Abstract:
:Whether lipopolysaccharide (LPS) can promote vasa vasorum (VV) proliferation for atherosclerosis in vivo is unclear. Eighteen rabbits with atherosclerosis were randomly assigned into one of three groups of six. Group A received biweekly injections of 10 mL saline after 2 weeks of balloon injury. Groups B and C received biweekly intravenous injections of 3.0 μg LPS in 10 mL saline at weeks 10 and 4, respectively, until study termination. LPS significantly increased the levels of triglycerides and C-reactive protein and decreased the level of high-density lipoprotein cholesterol. Group C had significant larger plaques and more macrophages than group A (p = 0.01 and p < 0.001, respectively). Contrast enhancement ultrasound imaging and histological detection demonstrated that plaques in group C had a significantly higher VV density than that in group A (p = 0.009 and p = 0.002, respectively). In summary, VV proliferation for plaque destabilization can be accelerated by LPS-induced systemic inflammation and changes in lipid profiles.
journal_name
Inflammationjournal_title
Inflammationauthors
Tian J,Hu S,Han X,Dong N,Yu H,Sun Y,Yu Bdoi
10.1007/s10753-012-9468-zsubject
Has Abstractpub_date
2012-08-01 00:00:00pages
1530-7issue
4eissn
0360-3997issn
1573-2576journal_volume
35pub_type
杂志文章相关文献
INFLAMMATION文献大全abstract::Tizoxanide is the main active metabolite of nitazoxanide. Nitazoxanide and tizoxanide have a broad-spectrum anti-infective effect, including parasites, bacteria, and virus. In the present study, we investigated the anti-inflammatory effect of tizoxanide on lipopolysaccharide (LPS)-stimulated RAW264.7 cells and reveale...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-019-00994-3
更新日期:2019-08-01 00:00:00
abstract::The present study evaluated the anti-inflammatory effect of nanoencapsulated curcuminoid preparations of poly(vinyl pyrrolidone) (Nano-cur) and free curcuminoids (Cur) in an experimental model of croton oil-induced cutaneous inflammation. Male Swiss mice, weighing 25-30 g, received oral treatment by gavage 1 h before ...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-020-01360-4
更新日期:2020-11-09 00:00:00
abstract::Obesity provokes an imbalance in the immune system, including an aberrant type I interferon response during some viral infections and after TLR stimulation. SOCS3 overexpression and altered systemic leptin levels could be responsible for the reduced type I interferon production in people with obesity and, eventually, ...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-016-0452-x
更新日期:2017-02-01 00:00:00
abstract::IFN-τ, which is a type I interferon with low cytotoxicity, is defined as a pregnancy recognition signal in ruminants. Type I interferons have been used as anti-inflammatory agents, but their side effects limit their clinical application. The present study aimed to determine the anti-inflammatory effects of IFN-τ in a ...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-016-0348-9
更新日期:2016-06-01 00:00:00
abstract::Macrophages are one of the most heterogenic immune cells involved in skeletal muscle regeneration. After skeletal muscle damage, M1 phenotypes exhibit pro-inflammatory reaction. In a later stage, they are converted to M2 phenotypes with anti-inflammatory properties. To study when gene expressions of macrophage polariz...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-014-0024-x
更新日期:2015-02-01 00:00:00
abstract::Induction of colitis by 2,4,6-Trinitrobenzenesulphonic acid (TNB) in the rat is a widely used experimental model of inflammatory bowel disease. Action of TNB as a hapten, induces colitis involving infiltration of colonic mucosa by neutrophils and macrophages and increased production of inflammatory mediators. The aim ...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1023/a:1020241028723
更新日期:1999-04-01 00:00:00
abstract::Two methods for quantitating polymorphonuclear leukocyte (PMN) accumulation in inflammatory skin lesions were studied. The lesions were produced in rats by intradermal injections of different dilutions of zymosan-activated plasma (ZAP). PMN accumulation in the skin lesions was estimated by determination of (1) homolog...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00917262
更新日期:1983-09-01 00:00:00
abstract::This study investigated the protective effect of Lactobacillus plantarum NDC 75017 (L. plantarum NDC 75017) against acute liver injury induced by lipopolysaccharide (LPS). Thirty male mice were randomly divided into the control, LPS, and LPS + L. plantarum NDC 75017 groups. In the LPS + L. plantarum group, the mice we...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-014-9886-1
