Abstract:
:Increased susceptibility of neonates to infection may be related to defects in newborn neutrophil (PMN) functional activities, including altered responses to complement fragments (Cf) and defective microbicidal activity. We therefore compared the kinetics of newborn and adult bovine PMN membrane shape change responses following stimulation with zymosan-activated plasma (ZAP) as a source of Cf. Measurement of PMN membrane shape change was a rapid, sensitive, and reproducible measure of Cf stimulation within a population of PMNs; a maximum of 67-85% of the PMNs exhibited easily detectable membrane ruffling, lamellipodia formation, and polarity within 2 min. Newborn PMNs exhibited significantly increased (P less than 0.01) membrane shape change at 20, 30, 60, 120, and 300 sec after Cf stimulation. A maximum of 85.8 +/- 3.2% of newborn PMNs exhibited such Cf-induced shape changes by 120 sec. which was significantly greater (P less than 0.01) than the maximum stimulation (67.7 +/- 4.3%) attained with adult PMNs. These data indicate enhanced kinetics of induced newborn PMN membrane shape change in response to Cf stimulation. We also compared stimulus-specific superoxide anion (O2-) generation as a measure of respiratory burst activity after incubation of newborn and adult PMNs with soluble (phorbol myristate acetate, PMA) and particulate (opsonized zymosan, OZ) stimuli. When PMA was used as the stimulus, newborn PMNs generated significantly less O2- (9.3 +/- 0.5 nmol O2-/10(6) PMN, P less than 0.05) than did adult PMNs (12.4 +/- 0.3 nmol O2-/10(6) PMN). This finding was reversed when OZ was used as the stimulus; newborn PMNs generated significantly more O2- (7.7 +/- 0.4 nmol O2-/10(6) PMN, P less than 0.05) than did adult PMNs (5.5 +/- 0.5 nmol O2-/10(6) PMN). These findings collectively document biochemical and morphological differences between newborn and adult PMNs as determined by stimulus-specific O2- generation and Cf-induced membrane shape change. Such differences may be important to neonatal disease susceptibility.
journal_name
Inflammationjournal_title
Inflammationauthors
Holden W,Slauson DO,Zwahlen RD,Suyemoto MM,Doré M,Neilsen NRdoi
10.1007/BF00914305subject
Has Abstractpub_date
1989-12-01 00:00:00pages
607-20issue
6eissn
0360-3997issn
1573-2576journal_volume
13pub_type
杂志文章相关文献
INFLAMMATION文献大全abstract::Rabbits were injected intramuscularly with cortisone acetate (2 mg/kg) on alternate days. Six days after the first injection these rabbits and controls were injected intradermally in multiple sites with BCG (the vaccine strain of tubercle bacillus). Periodically, over the next 2 months, the resulting lesions were meas...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00910737
更新日期:1978-06-01 00:00:00
abstract::The aim of this study is to investigate the effects of molecular hydrogen (H2) and suberoylanilide hydroxamic acid (SAHA), a histone deacetylase inhibitor, on paraquat (PQ)-stimulated production of reactive oxygen species (ROS) and tumor necrosis factor alpha (TNF-α) in macrophages. First, the PQ optimal concentration...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-016-0434-z
更新日期:2016-12-01 00:00:00
abstract::Endoplasmic reticulum stress (ERS) plays an important role in cerebral ischemia-reperfusion injury (CIRI) by regulating apoptosis. Although the role of long non-coding RNA (LncRNA) KCNQ1OT1 in CIRI has been reported, the specific mechanism is still unclear. In this paper, the regulation of ERS by LncRNA KCNQ1OT1 in CI...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-020-01295-w
更新日期:2020-12-01 00:00:00
abstract::A full understanding of rheumatoid arthritis depends on the appreciation of clinical, radiological, immunological, genetic, biochemical, and structural mechanisms. Rheumatoid arthritis is characterized by the destruction of tissue structures such as articular cartilage and bone, but may also involve tendonous tissue, ...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00915710
更新日期:1984-06-01 00:00:00
abstract::Air pollution events frequently occur in China during the winter. Most investigations of pollution studies have focused on the physical and chemical properties of PM2.5. Many of these studies have indicated that PM2.5 exacerbates asthma or eosinophil inflammation. However, few studies have evaluated the relationship b...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-019-01071-5
更新日期:2020-02-01 00:00:00
abstract::Macrophage polarization is a dynamic and integral process of tissue inflammation and remodeling. Here we demonstrate an important role of Aurora kinase A in the regulation of inflammatory M1 macrophage polarization. We found that there was an elevated expression of Aurora-A in M1 macrophages and inhibition of Aurora-A...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-014-9990-2
更新日期:2015-04-01 00:00:00
abstract::To investigate the role of glutathione (GSH) synthesis in the regulation on nuclear factor (NF)-kappaB activity and tumor necrosis factor-alpha (TNF-alpha) release by glutamine (GLN) in lipopolysaccharide (LPS)-stimulated alveolar type II (AT-II) epithelial cells of rat lungs. Primary cultured AT-II cells were pre-tre...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-008-9084-0
更新日期:2008-10-01 00:00:00
