Abstract:
:Chronic obstructive pulmonary disease (COPD), characterized by progressive airway inflammation and irreversible airflow limitation, leads to serious decline in life quality. The acute exacerbation of COPD (AECOPD) results in high healthcare costs as well as a significant mortality rate. The most common cause of acute exacerbation is infection. Immune deficiency, which induces dysfunction of anti-infection, plays an important role in the pathogenesis of acute exacerbation. As described in this review, the immune dysfunction in patients with AECOPD can be a major focus of efforts to therapeutic strategy.
journal_name
Inflammationjournal_title
Inflammationauthors
Xie S,Wang K,Zhang W,Xiao K,Yan P,Li Y,He W,Zhang Y,Xie Ldoi
10.1007/s10753-018-0830-7subject
Has Abstractpub_date
2018-10-01 00:00:00pages
1582-1589issue
5eissn
0360-3997issn
1573-2576pii
10.1007/s10753-018-0830-7journal_volume
41pub_type
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