当前位置： SCI文献检索 > INFLAMMATION期刊下所有文献 > Protective effects of Lactobacillus plantarum NDC 75017 against lipopolysaccharide-induced liver injury in mice.

Protective effects of Lactobacillus plantarum NDC 75017 against lipopolysaccharide-induced liver injury in mice.

Abstract：

:This study investigated the protective effect of Lactobacillus plantarum NDC 75017 (L. plantarum NDC 75017) against acute liver injury induced by lipopolysaccharide (LPS). Thirty male mice were randomly divided into the control, LPS, and LPS + L. plantarum NDC 75017 groups. In the LPS + L. plantarum group, the mice were orally pretreated with L. plantarum NDC 75017 for 15 days. At 16 days, the mice in the LPS and LPS + L. plantarum NDC 75017 groups were intraperitoneally injected with LPS at 4 mg/kg body weight, whereas the control mice were treated with an equal amount of saline. After 8 h, the serum alanine transaminase (ALT), aspartate aminotransferase (AST), and histology changes were examined. The oxidative stress markers and pro-inflammatory cytokines in the liver were also examined. Meanwhile, the expression of nuclear factor κB (NF-κB) mRNA and toll-like receptor 4 (TLR4) in the liver was determined by qRT-PCR. The LPS group showed an increase in ALT and AST, whereas the LPS + L. plantarum NDC 75017 group showed a significant decrease. In addition, pretreatment with L. plantarum NDC 75017 can attenuate LPS-induced oxidative stress and inflammatory response. Furthermore, the increase of hepatic NF-κB and TLR4 mRNA induced by LPS was significantly downregulated by the pretreatment with L. plantarum NDC 75017. These data show that pretreatment with L. plantarum NDC 75017 protects against LPS-induced oxidative stress and inflammatory injury in the liver of mice, which may be attributed to the inhibition of the TLR4-NF-κB pathway.

journal_name

Inflammation

journal_title

Inflammation

authors

Peng X,Jiang Y

doi

10.1007/s10753-014-9886-1

subject

Has Abstract

pub_date

2014-10-01 00:00:00

pages

1599-607

issue

5

eissn

0360-3997

issn

1573-2576

journal_volume

37

pub_type

杂志文章

相关文献

INFLAMMATION文献大全
  • Oroxylin A Inhibits Allergic Airway Inflammation in Ovalbumin (OVA)-Induced Asthma Murine Model.

    abstract：:Oroxylin A, a natural flavonoid isolated from the medicinal herb Scutellaria baicalensis Georgi, has been reported to have anti-inflammatory property. In this study, we aimed to investigate the protective effects and mechanism of oroxylin A on allergic inflammation in OVA-induced asthma murine model. BABL/c mice were ...

    journal_title：Inflammation

    pub_type： 杂志文章

    doi：10.1007/s10753-016-0317-3

    authors： Zhou DG,Diao BZ,Zhou W,Feng JL

    更新日期：2016-04-01 00:00:00

  • Dichloromethane fraction of Laminaria japonica ethanolic extract inhibits lipopolysaccharide-induced nitric oxide synthase and cyclooxygenase-2 expression in RAW 264.7 cells via NF-κB pathway.

    abstract：:Strong anti-inflammatory activity has been found in Laminaria japonica dichloromethane fraction (LDF); however, the molecular mechanisms underlying its anti-inflammatory activity are not reported. Our results indicated that LDF inhibited LPS-induced nitric oxide and prostaglandin E(2) production in a dose-dependent ma...

    journal_title：Inflammation

    pub_type： 杂志文章

    doi：10.1007/s10753-012-9481-2

    authors： Lee JY,Lee MS,Choi JW,Shin TS,Woo HC,Kim HR

    更新日期：2012-10-01 00:00:00

  • Protein kinase C inhibitor calphostin C prevents cytokine-induced angiogenesis in the rat.

