当前位置： SCI文献检索 > INFLAMMATION期刊下所有文献 > The Sesquiterpene Lactone, Budlein A, Inhibits Antigen-Induced Arthritis in Mice: Role of NF-κB and Cytokines.

The Sesquiterpene Lactone, Budlein A, Inhibits Antigen-Induced Arthritis in Mice: Role of NF-κB and Cytokines.

Abstract：

:Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by debilitating pain, cartilage destruction, and loss of joint function. Management of RA includes drugs that target NF-κB and downstream cytokine production. Therefore, molecules that act by inhibiting this signaling pathway without the severe side effects of, for instance, corticoids would be suitable therapeutic strategies. Budlein A is a sesquiterpene lactone with antinociceptive and anti-inflammatory properties related to the inhibition of pro-inflammatory cytokines and neutrophil recruitment. In this study, the effect of budlein A was evaluated in antigen-induced arthritis (AIA) in mice. At the 26th day, leukocyte recruitment to the knee joint, knee contents of proteoglycans, blood levels of ALT and AST, stomach tissue myeloperoxidase activity, and RT-qPCR for pro-inflammatory gene mRNA expression in knee joint samples was performed. NF-κB luciferase activity was evaluated in RAW 264.7 macrophages. Budlein A treatment dose-dependently inhibited AIA-induced mechanical hyperalgesia, edema, total leukocytes and neutrophil recruitment, and proteoglycan degradation. Budlein A did not induce gastric or liver damage. Budlein also inhibited AIA-induced Il-33, Tnf, Il-1β, preproET-1, and Cox-2 mRNA expression. In vitro, budlein reduced TNF- and IL-1β-induced NF-κB activity in RAW 264.7 macrophages. Altogether, we demonstrate that budlein A ameliorates AIA-induced inflammation and pain by targeting NF-κB. Importantly, budlein A does not induce in vivo side effects, suggesting that it possesses a favorable pre-clinical profile as analgesic and it is a prosperous molecule to be further investigated for the treatment of RA.

journal_name

Inflammation

journal_title

Inflammation

authors

Zarpelon AC,Fattori V,Souto FO,Pinto LG,Pinho-Ribeiro FA,Ruiz-Miyazawa KW,Turato WM,Cunha TM,da Costa FB,Cunha FQ,Casagrande R,Arakawa NS,Verri WA Jr

doi

10.1007/s10753-017-0642-1

subject

Has Abstract

pub_date

2017-12-01 00:00:00

pages

2020-2032

issue

6

eissn

0360-3997

issn

1573-2576

pii

10.1007/s10753-017-0642-1

journal_volume

40

pub_type

杂志文章

相关文献

INFLAMMATION文献大全
  • HSP90 Inhibition Suppresses PGE2 Production via Modulating COX-2 and 15-PGDH Expression in HT-29 Colorectal Cancer Cells.

    abstract：:The existence of multiple-interactive roles between several signaling pathways in tumorigenesis shows the significance of pharmacological factors like heat shock protein 90 (HSP90) inhibitors which control several signaling pathways simultaneously. HSP90 as a molecular chaperone supports the active conformational stru...

    journal_title：Inflammation

    pub_type： 杂志文章

    doi：10.1007/s10753-016-0343-1

    authors： Mohammadi A,Yaghoobi MM,Gholamhoseinian Najar A,Kalantari-Khandani B,Sharifi H,Saravani M

    更新日期：2016-06-01 00:00:00

  • Improvement of bioavailability and anti-inflammatory potential of curcumin in combination with emu oil.

    abstract：:The purpose of the present study is to evaluate the effect of emu oil on bioavailability of curcumin when co-administered and to evaluate the property that enhances the anti-inflammatory potential of curcumin. Oral bioavailability of curcumin in combination with emu oil was determined by measuring the plasma concentra...

