membrane destruction: evidence of a terminal signal.

    abstract::Four methods of severe disruption of human neutrophil membrane integrity resulted in the formation of substantial amounts of leukotriene B4 and its isomers. This synthesis took place from endogenous substrate in the absence of any cell activators. It is postulated that leukotriene formation could be a preserved cell f...

    journal_title:Inflammation

    pub_type: 杂志文章

    doi:10.1007/BF00916396

    authors: Green FA

    更新日期:1988-04-01 00:00:00

  • Different effects of melatonin on experimental granulomatous inflammation.

    abstract::Several experiments have detected that melatonin exerts a marked influence on the inflammatory process. In the present study we evaluated the effect of exogenous melatonin on the experimental granulomatous tissues in rat. Our data show that subcutaneous administration of different doses of melatonin given daily during...

    journal_title:Inflammation

    pub_type: 杂志文章

    doi:10.1023/b:ifla.0000049043.89586.89

    authors: de la Rocha NE,Rotelli AE,Guardia T,Pelzer LE

    更新日期:2004-08-01 00:00:00

  • TanshinoneIIA Alleviates Inflammatory Response and Directs Macrophage Polarization in Lipopolysaccharide-Stimulated RAW264.7 Cells.

    abstract::TanshinoneIIA (TanIIA) has been demonstrated to possess numerous biological effects. However, the specific effect of TanIIA on macrophage polarization has not been reported. In this study, it was revealed that TanIIA might play a pivotal role in macrophage polarization. As our results indicated, cell morphology was ch...

    journal_title:Inflammation

    pub_type: 杂志文章

    doi:10.1007/s10753-018-0891-7

    authors: Gao S,Wang Y,Li D,Guo Y,Zhu M,Xu S,Mao J,Fan G

    更新日期:2019-02-01 00:00:00

  • Gram-negative, but not Gram-positive, bacteria elicit strong PGE2 production in human monocytes.

    abstract::Gram-positive and Gram-negative bacteria induce different cytokine patterns in human mononuclear cells. We have seen that Gram-positives preferentially induce IL-12 and TNF-alpha, whereas Gram-negatives induce more IL-10, IL-6, and IL-8. In this study, we compared the capacity of these two groups of bacteria to induce...

    journal_title:Inflammation

    pub_type: 杂志文章

    doi:10.1023/b:ifla.0000006700.41614.21

    authors: Hessle CC,Andersson B,Wold AE

    更新日期:2003-12-01 00:00:00

  • Correction to: Inhibition of C3a/C3aR Axis in Diverse Stages of Ulcerative Colitis Affected the Prognosis of UC by Modulating the Pyroptosis and Expression of Caspase-11.

    abstract::Following publication of our article [1], we noticed an error in Fig. 1. ...

    journal_title:Inflammation

    pub_type: 已发布勘误

    doi:10.1007/s10753-020-01380-0

    authors: Zhang X,Chen Y,Yu S,Jin B,Liu W

    更新日期:2020-11-10 00:00:00

  • Do NSAIDs affect the progression of osteoarthritis?

    abstract::NSAIDs are widely used to alleviate the symptoms of OA. It remains controversial as to what effects these agents have on the progression of OA. In vitro studies showed several types of NSAIDs (e.g., sodium salicylate, indomethacin) inhibited the synthesis of cartilage matrix component, but some types of NSAIDs (e.g., ...

    journal_title:Inflammation

    pub_type: 杂志文章,评审

    doi:10.1023/a:1015504632021

    authors: Ding C

    更新日期:2002-06-01 00:00:00

  • The association between self-reported symptoms of recent airway infection and CRP values in a general population.

    abstract::C-reactive protein (CRP) is a much used biomarker for respiratory tract infection; however, the influence of airway infection on the CRP level in the general population has not been well described. The study aimed to evaluate the impact of recent symptoms of airway infection on the CRP level and how the predictive pow...

    journal_title:Inflammation

    pub_type: 杂志文章

    doi:10.1007/s10753-011-9405-6

    authors: Melbye H,Amundsen K,Brox J,Eggen AE

    更新日期:2012-06-01 00:00:00

  • STAT1 regulates MD-2 expression in monocytes of sepsis via miR-30a.

    abstract::Sepsis is a major cause of morbidity and mortality in critically ill patients. MD-2 is a 25-kDa lipopolysaccharide (LPS)-binding protein that forms a heterodimer with TLR42, but its regulation in sepsis is not clear. This study aims to investigate the molecular mechanism of regulation of MD-2. Inflammation cytokines i...

