Abstract:
:Recombinant human tumor necrosis factor-alpha (rTNF) stimulated increased generation of superoxide anion (O2-) by human neutrophils in a concentration-dependent fashion. Preincubation of human neutrophils with rTNF (2.2-2200 units/ml) for 10 min enhanced the subsequent generation of O2- in response to C5a and f-Met-Leu-Phe (FMLP). Recombinant TNF did not enhance O2- generation by neutrophils stimulated with phorbol myristate acetate (PMA). Recombinant TNF alone failed to induce release of myeloperoxidase (MPO) and lysozyme by neutrophils. However, it did enhance the release of MPO and lysozyme by neutrophils stimulated with C5a and FMLP, but not with PMA. Although rTNF alone (0.001-50,000 units/ml) was not chemotactic for neutrophils, preincubation of neutrophils with rTNF (0.001-0.1 units/ml) enhanced the chemotactic activity of suboptimal concentrations of C5a (0.1 nM) and FMLP (5 nM). Neutrophils treated with high concentrations of rTNF (100-10,000 units/ml) showed inhibition of random movement and of chemotaxis induced by C5a or FMLP. We conclude from these studies that rTNF primes neutrophils for enhanced responses to subsequent stimuli and thus may augment the inflammatory response by increased oxidant production and lysosomal enzyme release and promote down-regulation of chemotactic movement.
journal_name
Inflammationjournal_title
Inflammationauthors
Bajaj MS,Kew RR,Webster RO,Hyers TMdoi
10.1007/BF00918813keywords:
subject
Has Abstractpub_date
1992-06-01 00:00:00pages
241-50issue
3eissn
0360-3997issn
1573-2576journal_volume
16pub_type
杂志文章相关文献
INFLAMMATION文献大全abstract::Postoperative ileus is a common complication after intra-abdominal surgery. Nitric oxide produced by macrophages in the inflamed gastrointestinal tract plays a crucial role in the pathogeny of postoperative ileus. Honokiol, extracted from the bark of Magnolia spp., is a natural compound with a biphenolic structure. In...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-017-0576-7
更新日期:2017-08-01 00:00:00
abstract::Induction of colitis by 2,4,6-Trinitrobenzenesulphonic acid (TNB) in the rat is a widely used experimental model of inflammatory bowel disease. Action of TNB as a hapten, induces colitis involving infiltration of colonic mucosa by neutrophils and macrophages and increased production of inflammatory mediators. The aim ...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1023/a:1020241028723
更新日期:1999-04-01 00:00:00
abstract::We aim to determine the extent of the CD40-CD40L pathway involvement in activated platelet-induced changes in human umbilical endothelial cells (HUVECs). Activated platelets were co-incubated with HUVECs in the presence or absence of CD40LmAb. HUVECs were also directly stimulated with rhCD40L. HUVEC endothelial cycloo...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-011-9427-0
更新日期:2012-06-01 00:00:00
abstract::The release of inflammatory cytokines and chemokines and autophagy has been reported to be involved in the pathogenic mechanism of acute lung injury (ALI). Reportedly, alpha-7 nicotinic acetylcholine receptors (α7nAchR) might play a protective role in LPS-induced ALI. In the current research, we established LPS-induce...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-019-01088-w
更新日期:2019-12-01 00:00:00
abstract::The aim of this present study is to compare the effect of pressure-controlled ventilation and volume-controlled ventilation on pulmonary mechanics and inflammatory markers in prone position. The study included 41 patients undergoing to vertebrae surgery. The patients were randomized into two groups: Group 1 received v...
