Immunodeficiency in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease.

Abstract:

:Chronic obstructive pulmonary disease (COPD), characterized by progressive airway inflammation and irreversible airflow limitation, leads to serious decline in life quality. The acute exacerbation of COPD (AECOPD) results in high healthcare costs as well as a significant mortality rate. The most common cause of acute exacerbation is infection. Immune deficiency, which induces dysfunction of anti-infection, plays an important role in the pathogenesis of acute exacerbation. As described in this review, the immune dysfunction in patients with AECOPD can be a major focus of efforts to therapeutic strategy.

journal_name

Inflammation

journal_title

Inflammation

authors

Xie S,Wang K,Zhang W,Xiao K,Yan P,Li Y,He W,Zhang Y,Xie L

doi

10.1007/s10753-018-0830-7

subject

Has Abstract

pub_date

2018-10-01 00:00:00

pages

1582-1589

issue

5

eissn

0360-3997

issn

1573-2576

pii

10.1007/s10753-018-0830-7

journal_volume

41

pub_type

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