Abstract:
:Isoliquiritigenin (ILG), a major ingredient of licorice, has been reported to have anti-oxidative and anti-inflammatory effects. The aim of this study was to investigate the protective effects of ILG on lung injury using an animal model of lipopolysaccharide (LPS)-induced acute lung injury (ALI). Male BALB/c mice were conditioned with ILG 1 h before intranasal instillation of LPS. The effects of ILG on lung injury were assessed by measuring lung histopathological examination, MPO assay, wet/dry (W/D) ratio, and inflammatory cytokine production. The results showed that ILG significantly inhibited LPS-induced lung histopathological changes and the MPO activity. Meanwhile, it attenuated the wet/dry (W/D) ratio in the lung tissues. The results also indicated that ILG inhibited LPS-induced ALI in the expression of inflammatory cytokines in the BALF. Furthermore, ILG can decrease the activity of NF-κB and can increase the expression of PPAR-γ. These findings suggested that ILG inhibited the inflammatory of LPS-induced lung injury by activating PPAR-γ and inhibiting NF-κB activation.
journal_name
Inflammationjournal_title
Inflammationauthors
Zhang W,Wang G,Zhou Sdoi
10.1007/s10753-018-0777-8subject
Has Abstractpub_date
2018-08-01 00:00:00pages
1290-1296issue
4eissn
0360-3997issn
1573-2576pii
10.1007/s10753-018-0777-8journal_volume
41pub_type
杂志文章相关文献
INFLAMMATION文献大全abstract::Paeonol, a major ingredient isolated from Moutan Cort, has various pharmacological effects. Our previous studies have shown that paeonol can exert antioxidant and anti-inflammatory therapeutic effects on ethanol-induced experimental gastric ulcer (GU). Therefore, in this study, we designed two GU models in rats induce...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-020-01285-y
更新日期:2020-12-01 00:00:00
abstract::Praeruptorin C, D, and E (PC, PD, and PE) are three pyranocoumarins isolated from the dried root of Peucedanum praeruptorum Dunn of Umbelliferae. In the present study, we investigated the anti-inflammatory effect of these compounds in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells. Pyranocoumarins signi...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-011-9400-y
更新日期:2012-06-01 00:00:00
abstract::The aim of the study was to determine the effect of direct application of rifampin, povidone-iodine, and hydrogen peroxide on the formation of epidural fibrosis in rats. Forty-eight adult male Wistar albino rats were equally and randomly divided into four groups (laminectomy, topical rifampin, topical povidone-iodine,...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-016-0383-6
更新日期:2016-08-01 00:00:00
abstract::Berberine (Ber), the major constituent of Coptidis Rhizoma, possesses anti-inflammatory properties. In this study, we investigated the effects of Ber on cigarette smoke (CS)-mediated acute lung inflammation. C57BL/6 mice (6-8 weeks) were exposed to CS to induce acute lung injury. Ber was used to pretreat CS-exposed mi...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-013-9640-0
更新日期:2013-10-01 00:00:00
abstract::Induction of hypoxia for 2.5 h in perfused cat livers resulted in a 10-fold increase in cathepsin D and a 15-fold increase in lactic dehydrogenase (LDH) activities in the perfusate and a 42% depression of the clearance rate of particles by the reticuloendothelial system (RES). Addition of 10(-3) M methylprednisolone (...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00920336
更新日期:1976-12-01 00:00:00
abstract::Chemerin is shown to be associated with inflammation which is involved in the pathogenesis of diabetic nephropathy. This study aims to determine whether rosiglitazone and pioglitazone ameliorate renal function through an effect on the expression of chemerin and ChemR23 in streptozotocin-induced diabetic rats. The rats...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-012-9440-y
更新日期:2012-08-01 00:00:00
abstract::Pig alveolar macrophages are a heterogeneous population of cells. Three subpopulations or bands exist when the whole population is separated according to density. Band 1 cells are the least dense cells and constitute 9% of the total population. Bands 2 and 3 represent 44 and 47% of the total population. The three subp...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00915841
更新日期:1987-09-01 00:00:00
abstract::The excessive activation of microglia plays a key role in the pathogenesis of neurodegenerative diseases. The neuroprotective properties of rosmarinic acid have been reported in a variety of disease models both in vitro and in vivo; however, the mechanism underlying its anti-neuroinflammatory activity has not been cle...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-017-0728-9
