Novel Treatment of Experimental Autoimmune Prostatitis by Nanoparticle-Conjugated Autoantigen Peptide T2.

abstract：:Recent data demonstrated that chemokine CXCL13 mediates neuroinflammation and contributes to the maintenance of neuropathic pain after nerve injury in the spinal cord. Pro-nociceptive chemokines activate mitogen-activated protein kinases (MAPKs) which are potential signaling pathways contributing to the nociceptive be...

journal_title：Inflammation

authors： Zhang Q,Zhu MD,Cao DL,Bai XQ,Gao YJ,Wu XB

更新日期：2017-06-01 00:00:00

abstract：:Bee venom (BV) is used in folk medicine to treat arthritis. It has antiinflammatory effects in animal models of rheumatic disease. We have studied the effects of BV on human neutrophil production of superoxide (O2-) and hydrogen peroxide, finding potent, nontoxic, dose-dependent production inhibition. Melittin, the ma...

journal_title：Inflammation

authors： Somerfield SD,Stach JL,Mraz C,Gervais F,Skamene E

更新日期：1986-06-01 00:00:00

abstract：:Strong anti-inflammatory activity has been found in Laminaria japonica dichloromethane fraction (LDF); however, the molecular mechanisms underlying its anti-inflammatory activity are not reported. Our results indicated that LDF inhibited LPS-induced nitric oxide and prostaglandin E(2) production in a dose-dependent ma...

journal_title：Inflammation

authors： Lee JY,Lee MS,Choi JW,Shin TS,Woo HC,Kim HR

更新日期：2012-10-01 00:00:00

abstract：:Endothelial activation with excessive recruitment and adhesion of immune cells plays a central role in the progression of sepsis. We established a microfluidic system to study the activation of human umbilical vein endothelial cells by conditioned medium containing plasma from lipopolysaccharide-stimulated whole blood...

journal_title：Inflammation

authors： Eichhorn T,Rauscher S,Hammer C,Gröger M,Fischer MB,Weber V

更新日期：2016-10-01 00:00:00

abstract：:Thermal injury in rats leads to an impairment of polymorphonuclear leukocyte (PMN) functions, particularly oxidative metabolism and phosphoinositide turnover. As prostaglandin E2, which has immunosuppressive properties, is released in high levels after burn trauma, we investigated the in vitro and in vivo effects of a...

journal_title：Inflammation

authors： Tissot M,Roch-Arveiller M,Fontagne J,Giroud JP

更新日期：1992-12-01 00:00:00

abstract：:Lipopolysaccharide (LPS) can activate endothelial cells and induce inflammatory injury. Toll-like receptor-4 (TLR-4) is integrally involved in LPS signaling and has a requisite role in the activation of nuclear factor (NF)-κB. A number of studies have demonstrated the cytoprotective action of perfluorocarbon (PFC) bot...

journal_title：Inflammation

authors： Xu S,Wang P,Wei K,Liu F,Liang Z,Zhao X,Li A,Chen L

更新日期：2013-04-01 00:00:00

abstract：:Muscle strength is of importance for postsurgical rehabilitation. Myostatin is a growth factor that regulates the size of muscles and could thus influence muscle mass and function in the postsurgical period. The aim of the present study was to study the changes in myostatin levels during the postsurgical inflammatory ...

journal_title：Inflammation

authors： Åkerfeldt T,Helmersson-Karlqvist J,Gunningberg L,Swenne CL,Larsson A

更新日期：2015-08-01 00:00:00

abstract：:Two different substances, glycogen and thioglycollate, were used to recruit early peritoneal exudate cells (4h). In the acute phase of the inflammatory response the cellular infiltrate is large, and the predominant cell (greater than 95%) is the polymorphonuclear neutrophil. Supernatant had differing effects on lympho...

journal_title：Inflammation

authors： Rodrick ML,Lamster IB,Sonis ST,Pender SG,Kolodkin AB,Fitzgerald JE,Wilson RE

更新日期：1982-03-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is a chronic inflammation that can lead to loss of range of joint abnormalities in severe cases. Diosgenin has anti-inflammatory effects. This paper discussed the effect and mechanism of diosgenin on excessive proliferation and inflammatory response of synovial cells in RA. CCK-8 detected the...

journal_title：Inflammation

authors： Wang R,Sun Y,Jin X,Wen W,Cao Y

更新日期：2020-11-25 00:00:00

abstract：:Interferon gamma (IFNγ)-mediated activation of the myelomonocytic cell line HL-60 and peripheral blood monocytes will induce expression of an epitope for the monoclonal antibody which recognizes human αEβ7 integrin, HML-1. Here, we found that the anti-human αEβ7 monoclonal antibody Ber-ACT8 did not recognize IFNγ-stim...

