Abstract:
:A new glycoprotein with an apparent molecular weight of 130,000 was isolated, purified, and partially characterized from the pulmonary secretions which accumulate so massively in the lungs of patients suffering from pulmonary alveolar proteinosis. The amino acid analysis of the glycoprotein showed the presence of relatively high amounts of glycine, glutamic acid, aspartic acid, leucine, and valine, and small amounts of hydroxyproline, but no hydroxylysine. It contains approximately 6% hexose, 3% sialic acid, and 4% glucosamine. The neutral sugars are galactose, mannose, and fucose. This alveolar glycoprotein cross-reacted with an antiserum prepared in rabbits against a larger glycoprotein (250,000 mol wt) isolated from the same source, suggesting that the larger alveolar glycoprotein may be the precursor of the smaller one.
journal_name
Inflammationjournal_title
Inflammationauthors
Sahu S,Lynn WSdoi
10.1007/BF00913501subject
Has Abstractpub_date
1979-09-01 00:00:00pages
437-45issue
4eissn
0360-3997issn
1573-2576journal_volume
3pub_type
杂志文章相关文献
INFLAMMATION文献大全abstract::Bee venom (BV) is used in folk medicine to treat arthritis. It has antiinflammatory effects in animal models of rheumatic disease. We have studied the effects of BV on human neutrophil production of superoxide (O2-) and hydrogen peroxide, finding potent, nontoxic, dose-dependent production inhibition. Melittin, the ma...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00915999
更新日期:1986-06-01 00:00:00
abstract::We have previously shown that deuterium oxide (D2O) enhances the oxidation of methionine, a myeloperoxidase (MPO) -mediated reaction, by human neutrophils during phagocytosis. However, D2O has no effect on the oxidation of methionine by the purified MPO-H2O2-Cl- system. To explain this observation, we studied the effe...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00917309
更新日期:1982-12-01 00:00:00
abstract::Air pollution events frequently occur in China during the winter. Most investigations of pollution studies have focused on the physical and chemical properties of PM2.5. Many of these studies have indicated that PM2.5 exacerbates asthma or eosinophil inflammation. However, few studies have evaluated the relationship b...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-019-01071-5
更新日期:2020-02-01 00:00:00
abstract::The adhesive interactions between phagocytes and endothelial cells (EC) can be modulated by inflammatory cytokines and chemotactic proteins which are released during an inflammatory response. The aim of the present study was to investigate first whether the adhesive properties of granulocytes and monocytes from asthma...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1023/a:1022344307926
更新日期:1998-04-01 00:00:00
abstract::We aimed to compare serum levels of the inflammatory mediators including C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), and asymmetric dimethylarginine (ADMA) in chronic obstructive pulmonary disease (COPD), obstructive sleep apnea syndrome (OSAS), and their coexistence called overlap syndrome (OVS). In ad...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-012-9520-z
更新日期:2013-02-01 00:00:00
abstract::A full understanding of rheumatoid arthritis depends on the appreciation of clinical, radiological, immunological, genetic, biochemical, and structural mechanisms. Rheumatoid arthritis is characterized by the destruction of tissue structures such as articular cartilage and bone, but may also involve tendonous tissue, ...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00915710
更新日期:1984-06-01 00:00:00
abstract::Nicotine has anti- and pro-inflammatory properties in various cells. Its role in aortic vascular smooth muscle cells (VSMC) was explored. Human aortic VSMC were cultured. After nicotine (1.0 μM) and/or pyrrolidinedithiocarbamic acid (PDTC, 50 μM) treatment, the activation of nuclear factor κB (NFκB) was investigated. ...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-011-9324-6
更新日期:2012-02-01 00:00:00
abstract::NSAIDs are widely used to alleviate the symptoms of OA. It remains controversial as to what effects these agents have on the progression of OA. In vitro studies showed several types of NSAIDs (e.g., sodium salicylate, indomethacin) inhibited the synthesis of cartilage matrix component, but some types of NSAIDs (e.g., ...