    journal_title：Inflammation

    pub_type： 杂志文章

    doi：10.1007/s10753-014-9948-4

    authors： Jeengar MK,Shrivastava S,Nair K,Singareddy SR,Putcha UK,Talluri MV,Naidu VG,Sistla R

    更新日期：2014-12-01 00:00:00

  • miR-320b Is Down-Regulated in Psoriasis and Modulates Keratinocyte Proliferation by Targeting AKT3.

    abstract：:We investigated the molecular mechanisms underlying the role of miRNAs in the pathogenesis of psoriasis to discover novel potential diagnostic markers and treatment targets. We screened Chinese Han individuals using gene chip technology to identify differentially expressed miRNAs in the epidermal tissue of lesions fro...

    journal_title：Inflammation

    pub_type： 杂志文章

    doi：10.1007/s10753-018-0859-7

    authors： Wang Y,Yu X,Wang L,Ma W,Sun Q

    更新日期：2018-12-01 00:00:00

  • Characterization of a 130,000-dalton glycoprotein isolated from pulmonary secretions of patients with alveolar proteinosis.

    abstract：:A new glycoprotein with an apparent molecular weight of 130,000 was isolated, purified, and partially characterized from the pulmonary secretions which accumulate so massively in the lungs of patients suffering from pulmonary alveolar proteinosis. The amino acid analysis of the glycoprotein showed the presence of rela...

    journal_title：Inflammation

    pub_type： 杂志文章

    doi：10.1007/BF00913501

    authors： Sahu S,Lynn WS

    更新日期：1979-09-01 00:00:00

  • Expression of the HML-1 Epitope on Human Monocytes is Independent of αE Integrin mRNA.

    abstract：:Interferon gamma (IFNγ)-mediated activation of the myelomonocytic cell line HL-60 and peripheral blood monocytes will induce expression of an epitope for the monoclonal antibody which recognizes human αEβ7 integrin, HML-1. Here, we found that the anti-human αEβ7 monoclonal antibody Ber-ACT8 did not recognize IFNγ-stim...

    journal_title：Inflammation

    pub_type： 杂志文章

    doi：10.1023/a:1007007428255

    authors： Miller LA,Li C,Hyde DM

    更新日期：2000-06-01 00:00:00

  • Protection of hypoxic cytotoxicity by glucocorticoid in the liver.

    abstract：:Induction of hypoxia for 2.5 h in perfused cat livers resulted in a 10-fold increase in cathepsin D and a 15-fold increase in lactic dehydrogenase (LDH) activities in the perfusate and a 42% depression of the clearance rate of particles by the reticuloendothelial system (RES). Addition of 10(-3) M methylprednisolone (...

    journal_title：Inflammation

    pub_type： 杂志文章

    doi：10.1007/BF00920336

    authors： Carlson RP,Lefer AM

    更新日期：1976-12-01 00:00:00

  • Lipopolysaccharide-induced proliferation of the vasa vasorum in a rabbit model of atherosclerosis as evaluated by contrast-enhanced ultrasound imaging and histology.

    abstract：:Whether lipopolysaccharide (LPS) can promote vasa vasorum (VV) proliferation for atherosclerosis in vivo is unclear. Eighteen rabbits with atherosclerosis were randomly assigned into one of three groups of six. Group A received biweekly injections of 10 mL saline after 2 weeks of balloon injury. Groups B and C receive...

    journal_title：Inflammation

    pub_type： 杂志文章

    doi：10.1007/s10753-012-9468-z

    authors： Tian J,Hu S,Han X,Dong N,Yu H,Sun Y,Yu B

    更新日期：2012-08-01 00:00:00

  • Baicalin Inhibits Lipopolysaccharide-Induced Inflammation Through Signaling NF-κB Pathway in HBE16 Airway Epithelial Cells.

    abstract：:Baicalin, a flavonoid monomer derived from Scutellaria baicalensis called Huangqin in mandarin, is the main active ingredient contributing to S. baicalensis' efficacy. It is known in China that baicalin has potential therapeutic effects on inflammatory diseases. However, its anti-inflammatory mechanism has still not b...

