Abstract:
:Current treatments for ischemia-reperfusion (IR)-induced acute lung injury are limited. Mesenchymal stem cell-conditioned medium (CM) has been reported to attenuate lung injury. Neural crest stem cells (NCSCs), a type of multipotent stem cells, are more easily obtained than mesenchymal stem cells. We hypothesize that NCSC-CM has anti-inflammatory properties that could protect against IR-induced lung injury in rats. In this study, NCSC-CM was derived from rat NCSCs. Typical acute lung injury was induced by 30-min ischemia followed by 90-min reperfusion in adult male Sprague-Dawley rats. Bronchoalveolar lavage fluid (BALF) and lung tissues were collected to analyze the degree of lung injury after the experiment. NCSC-CM was administered before ischemia and after reperfusion. NCSC-CM treatment significantly attenuated IR-induced lung edema, as indicated by decreases in pulmonary vascular permeability, lung weight gain, wet to dry weight ratio, lung weight to body weight ratio, pulmonary arterial pressure, and protein level in BALF. The levels of tumor necrosis factor-α and interleukin-6 in the BALF were also significantly decreased. Additionally, NCSC-CM improved lung pathology and neutrophil infiltration in the lung tissue, and significantly suppressed nuclear factor (NF)-κB activity and IκB-α degradation in the lung. However, heating NCSC-CM eliminated these protective effects. Our experiment demonstrates that NCSC-CM treatment decreases IR-induced acute lung injury and that the protective mechanism may be attributable to the inhibition of NF-κB activation and the inflammatory response. Therefore, NCSC-CM may be a novel approach for treating IR-induced lung injury.
journal_name
Inflammationjournal_title
Inflammationauthors
Peng CK,Wu SY,Tang SE,Li MH,Lin SS,Chu SJ,Huang KLdoi
10.1007/s10753-017-0594-5subject
Has Abstractpub_date
2017-10-01 00:00:00pages
1532-1542issue
5eissn
0360-3997issn
1573-2576pii
10.1007/s10753-017-0594-5journal_volume
40pub_type
杂志文章相关文献
INFLAMMATION文献大全abstract::Cyanidin-3-O-glucoside (C3G), an anthocyanin belonging to the flavonoid family and commonly present in food and vegetables in human diet, has exhibited anti-inflammatory and anti-oxidant effects. This study aimed to investigate the protective ability of C3G against inflammatory and oxidative injuries, as well as to cl...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-015-0144-y
更新日期:2015-08-01 00:00:00
abstract::Macrophages are one of the most heterogenic immune cells involved in skeletal muscle regeneration. After skeletal muscle damage, M1 phenotypes exhibit pro-inflammatory reaction. In a later stage, they are converted to M2 phenotypes with anti-inflammatory properties. To study when gene expressions of macrophage polariz...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-014-0024-x
更新日期:2015-02-01 00:00:00
abstract::The respiratory epithelium is often exposed to oxidant gases, including ozone from photochemical smog and toxic oxygen metabolites released from neutrophils recruited in conditions of airway inflammation. We evaluated DNA single strand break formation by alkaline elution as a measure of oxidant-induced DNA damage to b...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00920476
更新日期:1993-12-01 00:00:00
abstract::C3b receptor (CR1) expression by neutrophils (PMNs) and erythrocytes (Es) from patients with chronic granulomatous disease (CGD) or with hyper-IgE, frequent infection (Job's) syndrome was compared with that of control subjects. The control subjects consisted of one group of patients with infections and a second group ...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00918218
更新日期:1984-12-01 00:00:00
abstract::Asthma is the most common chronic disease of childhood, chronic airway inflammation; bronchial tissue fibrosis, is a pathological feature common to children asthma, and an emerging data has indicted that autophagy plays critical roles in airway inflammation and fibrosis-mediated airway remodeling. The aim of this stud...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-019-01076-0
更新日期:2020-02-01 00:00:00
abstract::The present study aimed at characterizing the phenotype and functions of adherent synovial fluid (SF) cells derived from rheumatoid arthritis (RA), comparing with fibroblast-like synoviocytes (FLS) derived from RA synovial tissue (ST). Adherent SF-derived cells were spindle-shaped from passages 1-6 under light microsc...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-008-9087-x
更新日期:2008-12-01 00:00:00
abstract::Vascular inflammation plays a key role in the initiation and progression of atherosclerosis, a major complication of diabetes mellitus. Orientin, a C-glycosyl flavonoid, is known to have anxiolytic and antioxidative activity. In this study, we assessed whether orientin can suppress vascular inflammation induced by hig...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-014-9950-x