    journal_title:Inflammation

    pub_type: 杂志文章

    doi:10.1007/s10753-014-9922-1

    authors: Wang Y,Li T,Wu B,Liu H,Luo J,Feng D,Shi Y

    更新日期:2014-12-01 00:00:00

  • Contrasting inflammatory responses in severe and non-severe community-acquired pneumonia.

    abstract::The objective of this study was to compare systemic and local cytokine profiles and neutrophil responses in patients with severe versus non-severe community-acquired pneumonia (CAP). Hospitalized patients with CAP were grouped according to the pneumonia severity index (PSI), as non-severe (PSI < 91 points) or severe (...

    journal_title:Inflammation

    pub_type: 杂志文章

    doi:10.1007/s10753-014-9840-2

    authors: Fernandez-Botran R,Uriarte SM,Arnold FW,Rodriguez-Hernandez L,Rane MJ,Peyrani P,Wiemken T,Kelley R,Uppatla S,Cavallazzi R,Blasi F,Morlacchi L,Aliberti S,Jonsson C,Ramirez JA,Bordon J

    更新日期:2014-08-01 00:00:00

  • Hydrogen peroxide in exhaled breath condensate (EBC) vs eosinophil count in induced sputum (IS) in parenchymal vs airways lung diseases.

    abstract::We compared exhaled breath condensate (EBC) and induced sputum (IS) for assessing inflammation in pulmonary diseases in patients with obstructive lung disease (n = 20), persistent cough >6 months (n = 20), interstitial lung disease (n = 25) and controls (n = 10). EBC was collected by suspending a Teflon perfluoroalkox...

    journal_title:Inflammation

    pub_type: 杂志文章

    doi:10.1007/s10753-007-9020-8

    authors: Fireman E,Shtark M,Priel IE,Shiner R,Mor R,Kivity S,Fireman Z

    更新日期:2007-04-01 00:00:00

  • Sinapic Acid Inhibits the IL-1β-Induced Inflammation via MAPK Downregulation in Rat Chondrocytes.

    abstract::Osteoarthritis (OA) is a degenerative joint disease frequently seen in the elderly population. Sinapic acid (SA), a commonly found phenolic acid, has been pharmacologically evaluated for its anti-inflammation effects in various studies. To explore its potential therapeutic role for OA, rat chondrocytes were treated wi...

    journal_title:Inflammation

    pub_type: 杂志文章

    doi:10.1007/s10753-017-0712-4

    authors: Huang X,Pan Q,Mao Z,Zhang R,Ma X,Xi Y,You H

    更新日期:2018-03-01 00:00:00

  • Effect of human leukocyte extracts and gingival exudate on periodontopathic bacteria.

    abstract::The effect of leukocyte hydrolytic enzymes on periodontopathic bacteria was examined in vitro. A frozen and thawed extract of human peripheral blood leukocytes (LE) and human gingival crevicular exudate (GE) were shown to be able to cause the release of 50% of the radioactivity from a leukotoxic strain of Actinobacill...

    journal_title:Inflammation

    pub_type: 杂志文章

    doi:10.1007/BF00917824

    authors: Sela MN

    更新日期:1983-06-01 00:00:00

  • Imbalance between macrophage migration inhibitory factor and cortisol induces multiple organ dysfunction in patients with blunt trauma.

    abstract::Migration inhibitory factor (MIF) is associated with multiple organ dysfunction syndrome (MODS) in patients with systemic inflammatory response syndrome (SIRS). Our purposes were to determine the serum MIF, cortisol, and tumor narcosis factor-α (TNF-α) and to investigate the influences of the balance between the level...

    journal_title:Inflammation

    pub_type: 杂志文章

    doi:10.1007/s10753-010-9223-2

    authors: Hayakawa M,Katabami K,Wada T,Minami Y,Sugano M,Shimojima H,Kubota N,Uegaki S,Sawamura A,Gando S

    更新日期:2011-06-01 00:00:00

  • Bee venom melittin blocks neutrophil O2- production.

    abstract::Bee venom (BV) is used in folk medicine to treat arthritis. It has antiinflammatory effects in animal models of rheumatic disease. We have studied the effects of BV on human neutrophil production of superoxide (O2-) and hydrogen peroxide, finding potent, nontoxic, dose-dependent production inhibition. Melittin, the ma...

