Abstract:
:Neuroinflammation is believed to be involved in the pathogenesis of neurodegenerative diseases. Our novel synthetic compound 2-acetyl-1-ethyl-7-hydroxy-6-methoxy-1, 2, 3, 4-tetrahydroisoquinoline (AETIQ) was tested for its anti-inflammatory properties in activated microglial BV-2 cells. AETIQ attenuated nitric oxide (NO) and reactive oxygen species generation. It also downregulated the production of the proinflammatory enzymes inducible NO synthase, cyclooxygenase-2, and matrix metalloproteinase-3 at both mRNA and protein levels. Furthermore, AETIQ suppressed generation of the proinflammatory cytokines IL-1β and TNF-α as determined by reverse transcriptase-polymerase chain reaction (RT-PCR) and ELISA assays. AETIQ attenuated NFκB signaling by downregulating NFκB nuclear translocation. The compound was stable against the liver enzymes in the microsomal and S9 fractions, indicative of good bioavailability. These results suggested that AETIQ might be utilized towards development of a therapy for neuroinflammation-related diseases.
journal_name
Inflammationjournal_title
Inflammationauthors
Son HJ,Shin N,Shin EJ,Chi DY,Seo JW,Lee CS,Hwang Odoi
10.1007/s10753-013-9795-8subject
Has Abstractpub_date
2014-06-01 00:00:00pages
766-74issue
3eissn
0360-3997issn
1573-2576journal_volume
37pub_type
杂志文章相关文献
INFLAMMATION文献大全abstract::Effects of several cytokines on kinetics of Intercellular Adhesion Molecule-1 (ICAM-1) and Vascular Cell Adhesion Molecule-1 (VCAM-1) expression were studied on a bronchial epithelial cell line (BEAS-2B). VCAM-I was neither constitutively expressed on BEAS-2B cells nor induced by Interferon-gamma (IFN-gamma). Tumor Ne...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1023/a:1012850630351
更新日期:2001-12-01 00:00:00
abstract::Immune dysfunction contributes to secondary infection and worse outcomes in sepsis. Regulatory T cells (Tregs) have been implicated in sepsis-induced immunosuppression. Nevertheless, the role of Tregs in secondary infection after sepsis remains to be determined. In the present study, a two-hit model which mimics clini...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-018-0821-8
更新日期:2018-10-01 00:00:00
abstract::Dysregulated release of neutrophil reactive oxygen species and proteolytic enzymes contributes to both acute and chronic inflammatory diseases. Therefore, molecular regulators of these processes are potential targets for new anti-inflammatory therapies. We have shown previously that myristoylated alanine-rich C-kinase...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-014-0078-9
更新日期:2015-01-01 00:00:00
abstract::IFN-τ, which is a type I interferon with low cytotoxicity, is defined as a pregnancy recognition signal in ruminants. Type I interferons have been used as anti-inflammatory agents, but their side effects limit their clinical application. The present study aimed to determine the anti-inflammatory effects of IFN-τ in a ...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-016-0348-9
更新日期:2016-06-01 00:00:00
abstract::Drug delivery into immune cells has high potential for the treatment of all kinds of inflammation, allowing a target-oriented transport of active agents. The advantage of this local drug release is the prevention of negative effects of systemic applications and low-dose application. Thereby, the phagocytotic capabilit...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-010-9213-4
更新日期:2011-04-01 00:00:00
abstract::The signaling system of phosphoinositides (PI) is involved in a variety of cell and tissue functions, including membrane trafficking, ion channel activity, cell cycle, apoptosis, differentiation, and cell and tissue polarity. Recently, PI and related molecules, such as the phosphoinositide-specific phospholipases C (P...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-013-9613-3
更新日期:2013-08-01 00:00:00
abstract::Recombinant human interleukin-1 beta (IL-1) and tumor necrosis factor-alpha (TNF) synergistically stimulated BALB/c 3T3 cells to produce a chemotactic factor for rat polymorphonuclear leukocytes (PMNs), whereas an addition of 10(-11)-10(-8) M IL-1 or TNF alone to the cell culture resulted in a slight increase in the p...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00916761
更新日期:1989-10-01 00:00:00
abstract::Neurodegenerative diseases such as Alzheimer, Parkinson, amyotrophic lateral sclerosis, and Huntington are incurable and debilitating conditions that result in progressive death of the neurons. The definite diagnosis of a neurodegenerative disorder is disadvantaged by the difficulty in obtaining biopsies and thereby t...
