Comparison of in vivo effects of intravenous infusion of N-formyl-methionyl-leucyl-phenylalanine and phorbol myristate acetate in rabbits.

abstract：:The influences of extracellular Ca2+ and Mg2+ on chemotactic factor-induced rabbit polymorphonuclear neutrophil (PMN) aggregation was studied using a recently described Coulter counter assay technique. Compared with those of other PMN functional assays (adhesion, chemotaxis, degranulation, and phagocytosis), the catio...

journal_title：Inflammation

authors： O'Flaherty JT,Showell HJ,Ward PA

更新日期：1977-12-01 00:00:00

abstract：:This study aims to provide experimental proof that Rab6a is an efficient target of microRNA-155 in regulating pro-inflammatory tumor necrosis factor (TNF) secretion stimulated by lipopolysaccharide (LPS) in macrophages. We identified Rab6a as a new target of microRNA-155 (miR-155) and found that overexpression of miR-...

journal_title：Inflammation

authors： Yang Y,Yang L

更新日期：2016-02-01 00:00:00

abstract：:Recent data demonstrated that chemokine CXCL13 mediates neuroinflammation and contributes to the maintenance of neuropathic pain after nerve injury in the spinal cord. Pro-nociceptive chemokines activate mitogen-activated protein kinases (MAPKs) which are potential signaling pathways contributing to the nociceptive be...

journal_title：Inflammation

authors： Zhang Q,Zhu MD,Cao DL,Bai XQ,Gao YJ,Wu XB

更新日期：2017-06-01 00:00:00

abstract：:Interleukin-10 (IL-10) is a pleiotropic cytokine and plays an important role in the pathogenesis of systemic lupus erythematosus (SLE). Unlike IL-10 protein, few studies have focused on the potential association between IL-10 receptor (IL-10R) and SLE. The purpose of this study was to examine the association of a sing...

journal_title：Inflammation

authors： Peng H,Liu CY,Zhou M,Wen PF,Zhang M,Qiu LJ,Ni J,Liang Y,Pan HF,Ye DQ

更新日期：2013-12-01 00:00:00

abstract：:This study aimed to investigate the protective effect of emodin on endoplasmic reticulum (ER) stress in rats with severe acute pancreatitis (SAP) and the underlying molecular mechanism. Sprague-Dawley male rats were randomly divided into sham operation group, SAP model group, and emodin treatment group. SAP was constr...

journal_title：Inflammation

authors： Wu L,Cai B,Zheng S,Liu X,Cai H,Li H

更新日期：2013-10-01 00:00:00

abstract：:A variety of steroidal and nonsteroidal antiinflammatory agents (NSAs) were compared for their effectiveness against a developing acute inflammatory reaction. Only BW 755C [3-amino-1-(m-trifluoromethyl)-phenyl-2-pyrazole] was immediately effective when administered 2 h after carrageenin, as the 3-h swelling was signif...

journal_title：Inflammation

authors： Holsapple MP,Yim GK

更新日期：1984-09-01 00:00:00

abstract：:Endoplasmic reticulum stress (ERS) plays an important role in cerebral ischemia-reperfusion injury (CIRI) by regulating apoptosis. Although the role of long non-coding RNA (LncRNA) KCNQ1OT1 in CIRI has been reported, the specific mechanism is still unclear. In this paper, the regulation of ERS by LncRNA KCNQ1OT1 in CI...

journal_title：Inflammation

authors： Li Y,Yi M,Wang D,Zhang Q,Yang L,Yang C

更新日期：2020-12-01 00:00:00

abstract：:Statins are widely used hypocholesterolemic drugs that block the mevalonate pathway. Some studies have shown that statins may have the potential to inhibit intervertebral disk (IVD) degeneration (IDD). Interleukin (IL)-1β, a catabolic cytokine, is a key regulator of IDD. This study aimed to investigate the mechanism u...

journal_title：Inflammation

authors： Tu J,Li W,Zhang Y,Wu X,Song Y,Kang L,Liu W,Wang K,Li S,Hua W,Yang C

更新日期：2017-06-01 00:00:00

abstract：:To investigate the role of glutathione (GSH) synthesis in the regulation on nuclear factor (NF)-kappaB activity and tumor necrosis factor-alpha (TNF-alpha) release by glutamine (GLN) in lipopolysaccharide (LPS)-stimulated alveolar type II (AT-II) epithelial cells of rat lungs. Primary cultured AT-II cells were pre-tre...

journal_title：Inflammation

authors： Zhang F,Wang X,Wang W,Li N,Li J

更新日期：2008-10-01 00:00:00

abstract：:Alveolar macrophages (AMs) can initiate lung inflammation by producing pro-inflammatory cytokines and chemokines, but they participate actively in the prevention of inflammation during acute lung injury (ALI). Heme oxygenase-1 (HO-1) is mainly expressed in AMs and has anti-inflammatory properties in ALI, but the anti-...