journal_title：Inflammation

authors： Miller LA,Li C,Hyde DM

更新日期：2000-06-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by debilitating pain, cartilage destruction, and loss of joint function. Management of RA includes drugs that target NF-κB and downstream cytokine production. Therefore, molecules that act by inhibiting this signaling pathway without the severe si...

journal_title：Inflammation

authors： Zarpelon AC,Fattori V,Souto FO,Pinto LG,Pinho-Ribeiro FA,Ruiz-Miyazawa KW,Turato WM,Cunha TM,da Costa FB,Cunha FQ,Casagrande R,Arakawa NS,Verri WA Jr

更新日期：2017-12-01 00:00:00

abstract：:In an effort to determine the mechanism of papain action in causing an emphysema-like lesion in hamsters, the number and types of cells and the activities of two lysosomal enzymes in the lung were determined after papain exposure. Three and four weeks after a 3-h exposure to an aerosol of 3% papain the following alter...

journal_title：Inflammation

authors： Ackerman NR,Corkey R,Perkins D

更新日期：1978-03-01 00:00:00

abstract：:Vascular inflammation plays a key role in the initiation and progression of atherosclerosis, a major complication of diabetes mellitus. Orientin, a C-glycosyl flavonoid, is known to have anxiolytic and antioxidative activity. In this study, we assessed whether orientin can suppress vascular inflammation induced by hig...

journal_title：Inflammation

authors： Ku SK,Kwak S,Bae JS

更新日期：2014-12-01 00:00:00

abstract：:NSAIDs are widely used to alleviate the symptoms of OA. It remains controversial as to what effects these agents have on the progression of OA. In vitro studies showed several types of NSAIDs (e.g., sodium salicylate, indomethacin) inhibited the synthesis of cartilage matrix component, but some types of NSAIDs (e.g., ...

journal_title：Inflammation

authors： Ding C

更新日期：2002-06-01 00:00:00

abstract：:We aim to determine the extent of the CD40-CD40L pathway involvement in activated platelet-induced changes in human umbilical endothelial cells (HUVECs). Activated platelets were co-incubated with HUVECs in the presence or absence of CD40LmAb. HUVECs were also directly stimulated with rhCD40L. HUVEC endothelial cycloo...

journal_title：Inflammation

authors： Wu YQ,Chen XS,Chai JB

更新日期：2012-06-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is a chronic autoimmune disease which involves many organs and presents with various symptoms. It has been shown that genetic and environmental factors play a major role in this disease and may affect the onset, activity, damage, and mortality of the disease. According to recent stud...

journal_title：Inflammation

authors： Alesaeidi S,Karami J,Mahmoudi M,Akbarian M,Poursani S,Amirzadeh A,Haddadi NS,Saffari E,Jamshidi AR

更新日期：2015-12-01 00:00:00

abstract：:This study aimed to investigate molecule B7-H3 expression profiles of patients with ankylosing spondylitis (AS) and the clinical significance of B7-H3 in the pathogenesis of AS. Serum B7-H3 levels were measured by ELISA in patients with AS and healthy controls. The expression of B7-H3 protein and mRNA on CD14+ monocyt...

journal_title：Inflammation

authors： Yan R,Hu Y,Yu P,Wen H,Feng P,Yang S

更新日期：2015-01-01 00:00:00

abstract：:We analyzed the effect of the PAF receptor antagonist (+)-cis-3,5-dimethyl-2-(3-pyridyl)thiazolidin-4-one hydrochloride (SM-12502) on human platelet aggregation as well as mediator release. After incubation of human platelet with different concentrations of SM-12502 the cells were subsequently stimulated with either t...

journal_title：Inflammation

authors： Köller M,Hilger RA,König W

更新日期：1996-02-01 00:00:00

abstract：:In our study, we explored the bidirectional communication via soluble factors between bone cells and endotoxin-stimulated splenic lymphocytes in an in vitro coculture model that mimics the inflammatory environment. Both the ability of lymphocytes to affect differentiation and immune properties of bone cells, osteoblas...

journal_title：Inflammation

authors： Cvija H,Kovacic N,Katavic V,Ivcevic S,Aguila HL,Marusic A,Grcevic D

更新日期：2012-10-01 00:00:00

abstract：:Experimental studies indicate that sepsis causes remote organ injury although the molecular mechanism has not been clearly defined. In this report, the role of oxidative damage, and inflammation on lung injury, following sepsis model by cecal ligation and puncture, and the effects of quercetin, antioxidant, and anti-i...