    abstract：:A rat sponge implant model was used to examine the role of protein kinase C (PKC) in angiogenesis. Neovascular response was determined by measurements of relative sponge blood flow by a 133Xe clearance technique and confirmed histologically. Morphometric analysis was used to quantitate the amount of fibrovascular grow...

    journal_title：Inflammation

    pub_type： 杂志文章

    doi：10.1007/BF01534379

    authors： Hu DE,Fan TP

    更新日期：1995-02-01 00:00:00

  • Role of T-lymphocytes in the resolution of endotoxin-induced lung injury.

    abstract：:An acute neutrophilic lung injury was compared in Balb/c normal and nu/nu (nude) mice to assess the role of T lymphocytes in the resolution of acute pulmonary neutrophilic inflammation following the administration of endotoxin. Maximal neutrophilic infiltration occurred on day 1 post-endotoxin treatment and declined t...

    journal_title：Inflammation

    pub_type： 杂志文章

    doi：10.1023/a:1027393715300

    authors： Morris PE,Glass J,Cross R,Cohen DA

    更新日期：1997-06-01 00:00:00

  • Simvastatin Inhibits IL-1β-Induced Apoptosis and Extracellular Matrix Degradation by Suppressing the NF-kB and MAPK Pathways in Nucleus Pulposus Cells.

    abstract：:Statins are widely used hypocholesterolemic drugs that block the mevalonate pathway. Some studies have shown that statins may have the potential to inhibit intervertebral disk (IVD) degeneration (IDD). Interleukin (IL)-1β, a catabolic cytokine, is a key regulator of IDD. This study aimed to investigate the mechanism u...

    journal_title：Inflammation

    pub_type： 杂志文章

    doi：10.1007/s10753-017-0516-6

    authors： Tu J,Li W,Zhang Y,Wu X,Song Y,Kang L,Liu W,Wang K,Li S,Hua W,Yang C

    更新日期：2017-06-01 00:00:00

  • Bergenin Plays an Anti-Inflammatory Role via the Modulation of MAPK and NF-κB Signaling Pathways in a Mouse Model of LPS-Induced Mastitis.

    abstract：:Mastitis is a major disease in humans and other animals and is characterized by mammary gland inflammation. It is a major disease of the dairy industry. Bergenin is an active constituent of the plants of genus Bergenia. Research indicates that bergenin has multiple biological activities, including anti-inflammatory an...

    journal_title：Inflammation

    pub_type： 杂志文章

    doi：10.1007/s10753-014-0079-8

    authors： Gao XJ,Guo MY,Zhang ZC,Wang TC,Cao YG,Zhang NS

    更新日期：2015-01-01 00:00:00

  • Modulation of leukotaxis by ibuprofen. A quantitative determination in vivo.

    abstract：:The purpose of this study was to evaluate the rabbit anterior eye chamber as a quantitative measure of leukotaxis using 51Cr-labeled homologous leukocytes and then to determine the effects of ibuprofen on N-formyl-methionyl-leucyl-phenylalanine (FMLP) -induced leukotaxis. Leukocyte accumulation was assessed at various...

    journal_title：Inflammation

    pub_type： 杂志文章

    doi：10.1007/BF00916277

    authors： Shimanuki T,Nakamura RM,Dizerega GS

    更新日期：1985-09-01 00:00:00

  • A Spotlight on the Underlying Activation Mechanisms of the NLRP3 Inflammasome and its Role in Atherosclerosis: A Review.

    abstract：:The world's number one cause of death is cardiovascular diseases. The pathogenesis of different disease entities in the cardiovascular disease spectrum is complicated and multifactorial. Inflammation in these complicated etiologies serves as a key position and is a significant cause of atherosclerosis, which contribut...

    journal_title：Inflammation

    pub_type： 杂志文章,评审

    doi：10.1007/s10753-020-01290-1

    authors： Liaqat A,Asad M,Shoukat F,Khan AU

    更新日期：2020-12-01 00:00:00

  • Transient exposure of human bronchial epithelial cells to cytokines leads to persistent increased expression of ICAM-1.

