Abstract：
:The aim of this study is to explore the dynamic changes in IL-17-expressing T cells (Th17)/Treg expression in monophasic experimental autoimmune uveitis (mEAU). mEAU was induced in Lewis rats with IRBP1177-1191 peptide and evaluated clinically and pathologically on days 9, 13, 18, 23, 28, 35, and 48. Lymphocytes isolated from inguinal lymph nodes were subjected to flow cytometry to analyze the frequency of Th17/Treg cells. The levels of cytokines (IL-17, IL-6, IL-10, transforming growth factor (TGF)-β) in serum were detected by enzyme-linked immunosorbent assay (ELISA). Real-time quantitative PCR (RT-PCR) was used for measuring the levels of IL-17, IL-6, TGF-β, and Foxp3. Clinical and histopathologic assessment showed that mEAU began on day 9, peaked on day 13, and decreased to normal on day 18. The frequency of Th17 cells increased obviously on day 9, peaking on day 13, while the frequency of Treg cells increased on day 13, peaked on day 18, and remained at a high level until day 48. In the serum, the levels of IL-17 and IL-6 peaked on day 9 and gradually decreased to normal on day 28. The level of TGF-β increased on day 9, peaked on day 13, and decreased to normal on day 35. Meanwhile, the level of IL-10 increased on day 9 and stayed at a high level until day 48. Additionally, the above results were further confirmed by RT-PCR. The imbalance between Th17 and Treg cells contributes to the onset and progression of mEAU, and a compartmental imbalance of Treg over Th17 exists in the recovery phase of mEAU.
journal_name
Inflammationjournal_title
Inflammationauthors
Zhang L,Wan F,Song J,Tang K,Zheng F,Guo J,Guo D,Bi Hdoi
10.1007/s10753-015-0229-7subject
Has Abstractpub_date
2016-02-01 00:00:00pages
113-122issue
1eissn
0360-3997issn
1573-2576pii
10.1007/s10753-015-0229-7journal_volume
39pub_type
杂志文章相关文献
INFLAMMATION文献大全abstract：:Whether lipopolysaccharide (LPS) can promote vasa vasorum (VV) proliferation for atherosclerosis in vivo is unclear. Eighteen rabbits with atherosclerosis were randomly assigned into one of three groups of six. Group A received biweekly injections of 10 mL saline after 2 weeks of balloon injury. Groups B and C receive...
journal_title：Inflammation
pub_type： 杂志文章
doi：10.1007/s10753-012-9468-z
更新日期：2012-08-01 00:00:00
abstract：:In this study, we aimed to investigate the effect of electro-acupuncture (EA) pretreatment at zusanli (ST36) acupoint on lipopolysaccharide (LPS)-induced endotoxemic rat model and explore the underlying molecular mechanisms. Rats were treated with EA at ST36 for 7 days before being subjected to LPS. Two hours post-LPS...
journal_title：Inflammation
pub_type： 杂志文章
doi：10.1007/s10753-018-0885-5
更新日期：2019-02-01 00:00:00
abstract：:The levels of mRNA for plasma proteins and for metallothionein in rat liver during the acute-phase response were studied by hybridization to specific cDNA probes. The mRNA for alpha 2-macroglobulin, the beta-chain of fibrinogen, alpha 1-acid glycoprotein (so-called acute-phase reactants) reached a maximum level betwee...
journal_title：Inflammation
pub_type： 杂志文章
doi：10.1007/BF00916041
更新日期：1986-03-01 00:00:00
abstract：:This study aimed to investigate molecule B7-H3 expression profiles of patients with ankylosing spondylitis (AS) and the clinical significance of B7-H3 in the pathogenesis of AS. Serum B7-H3 levels were measured by ELISA in patients with AS and healthy controls. The expression of B7-H3 protein and mRNA on CD14+ monocyt...