journal_title:Inflammation
pub_type: 杂志文章,评审
doi:10.1023/a:1015504632021
更新日期:2002-06-01 00:00:00
abstract::Macrophage polarization is a dynamic and integral process of tissue inflammation and remodeling. Here we demonstrate an important role of Aurora kinase A in the regulation of inflammatory M1 macrophage polarization. We found that there was an elevated expression of Aurora-A in M1 macrophages and inhibition of Aurora-A...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-014-9990-2
更新日期:2015-04-01 00:00:00
abstract::The influences of extracellular Ca2+ and Mg2+ on chemotactic factor-induced rabbit polymorphonuclear neutrophil (PMN) aggregation was studied using a recently described Coulter counter assay technique. Compared with those of other PMN functional assays (adhesion, chemotaxis, degranulation, and phagocytosis), the catio...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00921006
更新日期:1977-12-01 00:00:00
abstract::Drug delivery into immune cells has high potential for the treatment of all kinds of inflammation, allowing a target-oriented transport of active agents. The advantage of this local drug release is the prevention of negative effects of systemic applications and low-dose application. Thereby, the phagocytotic capabilit...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-010-9213-4
更新日期:2011-04-01 00:00:00
abstract::Simvastatin, which is primarily prescribed to lower cholesterol, may also mitigate lung injury caused by sepsis, although the mechanisms remain elusive. This study aimed to evaluate the protective effect of simvastatin on acute lung injury in rats with sepsis and to investigate possible mechanisms. Male Wistar rats we...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-017-0668-4
更新日期:2018-02-01 00:00:00
abstract::The objective of this study was to compare systemic and local cytokine profiles and neutrophil responses in patients with severe versus non-severe community-acquired pneumonia (CAP). Hospitalized patients with CAP were grouped according to the pneumonia severity index (PSI), as non-severe (PSI < 91 points) or severe (...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-014-9840-2
更新日期:2014-08-01 00:00:00
abstract::Acute lung injury (ALI) is a serious disease with morbidity and mortality in patients. Engeletin (dihydrokaempferol 3-rhamnoside) is a flavanonol glycoside. It can be found in the skin of white grapes and white wine and is widely distributed in southeast Asia. In our study, we evaluated the protective and therapeutic ...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-018-0773-z
更新日期:2018-08-01 00:00:00
abstract::In vivo effects of cytokine-induced neutrophil chemotactic factor (CINC) derived from rats on neutrophil infiltration were investigated using an air-pouch-type inflammation model in rats, and effects of dexamethasone on neutrophil infiltration induced by CINC was also examined in order to gain further insight into the...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00918958
更新日期:1992-04-01 00:00:00
abstract::An acute neutrophilic lung injury was compared in Balb/c normal and nu/nu (nude) mice to assess the role of T lymphocytes in the resolution of acute pulmonary neutrophilic inflammation following the administration of endotoxin. Maximal neutrophilic infiltration occurred on day 1 post-endotoxin treatment and declined t...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1023/a:1027393715300
更新日期:1997-06-01 00:00:00
abstract::Inflammatory cells, macrophages induced by lipopolysaccharide (LPS) stimulation, lead to the production of inflammatory cytokines, which are crucial to host defense. MicroRNAs are short noncoding RNAs that regulate key biological processes via suppression of gene expression at posttranscriptional levels. Recently, miR...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-013-9713-0
更新日期:2014-02-01 00:00:00
abstract::It has been well established that diet high in cholesterol and saturated fatty acids could significantly elevate plasma cholesterol levels and also increase the risk of cardiovascular diseases. We hypothesize that repeated systemic Escherichia coli (E. coli) in conjunction with hypercholesterolemia, leads to developme...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-009-9107-5
更新日期:2009-04-01 00:00:00
abstract::Myeloperoxidase (MPO), next to the NO synthase2 (NOS2), and NADPH oxidase, is the key enzyme of the oxidative burst responsible for the antimicrobial immunity. Because MPO participates in the eradication of Mycobacterium tuberculosis in the in vitro model and the extracellular enzyme may activate cells to cytokine syn...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1023/b:ifla.0000033020.28446.a6