    abstract：:Effects of several cytokines on kinetics of Intercellular Adhesion Molecule-1 (ICAM-1) and Vascular Cell Adhesion Molecule-1 (VCAM-1) expression were studied on a bronchial epithelial cell line (BEAS-2B). VCAM-I was neither constitutively expressed on BEAS-2B cells nor induced by Interferon-gamma (IFN-gamma). Tumor Ne...

    journal_title：Inflammation

    pub_type： 杂志文章

    doi：10.1023/a:1012850630351

    authors： Subauste MC,Choi DC,Proud D

    更新日期：2001-12-01 00:00:00

  • Novel Treatment of Experimental Autoimmune Prostatitis by Nanoparticle-Conjugated Autoantigen Peptide T2.

    abstract：:The exact etiology and pathogenesis of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) are still unknown, as a result, available therapeutic options for patients are far from satisfactory. Therefore, there is a need to develop a valid therapeutic approach that can ameliorate the manifestations of CP/CPPS. F...

    journal_title：Inflammation

    pub_type： 杂志文章

    doi：10.1007/s10753-019-00968-5

    authors： Cheng Y,Cao Y,Ihsan AU,Khan FU,Li X,Xie D,Cui X,Wang W,Liu Z,Li C,Ahmad KA,Sembatya KR,Mikrani R,Zhou X

    更新日期：2019-06-01 00:00:00

  • Experimental Study of the Protective Effect of Simvastatin on Lung Injury in Rats with Sepsis.

    abstract：:Simvastatin, which is primarily prescribed to lower cholesterol, may also mitigate lung injury caused by sepsis, although the mechanisms remain elusive. This study aimed to evaluate the protective effect of simvastatin on acute lung injury in rats with sepsis and to investigate possible mechanisms. Male Wistar rats we...

    journal_title：Inflammation

    pub_type： 杂志文章

    doi：10.1007/s10753-017-0668-4

    authors： Wang Y,Yang W,Zhao X,Zhang R

    更新日期：2018-02-01 00:00:00

  • The nitrone spin trap 5,5-dimethyl-1-pyrroline N-oxide affects stress response and fate of lipopolysaccharide-primed RAW 264.7 macrophage cells.

    abstract：:The nitrone spin trap 5,5-dimethyl-1-pyrroline N-oxide (DMPO) is commonly used to study free radicals. Due to its free radical trapping properties, DMPO is thought to reduce free radial-mediated oxidative damage and other related cellular responses. The purpose of this study was to assess the effect of DMPO on lipopol...

    journal_title：Inflammation

    pub_type： 杂志文章

    doi：10.1007/s10753-012-9552-4

    authors： Zhai Z,Gomez-Mejiba SE,Ramirez DC

    更新日期：2013-04-01 00:00:00

  • Effects of Salidroside on Myocardial Injury In Vivo In Vitro via Regulation of Nox/NF-κB/AP1 Pathway.

    abstract：:Salidroside (Sal), a phenylpropanoid glycoside isolated from a popular traditional Chinese medicinal plant Rhodiola rosea L., possesses multiple pharmacological actions. This aim of this study is to investigate the effects of Sal against isoproterenol (ISO)-induced myocardial ischemia. Fifty male Sprague-Dawley rats w...

    journal_title：Inflammation

    pub_type： 杂志文章

    doi：10.1007/s10753-015-0134-0

    authors： Zhu L,Wei T,Chang X,He H,Gao J,Wen Z,Yan T

    更新日期：2015-08-01 00:00:00

  • A role of piperine on monosodium urate crystal-induced inflammation--an experimental model of gouty arthritis.

    abstract：:In the present study, the anti-inflammatory effect of piperine was investigated on monosodium urate crystal-induced inflammation in mice, an experimental model for gouty arthritis, and compared it with that of the nonsteroidal anti-inflammatory drug, indomethacin. The levels of lysosomal enzymes, lipid peroxidation, t...