journal_title:Inflammation
pub_type: 杂志文章,评审
doi:10.1007/s10753-013-9780-2
更新日期:2014-06-01 00:00:00
abstract::Central nervous system tuberculosis (CNS-TB) is caused by infection with Mycobacterium tuberculosis (Mtb). The inflammatory response following CNS-TB involves the activation of resident microglia and the infiltration of macrophages. However, it has not been clarified whether microglia can be polarized into the classic...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-015-0136-y
更新日期:2015-08-01 00:00:00
abstract::Rabbits were injected intramuscularly with cortisone acetate (2 mg/kg) on alternate days. Six days after the first injection these rabbits and controls were injected intradermally in multiple sites with BCG (the vaccine strain of tubercle bacillus). Periodically, over the next 2 months, the resulting lesions were meas...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00910737
更新日期:1978-06-01 00:00:00
abstract::A new glycoprotein with an apparent molecular weight of 130,000 was isolated, purified, and partially characterized from the pulmonary secretions which accumulate so massively in the lungs of patients suffering from pulmonary alveolar proteinosis. The amino acid analysis of the glycoprotein showed the presence of rela...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00913501
更新日期:1979-09-01 00:00:00
abstract::We investigated whether TESPA1 gene polymorphisms were associated with increased risk of developing ankylosing spondylitis (AS). We also studied whether TESPA1 gene interacts with environmental factors. A total of 494 patients with AS and 478 matched healthy controls were genotyped for four SNPs (rs1801876, rs2171497,...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-014-9936-8
更新日期:2014-12-01 00:00:00
abstract::In this study, we assessed the underlying mechanisms by which proteinases released from activated neutrophils mediate fibronectin degradation. Purified human neutrophils (1 x 10(6)) were incubated for 1 hr with 1 microM PMA in the absence or presence of different proteinase inhibitors in 96-well microtiter plates that...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00918993
更新日期:1993-06-01 00:00:00
abstract::Simvastatin, which is primarily prescribed to lower cholesterol, may also mitigate lung injury caused by sepsis, although the mechanisms remain elusive. This study aimed to evaluate the protective effect of simvastatin on acute lung injury in rats with sepsis and to investigate possible mechanisms. Male Wistar rats we...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-017-0668-4
更新日期:2018-02-01 00:00:00
abstract::Paeonol, a major ingredient isolated from Moutan Cort, has various pharmacological effects. Our previous studies have shown that paeonol can exert antioxidant and anti-inflammatory therapeutic effects on ethanol-induced experimental gastric ulcer (GU). Therefore, in this study, we designed two GU models in rats induce...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-020-01285-y
更新日期:2020-12-01 00:00:00
abstract::We analyzed the effect of the PAF receptor antagonist (+)-cis-3,5-dimethyl-2-(3-pyridyl)thiazolidin-4-one hydrochloride (SM-12502) on human platelet aggregation as well as mediator release. After incubation of human platelet with different concentrations of SM-12502 the cells were subsequently stimulated with either t...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF01487746
更新日期:1996-02-01 00:00:00
abstract::Oroxylin A, a natural flavonoid isolated from the medicinal herb Scutellaria baicalensis Georgi, has been reported to have anti-inflammatory property. In this study, we aimed to investigate the protective effects and mechanism of oroxylin A on allergic inflammation in OVA-induced asthma murine model. BABL/c mice were ...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-016-0317-3
更新日期:2016-04-01 00:00:00
abstract::Most cases of posttraumatic ankle osteoarthritis (PTAOA) represent a sequela of ankle fractures. The cytoplasmic polyadenylation element-binding protein 1 (CPEB1) is an RNA binding protein that controls protein expression. Here, we report the previously unappreciated association of CPEB1 with PTAOA. We found that CPEB...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-018-0920-6
更新日期:2019-04-01 00:00:00
abstract::The newly discovered gamma-PKC-related-protein of human leukocytes (gamma-rp) crossreacts with a polyclonal antibody preparation originally designed to be specific for PKC-gamma (gammaMb-Ab). As this antibody is currently the only suitable probe for gamma-rp, we sought to characterize the binding of the two proteins. ...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1023/a:1020265701407