    journal_title:Inflammation

    pub_type: 杂志文章

    doi:10.1007/BF00915999

    authors: Somerfield SD,Stach JL,Mraz C,Gervais F,Skamene E

    更新日期:1986-06-01 00:00:00

  • Review: the Role and Mechanisms of Macrophage Autophagy in Sepsis.

    abstract::Sepsis is a systemic inflammatory response syndrome caused by infection. The core mechanism underlying sepsis is immune dysfunction, with macrophages, as important cells of the innate immune system, playing an essential role. Autophagy has been shown to be closely related to inflammation and immunity, and autophagy en...

    journal_title:Inflammation

    pub_type: 杂志文章,评审

    doi:10.1007/s10753-018-0890-8

    authors: Qiu P,Liu Y,Zhang J

    更新日期:2019-02-01 00:00:00

  • Induction of neutrophil Mac-1 integrin expression and superoxide production by the medicinal plant extract gossypol.

    abstract::Gossypol is present in antiinflammatory poultices made from the medicinal tree Thespesia populnea. Isolated human neutrophils exposed to 3-20 microM gossypol for 15-90 min were assayed in vitro for superoxide production and surface expression of Mac-1 (CD11b/CD18). Gossypol increased superoxide production in a time- a...

    journal_title:Inflammation

    pub_type: 杂志文章

    doi:10.1007/BF01560692

    authors: Benhaim P,Mathes SJ,Hunt TK,Scheuenstuhl H,Benz CC

    更新日期:1994-10-01 00:00:00

  • Cyanidin-3-O-Glucoside Ameliorates Lipopolysaccharide-Induced Injury Both In Vivo and In Vitro Suppression of NF-κB and MAPK Pathways.

    abstract::Cyanidin-3-O-glucoside (C3G), an anthocyanin belonging to the flavonoid family and commonly present in food and vegetables in human diet, has exhibited anti-inflammatory and anti-oxidant effects. This study aimed to investigate the protective ability of C3G against inflammatory and oxidative injuries, as well as to cl...

    journal_title:Inflammation

    pub_type: 杂志文章

    doi:10.1007/s10753-015-0144-y

    authors: Ma MM,Li Y,Liu XY,Zhu WW,Ren X,Kong GQ,Huang X,Wang LP,Luo LQ,Wang XZ

    更新日期:2015-08-01 00:00:00

  • Roburic Acid Suppresses NO and IL-6 Production via Targeting NF-κB and MAPK Pathway in RAW264.7 Cells.

    abstract::In the present study, we investigated the anti-inflammatory effect of roburic acid on production of nitric oxide (NO) and interlukin-6 (IL-6) in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells. We found that roburic acid reduced production of NO and IL-6, and the expression of inducible nitric oxide synt...

    journal_title:Inflammation

    pub_type: 杂志文章

    doi:10.1007/s10753-017-0636-z

    authors: Chen Y,Ji N,Pan S,Zhang Z,Wang R,Qiu Y,Jin M,Kong D

    更新日期:2017-12-01 00:00:00

  • Propofol Protects Rats and Human Alveolar Epithelial Cells Against Lipopolysaccharide-Induced Acute Lung Injury via Inhibiting HMGB1 Expression.

    abstract::High-mobility group box 1 (HMGB1) plays a key role in the development of acute lung injury (ALI). Propofol, a general anesthetic with anti-inflammatory properties, has been suggested to be able to modulate lipopolysaccharide (LPS)-induced ALI. In this study, we investigated the effects of propofol on the expression of...

    journal_title:Inflammation

    pub_type: 杂志文章

    doi:10.1007/s10753-016-0330-6

    authors: Wang X,Liu C,Wang G

    更新日期:2016-06-01 00:00:00

  • The anti-inflammatory mechanism of heme oxygenase-1 induced by hemin in primary rat alveolar macrophages.

    abstract::Alveolar macrophages (AMs) can initiate lung inflammation by producing pro-inflammatory cytokines and chemokines, but they participate actively in the prevention of inflammation during acute lung injury (ALI). Heme oxygenase-1 (HO-1) is mainly expressed in AMs and has anti-inflammatory properties in ALI, but the anti-...

    journal_title:Inflammation

    pub_type: 杂志文章

    doi:10.1007/s10753-011-9415-4

    authors: Hualin C,Wenli X,Dapeng L,Xijing L,Xiuhua P,Qingfeng P

    更新日期:2012-06-01 00:00:00

  • No Association Between -159C/T Polymorphism of the CD14 Gene and Asthma Risk: a Meta-Analysis of 36 Case-Control Studies.