    journal_title：Inflammation

    pub_type： 杂志文章

    doi：10.1007/s10753-015-0124-2

    authors： Dong SJ,Zhong YQ,Lu WT,Li GH,Jiang HL,Mao B

    更新日期：2015-08-01 00:00:00

  • Pathological and behavioral risk factors for higher serum C-reactive protein concentrations in free-living adults--a Brazilian community-based study.

    abstract：:Low-grade chronic systemic inflammation is often associated with chronic non-communicable diseases, and its most frequently used marker, the C-reactive protein (CRP), has become an identifier of such diseases as well as an independent predictor for cardiovascular disorders and mortality. CRP is produced in response to...

    journal_title：Inflammation

    pub_type： 杂志文章

    doi：10.1007/s10753-012-9515-9

    authors： Moreto F,de Oliveira EP,Manda RM,Torezan GA,Teixeira O,Michelin E,Burini RC

    更新日期：2013-02-01 00:00:00

  • MiR-146a regulates IL-6 production in lipopolysaccharide-induced RAW264.7 macrophage cells by inhibiting Notch1.

    abstract：:Inflammatory cells, macrophages induced by lipopolysaccharide (LPS) stimulation, lead to the production of inflammatory cytokines, which are crucial to host defense. MicroRNAs are short noncoding RNAs that regulate key biological processes via suppression of gene expression at posttranscriptional levels. Recently, miR...

    journal_title：Inflammation

    pub_type： 杂志文章

    doi：10.1007/s10753-013-9713-0

    authors： He Y,Sun X,Huang C,Long XR,Lin X,Zhang L,Lv XW,Li J

    更新日期：2014-02-01 00:00:00

  • Effects of Salidroside on Myocardial Injury In Vivo In Vitro via Regulation of Nox/NF-κB/AP1 Pathway.

    abstract：:Salidroside (Sal), a phenylpropanoid glycoside isolated from a popular traditional Chinese medicinal plant Rhodiola rosea L., possesses multiple pharmacological actions. This aim of this study is to investigate the effects of Sal against isoproterenol (ISO)-induced myocardial ischemia. Fifty male Sprague-Dawley rats w...

    journal_title：Inflammation

    pub_type： 杂志文章

    doi：10.1007/s10753-015-0134-0

    authors： Zhu L,Wei T,Chang X,He H,Gao J,Wen Z,Yan T

    更新日期：2015-08-01 00:00:00

  • Effect of guanosine nucleotides on the respiratory burst oxidase from human neutrophils.

    abstract：:The respiratory burst is a series of metabolic events which result in the production of microbicidal oxidants by phagocytes. The enzyme responsible for the respiratory burst is a membrane-bound oxidase which catalyzes the production of O-2 by the NADPH-dependent reduction of oxygen. Activity of this oxidase is diminis...

    journal_title：Inflammation

    pub_type： 杂志文章

    doi：10.1007/BF00917260

    authors： Kaufman MR,Babior BM

    更新日期：1983-09-01 00:00:00

  • Effect of interleukin-8 and monocyte chemotactic protein-1 on adhesion of circulating granulocytes and monocytes from asthma patients to human venous endothelial cells.

    abstract：:The adhesive interactions between phagocytes and endothelial cells (EC) can be modulated by inflammatory cytokines and chemotactic proteins which are released during an inflammatory response. The aim of the present study was to investigate first whether the adhesive properties of granulocytes and monocytes from asthma...

    journal_title：Inflammation

    pub_type： 杂志文章

    doi：10.1023/a:1022344307926

    authors： Verdegaal EM,Zegveld ST,Beekhuizen H,Bakker W,van Furth R

    更新日期：1998-04-01 00:00:00

  • Downhill exercise-induced changes in gene expression related with macrophage polarization and myogenic cells in the triceps long head of rats.