更新日期:1999-08-01 00:00:00
abstract::Lipids from the sputum of patients with asthma and with cystic fibrosis were isolated and characterized. In both cases, lipids constituted approximately 30% of the dry material. Phosphatidlycholine was the most abundant lipid, Significant amounts of phosphatidylethanolamine and phosphatidylglycerol were present. Hexos...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00917319
更新日期:1978-03-01 00:00:00
abstract::Alveolar macrophages (AMs) can initiate lung inflammation by producing pro-inflammatory cytokines and chemokines, but they participate actively in the prevention of inflammation during acute lung injury (ALI). Heme oxygenase-1 (HO-1) is mainly expressed in AMs and has anti-inflammatory properties in ALI, but the anti-...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-011-9415-4
更新日期:2012-06-01 00:00:00
abstract::The widely used mouse air pouch model of acute inflammation is inducible in a variety of inbred strains, but the potential influence of genetic background and gender on inflammation severity has never been examined. We directly compared the degree of inflammation induced in the air pouch model across four commonly uti...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-006-8962-6
更新日期:2005-02-01 00:00:00
abstract::Chronic obstructive pulmonary disease (COPD) is a common chronic inflammatory disease with high morbidity and mortality rates. Cystatin C (Cys C) is a sensitive indicator for various chronic inflammatory diseases. In this study, we aimed to evaluate the role of Cys C in COPD patients comparing with the other well-know...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-015-0287-x
更新日期:2016-04-01 00:00:00
abstract::The original version of this article contained mistakes, and the authors would like to correct them. ...
journal_title:Inflammation
pub_type: 杂志文章,已发布勘误
doi:10.1007/s10753-018-0770-2
更新日期:2018-06-01 00:00:00
abstract::Naringin (COG) is a flavanone with various bioactivities including an expectorant effect, antitussive effect, and inhibitory effect on asthma and acute lung injury. The aims of the present study were to investigate the antiarthritis activities of COG and elucidate the underlying mechanisms with regard to its molecular...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-014-0027-7
更新日期:2015-02-01 00:00:00
abstract::Isoliquiritigenin (ILG), a major ingredient of licorice, has been reported to have anti-oxidative and anti-inflammatory effects. The aim of this study was to investigate the protective effects of ILG on lung injury using an animal model of lipopolysaccharide (LPS)-induced acute lung injury (ALI). Male BALB/c mice were...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-018-0777-8
更新日期:2018-08-01 00:00:00
abstract::Aqueous extracts of calf thymus from immunologically stimulated animals contain trypsin- and neuraminidase-labile macromolecules with molecular weights of less than 30,000 daltons which will specifically attract chemotactically lymphocytes. This activity we ascribe to "lymphotactin." ...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00917531
更新日期:1976-03-01 00:00:00
abstract::Recent data demonstrated that chemokine CXCL13 mediates neuroinflammation and contributes to the maintenance of neuropathic pain after nerve injury in the spinal cord. Pro-nociceptive chemokines activate mitogen-activated protein kinases (MAPKs) which are potential signaling pathways contributing to the nociceptive be...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-017-0520-x
更新日期:2017-06-01 00:00:00
abstract::Endothelial-neutrophil adhesion is a critical step in acute inflammatory diseases, which is mediated in part by P-selectin and platelet-activating factor (PAF). Nitric oxide (NO) is well known as an endogenous second messenger derived from endothelial cells, and regulates many important physiological events, however, ...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1023/a:1020287516911
更新日期:1999-02-01 00:00:00
abstract::Leukocyte chemoattractants markedly alter the morphology and membrane functions of leukocytes. Bacterial collagenase causes a change in cell shape similar to that seen with the leukocyte chemoattractant, f-Met-Leu-Phe, and also promotes capping of concanavalin A. Human neutrophils in suspension or adherent to cover gl...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00915819
更新日期:1986-12-01 00:00:00