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Imbalance between macrophage migration inhibitory factor and cortisol induces multiple organ dysfunction in patients with blunt trauma.

Abstract：

:Migration inhibitory factor (MIF) is associated with multiple organ dysfunction syndrome (MODS) in patients with systemic inflammatory response syndrome (SIRS). Our purposes were to determine the serum MIF, cortisol, and tumor narcosis factor-α (TNF-α) and to investigate the influences of the balance between the levels of MIF and cortisol in patients with blunt trauma. The cortisol levels were identical between the patients with and without MODS. However, the MIF and TNF-α levels in the patients with MODS were statistically higher than those of the patients without MODS. The cortisol/MIF ratios in the patients with MODS were statistically higher than those of the patients without MODS. The results show that MIF and TNF-α play an important role together in posttraumatic inflammatory response. An excessive serum MIF elevation overrides the anti-inflammatory effects of cortisol and leads to persistent SIRS followed by MODS in blunt trauma patients.

journal_name

Inflammation

journal_title

Inflammation

authors

Hayakawa M,Katabami K,Wada T,Minami Y,Sugano M,Shimojima H,Kubota N,Uegaki S,Sawamura A,Gando S

doi

10.1007/s10753-010-9223-2

subject

Has Abstract

pub_date

2011-06-01 00:00:00

pages

193-7

issue

3

eissn

0360-3997

issn

1573-2576

journal_volume

34

pub_type

杂志文章

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