    abstract：:Macrophages are one of the most heterogenic immune cells involved in skeletal muscle regeneration. After skeletal muscle damage, M1 phenotypes exhibit pro-inflammatory reaction. In a later stage, they are converted to M2 phenotypes with anti-inflammatory properties. To study when gene expressions of macrophage polariz...

    journal_title：Inflammation

    pub_type： 杂志文章

    doi：10.1007/s10753-014-0024-x

    authors： Minari AL,Oyama LM,Dos Santos RV

    更新日期：2015-02-01 00:00:00

  • Cyclophilin A Aggravates Collagen-Induced Arthritis via Promoting Classically Activated Macrophages.

    abstract：:Activated macrophages exhibiting diverse phenotypes and various functions contribute to the pathogenesis or amelioration of different diseases like cancer, inflammation, and infectious and autoimmune diseases. However, the mechanisms of macrophage polarization in inflamed joint and its effects on rheumatoid arthritis ...

    journal_title：Inflammation

    pub_type： 杂志文章

    doi：10.1007/s10753-017-0619-0

    authors： Dongsheng Z,Zhiguang F,Junfeng J,Zifan L,Li W

    更新日期：2017-10-01 00:00:00

  • Transient endotoxemia during burn wound revision causes leukocyte beta 2 integrin up-regulation and cytokine release.

    abstract：:After severe burns, a wound revision is often done to remove devitalized tissue and minimize bacterial growth. After such revision, the patient may show signs of sepsis. In a group of burned patients we found a transient endotoxemia, and a subsequent leukocyte activation, monitored as increased expression of the beta ...

    journal_title：Inflammation

    pub_type： 杂志文章

    doi：10.1007/BF01534579

    authors： Ljunghusen O,Berg S,Hed J,Lundahl J,Nettelblad H,Sjögren F,Stendahl O

    更新日期：1995-08-01 00:00:00

  • Partial Depletion of Regulatory T Cells Enhances Host Inflammatory Response Against Acute Pseudomonas aeruginosa Infection After Sepsis.

    abstract：:Immune dysfunction contributes to secondary infection and worse outcomes in sepsis. Regulatory T cells (Tregs) have been implicated in sepsis-induced immunosuppression. Nevertheless, the role of Tregs in secondary infection after sepsis remains to be determined. In the present study, a two-hit model which mimics clini...

    journal_title：Inflammation

    pub_type： 杂志文章

    doi：10.1007/s10753-018-0821-8

    authors： Hu ZQ,Yao YM,Chen W,Bian JL,Zhao LJ,Chen LW,Hong GL,Lu ZQ,Zhao GJ

    更新日期：2018-10-01 00:00:00

  • MeCP2 Regulates PTCH1 Expression Through DNA Methylation in Rheumatoid Arthritis.

    abstract：:Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease, in which pathogenesis is not clear. Many research demonstrated that fibroblast-like synoviocytes (FLSs) play a key role in RA pathogenesis, join in the cartilage injury and hyperplasia of the synovium, and contribute to the release of inflammatory...

    journal_title：Inflammation

    pub_type： 杂志文章

    doi：10.1007/s10753-017-0591-8

    authors： Sun ZH,Liu YH,Liu JD,Xu DD,Li XF,Meng XM,Ma TT,Huang C,Li J

    更新日期：2017-10-01 00:00:00

  • KCNQ1OT1 Exacerbates Ischemia-Reperfusion Injury Through Targeted Inhibition of miR-140-3P.

    abstract：:Potassium voltage-gated channel subfamily Q member 1 opposite strand 1 (KCNQ1OT1), a long non-coding RNA found in the KCNQ1 locus, has been evidenced to play important roles in the aggravation of inflammatory and oxidative stresses under hypoxia, but whether and how KCNQ1OT1 contributes to neuronal damages in the cere...

    journal_title：Inflammation

    pub_type： 杂志文章

    doi：10.1007/s10753-020-01257-2

    authors： Yi M,Li Y,Wang D,Zhang Q,Yang L,Yang C

    更新日期：2020-10-01 00:00:00

  • Protective Effects of a Rho Kinase Inhibitor on Paraquat-Induced Acute Lung Injuries in Rats.