更新日期:2004-04-01 00:00:00
abstract::The effects of an intravenous injection (i.v.) of Sephadex beads (20 mg kg(-1)) were examined on bronchial responsiveness to ACh (1-200 microg kg(-1) i.v.) as well as on cell accumulation in guinea-pig lung. Bronchial hyperreactivity to ACh, measured as increase in pulmonary insufflation pressure (PIP), was observed 3...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1023/a:1021913009742
更新日期:1999-10-01 00:00:00
abstract::Chronic obstructive pulmonary disease (COPD) is a common chronic inflammatory disease with high morbidity and mortality rates. Cystatin C (Cys C) is a sensitive indicator for various chronic inflammatory diseases. In this study, we aimed to evaluate the role of Cys C in COPD patients comparing with the other well-know...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-015-0287-x
更新日期:2016-04-01 00:00:00
abstract::Baicalin, a flavonoid monomer derived from Scutellaria baicalensis called Huangqin in mandarin, is the main active ingredient contributing to S. baicalensis' efficacy. It is known in China that baicalin has potential therapeutic effects on inflammatory diseases. However, its anti-inflammatory mechanism has still not b...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-015-0124-2
更新日期:2015-08-01 00:00:00
abstract::Previous data that alimentation with fish oil rich in eicosapentaenoic acid (EPA; 20:n-3) or vegetable oil rich in gamma-linolenic acid (GLA; 18:3n-6) can reduce symptoms of inflammatory skin disorders lead us to determine the effects of dietary supplements of oils rich in EPA or GLA on guinea pig (GP) neutrophil (PMN...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00914278
更新日期:1990-10-01 00:00:00
abstract::We analyzed the effect of the PAF receptor antagonist (+)-cis-3,5-dimethyl-2-(3-pyridyl)thiazolidin-4-one hydrochloride (SM-12502) on human platelet aggregation as well as mediator release. After incubation of human platelet with different concentrations of SM-12502 the cells were subsequently stimulated with either t...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF01487746
更新日期:1996-02-01 00:00:00
abstract::This study investigated the protective effect of Lactobacillus plantarum NDC 75017 (L. plantarum NDC 75017) against acute liver injury induced by lipopolysaccharide (LPS). Thirty male mice were randomly divided into the control, LPS, and LPS + L. plantarum NDC 75017 groups. In the LPS + L. plantarum group, the mice we...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-014-9886-1
更新日期:2014-10-01 00:00:00
abstract::The present study evaluated the anti-inflammatory effect of nanoencapsulated curcuminoid preparations of poly(vinyl pyrrolidone) (Nano-cur) and free curcuminoids (Cur) in an experimental model of croton oil-induced cutaneous inflammation. Male Swiss mice, weighing 25-30 g, received oral treatment by gavage 1 h before ...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-020-01360-4
更新日期:2020-11-09 00:00:00
abstract::The aim of this study was to investigate the effect of high-intensity swimming exercise (HISE) on atopic dermatitis (AD). For the study, we established an AD model in BALB/c mice by repeated local exposure of house dust mite extract (Dermatophagoides farinae extract, DFE) and 1-chloro-2,4-dinitrobenzene (CDNB) to the ...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-014-9843-z
更新日期:2014-08-01 00:00:00
abstract::Chemerin is shown to be associated with inflammation which is involved in the pathogenesis of diabetic nephropathy. This study aims to determine whether rosiglitazone and pioglitazone ameliorate renal function through an effect on the expression of chemerin and ChemR23 in streptozotocin-induced diabetic rats. The rats...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-012-9440-y
更新日期:2012-08-01 00:00:00
abstract::Corynoline, a bioactive compound isolated from Corydalis bungeana Turcz., has been known to have anti-inflammatory activity. However, its effects on the inflammation of the cardiovascular system have not been reported yet. The aim of this study was to investigate the anti-inflammatory effects of corynoline on lipopoly...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-018-0807-6
更新日期:2018-10-01 00:00:00
abstract::Platelets activated with physiological agonists, such as thrombin, ADP, or collagen, released products able to modulate neutrophil functions. In particular, platelet supernatant contained an inhibitor of superoxide anion generation induced by phorbol ester and a chemotactic factor for human neutrophils. The proteolyti...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00918954
更新日期:1992-04-01 00:00:00