journal_title:Inflammation
pub_type: 杂志文章,随机对照试验
doi:10.1007/s10753-016-0379-2
更新日期:2016-08-01 00:00:00
abstract:BACKGROUND:Accumulation of immune complexes in the mesangium is a common finding. Since migration of macrophages (Mphi) in the mesangium has been demonstrated to be an important event in the development of glomerular lesions, we studied the role of immune complexes and mesangial cell (MC) interaction in the transmigrat...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1023/a:1007073306394
更新日期:2000-12-01 00:00:00
abstract::A full understanding of rheumatoid arthritis depends on the appreciation of clinical, radiological, immunological, genetic, biochemical, and structural mechanisms. Rheumatoid arthritis is characterized by the destruction of tissue structures such as articular cartilage and bone, but may also involve tendonous tissue, ...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00915710
更新日期:1984-06-01 00:00:00
abstract::Ovarian cancer is one of the most deadly cancers with rapid proliferation and poor prognosis among patients. Therapies focusing on regulation of tumor immunity and microenvironments are developing. MiR-217 was dysregulated in cancer progress and plays important roles in tumorigenesis and metastasis. However, the role ...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-019-01004-2
更新日期:2019-10-01 00:00:00
abstract::Current treatments for ischemia-reperfusion (IR)-induced acute lung injury are limited. Mesenchymal stem cell-conditioned medium (CM) has been reported to attenuate lung injury. Neural crest stem cells (NCSCs), a type of multipotent stem cells, are more easily obtained than mesenchymal stem cells. We hypothesize that ...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-017-0594-5
更新日期:2017-10-01 00:00:00
abstract::To elucidate the role of major chemotactic factors, cytokine-induced neutrophil chemoattractant (CINC), leukotriene B4 (LTB4) and C5a in lipopolysaccharide (LPS)-induced acute lung injury in rat, we employed three reagents: anti-CINC-1 antibody, an LTB4 receptor antagonist (ONO-4057) and an anti-complementary agent (K...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1023/a:1020278104132
更新日期:1999-06-01 00:00:00
abstract::In this study, the potential effects of thalidomide (Thal) on bleomycin (BLM)-induced pulmonary fibrosis were investigated. BALB/C mice model of pulmonary fibrosis induced by an intratracheal instillation of BLM was adopted, and then was intraperitoneally injected with Thal (10, 20, 50 mg/kg) daily for 8 days, while t...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-017-0625-2
更新日期:2017-12-01 00:00:00
abstract::Synovium-derived mesenchymal stem cells (SMSCs) can migrate to the site of destroyed condylar cartilage and differentiate into chondrocytes to repair temporomandibular joint (TMJ) damage. Interleukin (IL)-1β-induced IL-6 secretion has been shown to inhibit the chondrogenic potential of SMSCs. The histone deacetylase i...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-020-01204-1
更新日期:2020-08-01 00:00:00
abstract::The present study aimed at characterizing the phenotype and functions of adherent synovial fluid (SF) cells derived from rheumatoid arthritis (RA), comparing with fibroblast-like synoviocytes (FLS) derived from RA synovial tissue (ST). Adherent SF-derived cells were spindle-shaped from passages 1-6 under light microsc...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-008-9087-x
更新日期:2008-12-01 00:00:00
abstract::Asthma is a complex disease linked to various pathophysiological events, including proteinase activity. In this study, we examined whether a Diospyros blancoi methanolic extract (DBE) exerts protective effects on allergic asthma in a murine asthma model. To investigate the specific role of DBE, we employed a murine mo...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-011-9354-0
更新日期:2012-04-01 00:00:00
abstract::Chronic obstructive pulmonary disease (COPD) is a common chronic inflammatory disease with high morbidity and mortality rates. Cystatin C (Cys C) is a sensitive indicator for various chronic inflammatory diseases. In this study, we aimed to evaluate the role of Cys C in COPD patients comparing with the other well-know...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-015-0287-x
更新日期:2016-04-01 00:00:00
abstract::Various disease states are associated with eosinophilia and the release of eosinophil peroxidase (EPO) into the microenvironment. The present study targets the effects of low levels of EPO on macrophage (M phi) phagocytosis and intracellular killing of Candida albicans as well as M phi oxidative activity measured as t...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1023/a:1027366119901
更新日期:1997-04-01 00:00:00
abstract::C-reactive protein (CRP) is a much used biomarker for respiratory tract infection; however, the influence of airway infection on the CRP level in the general population has not been well described. The study aimed to evaluate the impact of recent symptoms of airway infection on the CRP level and how the predictive pow...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-011-9405-6
更新日期:2012-06-01 00:00:00
abstract::Dysregulated release of neutrophil reactive oxygen species and proteolytic enzymes contributes to both acute and chronic inflammatory diseases. Therefore, molecular regulators of these processes are potential targets for new anti-inflammatory therapies. We have shown previously that myristoylated alanine-rich C-kinase...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-014-0078-9
更新日期:2015-01-01 00:00:00
abstract::This study investigated the protective effect of Lactobacillus plantarum NDC 75017 (L. plantarum NDC 75017) against acute liver injury induced by lipopolysaccharide (LPS). Thirty male mice were randomly divided into the control, LPS, and LPS + L. plantarum NDC 75017 groups. In the LPS + L. plantarum group, the mice we...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-014-9886-1
更新日期:2014-10-01 00:00:00
abstract::Heat shock (HS) proteins (HSP) are a family of molecular chaperones induced by environmental stresses such as oxidative injury, and contribute to protection from and adaptation to cellular stress. We investigated in human monocytes the expression and subcellular distribution of hsp70 and hsc70 after HS and inflammatio...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1023/a:1027338323296
更新日期:1997-12-01 00:00:00
abstract::Sepsis is a systemic inflammatory response syndrome caused by infection. The core mechanism underlying sepsis is immune dysfunction, with macrophages, as important cells of the innate immune system, playing an essential role. Autophagy has been shown to be closely related to inflammation and immunity, and autophagy en...