abstract::Current treatments for ischemia-reperfusion (IR)-induced acute lung injury are limited. Mesenchymal stem cell-conditioned medium (CM) has been reported to attenuate lung injury. Neural crest stem cells (NCSCs), a type of multipotent stem cells, are more easily obtained than mesenchymal stem cells. We hypothesize that ...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-017-0594-5
更新日期:2017-10-01 00:00:00
abstract::Isoliquiritigenin (ILG), a major ingredient of licorice, has been reported to have anti-oxidative and anti-inflammatory effects. The aim of this study was to investigate the protective effects of ILG on lung injury using an animal model of lipopolysaccharide (LPS)-induced acute lung injury (ALI). Male BALB/c mice were...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-018-0777-8
更新日期:2018-08-01 00:00:00
abstract::Interleukin-10 (IL-10) is a pleiotropic cytokine and plays an important role in the pathogenesis of systemic lupus erythematosus (SLE). Unlike IL-10 protein, few studies have focused on the potential association between IL-10 receptor (IL-10R) and SLE. The purpose of this study was to examine the association of a sing...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-013-9658-3
更新日期:2013-12-01 00:00:00
abstract::The bacterial keratitis causes viability loss and apoptosis in the corneal epithelial cells (CECs). The cyanidin-3-O-glucoside (C3G) benefits visual system and also possess anti-bacterial and anti-inflammatory potentials. In the current study, the effects of C3G on human CECs (HCECs) against bacterial lipopolysacchari...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-020-01194-0
更新日期:2020-06-01 00:00:00
abstract::The role of peptide leukotrienes (p-LTs), especially LTC4 and LTD4 in liver disease, was investigated in mice experimental liver injury models. The liver injury was induced by the injection of bacterial lipopolysaccharide (LPS) into Corynebacterium parvum pretreated mice. Carbon tetrachloride (CCl4)-induced liver inju...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00914311
更新日期:1989-12-01 00:00:00
abstract::Methicillin-resistant Staphylococcus aureus (MRSA) with exogenous cassette DNA containing the methicillin-resistant gene mecA (SCCmec) poses a problem as a drug-resistant bacterium responsible for hospital- and community-acquired infections. The frequency of MRSA detection has recently been increasing rapidly in Japan...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-011-9395-4
更新日期:2012-06-01 00:00:00
abstract::C-reactive protein (CRP) is a much used biomarker for respiratory tract infection; however, the influence of airway infection on the CRP level in the general population has not been well described. The study aimed to evaluate the impact of recent symptoms of airway infection on the CRP level and how the predictive pow...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-011-9405-6
更新日期:2012-06-01 00:00:00
abstract::The aim of this present study is to compare the effect of pressure-controlled ventilation and volume-controlled ventilation on pulmonary mechanics and inflammatory markers in prone position. The study included 41 patients undergoing to vertebrae surgery. The patients were randomized into two groups: Group 1 received v...
journal_title:Inflammation
pub_type: 杂志文章,随机对照试验
doi:10.1007/s10753-016-0379-2
更新日期:2016-08-01 00:00:00
abstract::The aim of the study was to determine the effect of direct application of rifampin, povidone-iodine, and hydrogen peroxide on the formation of epidural fibrosis in rats. Forty-eight adult male Wistar albino rats were equally and randomly divided into four groups (laminectomy, topical rifampin, topical povidone-iodine,...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-016-0383-6
更新日期:2016-08-01 00:00:00
abstract::This experiment was conducted to investigate the effects of a benzylideneacetophenone derivative ((2E)-3-(4-hydroxy-3-methoxyphenyl)phenylpro-2-en-l-one (JC3)) on trimellitic anhydride (TMA)-induced atopic dermatitis (AD)-like symptoms in mice. To induce AD, the dorsal skins of mice were treated with 5% TMA on day 0 a...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-019-00971-w
更新日期:2019-06-01 00:00:00
abstract::Interactions between the enteric nervous system and the immune system are suggested to play an important role in the pathophysiology of inflammatory bowel disease (IBD). This study aims to determine if chromogranin A (CgA), chromogranin B (CgB), and secretoneurin (SN) are detectable in feces (F) from patients with col...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-013-9612-4
更新日期:2013-08-01 00:00:00
abstract::Bee venom (BV) is used in folk medicine to treat arthritis. It has antiinflammatory effects in animal models of rheumatic disease. We have studied the effects of BV on human neutrophil production of superoxide (O2-) and hydrogen peroxide, finding potent, nontoxic, dose-dependent production inhibition. Melittin, the ma...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00915999
更新日期:1986-06-01 00:00:00
abstract::Neurodegenerative diseases such as Alzheimer, Parkinson, amyotrophic lateral sclerosis, and Huntington are incurable and debilitating conditions that result in progressive death of the neurons. The definite diagnosis of a neurodegenerative disorder is disadvantaged by the difficulty in obtaining biopsies and thereby t...