journal_title：Inflammation
pub_type： 杂志文章
doi：10.1007/s10753-014-0103-z
更新日期：2015-01-01 00:00:00
abstract：:Intrapleural tetracycline (TCN) results in pleural macrophage influx and pleural fibrosis; intrapleural carrageenan (CAR) induces macrophage influx without fibrosis. Because macrophage products can modulate mesothelial cell activity, we investigated the role of TCN- and CAR-induced pleural macrophages on mesothelial c...
journal_title：Inflammation
pub_type： 杂志文章
doi：10.1007/BF00916387
更新日期：1993-02-01 00:00:00
abstract：:The possibility of inflammation and neutrophil activation in response to indoor air pollution (IAP) from biomass fuel use has been investigated. For this, 142 premenopausal, never-smoking women (median age, 34 years) who cook exclusively with biomass (wood, dung, crop wastes) and 126 age-matched control women who cook...
journal_title：Inflammation
pub_type： 杂志文章
doi：10.1007/s10753-011-9360-2
更新日期：2012-04-01 00:00:00
abstract：:High concentrations of corticosteroids inhibit granulocyte responses and disrupt agonist receptor function. Dose-response and time-course considerations make it unlikely that these effects are mediated via the glucocorticoid receptor, a concept further supported by the ability of sex steroids to work similar effects. ...
journal_title：Inflammation
pub_type： 杂志文章
doi：10.1007/BF00914030
更新日期：1990-02-01 00:00:00
abstract：:The aim of the study was to determine the effect of direct application of rifampin, povidone-iodine, and hydrogen peroxide on the formation of epidural fibrosis in rats. Forty-eight adult male Wistar albino rats were equally and randomly divided into four groups (laminectomy, topical rifampin, topical povidone-iodine,...
journal_title：Inflammation
pub_type： 杂志文章
doi：10.1007/s10753-016-0383-6
更新日期：2016-08-01 00:00:00
abstract：:We have previously shown that deuterium oxide (D2O) enhances the oxidation of methionine, a myeloperoxidase (MPO) -mediated reaction, by human neutrophils during phagocytosis. However, D2O has no effect on the oxidation of methionine by the purified MPO-H2O2-Cl- system. To explain this observation, we studied the effe...
journal_title：Inflammation
pub_type： 杂志文章
doi：10.1007/BF00917309
更新日期：1982-12-01 00:00:00
abstract：:Chronic obstructive pulmonary disease (COPD) is a common chronic inflammatory disease with high morbidity and mortality rates. Cystatin C (Cys C) is a sensitive indicator for various chronic inflammatory diseases. In this study, we aimed to evaluate the role of Cys C in COPD patients comparing with the other well-know...
journal_title：Inflammation
pub_type： 杂志文章
doi：10.1007/s10753-015-0287-x
更新日期：2016-04-01 00:00:00
abstract：:The aim of this study is to investigate the cardioprotective effects of morroniside in rats following acute myocardial infarction. An acute myocardial infarction (AMI) was induced by ligating the anterior descending coronary artery (LAD) [1]. Following AMI, morroniside was administered intragastrically for 24 h at dos...
journal_title：Inflammation
pub_type： 杂志文章
doi：10.1007/s10753-017-0699-x
更新日期：2018-03-01 00:00:00
abstract：:This study analyzed the neutrophils and sera of patients with rheumatoid arthritis and of normal controls. No significant differences were found in the activities of the granular enzymes beta-glucuronidase and lysozyme or the cytoplasmic enzyme lactic dehydrogenase (LDH). Normal neutrophils were found to release signi...
journal_title：Inflammation
pub_type： 杂志文章
doi：10.1007/BF00914189
更新日期：1979-07-01 00:00:00
abstract：:Our study is based on the establishment of a cohort of human obese omental adipose tissue and the culture of adipocytes in vitro. To observe the effect of high level of free fatty acid (FFA) on the expression of DNA methyltransferases (DNMTs) and the anti-inflammatory factor Kruppel-like factor 4 (KLF4) in adipocytes ...