journal_title:Inflammation
pub_type: 杂志文章,评审
doi:10.1007/s10753-018-0890-8
更新日期:2019-02-01 00:00:00
abstract::The objective of this study is to investigate the role of Calmodulin-dependent protein kinase IV (CaMKIV) in Cardiotoxin (CTX)-induced mice muscle inflammation. CTX injection i.m. was performed to induce B6 mice acute tibialis anterior (TA) muscle injury. The mice were then injected i.p. with the recombinant CaMKIV pr...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-017-0678-2
更新日期:2018-02-01 00:00:00
abstract::Inflammatory response is required to proceed the optimal liver regeneration after liver injury. Recent reports demonstrated that inflammasomes are involved in the innate immune response. Several NOD-Like receptors (NLRs) participated in the formation of the inflammasomes. NACHT, LRR, and PYD domain-containing protein ...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-017-0613-6
更新日期:2017-10-01 00:00:00
abstract::Diets enriched in omega-3 fatty acids exert antiinflammatory properties by suppressing some neutrophil (PMN) functions. Changes in cytosolic Ca2+ concentration, [Ca2+]i, are important for PMN activation and are in part regulated by membrane Ca2+ ATPases. Since membrane proteins are influenced by their lipid environmen...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00919440
更新日期:1988-10-01 00:00:00
abstract::The ability of peripheral blood neutrophils to injure elements of the alveolar septum was assessed. Experiments consisted of activating previously isolated neutrophils (PMNs) with a soluble (phorbol myristate acetate, PMA) and a particulate (zymosan) trigger, and measuring detachment of 51Cr-labeled epithelial cells. ...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00917512
更新日期:1992-02-01 00:00:00
abstract::High concentrations of corticosteroids inhibit granulocyte responses and disrupt agonist receptor function. Dose-response and time-course considerations make it unlikely that these effects are mediated via the glucocorticoid receptor, a concept further supported by the ability of sex steroids to work similar effects. ...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00914030
更新日期:1990-02-01 00:00:00
abstract::A heat-stable factor present in extracts of human blood leukocytes is capable of lysing young Staphylococcus aureus at pH 5.0. Lysis is characterized by breakdown of cell-wall components as judged by electron microscopic and biochemical analysis. The leukocyte extracts can be replaced by a variety of agents known to i...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00918678
更新日期:1977-06-01 00:00:00
abstract::Chronic prostatitis was the most common type of prostatitis and oxidative stress was reported to be highly elevated in prostatitis patients. In this study, we determined the effect of N-acetylcysteine (NAC) on prostatitis and the molecular mechanism involved in it. Male Sprague-Dawley rats were divided into three grou...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-016-0327-1
更新日期:2016-04-01 00:00:00
abstract::Ziprasidone (ZIP) is an effective antipsychotic with low side effects than other second-generation antipsychotics. Despite this, there are reports of adverse events and previous studies associating the use of ZIP the inflammatory response. It is possible to infer that bioactive molecules present in some foods could at...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-018-0946-9
更新日期:2019-06-01 00:00:00
abstract::Alveolar macrophages (AM) are the primary target cell of the lung for inhaled mycobacterial pathogens. We investigated the effect of the synthetic lipopeptide MALP-2 on the interaction between AM from rats and Mycobacterium bovis BCG. AM were infected with M. bovis BCG at a multiplicity of infection (MOI) of 10 and th...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-009-9127-1
更新日期:2009-08-01 00:00:00