更新日期:2014-10-01 00:00:00
abstract::Integrin-α9 (ITGA9) and its corresponding ligands are involved in inflammatory and immune responses. The present study aimed to investigate whether ITGA9 participates in the development of chronic periodontitis (ChP) and to explore the underlying mechanisms. We collected gingival tissue and gingival crevicular fluid i...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-020-01226-9
更新日期:2020-08-01 00:00:00
abstract::Inflammatory bowel disease (IBD) in humans is closely related to bacterial infection and the disruption of the intestinal barrier. Paeoniflorin (PF), a bioactive compound from Paeonia lactiflora Pallas plants, exerts a potential effect of anti-inflammatory reported in various researches. However, the effect of PF on i...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-019-01085-z
更新日期:2019-12-01 00:00:00
abstract::The exact etiology and pathogenesis of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) are still unknown, as a result, available therapeutic options for patients are far from satisfactory. Therefore, there is a need to develop a valid therapeutic approach that can ameliorate the manifestations of CP/CPPS. F...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-019-00968-5
更新日期:2019-06-01 00:00:00
abstract::A variety of steroidal and nonsteroidal antiinflammatory agents (NSAs) were compared for their effectiveness against a developing acute inflammatory reaction. Only BW 755C [3-amino-1-(m-trifluoromethyl)-phenyl-2-pyrazole] was immediately effective when administered 2 h after carrageenin, as the 3-h swelling was signif...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00916412
更新日期:1984-09-01 00:00:00
abstract::The purpose of the present study is to evaluate the effect of emu oil on bioavailability of curcumin when co-administered and to evaluate the property that enhances the anti-inflammatory potential of curcumin. Oral bioavailability of curcumin in combination with emu oil was determined by measuring the plasma concentra...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-014-9948-4
更新日期:2014-12-01 00:00:00
abstract::Protamine sulfate induces enzyme secretion from rabbit neutrophils. Enzyme secretion is mainly due to exocytosis but, depending on the experimental conditions, a small amount of cytolysis may occur. As compared with stimulation of neutrophil functions by other activators, protamine sulfate-induced enzyme release by ex...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00915825
更新日期:1986-12-01 00:00:00
abstract::Gossypol is present in antiinflammatory poultices made from the medicinal tree Thespesia populnea. Isolated human neutrophils exposed to 3-20 microM gossypol for 15-90 min were assayed in vitro for superoxide production and surface expression of Mac-1 (CD11b/CD18). Gossypol increased superoxide production in a time- a...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF01560692
更新日期:1994-10-01 00:00:00
abstract::Methicillin-resistant Staphylococcus aureus (MRSA) with exogenous cassette DNA containing the methicillin-resistant gene mecA (SCCmec) poses a problem as a drug-resistant bacterium responsible for hospital- and community-acquired infections. The frequency of MRSA detection has recently been increasing rapidly in Japan...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-011-9395-4
更新日期:2012-06-01 00:00:00
abstract::This study investigated the expression of miRNA-221 in asthmatics in order to determine whether miRNA-221 plays a role in the development of asthma. Real-time PCR was used to detect the miRNA-221 in both asthmatic and control subjects. In addition, airway inflammation was evaluated by cell counting and tissue biopsy i...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-012-9474-1
更新日期:2012-08-01 00:00:00
abstract::Recent data demonstrated that chemokine CXCL13 mediates neuroinflammation and contributes to the maintenance of neuropathic pain after nerve injury in the spinal cord. Pro-nociceptive chemokines activate mitogen-activated protein kinases (MAPKs) which are potential signaling pathways contributing to the nociceptive be...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-017-0520-x
更新日期:2017-06-01 00:00:00
abstract::The liver is an immunocompetent organ that plays a key role in the immune response to infections, and the development of hepatic immune function during early postnatal stages has not been thoroughly characterized. This study analyzed the constitutive expression of complement factors, namely C3 and C9, and pattern reco...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-010-9265-5