    journal_title：Inflammation

    pub_type： 杂志文章

    doi：10.1007/s10753-010-9222-3

    authors： Sabina EP,Nagar S,Rasool M

    更新日期：2011-06-01 00:00:00

  • Effect of interleukin-8 and monocyte chemotactic protein-1 on adhesion of circulating granulocytes and monocytes from asthma patients to human venous endothelial cells.

    abstract：:The adhesive interactions between phagocytes and endothelial cells (EC) can be modulated by inflammatory cytokines and chemotactic proteins which are released during an inflammatory response. The aim of the present study was to investigate first whether the adhesive properties of granulocytes and monocytes from asthma...

    journal_title：Inflammation

    pub_type： 杂志文章

    doi：10.1023/a:1022344307926

    authors： Verdegaal EM,Zegveld ST,Beekhuizen H,Bakker W,van Furth R

    更新日期：1998-04-01 00:00:00

  • Protective and Therapeutic Effects of Engeletin on LPS-Induced Acute Lung Injury.

    abstract：:Acute lung injury (ALI) is a serious disease with morbidity and mortality in patients. Engeletin (dihydrokaempferol 3-rhamnoside) is a flavanonol glycoside. It can be found in the skin of white grapes and white wine and is widely distributed in southeast Asia. In our study, we evaluated the protective and therapeutic ...

    journal_title：Inflammation

    pub_type： 杂志文章

    doi：10.1007/s10753-018-0773-z

    authors： Jiang X,Chen L,Zhang Z,Sun Y,Wang X,Wei J

    更新日期：2018-08-01 00:00:00

  • Diet and diet combined with chronic aerobic exercise decreases body fat mass and alters plasma and adipose tissue inflammatory markers in obese women.

    abstract：:The purpose of this study was to investigate the effect of 6 months aerobic exercise and diet alone or in combination on markers of inflammation (MOI) in circulation and in adipose abdominal tissue (AT) in obese women. Thirty obese subjects were randomized into a 24-week intervention: (1) exercise (EX), (2) diet (DI),...

    journal_title：Inflammation

    pub_type： 杂志文章

    doi：10.1007/s10753-013-9661-8

    authors： Lakhdar N,Denguezli M,Zaouali M,Zbidi A,Tabka Z,Bouassida A

    更新日期：2013-12-01 00:00:00

  • Paeoniflorin Suppressed High Glucose-Induced Retinal Microglia MMP-9 Expression and Inflammatory Response via Inhibition of TLR4/NF-κB Pathway Through Upregulation of SOCS3 in Diabetic Retinopathy.

    abstract：:Diabetic retinopathy (DR) is a serious-threatening complication of diabetes and urgently needed to be treated. Evidence has accumulated indicating that microglia inflammation within the retina plays a critical role in DR. Microglial matrix metalloproteinase 9 (MMP-9) has an important role in the destruction of the int...

    journal_title：Inflammation

    pub_type： 杂志文章

    doi：10.1007/s10753-017-0571-z

    authors： Zhu SH,Liu BQ,Hao MJ,Fan YX,Qian C,Teng P,Zhou XW,Hu L,Liu WT,Yuan ZL,Li QP

    更新日期：2017-10-01 00:00:00

  • Postsurgical Acute Phase Reaction is Associated with Decreased Levels of Circulating Myostatin.

    abstract：:Muscle strength is of importance for postsurgical rehabilitation. Myostatin is a growth factor that regulates the size of muscles and could thus influence muscle mass and function in the postsurgical period. The aim of the present study was to study the changes in myostatin levels during the postsurgical inflammatory ...

    journal_title：Inflammation

    pub_type： 杂志文章

    doi：10.1007/s10753-015-0149-6

    authors： Åkerfeldt T,Helmersson-Karlqvist J,Gunningberg L,Swenne CL,Larsson A

    更新日期：2015-08-01 00:00:00

  • The effect of epigallocatechin gallate on lipopolysaccharide-induced acute lung injury in a murine model.

