Protective and Therapeutic Effects of Engeletin on LPS-Induced Acute Lung Injury.

abstract：:Current treatments for ischemia-reperfusion (IR)-induced acute lung injury are limited. Mesenchymal stem cell-conditioned medium (CM) has been reported to attenuate lung injury. Neural crest stem cells (NCSCs), a type of multipotent stem cells, are more easily obtained than mesenchymal stem cells. We hypothesize that ...

journal_title：Inflammation

authors： Peng CK,Wu SY,Tang SE,Li MH,Lin SS,Chu SJ,Huang KL

更新日期：2017-10-01 00:00:00

abstract：:Ziprasidone (ZIP) is an effective antipsychotic with low side effects than other second-generation antipsychotics. Despite this, there are reports of adverse events and previous studies associating the use of ZIP the inflammatory response. It is possible to infer that bioactive molecules present in some foods could at...

journal_title：Inflammation

authors： Duarte T,Barbisan F,da Cunha BSN,Azzolin VF,Turra BO,Duarte MMMF,da Cruz Jung IE,Ribeiro EE,do Prado-Lima PA,da Cruz IBM

更新日期：2019-06-01 00:00:00

abstract：:The intracellular signaling pathways involved in human monocyte chemotaxis toward a variety of chemoattractant molecules were evaluated using selected pharmacological agents. Neither phosphatidylinositol-3-kinase (P13K) or extracellular signal-regulated kinase (ERK) activity were required for monocyte migration toward...

journal_title：Inflammation

authors： Fine JS,Byrnes HD,Zavodny PJ,Hipkin RW

更新日期：2001-04-01 00:00:00

abstract：:The nonspecific (nonallergic) inflammatory activity of melittin, a protein toxin from honeybees, was correlated with specific amino acid sequences. Two different amino acid sequences of melittin were found to contribute to nonspecific inflammatory activities in guinea pig skin. Carboxy terminal peptide sequences of 7-...

journal_title：Inflammation

authors： Mackler BF,Kreil G

更新日期：1977-03-01 00:00:00

abstract：:Activated macrophages exhibiting diverse phenotypes and various functions contribute to the pathogenesis or amelioration of different diseases like cancer, inflammation, and infectious and autoimmune diseases. However, the mechanisms of macrophage polarization in inflamed joint and its effects on rheumatoid arthritis ...

journal_title：Inflammation

authors： Dongsheng Z,Zhiguang F,Junfeng J,Zifan L,Li W

更新日期：2017-10-01 00:00:00

abstract：:Ovarian cancer is one of the most deadly cancers with rapid proliferation and poor prognosis among patients. Therapies focusing on regulation of tumor immunity and microenvironments are developing. MiR-217 was dysregulated in cancer progress and plays important roles in tumorigenesis and metastasis. However, the role ...

journal_title：Inflammation

authors： Jiang B,Zhu SJ,Xiao SS,Xue M

更新日期：2019-10-01 00:00:00

abstract：:NO generation in the course of two acute, non immune, inflammatory reactions (pleurisy induced by rat isologous serum and carrageenan) was assessed by means of nitrite measurement in pleural exudate from 0.5 to 24 h. NO release varied time-dependently, similarly for the two inflammatory reactions. A first, but transie...

journal_title：Inflammation

authors： Regnault C,Roch-Arveiller M,Florentin I,Giroud JP,Postaire E,Delaforge M

更新日期：1996-12-01 00:00:00

abstract：:A heat-stable factor present in extracts of human blood leukocytes is capable of lysing young Staphylococcus aureus at pH 5.0. Lysis is characterized by breakdown of cell-wall components as judged by electron microscopic and biochemical analysis. The leukocyte extracts can be replaced by a variety of agents known to i...

journal_title：Inflammation

authors： Lahav M,Ginsburg I

更新日期：1977-06-01 00:00:00

abstract：:Tumour necrosis factor-α (TNFα) and polymorphonuclear neutrophils play key and interrelated roles in the inflammatory response against infectious agents. However, these entities can mediate significant tissue damage if their biological activity becomes deregulated. We have previously shown that canine hyperimmune froz...

journal_title：Inflammation

authors： Essien BE,Kotiw M

更新日期：2012-02-01 00:00:00

abstract：:The world's number one cause of death is cardiovascular diseases. The pathogenesis of different disease entities in the cardiovascular disease spectrum is complicated and multifactorial. Inflammation in these complicated etiologies serves as a key position and is a significant cause of atherosclerosis, which contribut...

journal_title：Inflammation

authors： Liaqat A,Asad M,Shoukat F,Khan AU

更新日期：2020-12-01 00:00:00

abstract：:The aim of this prospective case control study is to determine CD4(+), CD25(+), and FoxP3(+) T regulatory cells (Tregs) and T helper cells (Ths) in obese, asthmatic, asthmatic obese, and healthy children. Obese (n = 40), asthmatic (n = 40), asthmatic obese (n = 40), and healthy children (n = 40) were included in this ...