更新日期:2011-12-01 00:00:00
abstract::Activated macrophages exhibiting diverse phenotypes and various functions contribute to the pathogenesis or amelioration of different diseases like cancer, inflammation, and infectious and autoimmune diseases. However, the mechanisms of macrophage polarization in inflamed joint and its effects on rheumatoid arthritis ...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-017-0619-0
更新日期:2017-10-01 00:00:00
abstract::Intrapleural tetracycline (TCN) results in pleural macrophage influx and pleural fibrosis; intrapleural carrageenan (CAR) induces macrophage influx without fibrosis. Because macrophage products can modulate mesothelial cell activity, we investigated the role of TCN- and CAR-induced pleural macrophages on mesothelial c...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00916387
更新日期:1993-02-01 00:00:00
abstract::Ischemic stroke is a major cause of death and motor disabilities all over the world. It is a muti-factorial disorder associated with inflammatory, apoptotic, and oxidative responses. Nateglinide (NAT), an insulinotropic agent used for the treatment of type 2 diabetes mellitus, recently showed potential anti-inflammato...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-019-01154-3
更新日期:2020-04-01 00:00:00
abstract::Naringin (COG) is a flavanone with various bioactivities including an expectorant effect, antitussive effect, and inhibitory effect on asthma and acute lung injury. The aims of the present study were to investigate the antiarthritis activities of COG and elucidate the underlying mechanisms with regard to its molecular...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-014-0027-7
更新日期:2015-02-01 00:00:00
abstract::The present study was designed to evaluate inflammatory changes in collapsed lungs during one-lung ventilation using the assistance of a bronchoscopic microsampling probe. Serial albumin and interleukin (IL)-8 concentrations in epithelial lining fluid (ELF) were measured in seven patients undergoing resection of lung ...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-012-9505-y
更新日期:2012-12-01 00:00:00
abstract::Current knowledge implicates pleural mesothelial cells as mainly responsible for inflammatory responses in the pleural space. However, a vast body of recent evidence underscores the important role of fibroblasts in the process of inflammation in several types of tissues. We hypothesize that HPFBs (human pleural fibrob...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1023/a:1014884127573
更新日期:2002-04-01 00:00:00
abstract::The phenotypic alterations between blood monocytes from 11 patients with end-stage renal disease, who had been on peritoneal dialysis for less than one week, and blood monocytes from 10 healthy controls, were analyzed. In addition, peritoneal macrophages in the dialysate effluent were enclosed. Analysis of functional ...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1023/a:1022395723972
更新日期:1998-02-01 00:00:00
abstract::Rheumatoid synovial fluids generated significantly greater amounts of superoxide, lysosomal enzymes, and superoxide dismutase from neutrophils into extracellular fluid than osteoarthritic synovial fluids. Rheumatoid factors isolated from serum suppressed superoxide-generating activity of performed immune complexes, bu...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00916016
更新日期:1987-06-01 00:00:00
abstract::Comparison of the physiologic responses in rabbits to the intravenous infusion of two polymorphonuclear neutrophil (PMN) activators, N-formyl-methionyl-leucyl-phenylalanine (FMLP) and phorbol myristate acetate (PMA), has revealed marked differences in kinetics for activation between these agents. FMLP infusion was ass...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00915990
更新日期:1987-12-01 00:00:00
abstract::Oroxylin A, a natural flavonoid isolated from the medicinal herb Scutellaria baicalensis Georgi, has been reported to have anti-inflammatory property. In this study, we aimed to investigate the protective effects and mechanism of oroxylin A on allergic inflammation in OVA-induced asthma murine model. BABL/c mice were ...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-016-0317-3
更新日期:2016-04-01 00:00:00
abstract::Alveolar type I epithelial cells (AECIs) play an important role in the pathogenesis of acute lung injury. The receptor for advanced glycation end-products (RAGEs) is expressed at a high basal level in AECIs, and its soluble isoform is suggested as a marker of AECI injury. However, the molecular mechanism by which RAGE...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-014-9889-y
更新日期:2014-10-01 00:00:00