journal_title：Inflammation

authors： Hualin C,Wenli X,Dapeng L,Xijing L,Xiuhua P,Qingfeng P

更新日期：2012-06-01 00:00:00

abstract：:Sepsis is a systemic inflammatory response syndrome caused by infection. The core mechanism underlying sepsis is immune dysfunction, with macrophages, as important cells of the innate immune system, playing an essential role. Autophagy has been shown to be closely related to inflammation and immunity, and autophagy en...

journal_title：Inflammation

authors： Qiu P,Liu Y,Zhang J

更新日期：2019-02-01 00:00:00

abstract：:Kurloff cells are mononuclear cells possessing a large cytoplasmic inclusion body specific to the guinea pig. In this report, we present strong evidence that Kurloff cells can mediate NC activity against tumor cells in addition to their previously reported NK activity. Using an 18 h 51Cr-release assay we have shown th...

journal_title：Inflammation

authors： Pouliot N,Maghni K,Sirois P,Rola-Pleszczynski M

更新日期：1996-06-01 00:00:00

abstract：:Ischemic stroke is a major cause of death and motor disabilities all over the world. It is a muti-factorial disorder associated with inflammatory, apoptotic, and oxidative responses. Nateglinide (NAT), an insulinotropic agent used for the treatment of type 2 diabetes mellitus, recently showed potential anti-inflammato...

journal_title：Inflammation

authors： Saad MAE,Fahmy MIM,Al-Shorbagy M,Assaf N,Hegazy AAE,El-Yamany MF

更新日期：2020-04-01 00:00:00

abstract：:The role of peptide leukotrienes (p-LTs), especially LTC4 and LTD4 in liver disease, was investigated in mice experimental liver injury models. The liver injury was induced by the injection of bacterial lipopolysaccharide (LPS) into Corynebacterium parvum pretreated mice. Carbon tetrachloride (CCl4)-induced liver inju...

journal_title：Inflammation

authors： Nagai H,Shimazawa T,Yakuo I,Aoki M,Koda A,Kasahara M

更新日期：1989-12-01 00:00:00

abstract：:Postoperative ileus is a common complication after intra-abdominal surgery. Nitric oxide produced by macrophages in the inflamed gastrointestinal tract plays a crucial role in the pathogeny of postoperative ileus. Honokiol, extracted from the bark of Magnolia spp., is a natural compound with a biphenolic structure. In...

journal_title：Inflammation

authors： Mihara T,Mikawa S,Kaji N,Endo M,Oikawa T,Tong-Rong J,Ozaki H,Hori M

更新日期：2017-08-01 00:00:00

abstract：:The intracellular signaling pathways involved in human monocyte chemotaxis toward a variety of chemoattractant molecules were evaluated using selected pharmacological agents. Neither phosphatidylinositol-3-kinase (P13K) or extracellular signal-regulated kinase (ERK) activity were required for monocyte migration toward...

journal_title：Inflammation

authors： Fine JS,Byrnes HD,Zavodny PJ,Hipkin RW

更新日期：2001-04-01 00:00:00

abstract：:Diets enriched in omega-3 fatty acids exert antiinflammatory properties by suppressing some neutrophil (PMN) functions. Changes in cytosolic Ca2+ concentration, [Ca2+]i, are important for PMN activation and are in part regulated by membrane Ca2+ ATPases. Since membrane proteins are influenced by their lipid environmen...

journal_title：Inflammation

authors： Georgilis K,Klempner MS

更新日期：1988-10-01 00:00:00

abstract：:Studies indicated that CC receptor 5 (CCR5), as a receptor for CC ligand 3, CCL4, and CCL5, plays important roles in the recruitment of T cytotoxic lymphocytes to the liver of chronic HBV (CHB)-infected patients. The main purpose of this study was to investigate the expression levels of CCR5 on the CD8(+) T lymphocyte...

journal_title：Inflammation

authors： Ahmadabadi BN,Hassanshahi G,Khoramdelazad H,Mirzaei V,Sajadi SM,Hajghani M,Khodadadi H,Pourali R,Arababadi MK,Kennedy D

更新日期：2013-02-01 00:00:00

abstract：:Recent studies show that nuclear factor-kappa B (NF-κB) signaling pathway plays a key role in contributing to the development of lipopolysaccharide (LPS)-induced acute lung injury (ALI). Tetrahydrocoptisine is one of the main active components of Chelidonium majus L. and has been described to be effective in suppressi...

journal_title：Inflammation

authors： Li W,Huang H,Niu X,Fan T,Hu H,Li Y,Yao H,Li H,Mu Q

更新日期：2014-12-01 00:00:00

abstract：:High concentrations of corticosteroids inhibit granulocyte responses and disrupt agonist receptor function. Dose-response and time-course considerations make it unlikely that these effects are mediated via the glucocorticoid receptor, a concept further supported by the ability of sex steroids to work similar effects. ...

