Abstract：
:Parthenolide, a naturally occurring sesquiterpene lactone derived from feverfew (Tanacetum parthenium), exhibits exceptional anti-cancer and anti-inflammatory properties, making it a prominent candidate for further studies and drug development. In this review, we briefly investigate molecular events and cell-specific activities of this chemical in relation to cytochrome c, nuclear factor kappa-light-chain enhancer of activated B cells (NF-κB), signal transduction and activation of transcription (STAT), reactive oxygen species (ROS), TCP, HDACs, microtubules, and inflammasomes. This paper reports that parthenolide shows strong NF-κB- and STAT-inhibition-mediated transcriptional suppression of pro-apoptotic genes. This compound acts both at the transcriptional level and by direct inhibition of associated kinases (IKK-β). Similarly, this review discusses parthenolide-induced ROS-mediated apoptosis of tumor cells via the intrinsic apoptotic signaling pathway. The unique ability of this compound to not harm normal cells but at the same time induce sensitization to extrinsic as well as intrinsic apoptosis signaling in cancer cells provides an important, novel therapeutic strategy for treatment of cancer and inflammation-related disorders.
journal_name
Inflammationjournal_title
Inflammationauthors
Mathema VB,Koh YS,Thakuri BC,Sillanpää Mdoi
10.1007/s10753-011-9346-0subject
Has Abstractpub_date
2012-04-01 00:00:00pages
560-5issue
2eissn
0360-3997issn
1573-2576journal_volume
35pub_type
杂志文章,评审相关文献
INFLAMMATION文献大全abstract：:To investigate patients with severe acute pancreatitis (SAP) by dynamic levels of pro-/anti-inflammatory cytokines and endotoxin (ET) in plasma and the relationship between immunity and infection, organ dysfunction. Seventy-two patients with SAP were recruited. The ET, tumor necrosis factor-α (TNF-α), interleukin-6 (I...
journal_title：Inflammation
pub_type： 杂志文章
doi：10.1007/s10753-010-9205-4
更新日期：2011-02-01 00:00:00
abstract：:Interleukin (IL)-8 and neutrophil inflammation play a vital role in the pathogenesis of chronic inflammatory airway diseases. A disintegrin and metalloproteinase 17 (ADAM17) cleaves ectodomains of various transmembrane proteins and is an important regulator of almost every cellular event. The aim of this work was to i...
journal_title：Inflammation
pub_type： 杂志文章
doi：10.1007/s10753-011-9386-5
更新日期：2012-06-01 00:00:00
abstract：:Dialysate and serum levels of granulocyte-colony stimulating factor (G-CSF), granulocyte macrophage colony stimulating factor (GM-CSF) and leukemia inhibitory factor (LIF) were analyzed in patients with continuous ambulatory peritoneal dialysis (CAPD). Samples from the peritoneal effluent and from serum were obtained ...
journal_title：Inflammation
pub_type： 杂志文章
doi：10.1023/a:1022320916105
更新日期：1998-08-01 00:00:00
abstract：:Neuroinflammation is believed to be involved in the pathogenesis of neurodegenerative diseases. Our novel synthetic compound 2-acetyl-1-ethyl-7-hydroxy-6-methoxy-1, 2, 3, 4-tetrahydroisoquinoline (AETIQ) was tested for its anti-inflammatory properties in activated microglial BV-2 cells. AETIQ attenuated nitric oxide (...
journal_title：Inflammation
pub_type： 杂志文章
doi：10.1007/s10753-013-9795-8
更新日期：2014-06-01 00:00:00
abstract：:Alveolar macrophages (AM) are the primary target cell of the lung for inhaled mycobacterial pathogens. We investigated the effect of the synthetic lipopeptide MALP-2 on the interaction between AM from rats and Mycobacterium bovis BCG. AM were infected with M. bovis BCG at a multiplicity of infection (MOI) of 10 and th...
journal_title：Inflammation
pub_type： 杂志文章
doi：10.1007/s10753-009-9127-1
更新日期：2009-08-01 00:00:00
abstract：:The purpose of this study was to evaluate the rabbit anterior eye chamber as a quantitative measure of leukotaxis using 51Cr-labeled homologous leukocytes and then to determine the effects of ibuprofen on N-formyl-methionyl-leucyl-phenylalanine (FMLP) -induced leukotaxis. Leukocyte accumulation was assessed at various...
journal_title：Inflammation
pub_type： 杂志文章
doi：10.1007/BF00916277
更新日期：1985-09-01 00:00:00
abstract：:Previous data that alimentation with fish oil rich in eicosapentaenoic acid (EPA; 20:n-3) or vegetable oil rich in gamma-linolenic acid (GLA; 18:3n-6) can reduce symptoms of inflammatory skin disorders lead us to determine the effects of dietary supplements of oils rich in EPA or GLA on guinea pig (GP) neutrophil (PMN...
journal_title：Inflammation
pub_type： 杂志文章
doi：10.1007/BF00914278
更新日期：1990-10-01 00:00:00
abstract：:Icariin is a flavonoid isolated from the traditional Chinese herbal medicine Epimedium brevicornum Maxim and has been reported to be effective for the treatment of a variety of cardiovascular diseases. The aim of the present study was to investigate the effect and mechanism of icariin on atherosclerosis (AS) using a h...
