Transient endotoxemia during burn wound revision causes leukocyte beta 2 integrin up-regulation and cytokine release.

abstract：:Thromboxane (Tx) A2 generation and subsequent selective pulmonary sequestration of neutrophils (PMNs) is characteristic of several forms of the adult respiratory distress syndrome (ARDS). Therefore, we examined PMN-dependent adhesion to cultured pulmonary microvessel and aortic endothelium (EC) in response to U46,619 ...

journal_title：Inflammation

authors： Wiles ME,Welbourn R,Goldman G,Hechtman HB,Shepro D

更新日期：1991-06-01 00:00:00

abstract：:Neurodegenerative diseases such as Alzheimer, Parkinson, amyotrophic lateral sclerosis, and Huntington are incurable and debilitating conditions that result in progressive death of the neurons. The definite diagnosis of a neurodegenerative disorder is disadvantaged by the difficulty in obtaining biopsies and thereby t...

journal_title：Inflammation

authors： Nuzzo D,Picone P,Caruana L,Vasto S,Barera A,Caruso C,Di Carlo M

更新日期：2014-06-01 00:00:00

abstract：:During phagocytosis of latex particles human polymorphonuclear leukocytes (PMNs) release a product that generates chemotactic activity from fresh human serum. Release of this product is maximal at 20-30 min of phagocytosis. It is present in resting PMNs, may be recovered from granule fractions, and functions at physio...

journal_title：Inflammation

authors： Wright DG,Gallin JI

更新日期：1975-03-01 00:00:00

abstract：:The intracellular signaling pathways involved in human monocyte chemotaxis toward a variety of chemoattractant molecules were evaluated using selected pharmacological agents. Neither phosphatidylinositol-3-kinase (P13K) or extracellular signal-regulated kinase (ERK) activity were required for monocyte migration toward...

journal_title：Inflammation

authors： Fine JS,Byrnes HD,Zavodny PJ,Hipkin RW

更新日期：2001-04-01 00:00:00

abstract：:Induction of hypoxia for 2.5 h in perfused cat livers resulted in a 10-fold increase in cathepsin D and a 15-fold increase in lactic dehydrogenase (LDH) activities in the perfusate and a 42% depression of the clearance rate of particles by the reticuloendothelial system (RES). Addition of 10(-3) M methylprednisolone (...

journal_title：Inflammation

authors： Carlson RP,Lefer AM

更新日期：1976-12-01 00:00:00

abstract：:Neuroinflammation is believed to be involved in the pathogenesis of neurodegenerative diseases. Our novel synthetic compound 2-acetyl-1-ethyl-7-hydroxy-6-methoxy-1, 2, 3, 4-tetrahydroisoquinoline (AETIQ) was tested for its anti-inflammatory properties in activated microglial BV-2 cells. AETIQ attenuated nitric oxide (...

journal_title：Inflammation

authors： Son HJ,Shin N,Shin EJ,Chi DY,Seo JW,Lee CS,Hwang O

更新日期：2014-06-01 00:00:00

abstract：:We analyzed the influence of heparins (unfractionated heparin, UFH and low molecular weight heparin certoparin) on the generation of IL-1ra, IL-6, IL-10, and IL-12p40 and from leukocyte fractions in vitro. Polymorphonuclear neutrophil leukocytes (PMN) and peripheral blood mononuclear cells (PBMC) from 16 different hea...

journal_title：Inflammation

authors： Köller M,Kutscha-Lissberg F,Brom J,Weidinger G,Muhr G

更新日期：2001-10-01 00:00:00

abstract：:The present study was designed to address the relationship between iron homeostasis and bone metabolism. Cultured hFOB 1.19 osteoblasts were incubated with selected concentrations of hepcidin (50, 100, and 200 nmol/L) for 20 h, harvested for extraction of total RNA and proteins, and the expression of ferroportin 1 was...

journal_title：Inflammation

authors： Xu Y,Zhang W,Zhang P,Xiao L,Wang A,Sirois P,Li K

更新日期：2012-06-01 00:00:00

abstract：:Karyopherin-α2 (KPNA2) functions as an adaptor that transports several proteins to the nucleus. We investigated the function and possible mechanisms of KPNA2 involved in rheumatoid arthritis (RA). Western blotting and immunohistochemistry showed the protein expression of KPNA2 increased in synovial tissue of RA patien...

journal_title：Inflammation

authors： Liu Z,Zhang D,Sun C,Tao R,Xu X,Xu L,Cheng H,Xiao M,Wang Y

更新日期：2015-12-01 00:00:00

abstract：:The respiratory epithelium is often exposed to oxidant gases, including ozone from photochemical smog and toxic oxygen metabolites released from neutrophils recruited in conditions of airway inflammation. We evaluated DNA single strand break formation by alkaline elution as a measure of oxidant-induced DNA damage to b...