journal_title：Inflammation

authors： Donma M,Karasu E,Ozdilek B,Turgut B,Topcu B,Nalbantoglu B,Donma O

更新日期：2015-08-01 00:00:00

abstract：:Endothelial activation with excessive recruitment and adhesion of immune cells plays a central role in the progression of sepsis. We established a microfluidic system to study the activation of human umbilical vein endothelial cells by conditioned medium containing plasma from lipopolysaccharide-stimulated whole blood...

journal_title：Inflammation

authors： Eichhorn T,Rauscher S,Hammer C,Gröger M,Fischer MB,Weber V

更新日期：2016-10-01 00:00:00

abstract：:Free radicals play an important role in the initiation and progression of inflammatory bowel disease (IBD). Therefore, the reduction or elimination of adverse oxidant effects can provide novel therapy for IBD. Here, the antioxidant capacity and protective effects of a new class of chemically modified hetastarch (polyn...

journal_title：Inflammation

authors： Park JH,Ma L,Oshima T,Carter P,Coe L,Ma JW,Specian R,Grisham MB,Trimble CE,Hsia CJ,Liu JE,Alexander JS

更新日期：2002-02-01 00:00:00

abstract：:The present study was designed to address the relationship between iron homeostasis and bone metabolism. Cultured hFOB 1.19 osteoblasts were incubated with selected concentrations of hepcidin (50, 100, and 200 nmol/L) for 20 h, harvested for extraction of total RNA and proteins, and the expression of ferroportin 1 was...

journal_title：Inflammation

authors： Xu Y,Zhang W,Zhang P,Xiao L,Wang A,Sirois P,Li K

更新日期：2012-06-01 00:00:00

abstract：:The present study was designed to evaluate inflammatory changes in collapsed lungs during one-lung ventilation using the assistance of a bronchoscopic microsampling probe. Serial albumin and interleukin (IL)-8 concentrations in epithelial lining fluid (ELF) were measured in seven patients undergoing resection of lung ...

journal_title：Inflammation

authors： Komatsu Y,Yamamoto H,Tsushima K,Furuya S,Yoshikawa S,Yasuo M,Kubo K,Yamazaki Y,Hasegawa J,Eguchi T,Kondo R,Yoshida K,Koizumi T

更新日期：2012-12-01 00:00:00

abstract：:Interleukin (IL)-8 and neutrophil inflammation play a vital role in the pathogenesis of chronic inflammatory airway diseases. A disintegrin and metalloproteinase 17 (ADAM17) cleaves ectodomains of various transmembrane proteins and is an important regulator of almost every cellular event. The aim of this work was to i...

journal_title：Inflammation

authors： Li Y,Yan J,Xu W,Wang H,Xia Y

更新日期：2012-06-01 00:00:00

abstract：:Alveolar macrophages (AM) are the primary target cell of the lung for inhaled mycobacterial pathogens. We investigated the effect of the synthetic lipopeptide MALP-2 on the interaction between AM from rats and Mycobacterium bovis BCG. AM were infected with M. bovis BCG at a multiplicity of infection (MOI) of 10 and th...

journal_title：Inflammation

authors： Jörgens G,Bange FC,Mühlradt PF,Pabst R,Maus UA,Tschernig T

更新日期：2009-08-01 00:00:00

abstract：:Interactions between the enteric nervous system and the immune system are suggested to play an important role in the pathophysiology of inflammatory bowel disease (IBD). This study aims to determine if chromogranin A (CgA), chromogranin B (CgB), and secretoneurin (SN) are detectable in feces (F) from patients with col...

journal_title：Inflammation

authors： Wagner M,Stridsberg M,Peterson CG,Sangfelt P,Lampinen M,Carlson M

更新日期：2013-08-01 00:00:00

abstract：:The synthetic compound 7-4-[Bis-(2-hydroxyethyl)-amino]-butoxy-5-hydroxy-8-methoxy-2-phenylchromen-4-one (V8) is a novel flavonoid-derived compound. In this study, we investigated the effects of V8 on Toll-like receptor 4 (TLR4)-mediated inflammatory reaction in human cervical cancer SiHa cells and lipopolysaccharide ...

journal_title：Inflammation

authors： He A,Ji R,Shao J,He C,Jin M,Xu Y

更新日期：2016-02-01 00:00:00

abstract：:Parthenolide, a naturally occurring sesquiterpene lactone derived from feverfew (Tanacetum parthenium), exhibits exceptional anti-cancer and anti-inflammatory properties, making it a prominent candidate for further studies and drug development. In this review, we briefly investigate molecular events and cell-specific ...