journal_title：Inflammation
pub_type： 杂志文章
doi：10.1007/s10753-019-01168-x
更新日期：2020-06-01 00:00:00
abstract：:The respiratory burst is a series of metabolic events which result in the production of microbicidal oxidants by phagocytes. The enzyme responsible for the respiratory burst is a membrane-bound oxidase which catalyzes the production of O-2 by the NADPH-dependent reduction of oxygen. Activity of this oxidase is diminis...
journal_title：Inflammation
pub_type： 杂志文章
doi：10.1007/BF00917260
更新日期：1983-09-01 00:00:00
abstract：:The purpose of the present study is to evaluate the effect of emu oil on bioavailability of curcumin when co-administered and to evaluate the property that enhances the anti-inflammatory potential of curcumin. Oral bioavailability of curcumin in combination with emu oil was determined by measuring the plasma concentra...
journal_title：Inflammation
pub_type： 杂志文章
doi：10.1007/s10753-014-9948-4
更新日期：2014-12-01 00:00:00
abstract：:Our study showed that S-methylisothiourea (SMT) had anti-inflammatory effects in treating herpes simplex encephalitis in mice, and SMT also induced apoptosis of herpes simplex virus (HSV-1)-infected microglial cells. Both animal and cell models were employed in this study. Both models included the following five group...
journal_title：Inflammation
pub_type： 杂志文章
doi：10.1007/s10753-010-9246-8
更新日期：2011-10-01 00:00:00
abstract：:In our study, we explored the bidirectional communication via soluble factors between bone cells and endotoxin-stimulated splenic lymphocytes in an in vitro coculture model that mimics the inflammatory environment. Both the ability of lymphocytes to affect differentiation and immune properties of bone cells, osteoblas...
journal_title：Inflammation
pub_type： 杂志文章
doi：10.1007/s10753-012-9477-y
更新日期：2012-10-01 00:00:00
abstract：:We have characterized leukocyte migration to the pleural cavity in a methylated-BSA (mBSA)-induced model of murine delayed-type hypersensitivity and evaluated the ability of IL-4 and IL-10 to modulate this response. Neutrophils, macrophages, T cells, and dendritic cells migrated to the pleural cavity in a time-depende...
journal_title：Inflammation
pub_type： 杂志文章
doi：10.1023/a:1025076111950
更新日期：2003-08-01 00:00:00
abstract：:This study investigated the protective effect of Lactobacillus plantarum NDC 75017 (L. plantarum NDC 75017) against acute liver injury induced by lipopolysaccharide (LPS). Thirty male mice were randomly divided into the control, LPS, and LPS + L. plantarum NDC 75017 groups. In the LPS + L. plantarum group, the mice we...
journal_title：Inflammation
pub_type： 杂志文章
doi：10.1007/s10753-014-9886-1
更新日期：2014-10-01 00:00:00
abstract：:The purpose of the study was to explore the association between plasma platelet activating factor (PAF) and platelet activating factor acetylhydrolase (PAF-AH) levels and risk of coronary heart disease (CHD) or blood stasis syndrome (BSS) of CHD. Questionnaire, routine clinical assays and plasma levels of PAF, PAF-AH ...
journal_title：Inflammation
pub_type： 杂志文章
doi：10.1007/s10753-012-9455-4
更新日期：2012-08-01 00:00:00
abstract：:Synovium-derived mesenchymal stem cells (SMSCs) can migrate to the site of destroyed condylar cartilage and differentiate into chondrocytes to repair temporomandibular joint (TMJ) damage. Interleukin (IL)-1β-induced IL-6 secretion has been shown to inhibit the chondrogenic potential of SMSCs. The histone deacetylase i...
journal_title：Inflammation
pub_type： 杂志文章
doi：10.1007/s10753-020-01204-1
更新日期：2020-08-01 00:00:00
abstract：:We investigated whether TESPA1 gene polymorphisms were associated with increased risk of developing ankylosing spondylitis (AS). We also studied whether TESPA1 gene interacts with environmental factors. A total of 494 patients with AS and 478 matched healthy controls were genotyped for four SNPs (rs1801876, rs2171497,...