更新日期:2014-12-01 00:00:00
abstract::The aim of this study is to explore the dynamic changes in IL-17-expressing T cells (Th17)/Treg expression in monophasic experimental autoimmune uveitis (mEAU). mEAU was induced in Lewis rats with IRBP1177-1191 peptide and evaluated clinically and pathologically on days 9, 13, 18, 23, 28, 35, and 48. Lymphocytes isola...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-015-0229-7
更新日期:2016-02-01 00:00:00
abstract::Central nervous system tuberculosis (CNS-TB) is caused by infection with Mycobacterium tuberculosis (Mtb). The inflammatory response following CNS-TB involves the activation of resident microglia and the infiltration of macrophages. However, it has not been clarified whether microglia can be polarized into the classic...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-015-0136-y
更新日期:2015-08-01 00:00:00
abstract::Obesity provokes an imbalance in the immune system, including an aberrant type I interferon response during some viral infections and after TLR stimulation. SOCS3 overexpression and altered systemic leptin levels could be responsible for the reduced type I interferon production in people with obesity and, eventually, ...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-016-0452-x
更新日期:2017-02-01 00:00:00
abstract::The objective of this study is to investigate the role of Calmodulin-dependent protein kinase IV (CaMKIV) in Cardiotoxin (CTX)-induced mice muscle inflammation. CTX injection i.m. was performed to induce B6 mice acute tibialis anterior (TA) muscle injury. The mice were then injected i.p. with the recombinant CaMKIV pr...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-017-0678-2
更新日期:2018-02-01 00:00:00
abstract::Cepharanthine (CEP), a biscoclaurine alkaloid isolated from Stephania cepharantha Hayata, has been reported to have potent anti-inflammatory properties. However, the anti-inflammatory effects of CEP on a mouse model of lipopolysaccharide (LPS)-induced mastitis and its underlying molecular mechanisms remain to be eluci...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-013-9744-6
更新日期:2014-04-01 00:00:00
abstract::This study investigated the expression of miRNA-221 in asthmatics in order to determine whether miRNA-221 plays a role in the development of asthma. Real-time PCR was used to detect the miRNA-221 in both asthmatic and control subjects. In addition, airway inflammation was evaluated by cell counting and tissue biopsy i...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-012-9474-1
更新日期:2012-08-01 00:00:00
abstract::The anti-inflammatory activities of kakkalide, a major constituent of the flower of Pueraria thunbergiana, and irisolidone, a metabolite of kakkalide produced by intestinal microflora, against carrageenan-induced inflammation in air pouches on the backs of mice and in lipopolysaccharide (LPS)-stimulated peritoneal mac...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-010-9240-1
更新日期:2011-10-01 00:00:00
abstract::Chemical alteration of the glucocorticoid, methylprednisolone, has led to the introduction of a new class of compounds called the 21-aminosteroids (21-ASs). The purpose of this study was to investigate the effect of the 21-AS, U74389G, on silica-induced acute lung injury. Male Fischer 344 rats were treated intraperito...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF01534376
更新日期:1995-02-01 00:00:00
abstract::Intervertebral disc degeneration (IVDD) is considered to be the fundamental cause of the occurrence and development of lumbar disc herniation (LDH). The degeneration of IVDD is mainly caused by the participation of inflammatory factors. Thus, it is of great significance to analyze the pathogenesis of IVDD, which may g...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-020-01254-5
更新日期:2020-10-01 00:00:00
abstract::We analyzed the effect of the PAF receptor antagonist (+)-cis-3,5-dimethyl-2-(3-pyridyl)thiazolidin-4-one hydrochloride (SM-12502) on human platelet aggregation as well as mediator release. After incubation of human platelet with different concentrations of SM-12502 the cells were subsequently stimulated with either t...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF01487746
更新日期:1996-02-01 00:00:00
abstract::Interleukin-1 receptor-associated kinase (IRAK1) is a key regulatory protein in TLR/IL1R-mediated cell activation during inflammatory response. Studies indicated that pending on the nature of the used inflammatory model, downregulation of IRAK1 may be beneficial or detrimental. However, the role of IRAK1 in affecting ...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-013-9692-1
更新日期:2013-12-01 00:00:00