journal_title：Inflammation
pub_type： 杂志文章
doi：10.1007/s10753-015-0242-x
更新日期：2016-02-01 00:00:00
abstract：:Lipopolysaccharide (LPS) increases serum TNF-alpha levels due to TNF-alpha secretion by macrophages. The serum TNF-alpha response to LPS was augmented 10x when FcgammaR ligation was induced by the intravenous injection of Gig-coated erythrocytes (IgG) prior to the administration of LPS. The macrophage population respo...
journal_title：Inflammation
pub_type： 杂志文章
doi：10.1023/a:1021468819285
更新日期：2002-12-01 00:00:00
abstract：:C3b receptor (CR1) expression by neutrophils (PMNs) and erythrocytes (Es) from patients with chronic granulomatous disease (CGD) or with hyper-IgE, frequent infection (Job's) syndrome was compared with that of control subjects. The control subjects consisted of one group of patients with infections and a second group ...
journal_title：Inflammation
pub_type： 杂志文章
doi：10.1007/BF00918218
更新日期：1984-12-01 00:00:00
abstract：:Cardiovascular diseases, including acute coronary syndrome (ACS), are the leading cause of death among humans. Adhesion proteins, owing to their involvement in the initiation and progression of atherosclerotic lesions, contribute to the progression of coronary disease and ACS occurrence. Considering ambiguosity of res...
journal_title：Inflammation
pub_type： 杂志文章
doi：10.1007/s10753-010-9198-z
更新日期：2010-12-01 00:00:00
abstract：:Neutrophil production of reactive oxygen species is dependent on an assembly process that involves a translocation of the cytosolic NADPH-oxidase components (p47phox; p67phox; Rac2) to a b cytochrome containing membrane. Based on the fact that an intracellular Ca2+ rise can activate the oxidase without any extracellul...
journal_title：Inflammation
pub_type： 杂志文章
doi：10.1023/a:1027363730746
更新日期：1997-10-01 00:00:00
abstract：:Rabbits were injected intramuscularly with cortisone acetate (2 mg/kg) on alternate days. Six days after the first injection these rabbits and controls were injected intradermally in multiple sites with BCG (the vaccine strain of tubercle bacillus). Periodically, over the next 2 months, the resulting lesions were meas...
journal_title：Inflammation
pub_type： 杂志文章
doi：10.1007/BF00910737
更新日期：1978-06-01 00:00:00
abstract：:Diabetic retinopathy (DR) is a serious-threatening complication of diabetes and urgently needed to be treated. Evidence has accumulated indicating that microglia inflammation within the retina plays a critical role in DR. Microglial matrix metalloproteinase 9 (MMP-9) has an important role in the destruction of the int...
journal_title：Inflammation
pub_type： 杂志文章
doi：10.1007/s10753-017-0571-z
更新日期：2017-10-01 00:00:00
abstract：:Ruta graveolens L. (Rutaceae) are traditionally used for the treatment of rheumatism, arthritis and other inflammatory conditions in the traditional medicine of India, were evaluated for their protective effect in acute and chronic models of inflammation. Carrageenan induced rat paw edema and adjuvant induced arthriti...
journal_title：Inflammation
pub_type： 杂志文章
doi：10.1007/s10753-009-9154-y
更新日期：2010-02-01 00:00:00
abstract：:To evaluate the role of ALA treatment on the healing of acetic acid-induced gastric ulcer, rats were given ALA (35 mg/kg/day) or saline for 3 days before the induction of ulcer and the treatment was continued twice daily for 2 days (early) or 10 days (late) until they were decapitated. Gastric ulcer index, microscopic...
journal_title：Inflammation
pub_type： 杂志文章
doi：10.1007/s10753-008-9100-4
更新日期：2009-02-01 00:00:00
abstract：:Lipids from the sputum of patients with asthma and with cystic fibrosis were isolated and characterized. In both cases, lipids constituted approximately 30% of the dry material. Phosphatidlycholine was the most abundant lipid, Significant amounts of phosphatidylethanolamine and phosphatidylglycerol were present. Hexos...
journal_title：Inflammation
pub_type： 杂志文章
doi：10.1007/BF00917319
更新日期：1978-03-01 00:00:00
abstract：:C-reactive protein (CRP) is a much used biomarker for respiratory tract infection; however, the influence of airway infection on the CRP level in the general population has not been well described. The study aimed to evaluate the impact of recent symptoms of airway infection on the CRP level and how the predictive pow...
journal_title：Inflammation
pub_type： 杂志文章
doi：10.1007/s10753-011-9405-6
更新日期：2012-06-01 00:00:00
abstract：:Calgranulins are small calcium-binding proteins with several immunological functions involved in inflammatory processes. Calgranulin A is reported to be mainly associated with acute inflammation while calgranulin B seems to play a role in chronic inflammatory disorders. In this study we used a proteomic approach to an...