journal_title：Inflammation
pub_type： 杂志文章
doi：10.1007/s10753-014-9936-8
更新日期：2014-12-01 00:00:00
abstract：:Damaged vascular endothelial cells after ischemic stroke release inflammatory cytokines and adhesion molecules, which could trigger platelet adhesion to vascular endothelial cells and platelet activation, and accelerate thrombus formation. Tetramethylpyrazine is the main bioactive component of Chuanxiong, which has de...
journal_title：Inflammation
pub_type： 杂志文章
doi：10.1007/s10753-019-01119-6
更新日期：2020-02-01 00:00:00
abstract：:Activated macrophages exhibiting diverse phenotypes and various functions contribute to the pathogenesis or amelioration of different diseases like cancer, inflammation, and infectious and autoimmune diseases. However, the mechanisms of macrophage polarization in inflamed joint and its effects on rheumatoid arthritis ...
journal_title：Inflammation
pub_type： 杂志文章
doi：10.1007/s10753-017-0619-0
更新日期：2017-10-01 00:00:00
abstract：:Interleukin-10 (IL-10) is a pleiotropic cytokine and plays an important role in the pathogenesis of systemic lupus erythematosus (SLE). Unlike IL-10 protein, few studies have focused on the potential association between IL-10 receptor (IL-10R) and SLE. The purpose of this study was to examine the association of a sing...
journal_title：Inflammation
pub_type： 杂志文章
doi：10.1007/s10753-013-9658-3
更新日期：2013-12-01 00:00:00
abstract：:Chemerin is shown to be associated with inflammation which is involved in the pathogenesis of diabetic nephropathy. This study aims to determine whether rosiglitazone and pioglitazone ameliorate renal function through an effect on the expression of chemerin and ChemR23 in streptozotocin-induced diabetic rats. The rats...
journal_title：Inflammation
pub_type： 杂志文章
doi：10.1007/s10753-012-9440-y
更新日期：2012-08-01 00:00:00
abstract：:Colchicine and methotrexate are commonly used in the treatment of gout and rheumatoid arthritis, respectively; however the mechanism(s) of action of these drugs remain(s) unknown. The objective of this study was to determine whether colchicine and methotrexate can modify the adhesion and emigration of leukocytes in po...
journal_title：Inflammation
pub_type： 杂志文章
doi：10.1007/BF00917514
更新日期：1992-02-01 00:00:00
abstract：:The excessive activation of microglia plays a key role in the pathogenesis of neurodegenerative diseases. The neuroprotective properties of rosmarinic acid have been reported in a variety of disease models both in vitro and in vivo; however, the mechanism underlying its anti-neuroinflammatory activity has not been cle...
journal_title：Inflammation
pub_type： 杂志文章
doi：10.1007/s10753-017-0728-9
更新日期：2018-03-01 00:00:00
abstract：:Aqueous extracts of calf thymus from immunologically stimulated animals contain trypsin- and neuraminidase-labile macromolecules with molecular weights of less than 30,000 daltons which will specifically attract chemotactically lymphocytes. This activity we ascribe to "lymphotactin." ...
journal_title：Inflammation
pub_type： 杂志文章
doi：10.1007/BF00917531
更新日期：1976-03-01 00:00:00
abstract：:Dialysate and serum levels of granulocyte-colony stimulating factor (G-CSF), granulocyte macrophage colony stimulating factor (GM-CSF) and leukemia inhibitory factor (LIF) were analyzed in patients with continuous ambulatory peritoneal dialysis (CAPD). Samples from the peritoneal effluent and from serum were obtained ...
journal_title：Inflammation
pub_type： 杂志文章
doi：10.1023/a:1022320916105
更新日期：1998-08-01 00:00:00