journal_title：Inflammation

authors： Lamche HR,Silberstein PT,Knabe AC,Thomas DD,Jacob HS,Hammerschmidt DE

更新日期：1990-02-01 00:00:00

abstract：:The existence of multiple-interactive roles between several signaling pathways in tumorigenesis shows the significance of pharmacological factors like heat shock protein 90 (HSP90) inhibitors which control several signaling pathways simultaneously. HSP90 as a molecular chaperone supports the active conformational stru...

journal_title：Inflammation

authors： Mohammadi A,Yaghoobi MM,Gholamhoseinian Najar A,Kalantari-Khandani B,Sharifi H,Saravani M

更新日期：2016-06-01 00:00:00

abstract：:We analyzed the effect of the PAF receptor antagonist (+)-cis-3,5-dimethyl-2-(3-pyridyl)thiazolidin-4-one hydrochloride (SM-12502) on human platelet aggregation as well as mediator release. After incubation of human platelet with different concentrations of SM-12502 the cells were subsequently stimulated with either t...

journal_title：Inflammation

authors： Köller M,Hilger RA,König W

更新日期：1996-02-01 00:00:00

abstract：:Four methods of severe disruption of human neutrophil membrane integrity resulted in the formation of substantial amounts of leukotriene B4 and its isomers. This synthesis took place from endogenous substrate in the absence of any cell activators. It is postulated that leukotriene formation could be a preserved cell f...

journal_title：Inflammation

authors： Green FA

更新日期：1988-04-01 00:00:00

abstract：:During phagocytosis of latex particles human polymorphonuclear leukocytes (PMNs) release a product that generates chemotactic activity from fresh human serum. Release of this product is maximal at 20-30 min of phagocytosis. It is present in resting PMNs, may be recovered from granule fractions, and functions at physio...

journal_title：Inflammation

authors： Wright DG,Gallin JI

更新日期：1975-03-01 00:00:00

abstract：:This experiment was conducted to investigate the effects of a benzylideneacetophenone derivative ((2E)-3-(4-hydroxy-3-methoxyphenyl)phenylpro-2-en-l-one (JC3)) on trimellitic anhydride (TMA)-induced atopic dermatitis (AD)-like symptoms in mice. To induce AD, the dorsal skins of mice were treated with 5% TMA on day 0 a...

journal_title：Inflammation

authors： Sur B,Kang S,Kim M,Oh S

更新日期：2019-06-01 00:00:00

abstract：:Human neutrophils (PMNs) which have been incubated with lipoteichoic acid (LTA) from group A streptococci generated large amounts of superoxide (O2- chemiluminescence and hydrogen peroxide when challenged with anti-LTA antibodies. Cytochalasin B further enhanced O2- generation. The onset of O2- generation by the LTA-a...

journal_title：Inflammation

authors： Ginsburg I,Fligiel SE,Ward PA,Varani J

更新日期：1988-12-01 00:00:00

abstract：:The aim of this present study is to compare the effect of pressure-controlled ventilation and volume-controlled ventilation on pulmonary mechanics and inflammatory markers in prone position. The study included 41 patients undergoing to vertebrae surgery. The patients were randomized into two groups: Group 1 received v...

journal_title：Inflammation

authors： Şenay H,Sıvacı R,Kokulu S,Koca B,Bakı ED,Ela Y

更新日期：2016-08-01 00:00:00

abstract：:The aim of our study was to evaluate the pro- and anti-inflammatory cytokine response during acute pancreatitis and its predictive value on severity of disease. A hospital-based prospective clinical study was conducted. Twenty patients with acute pancreatitis were enrolled during a 12-month period. Plasma concentratio...

journal_title：Inflammation

authors： Gunjaca I,Zunic J,Gunjaca M,Kovac Z

更新日期：2012-04-01 00:00:00

abstract：:Asthma is the most common chronic disease of childhood, chronic airway inflammation; bronchial tissue fibrosis, is a pathological feature common to children asthma, and an emerging data has indicted that autophagy plays critical roles in airway inflammation and fibrosis-mediated airway remodeling. The aim of this stud...

journal_title：Inflammation

authors： Li BB,Chen YL,Pang F

更新日期：2020-02-01 00:00:00

abstract：:Paeonol, a major ingredient isolated from Moutan Cort, has various pharmacological effects. Our previous studies have shown that paeonol can exert antioxidant and anti-inflammatory therapeutic effects on ethanol-induced experimental gastric ulcer (GU). Therefore, in this study, we designed two GU models in rats induce...

journal_title：Inflammation

authors： Guo Y,Du Y,Xie L,Pu Y,Yuan J,Wang Z,Zhang T,Wang B

更新日期：2020-12-01 00:00:00