    abstract：:This study was performed to evaluate the effects of epigallocatechin 3 gallate (EGCG) on lipopolysaccharide (LPS)-induced acute lung injury in a murine model. In the present study, production of TNF-alpha and MIP-2 and activation of extracellular signal-regulated kinases (ERK)1/2, c-Jun amino terminal kinases (JNK) an...

    journal_title：Inflammation

    pub_type： 杂志文章

    doi：10.1007/s10753-009-9161-z

    authors： Bae HB,Li M,Kim JP,Kim SJ,Jeong CW,Lee HG,Kim WM,Kim HS,Kwak SH

    更新日期：2010-04-01 00:00:00

  • Cepharanthine attenuates lipopolysaccharide-induced mice mastitis by suppressing the NF-κB signaling pathway.

    abstract：:Cepharanthine (CEP), a biscoclaurine alkaloid isolated from Stephania cepharantha Hayata, has been reported to have potent anti-inflammatory properties. However, the anti-inflammatory effects of CEP on a mouse model of lipopolysaccharide (LPS)-induced mastitis and its underlying molecular mechanisms remain to be eluci...

    journal_title：Inflammation

    pub_type： 杂志文章

    doi：10.1007/s10753-013-9744-6

    authors： Ershun Z,Yunhe F,Zhengkai W,Yongguo C,Naisheng Z,Zhengtao Y

    更新日期：2014-04-01 00:00:00

  • Effect of recombinant human interleukin 2 on neutrophil adherence to endothelial cells in vitro.

    abstract：:Human neutrophils were demonstrated to possess interleukin-2 receptor (IL-2R) beta and gamma chains, not alpha chain and the binding of IL-2 to the IL-2R beta chain on neutrophils plays an important regulatory role in neutrophil functions. We have investigated in this study the hypothesis that recombinant human IL-2 (...

    journal_title：Inflammation

    pub_type： 杂志文章

    doi：10.1007/BF01486739

    authors： Li J,Gyorffy S,Lee S,Kwok CS

    更新日期：1996-08-01 00:00:00

  • Generation of superoxide by immunologically stimulated normal human neutrophils and possible modulation by intracellular and extracellular SOD and rheumatoid factors.

    abstract：:Rheumatoid synovial fluids generated significantly greater amounts of superoxide, lysosomal enzymes, and superoxide dismutase from neutrophils into extracellular fluid than osteoarthritic synovial fluids. Rheumatoid factors isolated from serum suppressed superoxide-generating activity of performed immune complexes, bu...

    journal_title：Inflammation

    pub_type： 杂志文章

    doi：10.1007/BF00916016

    authors： Shingu M,Todoroki T,Nobunaga M

    更新日期：1987-06-01 00:00:00

  • Lung immunoreactivity and airway inflammation: their assessment after scorpion envenomation.

    abstract：:Release and activation of pro-inflammatory mediators are among the most important induced factors that are involved in the scorpion envenomation pathogenesis. Inflammatory response and lung reactivity were studied in mice following subcutaneous injection with Androctonus australis hector (Aah) venom. Venom immunodetec...

    journal_title：Inflammation

    pub_type： 杂志文章

    doi：10.1007/s10753-011-9338-0

    authors： Adi-Bessalem S,Mendil A,Hammoudi-Triki D,Laraba-Djebari F

    更新日期：2012-04-01 00:00:00

  • ApoM-S1P Modulates Ox-LDL-Induced Inflammation Through the PI3K/Akt Signaling Pathway in HUVECs.

    abstract：:Studies have shown that apolipoprotein M (apoM), the main carrier of sphingosine-1-phosphate (S1P), is closely related to lipid metabolism and inflammation. While there are many studies on apoM and lipid metabolism, little is known about the role of apoM in inflammation. Atherosclerosis is a chronic inflammatory proce...