abstract::The levels of mRNA for plasma proteins and for metallothionein in rat liver during the acute-phase response were studied by hybridization to specific cDNA probes. The mRNA for alpha 2-macroglobulin, the beta-chain of fibrinogen, alpha 1-acid glycoprotein (so-called acute-phase reactants) reached a maximum level betwee...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00916041
更新日期:1986-03-01 00:00:00
abstract::Comparison of the physiologic responses in rabbits to the intravenous infusion of two polymorphonuclear neutrophil (PMN) activators, N-formyl-methionyl-leucyl-phenylalanine (FMLP) and phorbol myristate acetate (PMA), has revealed marked differences in kinetics for activation between these agents. FMLP infusion was ass...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00915990
更新日期:1987-12-01 00:00:00
abstract::Diets enriched in omega-3 fatty acids exert antiinflammatory properties by suppressing some neutrophil (PMN) functions. Changes in cytosolic Ca2+ concentration, [Ca2+]i, are important for PMN activation and are in part regulated by membrane Ca2+ ATPases. Since membrane proteins are influenced by their lipid environmen...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00919440
更新日期:1988-10-01 00:00:00
abstract::Mitogen- and stress-activated protein kinase (MSK) is a recently identified nuclear cAMP-regulated enhancer B (CREB) and histone H3 kinase that responds to both mitogen- and stress-activated protein kinases. This study was designed to investigate the protective effect of MSK on the rats with focal ischemia-reperfusion...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-019-01080-4
更新日期:2019-12-01 00:00:00
abstract::Experimental studies indicate that sepsis causes remote organ injury although the molecular mechanism has not been clearly defined. In this report, the role of oxidative damage, and inflammation on lung injury, following sepsis model by cecal ligation and puncture, and the effects of quercetin, antioxidant, and anti-i...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-015-0296-9
更新日期:2016-04-01 00:00:00
abstract::Two different substances, glycogen and thioglycollate, were used to recruit early peritoneal exudate cells (4h). In the acute phase of the inflammatory response the cellular infiltrate is large, and the predominant cell (greater than 95%) is the polymorphonuclear neutrophil. Supernatant had differing effects on lympho...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00910714
更新日期:1982-03-01 00:00:00
abstract::We have previously reported the antifibrotic effects of pirfenidone (PD) in the bleomycin (BL)-hamster model of lung fibrosis. Since the development of fibrosis is generally preceded by acute lung inflammation, the present study was conducted to find out if dietary intake of PD (0.5%) has any effects on BL-induced lun...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1023/a:1007068313370
更新日期:2000-10-01 00:00:00
abstract::Granulocytes depend on anaerobic glycolysis for the energy required for chemotaxis, phagocytosis, and microbial killing. Two potential sources of the needed glucose are available: exogenous glucose and intracellular glycogen. These studies demonstrate that chemotaxin-induced movement of granulocytes induces accelerate...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00916406
更新日期:1982-09-01 00:00:00
abstract::Endoplasmic reticulum stress (ERS) plays an important role in cerebral ischemia-reperfusion injury (CIRI) by regulating apoptosis. Although the role of long non-coding RNA (LncRNA) KCNQ1OT1 in CIRI has been reported, the specific mechanism is still unclear. In this paper, the regulation of ERS by LncRNA KCNQ1OT1 in CI...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-020-01295-w
更新日期:2020-12-01 00:00:00
abstract::Currently, only tumor necrosis factor alpha (TNF-α) and interleukin family cytokines have been found to be elicited in Vibrio vulnificus (V. vulnificus)-infected animal models and humans. However, multiple other cytokines are also involved in the immune and inflammatory responses to foreign microorganism infection. An...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-015-0166-5
更新日期:2015-10-01 00:00:00
abstract::The possibility of inflammation and neutrophil activation in response to indoor air pollution (IAP) from biomass fuel use has been investigated. For this, 142 premenopausal, never-smoking women (median age, 34 years) who cook exclusively with biomass (wood, dung, crop wastes) and 126 age-matched control women who cook...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-011-9360-2
更新日期:2012-04-01 00:00:00
abstract::In this study, the effects of tyrosol were investigated in DSS-induced experimental ulcerative colitis model. For this purpose, rats were divided into five groups of seven rats in each: control group, colitis group (DSS-4%), tyrosol group (tyrosol 20 mg/kg), sulfasalazine (sulfasalazine+DSS 100 mg/kg), and treatment g...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-019-01028-8
更新日期:2019-10-01 00:00:00