    abstract：:Fasudil, a rock kinase inhibitor, can inhibit systemic inflammation and prevent paraquat (PQ)-induced acute lung injuries in rats; however, the mechanisms for these protective effects remain elusive. This study investigated how the Rho/ROCK signaling pathway enables fasudil to protect against acute lung injuries in PQ...

    journal_title：Inflammation

    pub_type： 杂志文章

    doi：10.1007/s10753-018-0860-1

    authors： Zhang L,Li Q,Liu Z,Liu W,Zhao M

    更新日期：2018-12-01 00:00:00

  • Trans-resveratrol attenuates high fatty acid-induced P2X7 receptor expression and IL-6 release in PC12 cells: possible role of P38 MAPK pathway.

    abstract：:Diabetic neuropathy (DNP) is the most common chronic complication of diabetes. Elevated free fatty acids (FFAs) have been recently recognized as major causes of inflammation and are relevant to the functional changes of nerve system in diabetes. Trans-resveratrol (RESV), a polyphenolic natural compound, has long been ...

    journal_title：Inflammation

    pub_type： 杂志文章

    doi：10.1007/s10753-014-0036-6

    authors： Xu H,Xiong C,He L,Wu B,Peng L,Cheng Y,Jiang F,Tan L,Tang L,Tu Y,Yang Y,Liu C,Gao Y,Li G,Zhang C,Liu S,Xu C,Wu H,Li G,Liang S

    更新日期：2015-02-01 00:00:00

  • Changes in pulmonary histology and exfoliated bronchoalveolar cells induced by in vivo introduction of the tumor necrosis factor-alpha gene.

    abstract：:An inflammatory cytokine, tumor necrosis factor (TNF)-alpha, has been implicated in the pathogenesis of inflammatory lung diseases such as interstitial pneumonia (IP). To clarify the role of the inflammatory cytokine in the pathogenesis of lung inflammation, we introduced a murine TNF-alpha gene into murine lungs by t...

    journal_title：Inflammation

    pub_type： 杂志文章

    doi：10.1023/a:1006992408052

    authors： Sakuma-Mochizuki J,Yoshida M,Abe K,Arai T,Mori M,Kaneda Y,Hayashi S

    更新日期：2000-02-01 00:00:00

  • Hydrogen peroxide in exhaled breath condensate (EBC) vs eosinophil count in induced sputum (IS) in parenchymal vs airways lung diseases.

    abstract：:We compared exhaled breath condensate (EBC) and induced sputum (IS) for assessing inflammation in pulmonary diseases in patients with obstructive lung disease (n = 20), persistent cough >6 months (n = 20), interstitial lung disease (n = 25) and controls (n = 10). EBC was collected by suspending a Teflon perfluoroalkox...

    journal_title：Inflammation

    pub_type： 杂志文章

    doi：10.1007/s10753-007-9020-8

    authors： Fireman E,Shtark M,Priel IE,Shiner R,Mor R,Kivity S,Fireman Z

    更新日期：2007-04-01 00:00:00

  • Lipid composition of sputum from patients with asthma and patients with cystic fibrosis.

    abstract：:Lipids from the sputum of patients with asthma and with cystic fibrosis were isolated and characterized. In both cases, lipids constituted approximately 30% of the dry material. Phosphatidlycholine was the most abundant lipid, Significant amounts of phosphatidylethanolamine and phosphatidylglycerol were present. Hexos...

    journal_title：Inflammation

    pub_type： 杂志文章

    doi：10.1007/BF00917319

    authors： Sahu S,Lynn WS

    更新日期：1978-03-01 00:00:00

  • Properties of lymphocyte chemotactic factor (lymphotactin) in thymus.