journal_title：Inflammation
pub_type： 杂志文章
doi：10.1007/s10753-008-9085-z
更新日期：2008-10-01 00:00:00
abstract：:We have characterized leukocyte migration to the pleural cavity in a methylated-BSA (mBSA)-induced model of murine delayed-type hypersensitivity and evaluated the ability of IL-4 and IL-10 to modulate this response. Neutrophils, macrophages, T cells, and dendritic cells migrated to the pleural cavity in a time-depende...
journal_title：Inflammation
pub_type： 杂志文章
doi：10.1023/a:1025076111950
更新日期：2003-08-01 00:00:00
abstract：:Karyopherin-α2 (KPNA2) functions as an adaptor that transports several proteins to the nucleus. We investigated the function and possible mechanisms of KPNA2 involved in rheumatoid arthritis (RA). Western blotting and immunohistochemistry showed the protein expression of KPNA2 increased in synovial tissue of RA patien...
journal_title：Inflammation
pub_type： 杂志文章
doi：10.1007/s10753-015-0205-2
更新日期：2015-12-01 00:00:00
abstract：:After severe burns, a wound revision is often done to remove devitalized tissue and minimize bacterial growth. After such revision, the patient may show signs of sepsis. In a group of burned patients we found a transient endotoxemia, and a subsequent leukocyte activation, monitored as increased expression of the beta ...
journal_title：Inflammation
pub_type： 杂志文章
doi：10.1007/BF01534579
更新日期：1995-08-01 00:00:00
abstract：:Methicillin-resistant Staphylococcus aureus (MRSA) with exogenous cassette DNA containing the methicillin-resistant gene mecA (SCCmec) poses a problem as a drug-resistant bacterium responsible for hospital- and community-acquired infections. The frequency of MRSA detection has recently been increasing rapidly in Japan...
journal_title：Inflammation
pub_type： 杂志文章
doi：10.1007/s10753-011-9395-4
更新日期：2012-06-01 00:00:00
abstract：:Exposure to ultraviolet (UV) light impairs the function of inflammatory cells. Urocanic acid (UCA) in an stratum corneum has been suggested as a mediator in the immunosuppression of lymphoid cells detected after irradiation with UVB (UV wavelengths 280-320 nm). In this study, we examined the effects of the two UCA iso...
journal_title：Inflammation
pub_type： 杂志文章
doi：10.1007/BF01487038
更新日期：1996-10-01 00:00:00
abstract：:We investigated the molecular mechanisms underlying the role of miRNAs in the pathogenesis of psoriasis to discover novel potential diagnostic markers and treatment targets. We screened Chinese Han individuals using gene chip technology to identify differentially expressed miRNAs in the epidermal tissue of lesions fro...
journal_title：Inflammation
pub_type： 杂志文章
doi：10.1007/s10753-018-0859-7
更新日期：2018-12-01 00:00:00
abstract：:A new glycoprotein with an apparent molecular weight of 130,000 was isolated, purified, and partially characterized from the pulmonary secretions which accumulate so massively in the lungs of patients suffering from pulmonary alveolar proteinosis. The amino acid analysis of the glycoprotein showed the presence of rela...
journal_title：Inflammation
pub_type： 杂志文章
doi：10.1007/BF00913501
更新日期：1979-09-01 00:00:00
abstract：:Several experiments have detected that melatonin exerts a marked influence on the inflammatory process. In the present study we evaluated the effect of exogenous melatonin on the experimental granulomatous tissues in rat. Our data show that subcutaneous administration of different doses of melatonin given daily during...
journal_title：Inflammation
pub_type： 杂志文章
doi：10.1023/b:ifla.0000049043.89586.89
更新日期：2004-08-01 00:00:00
abstract：:To determine the effect of heat stress on histopathology of acute lung injury (ALI) caused by administration of lipopolysaccharide (LPS), and to determine the roles of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, interferon (IFN)-gamma, IL-10 and surfactants in heat-induced tolerance to ALI, we administe...
journal_title：Inflammation
pub_type： 杂志文章
doi：10.1023/a:1011040515262
更新日期：2001-06-01 00:00:00
abstract：:1-O-Alkyl-2-O-acetyl-sn-glycerol-3-phosphorylcholine (i.e., platelet-activating factor) was prepared and confirmed to possess potent platelet aggregating activity. It was also potent in aggregating and degranulating rabbit and human neutrophils. When injected into rabbits, the lipid induced profound neutropenia, throm...
journal_title：Inflammation
pub_type： 杂志文章
doi：10.1007/BF00914443
更新日期：1981-09-01 00:00:00
abstract：:Lipopolysaccharide (LPS) is demonstrated to cause "two-hit" injury to liver. Proprotein convertase subtilisin/kexin type 9 (PCSK9) plays an important role in LPS clearance. Hepatocyte nuclear factor-1 alpha (HNF-1α) and sterol regulatory element-binding protein 2 (SREBP2) were reported to be responsible for PCSK9 gene...
journal_title：Inflammation
pub_type： 杂志文章
doi：10.1007/s10753-019-01114-x
更新日期：2020-02-01 00:00:00