journal_title：Inflammation

authors： McDonald RJ,Pan LC,St George JA,Hyde DM,Ducore JM

更新日期：1993-12-01 00:00:00

abstract：:Increased susceptibility of neonates to infection may be related to defects in newborn neutrophil (PMN) functional activities, including altered responses to complement fragments (Cf) and defective microbicidal activity. We therefore compared the kinetics of newborn and adult bovine PMN membrane shape change responses...

journal_title：Inflammation

authors： Holden W,Slauson DO,Zwahlen RD,Suyemoto MM,Doré M,Neilsen NR

更新日期：1989-12-01 00:00:00

abstract：:Diabetic neuropathy (DNP) is the most common chronic complication of diabetes. Elevated free fatty acids (FFAs) have been recently recognized as major causes of inflammation and are relevant to the functional changes of nerve system in diabetes. Trans-resveratrol (RESV), a polyphenolic natural compound, has long been ...

journal_title：Inflammation

authors： Xu H,Xiong C,He L,Wu B,Peng L,Cheng Y,Jiang F,Tan L,Tang L,Tu Y,Yang Y,Liu C,Gao Y,Li G,Zhang C,Liu S,Xu C,Wu H,Li G,Liang S

更新日期：2015-02-01 00:00:00

abstract：:The aim of this study was to investigate the effect of high-intensity swimming exercise (HISE) on atopic dermatitis (AD). For the study, we established an AD model in BALB/c mice by repeated local exposure of house dust mite extract (Dermatophagoides farinae extract, DFE) and 1-chloro-2,4-dinitrobenzene (CDNB) to the ...

journal_title：Inflammation

authors： Kim SH,Kim EK,Choi EJ

更新日期：2014-08-01 00:00:00

abstract：:DBA/1LacJ mice were immunized with type II collagen and boosted with bacterial lipopolysaccharide (LPS) 17 days later to induce accelerated arthritis. Clinical signs of inflammation were observed as early as Day 20. Matrix metalloproteinases MMP-2, -3, -9, and -13, but not MMP-12, mRNA levels were increased on Day 24....

journal_title：Inflammation

authors： Raychaudhuri A,Chou M,Weetall M,Jeng AY

更新日期：2003-04-01 00:00:00

abstract：:Superoxide dismutase (SOD) is known to regulate the level of superoxide radicals inside cells. The purpose of this work was to investigate the role of SOD activity in tissue damage produced by superoxide radicals. SOD was measured in polymorphonuclear cells of patients with rheumatoid arthritis and controls. The disti...

journal_title：Inflammation

authors： Pasquier C,Mach PS,Raichvarg D,Sarfati G,Amor B,Delbarre F

更新日期：1984-03-01 00:00:00

abstract：:Lipopolysaccharide (LPS) increases serum TNF-alpha levels due to TNF-alpha secretion by macrophages. The serum TNF-alpha response to LPS was augmented 10x when FcgammaR ligation was induced by the intravenous injection of Gig-coated erythrocytes (IgG) prior to the administration of LPS. The macrophage population respo...

journal_title：Inflammation

authors： Loegering DJ,Lennartz MR

更新日期：2002-12-01 00:00:00

abstract：:Type I allergy is characterized by the release of granule-associated mediators, lipid-derived substances, cytokines, and chemokines by activated mast cells. To evaluate the anti-allergic effects of macelignan isolated from Myristica fragrans Houtt., we determined its ability to inhibit calcium (Ca(2+)) influx, degranu...

journal_title：Inflammation

authors： Han YS,Kim MS,Hwang JK

更新日期：2012-10-01 00:00:00

abstract：:In this study, the effects of tyrosol were investigated in DSS-induced experimental ulcerative colitis model. For this purpose, rats were divided into five groups of seven rats in each: control group, colitis group (DSS-4%), tyrosol group (tyrosol 20 mg/kg), sulfasalazine (sulfasalazine+DSS 100 mg/kg), and treatment g...

journal_title：Inflammation

authors： Güvenç M,Cellat M,Özkan H,Tekeli İO,Uyar A,Gökçek İ,İşler CT,Yakan A

更新日期：2019-10-01 00:00:00

abstract：:Psoriasis, a common skin inflammatory disorder, is characterized by the aberrant growth and differentiation of keratinocytes. Ar-Turmerone, a main bioactive ingredient of Curcuma longa, has been found to alleviate skin inflammation in psoriasis-like mice. However, the effects and underlying mechanism of ar-turmerone o...

journal_title：Inflammation

authors： Yang S,Liu J,Jiao J,Jiao L

更新日期：2020-04-01 00:00:00

abstract：:Sublethal doses of LPS result in increased tolerance to high concentrations of oxygen and this is associated with decreased pulmonary inflammation in a rat model. To investigate the mechanism of decreased neutrophil influx into the lung in this model, we measured levels of mRNA in the lung for the endothelial adhesion...