    abstract::Numerous studies have evaluated the association between -159C/T polymorphism of the CD14 gene and asthma risk; however, these studies have yielded inconsistent results. We performed meta-analyses to investigate the association between CD14-159C/T polymorphism and asthma risk. Studies were identified from PubMed, Embas...

    journal_title:Inflammation

    pub_type: 杂志文章,meta分析

    doi:10.1007/s10753-015-0269-z

    authors: Zhang R,Deng R,Li H,Chen H

    更新日期:2016-02-01 00:00:00

  • Salidroside Decreases Atherosclerosis Plaque Formation via Inhibiting Endothelial Cell Pyroptosis.

    abstract::Pyroptosis, a new pro-inflammatory programmed cell death, is linked to atherosclerosis (AS). Our previous studies suggested that salidroside (SAL) can alleviate AS and exert anti-oxidative and anti-inflammatory properties. However, the effect of SAL on atherosclerosis-related pyroptosis has not been studied. Here, we ...

    journal_title:Inflammation

    pub_type: 杂志文章

    doi:10.1007/s10753-019-01106-x

    authors: Xing SS,Yang J,Li WJ,Li J,Chen L,Yang YT,Lei X,Li J,Wang K,Liu X

    更新日期:2020-04-01 00:00:00

  • Immunodeficiency in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease.

    abstract::Chronic obstructive pulmonary disease (COPD), characterized by progressive airway inflammation and irreversible airflow limitation, leads to serious decline in life quality. The acute exacerbation of COPD (AECOPD) results in high healthcare costs as well as a significant mortality rate. The most common cause of acute ...

    journal_title:Inflammation

    pub_type: 杂志文章,评审

    doi:10.1007/s10753-018-0830-7

    authors: Xie S,Wang K,Zhang W,Xiao K,Yan P,Li Y,He W,Zhang Y,Xie L

    更新日期:2018-10-01 00:00:00

  • An experimental study of the neurogenic and the immunological contribution to "tennis elbow" in rats.

    abstract::In the present study the content of substance P (SP)-, neurokinin A (NKA)-, calcitonin gene-related peptide (CGRP)- and neuropeptide Y (NPY)-like immunoreactivity (-LI) was measured in rats cerebrospinal fluid (CSF), plasma and perfusates (PF) from both elbow enthesis during acute inflammation. Either substance P, SP,...

    journal_title:Inflammation

    pub_type: 杂志文章,收录出版

    doi:10.1023/a:1027386724444

    authors: Haker E,Theodorsson E,Lundeberg T

    更新日期:1997-02-01 00:00:00

  • Pleural macrophages differentially alter mesothelial cell growth and collagen production.

    abstract::Intrapleural tetracycline (TCN) results in pleural macrophage influx and pleural fibrosis; intrapleural carrageenan (CAR) induces macrophage influx without fibrosis. Because macrophage products can modulate mesothelial cell activity, we investigated the role of TCN- and CAR-induced pleural macrophages on mesothelial c...

    journal_title:Inflammation

    pub_type: 杂志文章

    doi:10.1007/BF00916387

    authors: Baumann MH,Heinrich K,Sahn SA,Strange C

    更新日期:1993-02-01 00:00:00

  • A Spotlight on the Underlying Activation Mechanisms of the NLRP3 Inflammasome and its Role in Atherosclerosis: A Review.

    abstract::The world's number one cause of death is cardiovascular diseases. The pathogenesis of different disease entities in the cardiovascular disease spectrum is complicated and multifactorial. Inflammation in these complicated etiologies serves as a key position and is a significant cause of atherosclerosis, which contribut...

    journal_title:Inflammation

    pub_type: 杂志文章,评审

    doi:10.1007/s10753-020-01290-1

    authors: Liaqat A,Asad M,Shoukat F,Khan AU

    更新日期:2020-12-01 00:00:00

  • Granulocyte stimulating factor in patients on peritoneal dialysis and LPS stimulated peripheral blood mononuclear cells.

    abstract::Dialysate and serum levels of granulocyte-colony stimulating factor (G-CSF), granulocyte macrophage colony stimulating factor (GM-CSF) and leukemia inhibitory factor (LIF) were analyzed in patients with continuous ambulatory peritoneal dialysis (CAPD). Samples from the peritoneal effluent and from serum were obtained ...

    journal_title:Inflammation

    pub_type: 杂志文章

    doi:10.1023/a:1022320916105

    authors: Brauner A,Hylander B,Lu Y

    更新日期:1998-08-01 00:00:00