    journal_title：Inflammation

    pub_type： 杂志文章

    doi：10.1007/s10753-018-0918-0

    authors： Zheng Z,Zeng Y,Zhu X,Tan Y,Li Y,Li Q,Yi G

    更新日期：2019-04-01 00:00:00

  • Phenotypic characterization and invasive properties of synovial fluid-derived adherent cells in rheumatoid arthritis.

    abstract：:The present study aimed at characterizing the phenotype and functions of adherent synovial fluid (SF) cells derived from rheumatoid arthritis (RA), comparing with fibroblast-like synoviocytes (FLS) derived from RA synovial tissue (ST). Adherent SF-derived cells were spindle-shaped from passages 1-6 under light microsc...

    journal_title：Inflammation

    pub_type： 杂志文章

    doi：10.1007/s10753-008-9087-x

    authors： Ahn JK,Kim H,Lee J,Bae EK,Cha HS,Koh EM

    更新日期：2008-12-01 00:00:00

  • Levels of messenger ribonucleic acids for plasma proteins in rat liver during acute experimental inflammation.

    abstract：:The levels of mRNA for plasma proteins and for metallothionein in rat liver during the acute-phase response were studied by hybridization to specific cDNA probes. The mRNA for alpha 2-macroglobulin, the beta-chain of fibrinogen, alpha 1-acid glycoprotein (so-called acute-phase reactants) reached a maximum level betwee...

    journal_title：Inflammation

    pub_type： 杂志文章

    doi：10.1007/BF00916041

    authors： Schreiber G,Aldred AR,Thomas T,Birch HE,Dickson PW,Tu GF,Heinrich PC,Northemann W,Howlett GJ,de Jong FA

    更新日期：1986-03-01 00:00:00

  • Chemotactic and immunoregulatory properties of bone cells are modulated by endotoxin-stimulated lymphocytes.

    abstract：:In our study, we explored the bidirectional communication via soluble factors between bone cells and endotoxin-stimulated splenic lymphocytes in an in vitro coculture model that mimics the inflammatory environment. Both the ability of lymphocytes to affect differentiation and immune properties of bone cells, osteoblas...

    journal_title：Inflammation

    pub_type： 杂志文章

    doi：10.1007/s10753-012-9477-y

    authors： Cvija H,Kovacic N,Katavic V,Ivcevic S,Aguila HL,Marusic A,Grcevic D

    更新日期：2012-10-01 00:00:00

  • Increased interleukin-8 in epithelial lining fluid of collapsed lungs during one-lung ventilation for thoracotomy.

    abstract：:The present study was designed to evaluate inflammatory changes in collapsed lungs during one-lung ventilation using the assistance of a bronchoscopic microsampling probe. Serial albumin and interleukin (IL)-8 concentrations in epithelial lining fluid (ELF) were measured in seven patients undergoing resection of lung ...

    journal_title：Inflammation

    pub_type： 杂志文章

    doi：10.1007/s10753-012-9505-y

    authors： Komatsu Y,Yamamoto H,Tsushima K,Furuya S,Yoshikawa S,Yasuo M,Kubo K,Yamazaki Y,Hasegawa J,Eguchi T,Kondo R,Yoshida K,Koizumi T

    更新日期：2012-12-01 00:00:00

  • LncRNA KCNQ1OT1 Regulates Endoplasmic Reticulum Stress to Affect Cerebral Ischemia-Reperfusion Injury Through Targeting miR-30b/GRP78.

    abstract：:Endoplasmic reticulum stress (ERS) plays an important role in cerebral ischemia-reperfusion injury (CIRI) by regulating apoptosis. Although the role of long non-coding RNA (LncRNA) KCNQ1OT1 in CIRI has been reported, the specific mechanism is still unclear. In this paper, the regulation of ERS by LncRNA KCNQ1OT1 in CI...

    journal_title：Inflammation

    pub_type： 杂志文章

    doi：10.1007/s10753-020-01295-w

    authors： Li Y,Yi M,Wang D,Zhang Q,Yang L,Yang C

    更新日期：2020-12-01 00:00:00