journal_title：Inflammation

authors： Thompson LR,Keeney SE,Tarrant D,Rudloff E,Dallas DV,Schmalstieg FC

更新日期：2004-06-01 00:00:00

abstract：:The synthetic compound 7-4-[Bis-(2-hydroxyethyl)-amino]-butoxy-5-hydroxy-8-methoxy-2-phenylchromen-4-one (V8) is a novel flavonoid-derived compound. In this study, we investigated the effects of V8 on Toll-like receptor 4 (TLR4)-mediated inflammatory reaction in human cervical cancer SiHa cells and lipopolysaccharide ...

journal_title：Inflammation

authors： He A,Ji R,Shao J,He C,Jin M,Xu Y

更新日期：2016-02-01 00:00:00

abstract：:Immune dysfunction contributes to secondary infection and worse outcomes in sepsis. Regulatory T cells (Tregs) have been implicated in sepsis-induced immunosuppression. Nevertheless, the role of Tregs in secondary infection after sepsis remains to be determined. In the present study, a two-hit model which mimics clini...

journal_title：Inflammation

authors： Hu ZQ,Yao YM,Chen W,Bian JL,Zhao LJ,Chen LW,Hong GL,Lu ZQ,Zhao GJ

更新日期：2018-10-01 00:00:00

abstract：:Herein, we reported our experience in colchicine-resistant familial Mediterranean fever (FMF) patients who are treated with anti-interleukin-1 (IL-1) drugs. A retrospective review of medical records of anti-IL-1 recipients was performed. The main clinical characteristics of these patients and the evolution after anti-...

journal_title：Inflammation

authors： Cetin P,Sari I,Sozeri B,Cam O,Birlik M,Akkoc N,Onen F,Akar S

更新日期：2015-02-01 00:00:00

abstract：:Free radicals play an important role in the initiation and progression of inflammatory bowel disease (IBD). Therefore, the reduction or elimination of adverse oxidant effects can provide novel therapy for IBD. Here, the antioxidant capacity and protective effects of a new class of chemically modified hetastarch (polyn...

journal_title：Inflammation

authors： Park JH,Ma L,Oshima T,Carter P,Coe L,Ma JW,Specian R,Grisham MB,Trimble CE,Hsia CJ,Liu JE,Alexander JS

更新日期：2002-02-01 00:00:00

abstract：:Colchicine and methotrexate are commonly used in the treatment of gout and rheumatoid arthritis, respectively; however the mechanism(s) of action of these drugs remain(s) unknown. The objective of this study was to determine whether colchicine and methotrexate can modify the adhesion and emigration of leukocytes in po...

journal_title：Inflammation

authors： Asako H,Kubes P,Baethge BA,Wolf RE,Granger DN

更新日期：1992-02-01 00:00:00

abstract：:Chronic obstructive pulmonary disease (COPD), characterized by progressive airway inflammation and irreversible airflow limitation, leads to serious decline in life quality. The acute exacerbation of COPD (AECOPD) results in high healthcare costs as well as a significant mortality rate. The most common cause of acute ...

journal_title：Inflammation

authors： Xie S,Wang K,Zhang W,Xiao K,Yan P,Li Y,He W,Zhang Y,Xie L

更新日期：2018-10-01 00:00:00

abstract：:Cardiovascular diseases, including acute coronary syndrome (ACS), are the leading cause of death among humans. Adhesion proteins, owing to their involvement in the initiation and progression of atherosclerotic lesions, contribute to the progression of coronary disease and ACS occurrence. Considering ambiguosity of res...

journal_title：Inflammation

authors： Dabek J,Ligus J,Szota J

更新日期：2010-12-01 00:00:00

abstract：:The present study was designed to investigate the effects of pilose antler peptide (PAP) on lipopolysaccharide (LPS)-induced lung injury. BalB/c mice intraperitoneally received PAP (10 and 20 mg/kg) or dexamethasone (2 mg/kg) 1 h prior to intratracheal instillation of LPS. PAP significantly decreased lung wet-to-dry w...

journal_title：Inflammation

authors： Ma C,Long H,Yang C,Cai W,Zhang T,Zhao W

更新日期：2017-06-01 00:00:00

abstract：:Rheumatoid synovial fluids generated significantly greater amounts of superoxide, lysosomal enzymes, and superoxide dismutase from neutrophils into extracellular fluid than osteoarthritic synovial fluids. Rheumatoid factors isolated from serum suppressed superoxide-generating activity of performed immune complexes, bu...

journal_title：Inflammation

authors： Shingu M,Todoroki T,Nobunaga M

更新日期：1987-06-01 00:00:00

abstract：:Paeonol, a major ingredient isolated from Moutan Cort, has various pharmacological effects. Our previous studies have shown that paeonol can exert antioxidant and anti-inflammatory therapeutic effects on ethanol-induced experimental gastric ulcer (GU). Therefore, in this study, we designed two GU models in rats induce...

journal_title：Inflammation

authors： Guo Y,Du Y,Xie L,Pu Y,Yuan J,Wang Z,Zhang T,Wang B

更新日期：2020-12-01 00:00:00