journal_title:Inflammation
pub_type: 杂志文章,评审
doi:10.1007/s10753-013-9780-2
更新日期:2014-06-01 00:00:00
abstract::To investigate patients with severe acute pancreatitis (SAP) by dynamic levels of pro-/anti-inflammatory cytokines and endotoxin (ET) in plasma and the relationship between immunity and infection, organ dysfunction. Seventy-two patients with SAP were recruited. The ET, tumor necrosis factor-α (TNF-α), interleukin-6 (I...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-010-9205-4
更新日期:2011-02-01 00:00:00
abstract::Enzyme-inducing drugs such as phenobarbital (PB) increase serum concentrations of an acute-phase protein, alpha 1-acid glycoprotein (AGP), in man, dogs, and rats via an unknown mechanism. We studied the effects of PB on components of an acute inflammatory reaction in rats in order to determine if PB acts only on this ...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00923344
更新日期:1991-12-01 00:00:00
abstract::Simvastatin, which is primarily prescribed to lower cholesterol, may also mitigate lung injury caused by sepsis, although the mechanisms remain elusive. This study aimed to evaluate the protective effect of simvastatin on acute lung injury in rats with sepsis and to investigate possible mechanisms. Male Wistar rats we...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-017-0668-4
更新日期:2018-02-01 00:00:00
abstract::Our study is based on the establishment of a cohort of human obese omental adipose tissue and the culture of adipocytes in vitro. To observe the effect of high level of free fatty acid (FFA) on the expression of DNA methyltransferases (DNMTs) and the anti-inflammatory factor Kruppel-like factor 4 (KLF4) in adipocytes ...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-019-01168-x
更新日期:2020-06-01 00:00:00
abstract::The aim of our study was to evaluate the pro- and anti-inflammatory cytokine response during acute pancreatitis and its predictive value on severity of disease. A hospital-based prospective clinical study was conducted. Twenty patients with acute pancreatitis were enrolled during a 12-month period. Plasma concentratio...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-011-9371-z
更新日期:2012-04-01 00:00:00
abstract::CD4(+)Foxp3(+)T cells (Tregs) mediate homeostatic peripheral tolerance by suppressing helper T2 cells in allergy. However, the regulation of asthmatic inflammation by local (in situ) Tregs in asthma remains unclear. BALB/c mice sensitized and challenged with ovalbumin (OVA) (asthma group) developed asthmatic inflammat...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-014-9892-3
更新日期:2014-10-01 00:00:00
abstract::Aseptic joint loosening is a key factor that reduces the life span of arthroplasty. There are currently few effective treatments for joint loosening except surgical revision. We explored the inhibitory effects of p110β-targeted small interfering RNA (siRNA) and lentivirus on particle-induced inflammatory cytokine expr...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-013-9636-9
更新日期:2013-10-01 00:00:00
abstract::1,8-Cineol is a major monoterpene principally from eucalyptus essential oils and has been shown to exert anti-inflammatory, antiviral, and inhibitory of nuclear factor (NF)-kB effect. In the present study, we evaluated the effect of 1,8-cineol on mice infected with influenza A virus. We found that 1,8-cineol protects ...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-016-0394-3
更新日期:2016-08-01 00:00:00
abstract::Sanggenon C (SC), a natural flavonoid extracted from Cortex Mori (Sang Bai Pi), is reported to possess anti-inflammatory and antioxidant properties in hypoxia. The present study aimed to investigate the therapeutic potential and the underlying mechanisms of SC in cerebral ischemia-reperfusion (I/R) injury. A rat model...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-020-01225-w
更新日期:2020-08-01 00:00:00
abstract::The widely used mouse air pouch model of acute inflammation is inducible in a variety of inbred strains, but the potential influence of genetic background and gender on inflammation severity has never been examined. We directly compared the degree of inflammation induced in the air pouch model across four commonly uti...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-006-8962-6
更新日期:2005-02-01 00:00:00