Abstract:
:The respiratory burst is a series of metabolic events which result in the production of microbicidal oxidants by phagocytes. The enzyme responsible for the respiratory burst is a membrane-bound oxidase which catalyzes the production of O-2 by the NADPH-dependent reduction of oxygen. Activity of this oxidase is diminished by a variety of guanosine-containing nucleotides. The decrease in activity caused by GTP, the most potent of these, occurs rapidly and is not solely dependent on hydrolysis of terminal phosphate groups. GTP appears to diminish oxidase activity through both inhibition and inactivation. GTP-mediated inhibition is kinetically mixed with respect to NADPH.
journal_name
Inflammationjournal_title
Inflammationauthors
Kaufman MR,Babior BMdoi
10.1007/BF00917260subject
Has Abstractpub_date
1983-09-01 00:00:00pages
233-40issue
3eissn
0360-3997issn
1573-2576journal_volume
7pub_type
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