更新日期:2018-03-01 00:00:00
abstract::Drug delivery into immune cells has high potential for the treatment of all kinds of inflammation, allowing a target-oriented transport of active agents. The advantage of this local drug release is the prevention of negative effects of systemic applications and low-dose application. Thereby, the phagocytotic capabilit...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-010-9213-4
更新日期:2011-04-01 00:00:00
abstract::Gossypol is present in antiinflammatory poultices made from the medicinal tree Thespesia populnea. Isolated human neutrophils exposed to 3-20 microM gossypol for 15-90 min were assayed in vitro for superoxide production and surface expression of Mac-1 (CD11b/CD18). Gossypol increased superoxide production in a time- a...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF01560692
更新日期:1994-10-01 00:00:00
abstract::Activated macrophages exhibiting diverse phenotypes and various functions contribute to the pathogenesis or amelioration of different diseases like cancer, inflammation, and infectious and autoimmune diseases. However, the mechanisms of macrophage polarization in inflamed joint and its effects on rheumatoid arthritis ...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-017-0619-0
更新日期:2017-10-01 00:00:00
abstract::A full understanding of rheumatoid arthritis depends on the appreciation of clinical, radiological, immunological, genetic, biochemical, and structural mechanisms. Rheumatoid arthritis is characterized by the destruction of tissue structures such as articular cartilage and bone, but may also involve tendonous tissue, ...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00915710
更新日期:1984-06-01 00:00:00
abstract::This study investigated the protective effect of Lactobacillus plantarum NDC 75017 (L. plantarum NDC 75017) against acute liver injury induced by lipopolysaccharide (LPS). Thirty male mice were randomly divided into the control, LPS, and LPS + L. plantarum NDC 75017 groups. In the LPS + L. plantarum group, the mice we...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-014-9886-1
更新日期:2014-10-01 00:00:00
abstract::Influenza A virus pandemics and emerging antiviral resistance highlight the urgent need for novel generic pharmacological strategies that reduce both viral replication and inflammation of the lung. We have previously investigated the therapeutic efficacy of recombinant human catalase (rhCAT) against viral pneumonia in...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-013-9800-2
更新日期:2014-06-01 00:00:00
abstract::The bacterial keratitis causes viability loss and apoptosis in the corneal epithelial cells (CECs). The cyanidin-3-O-glucoside (C3G) benefits visual system and also possess anti-bacterial and anti-inflammatory potentials. In the current study, the effects of C3G on human CECs (HCECs) against bacterial lipopolysacchari...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-020-01194-0
更新日期:2020-06-01 00:00:00
abstract::Systemic sclerosis (SSc) is a disease characterized by skin and internal organ involvement. There is progressive accumulation of extracellular matrix components in the skin and involved organs. Tissue fibrosis is the prominent reason for mortality, and still, there is no satisfactory treatment. The aim of this study w...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-012-9521-y
更新日期:2013-02-01 00:00:00
abstract::High concentrations of corticosteroids inhibit granulocyte responses and disrupt agonist receptor function. Dose-response and time-course considerations make it unlikely that these effects are mediated via the glucocorticoid receptor, a concept further supported by the ability of sex steroids to work similar effects. ...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00914030
更新日期:1990-02-01 00:00:00
abstract::Currently, only tumor necrosis factor alpha (TNF-α) and interleukin family cytokines have been found to be elicited in Vibrio vulnificus (V. vulnificus)-infected animal models and humans. However, multiple other cytokines are also involved in the immune and inflammatory responses to foreign microorganism infection. An...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-015-0166-5
更新日期:2015-10-01 00:00:00
abstract::In our study, we explored the bidirectional communication via soluble factors between bone cells and endotoxin-stimulated splenic lymphocytes in an in vitro coculture model that mimics the inflammatory environment. Both the ability of lymphocytes to affect differentiation and immune properties of bone cells, osteoblas...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-012-9477-y