    abstract：:Aqueous extracts of calf thymus from immunologically stimulated animals contain trypsin- and neuraminidase-labile macromolecules with molecular weights of less than 30,000 daltons which will specifically attract chemotactically lymphocytes. This activity we ascribe to "lymphotactin." ...

    journal_title：Inflammation

    pub_type： 杂志文章

    doi：10.1007/BF00917531

    authors： Houck JC,Chang CM

    更新日期：1976-03-01 00:00:00

  • Transient exposure of human bronchial epithelial cells to cytokines leads to persistent increased expression of ICAM-1.

    abstract：:Effects of several cytokines on kinetics of Intercellular Adhesion Molecule-1 (ICAM-1) and Vascular Cell Adhesion Molecule-1 (VCAM-1) expression were studied on a bronchial epithelial cell line (BEAS-2B). VCAM-I was neither constitutively expressed on BEAS-2B cells nor induced by Interferon-gamma (IFN-gamma). Tumor Ne...

    journal_title：Inflammation

    pub_type： 杂志文章

    doi：10.1023/a:1012850630351

    authors： Subauste MC,Choi DC,Proud D

    更新日期：2001-12-01 00:00:00

  • Bee venom melittin blocks neutrophil O2- production.

    abstract：:Bee venom (BV) is used in folk medicine to treat arthritis. It has antiinflammatory effects in animal models of rheumatic disease. We have studied the effects of BV on human neutrophil production of superoxide (O2-) and hydrogen peroxide, finding potent, nontoxic, dose-dependent production inhibition. Melittin, the ma...

    journal_title：Inflammation

    pub_type： 杂志文章

    doi：10.1007/BF00915999

    authors： Somerfield SD,Stach JL,Mraz C,Gervais F,Skamene E

    更新日期：1986-06-01 00:00:00

  • The Effects of Molecular Hydrogen and Suberoylanilide Hydroxamic Acid on Paraquat-Induced Production of Reactive Oxygen Species and TNF-α in Macrophages.

    abstract：:The aim of this study is to investigate the effects of molecular hydrogen (H2) and suberoylanilide hydroxamic acid (SAHA), a histone deacetylase inhibitor, on paraquat (PQ)-stimulated production of reactive oxygen species (ROS) and tumor necrosis factor alpha (TNF-α) in macrophages. First, the PQ optimal concentration...

    journal_title：Inflammation

    pub_type： 杂志文章

    doi：10.1007/s10753-016-0434-z

    authors： Li J,Wu X,Chen Y,Zeng R,Zhao Y,Chang P,Wang D,Zhao Q,Deng Y,Li Y,Alam HB,Chong W

    更新日期：2016-12-01 00:00:00

  • Effect of leukocyte hydrolases on bacteria. X. The role played by leukocyte factors, cationic polyelectrolytes, and by membrane-damaging agents in the lysis of Staphylococcus aureus: relation to chronic inflammatory processes.

    abstract：:A heat-stable factor present in extracts of human blood leukocytes is capable of lysing young Staphylococcus aureus at pH 5.0. Lysis is characterized by breakdown of cell-wall components as judged by electron microscopic and biochemical analysis. The leukocyte extracts can be replaced by a variety of agents known to i...

    journal_title：Inflammation

    pub_type： 杂志文章

    doi：10.1007/BF00918678

    authors： Lahav M,Ginsburg I

    更新日期：1977-06-01 00:00:00

  • Influence of extracellular Ca2+ and Mg2+ on chemotactic factor-induced neutrophil aggregation.

    abstract：:The influences of extracellular Ca2+ and Mg2+ on chemotactic factor-induced rabbit polymorphonuclear neutrophil (PMN) aggregation was studied using a recently described Coulter counter assay technique. Compared with those of other PMN functional assays (adhesion, chemotaxis, degranulation, and phagocytosis), the catio...

    journal_title：Inflammation

    pub_type： 杂志文章

    doi：10.1007/BF00921006

    authors： O'Flaherty JT,Showell HJ,Ward PA

    更新日期：1977-12-01 00:00:00