journal_title：Inflammation

authors： Gerin F,Sener U,Erman H,Yilmaz A,Aydin B,Armutcu F,Gurel A

更新日期：2016-04-01 00:00:00

abstract：:To elucidate the role of major chemotactic factors, cytokine-induced neutrophil chemoattractant (CINC), leukotriene B4 (LTB4) and C5a in lipopolysaccharide (LPS)-induced acute lung injury in rat, we employed three reagents: anti-CINC-1 antibody, an LTB4 receptor antagonist (ONO-4057) and an anti-complementary agent (K...

journal_title：Inflammation

authors： Yamasawa H,Ishii Y,Kitamura S

更新日期：1999-06-01 00:00:00

abstract：:Numerous cytokines, including vascular endothelial growth factor (VEGF), are implicated in the pathogenesis of sepsis. While overexpression of VEGF produces pulmonary capillary leak, the role of VEGF in sepsis is less clear. We investigated VEGF in sepsis, utilizing a VEGF trap (VEGF(T)). Polymicrobial sepsis was indu...

journal_title：Inflammation

authors： Nolan A,Weiden MD,Thurston G,Gold JA

更新日期：2004-10-01 00:00:00

abstract：:Previous studies indicate that aspirin can promote neutrophil (PMN) adhesion to endothelial cells and neutrophil-mediated endothelial cell detachment. The objectives of the present study were to determine whether PMN adhesion is a prerequisite for aspirin-induced, PMN-mediated endothelial cell detachment and whether n...

journal_title：Inflammation

authors： Yoshida N,Cepinskas G,Granger DN,Anderson DC,Wolf RE,Kvietys PR

更新日期：1995-06-01 00:00:00

abstract：:Interleukin-10 (IL-10) is a pleiotropic cytokine and plays an important role in the pathogenesis of systemic lupus erythematosus (SLE). Unlike IL-10 protein, few studies have focused on the potential association between IL-10 receptor (IL-10R) and SLE. The purpose of this study was to examine the association of a sing...

journal_title：Inflammation

authors： Peng H,Liu CY,Zhou M,Wen PF,Zhang M,Qiu LJ,Ni J,Liang Y,Pan HF,Ye DQ

更新日期：2013-12-01 00:00:00

abstract：:The effects of an intravenous injection (i.v.) of Sephadex beads (20 mg kg(-1)) were examined on bronchial responsiveness to ACh (1-200 microg kg(-1) i.v.) as well as on cell accumulation in guinea-pig lung. Bronchial hyperreactivity to ACh, measured as increase in pulmonary insufflation pressure (PIP), was observed 3...

journal_title：Inflammation

authors： Conroy DM,Sirois P

更新日期：1999-10-01 00:00:00

abstract：:Sanggenon C (SC), a natural flavonoid extracted from Cortex Mori (Sang Bai Pi), is reported to possess anti-inflammatory and antioxidant properties in hypoxia. The present study aimed to investigate the therapeutic potential and the underlying mechanisms of SC in cerebral ischemia-reperfusion (I/R) injury. A rat model...

journal_title：Inflammation

authors： Zhao Y,Xu J

更新日期：2020-08-01 00:00:00

abstract：:To investigate patients with severe acute pancreatitis (SAP) by dynamic levels of pro-/anti-inflammatory cytokines and endotoxin (ET) in plasma and the relationship between immunity and infection, organ dysfunction. Seventy-two patients with SAP were recruited. The ET, tumor necrosis factor-α (TNF-α), interleukin-6 (I...

journal_title：Inflammation

authors： Shen Y,Cui N,Miao B,Zhao E

更新日期：2011-02-01 00:00:00

abstract：:Protamine sulfate induces enzyme secretion from rabbit neutrophils. Enzyme secretion is mainly due to exocytosis but, depending on the experimental conditions, a small amount of cytolysis may occur. As compared with stimulation of neutrophil functions by other activators, protamine sulfate-induced enzyme release by ex...

journal_title：Inflammation

authors： Elferink JG,Deierkauf M

更新日期：1986-12-01 00:00:00

abstract：:The aim of this study is to investigate the cardioprotective effects of morroniside in rats following acute myocardial infarction. An acute myocardial infarction (AMI) was induced by ligating the anterior descending coronary artery (LAD) [1]. Following AMI, morroniside was administered intragastrically for 24 h at dos...

journal_title：Inflammation

authors： Yu B,Wang W

更新日期：2018-03-01 00:00:00

abstract：:We analyzed the influence of heparins (unfractionated heparin, UFH and low molecular weight heparin certoparin) on the generation of IL-1ra, IL-6, IL-10, and IL-12p40 and from leukocyte fractions in vitro. Polymorphonuclear neutrophil leukocytes (PMN) and peripheral blood mononuclear cells (PBMC) from 16 different hea...

journal_title：Inflammation

authors： Köller M,Kutscha-Lissberg F,Brom J,Weidinger G,Muhr G

更新日期：2001-10-01 00:00:00