更新日期:2012-10-01 00:00:00
abstract::Studies indicated that CC receptor 5 (CCR5), as a receptor for CC ligand 3, CCL4, and CCL5, plays important roles in the recruitment of T cytotoxic lymphocytes to the liver of chronic HBV (CHB)-infected patients. The main purpose of this study was to investigate the expression levels of CCR5 on the CD8(+) T lymphocyte...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-012-9528-4
更新日期:2013-02-01 00:00:00
abstract::Herein, we reported our experience in colchicine-resistant familial Mediterranean fever (FMF) patients who are treated with anti-interleukin-1 (IL-1) drugs. A retrospective review of medical records of anti-IL-1 recipients was performed. The main clinical characteristics of these patients and the evolution after anti-...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-014-0004-1
更新日期:2015-02-01 00:00:00
abstract::Calgranulins are small calcium-binding proteins with several immunological functions involved in inflammatory processes. Calgranulin A is reported to be mainly associated with acute inflammation while calgranulin B seems to play a role in chronic inflammatory disorders. In this study we used a proteomic approach to an...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-008-9085-z
更新日期:2008-10-01 00:00:00
abstract::Dysregulated release of neutrophil reactive oxygen species and proteolytic enzymes contributes to both acute and chronic inflammatory diseases. Therefore, molecular regulators of these processes are potential targets for new anti-inflammatory therapies. We have shown previously that myristoylated alanine-rich C-kinase...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-014-0078-9
更新日期:2015-01-01 00:00:00
abstract::The respiratory epithelium is often exposed to oxidant gases, including ozone from photochemical smog and toxic oxygen metabolites released from neutrophils recruited in conditions of airway inflammation. We evaluated DNA single strand break formation by alkaline elution as a measure of oxidant-induced DNA damage to b...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00920476
更新日期:1993-12-01 00:00:00
abstract::1,8-Cineol is a major monoterpene principally from eucalyptus essential oils and has been shown to exert anti-inflammatory, antiviral, and inhibitory of nuclear factor (NF)-kB effect. In the present study, we evaluated the effect of 1,8-cineol on mice infected with influenza A virus. We found that 1,8-cineol protects ...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-016-0394-3
更新日期:2016-08-01 00:00:00
abstract::Lipopolysaccharide (LPS) increases serum TNF-alpha levels due to TNF-alpha secretion by macrophages. The serum TNF-alpha response to LPS was augmented 10x when FcgammaR ligation was induced by the intravenous injection of Gig-coated erythrocytes (IgG) prior to the administration of LPS. The macrophage population respo...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1023/a:1021468819285
更新日期:2002-12-01 00:00:00
abstract::The existence of multiple-interactive roles between several signaling pathways in tumorigenesis shows the significance of pharmacological factors like heat shock protein 90 (HSP90) inhibitors which control several signaling pathways simultaneously. HSP90 as a molecular chaperone supports the active conformational stru...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-016-0343-1
更新日期:2016-06-01 00:00:00
abstract::Induction of colitis by 2,4,6-Trinitrobenzenesulphonic acid (TNB) in the rat is a widely used experimental model of inflammatory bowel disease. Action of TNB as a hapten, induces colitis involving infiltration of colonic mucosa by neutrophils and macrophages and increased production of inflammatory mediators. The aim ...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1023/a:1020241028723
更新日期:1999-04-01 00:00:00
abstract::We compared exhaled breath condensate (EBC) and induced sputum (IS) for assessing inflammation in pulmonary diseases in patients with obstructive lung disease (n = 20), persistent cough >6 months (n = 20), interstitial lung disease (n = 25) and controls (n = 10). EBC was collected by suspending a Teflon perfluoroalkox...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-007-9020-8
更新日期:2007-04-01 00:00:00
abstract::D-limonene epoxidation generates (+)-limonene epoxide, an understudied compound in the pharmacologically point of view. Herein, we investigated the anti-inflammatory and antinociceptive potentialities of (+)-limonene epoxide and suggested a mechanism of action. The anti-inflammatory potential was analyzed using agents...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-016-0496-y
更新日期:2017-04-01 00:00:00