journal_title：Inflammation

authors： Mathema VB,Koh YS,Thakuri BC,Sillanpää M

更新日期：2012-04-01 00:00:00

abstract：:Current knowledge implicates pleural mesothelial cells as mainly responsible for inflammatory responses in the pleural space. However, a vast body of recent evidence underscores the important role of fibroblasts in the process of inflammation in several types of tissues. We hypothesize that HPFBs (human pleural fibrob...

journal_title：Inflammation

authors： Loghmani F,Mohammed KA,Nasreen N,Van Horn RD,Hardwick JA,Sanders KL,Antony VB

更新日期：2002-04-01 00:00:00

abstract：:Our study is based on the establishment of a cohort of human obese omental adipose tissue and the culture of adipocytes in vitro. To observe the effect of high level of free fatty acid (FFA) on the expression of DNA methyltransferases (DNMTs) and the anti-inflammatory factor Kruppel-like factor 4 (KLF4) in adipocytes ...

journal_title：Inflammation

authors： Deng Y,Qiu T,Zhang M,Wu J,Zhang X,Wang J,Chen K,Feng J,Ha X,Xie J,Wang C,Zhang J

更新日期：2020-06-01 00:00:00

abstract：:This study aims to provide experimental proof that Rab6a is an efficient target of microRNA-155 in regulating pro-inflammatory tumor necrosis factor (TNF) secretion stimulated by lipopolysaccharide (LPS) in macrophages. We identified Rab6a as a new target of microRNA-155 (miR-155) and found that overexpression of miR-...

journal_title：Inflammation

authors： Yang Y,Yang L

更新日期：2016-02-01 00:00:00

abstract：:Pig alveolar macrophages are a heterogeneous population of cells. Three subpopulations or bands exist when the whole population is separated according to density. Band 1 cells are the least dense cells and constitute 9% of the total population. Bands 2 and 3 represent 44 and 47% of the total population. The three subp...

journal_title：Inflammation

authors： Zeidler RB,Flynn JA,Arnold JC,Conley NS

更新日期：1987-09-01 00:00:00

abstract：:We aim to determine the extent of the CD40-CD40L pathway involvement in activated platelet-induced changes in human umbilical endothelial cells (HUVECs). Activated platelets were co-incubated with HUVECs in the presence or absence of CD40LmAb. HUVECs were also directly stimulated with rhCD40L. HUVEC endothelial cycloo...

journal_title：Inflammation

authors： Wu YQ,Chen XS,Chai JB

更新日期：2012-06-01 00:00:00

abstract：:The purpose of this study was to evaluate the rabbit anterior eye chamber as a quantitative measure of leukotaxis using 51Cr-labeled homologous leukocytes and then to determine the effects of ibuprofen on N-formyl-methionyl-leucyl-phenylalanine (FMLP) -induced leukotaxis. Leukocyte accumulation was assessed at various...

journal_title：Inflammation

authors： Shimanuki T,Nakamura RM,Dizerega GS

更新日期：1985-09-01 00:00:00

abstract：:This study aimed to investigate molecule B7-H3 expression profiles of patients with ankylosing spondylitis (AS) and the clinical significance of B7-H3 in the pathogenesis of AS. Serum B7-H3 levels were measured by ELISA in patients with AS and healthy controls. The expression of B7-H3 protein and mRNA on CD14+ monocyt...

journal_title：Inflammation

authors： Yan R,Hu Y,Yu P,Wen H,Feng P,Yang S

更新日期：2015-01-01 00:00:00

abstract：:Potassium voltage-gated channel subfamily Q member 1 opposite strand 1 (KCNQ1OT1), a long non-coding RNA found in the KCNQ1 locus, has been evidenced to play important roles in the aggravation of inflammatory and oxidative stresses under hypoxia, but whether and how KCNQ1OT1 contributes to neuronal damages in the cere...

journal_title：Inflammation

authors： Yi M,Li Y,Wang D,Zhang Q,Yang L,Yang C

更新日期：2020-10-01 00:00:00

abstract：:Two methods for quantitating polymorphonuclear leukocyte (PMN) accumulation in inflammatory skin lesions were studied. The lesions were produced in rats by intradermal injections of different dilutions of zymosan-activated plasma (ZAP). PMN accumulation in the skin lesions was estimated by determination of (1) homolog...

journal_title：Inflammation

authors： Lundberg C,Arfors KE

更新日期：1983-09-01 00:00:00

abstract：:Tissue macrophages can be activated by endogenous danger signals released from cells that are stressed or injured, leading to infiltration of inflammatory macrophages and neutrophils. We postulated that macrophage-related markers might be closely associated with the existence of endogenous danger signals, reflecting o...

journal_title：Inflammation

authors： Hayashi Y,Hanawa H,Jiao S,Hasegawa G,Ohno Y,Yoshida K,Suzuki T,Kashimura T,Obata H,Tanaka K,Watanabe T,Minamino T

更新日期：2015-12-01 00:00:00